КЛІНІЧНИЙ ВИПАДОК ГІПЕРПРОЛАКТИНЕМІЇ, ПОЄДНАНОЇ ІЗ ПІДВИЩЕННЯМ ТИРЕОТРОПНОГО ГОРМОНУ

Results and Discussion. Hyperprolactinemia is a permanent increased prolactin level in the blood plasma. It occurs in the form of physiological and pathological forms in women and men which frequency is near 17 cases per 100000 inhabitants. Hyperprolactinemia may be caused by pituitary tumors, primary hypothyroidism, chronic renal failure, liver cirrhosis, polycystic ovary syndrome and usage of some medications. Frequency of idiopathic hyperprolactinemia is near 30–40 %. Combination of hyperprolactinemia with high concentration of thyroid stimulating hormone results in a necessity to differentiate mixed pituitary adenoma and hyperprolactinemia that is a symptom of hypothyroidism. The article presents clinical case of hyperprolactinemia, combined with high level of thyroid stimulating hormone in the blood. Patient complained with general weakness fatigue and frequent headache due to intensity of school studying. Increased levels of TSH, prolactin and free thyroxine in the blood were diagnosed. Concentration of growth hormone, luteinizing, follicle-stimulating hormones and cortisol in the blood were normal. Locus with sizes 4×3 mm (possibly ade­noma) was found in the left part of the adenohypophysis. Case follow-up period included measurement of prolactin, TSH and free thyroxin in the blood and pituitary magnetic resonance. Treatment scheme was administered that included cabergoline, medication with dry extract of chaste tree fruits and L-thyroxine that let to achieve normoprolactin­aemia without decreasing of prolactin concentration below normal and keep TSH concentration up in normal range without causing symptoms of L-thyroxine overdose.Результати й обговорення. Гіперпролактинемія є стійким підвищенням вмісту пролактину в плазмі крові. Вона буває у вигляді фізіологічної і патологічної форм у жінок і чоловіків, частота якої складає близько 17 випадків на 100 тис. населення. Причинами гіперпролактинемії є пухлини гіпофіза, первинний гіпотиреоз, хронічна ниркова недостатність, цироз печінки, синдром полікістозних яєчників, приймання ряду лікарських засобів. Частота ідіопатичних гіперпролактинемій складає близько 30–40 %. Поєднання гіперпролактинемії із високою концентрацією ТТГ потребує диференціювати змішану аденому гіпофіза з гіперпролактинемією як проявом гіпотиреозу. В статті наведено клінічний випадок гіперпролактинемії, що поєднувалася із високою концентрацією ТТГ у крові. Пацієнтку турбували загальна слабість, втомлюваність, частий головний біль, що пов’язувала зі значною інтенсивністю навчання у школі. Виявлено підвищені рівні тиреотропного гормону в крові, пролактину і тироксину вільного. Вміст соматотропного, лютеїнізуючого, фолікулостимулюючого гормонів та кортизолу крові був у межах норми. В лівій половині аденогіпофіза виявлено вогнище розмірами 4×3 мм (ймовірніше мікроаденома). Проведено динамічне спостереження із визначенням рівнів пролактину, тиреотропного гормону і тироксину вільного, а також магнітно-резонансного дослідження гіпофіза. Лікування з комбінацією каберголіном, лікарським засобом, що містить сухий екстракт плодів прутняка звичайного, а також L-тироксином, дозволило досягти нормопролактинемії без зниження вмісту пролактину менше норми та утримувати рівень тиреотропного гормону та тироксину вільного в межах норми, не спричиняючи при цьому симптомів передозування L-тироксину

A Randomized Open Clinical Study of the Atherosclerosis Treatment Information Video Effect on Adherence to Long-Term Therapy in Patients with Cardiovascular Diseases

Aim. Study the effect of a study video, which was created by researchers and devoted to the atherosclerosis development and the effect of statin therapy on atherosclerotic plaque, on adherence to long-term therapy in patients with high or very high risk of cardiovascular complications.Material and methods. 120 patients admitted to hospital with cardiovascular diseases were included in the study. Patients were randomized into 2 groups: in the main group (n=60), the information video edited by the researchers was shown to patients on the eve of discharge, in addition to a printed brochure on lifestyle and diet modification, and in the control group (n=60), patients were given only a standard brochure. The motivating video shows the damage to the cardiovascular system by the atherosclerotic process and the beneficial effect on the body of constant intake of statins. After 1 and 3 months after discharge from the hospital, telephone calls were made, after which the patients had to visit the center for an objective examination by a researcher and control of laboratory parameters. After 1 month, 110 patients visited the center, after 3 months, 98 respondents visited the center.Results. The group with the information video demonstration noted more frequent adherence to medical recommendations compared to the control: after 1 month, 52 (96%) patients continued treatment versus 48 (86%) patients, 3 months after discharge 48 (96%) patients continued treatment versus 38 (79%) patients (p<0.05). After 1 month, 38 (70%) patients in the intervention group continued taking statins versus 29 (43%) respondents in the control group (p<0.05), 3 months after discharge, 40 (80%) patients in the intervention group continued to take statins versus 33 (69%) control patients (p<0.09).Conclusion. Demonstration of a motivating video about the effect of statins on the atherosclerosis course increases patient adherence to medicinal therapy, including adherence to statins

ИСПОЛЬЗОВАНИЕ МЕДНЫХ ИНДИКАТОРНЫХ ЭЛЕКТРОДОВ В ВОЛЬТАМПЕРОМЕТРИЧЕСКОМ АНАЛИЗЕ

The review describes the application of solid electrodes based on copper for voltammetric analysis of major classes of organic and inorganic substances over the last fifty years. Despite the fact that there are many reviews of individual solid electrodes this review offers the first comprehensive report on all forms of copper electrodes. The advantages and disadvantages of copper electrodes in comparison with electrodes made of other metals are discussed. Varieties of copper electrodes, their basic physico-chemical properties and some specific characteristics of their surface are described. The electrochemical behavior of copper in aqueous solutions and electrocatalytic mechanisms of transformations of matter on its surface are reported. Examples of the use of electrochemical copper sensors for flow-injection analysis and liquid chromatography are given. Recent trends of the use of copper micro- and nanostructured electrodes in electrochemical analysis are reviewed. The prospects of using copper as a material for the creation of new electrochemical sensors are shown.В обзоре рассматривается применение твердых электродов на основе меди для вольтамперометрического анализа основных классов органических и неорганических веществ за последние пятьдесят лет. Обсуждаются преимущества и недостатки медных электродов по сравнению с электродами из других металлов. Описаны электрохимическое поведение меди в водных растворах и механизмы электрокаталитических превращений вещества на её поверхности. Приведены примеры использования электрохимических медных датчиков для проточно-инжекционного анализа и жидкостной хроматографии. Рассмотрены современные тенденции использования медных микро- и наноструктурированных электродов в электрохимическом анализе. Показаны перспективы применения меди в качестве материала для создания новых электрохимических сенсоров

Acute diseases of the scrotum in newborn infantsand children of the first year of life

The article presents the results of a retrospective analysis of the treatment of 64 newborns and infants with acute diseases of the scrotal organ received by the department of surgery of the newborn Regional Children’s Clinical Hospital №1 of Yekaterinburg from 2007 to 2017. The structure of acute diseases of the scrotum organs in infants, the features of the clinic, specialized assistance. The most significant factors were identified, and risk groups were identified. It is established that the intrauterine testicle is the largest risk group.В статье представлены результаты ретроспективного анализа лечения 64 новорожденных и детей грудного возраста с острыми заболеваниями органов мошонки, поступивших в отделение хирургии новорожденных ОДКБ № 1 г. Екатеринбурга с 2007-го до 2017 год. Проанализированы структура острых заболеваний органов мошонки у детей раннего возраста, особенности клиники, сроки оказания специализированной помощи. Определены наиболее значимые факторы, выделены группы риска. Установлено, что внутриутробный заворот яичка составляет наибольшую группу риска

Эластичные наполнители - продукты вторичной переработки резин, получаемые методом высокотемпературного сдвигового измельчения

In this article matters of investigation of basic physical, chemical and technical properties of a product of recycling rubber by means of high-temperature shift crushing deformation are considered.В работе рассмотрены вопросы, связанные с изучением основных физико-химических и технических свойств продукта вторичной переработки резины, получаемого методом высокотемпературного сдвигового измельчения (ВСИ), на основе отработанных шин и резинотехнических изделий

Исследование влияния эластичных наполнителей на свойства эластомерных материалов

The article concerns an investigation of the influence of elastic fillers ratio - factice and the product of rubber recycling - on the properties of elastomeric materials based of binary polymer blend IR-BR.В работе рассмотрены вопросы, связанные с изучением влияния соотношения эластичных наполнителей - фактиса и продукта вторичной переработки резин на комплекс свойств эластомерных материалов на основе смеси каучуков СКИ-3-СКД

A Study of Strange Particles Produced in Neutrino Neutral Current Interactions in the NOMAD Experiment

Results of a detailed study of strange particle production in neutrino neutral current interactions are presented using the data from the NOMAD experiment. Integral yields of neutral strange particles (K0s, Lambda, Lambda-bar) have been measured. Decays of resonances and heavy hyperons with an identified K0s or Lambda in the final state have been analyzed. Clear signals corresponding to K* and Sigma(1385) have been observed. First results on the measurements of the Lambda polarization in neutral current interactions have been obtained.Comment: Accepted for publication in Nuclear Physics B as a rapid communicatio

JUNO Conceptual Design Report

The Jiangmen Underground Neutrino Observatory (JUNO) is proposed to determine the neutrino mass hierarchy using an underground liquid scintillator detector. It is located 53 km away from both Yangjiang and Taishan Nuclear Power Plants in Guangdong, China. The experimental hall, spanning more than 50 meters, is under a granite mountain of over 700 m overburden. Within six years of running, the detection of reactor antineutrinos can resolve the neutrino mass hierarchy at a confidence level of 3-4$\sigma$, and determine neutrino oscillation parameters $\sin^2\theta_{12}$, $\Delta m^2_{21}$, and $|\Delta m^2_{ee}|$ to an accuracy of better than 1%. The JUNO detector can be also used to study terrestrial and extra-terrestrial neutrinos and new physics beyond the Standard Model. The central detector contains 20,000 tons liquid scintillator with an acrylic sphere of 35 m in diameter. $\sim$17,000 508-mm diameter PMTs with high quantum efficiency provide $\sim$75% optical coverage. The current choice of the liquid scintillator is: linear alkyl benzene (LAB) as the solvent, plus PPO as the scintillation fluor and a wavelength-shifter (Bis-MSB). The number of detected photoelectrons per MeV is larger than 1,100 and the energy resolution is expected to be 3% at 1 MeV. The calibration system is designed to deploy multiple sources to cover the entire energy range of reactor antineutrinos, and to achieve a full-volume position coverage inside the detector. The veto system is used for muon detection, muon induced background study and reduction. It consists of a Water Cherenkov detector and a Top Tracker system. The readout system, the detector control system and the offline system insure efficient and stable data acquisition and processing.Comment: 328 pages, 211 figure