SOCIAL-PSYCHOLOGICAL PREREQUISITES FOR FORMING THE YOUTH’S SELF-PERFORMANCE

In the article the questions of forming independency and separation from parent family by modern young people are reviewed. Characteristics of independency are described, reasoning is given that nurturing of independency requires forming of dedication, independency, breadth of views, thinking, flexibility of mind and deals, enterprise and sober analysis of situations and events going on in life. Results of the study of preconditions to forming independency in modern students are given. Preconditions that had been found as a result of the questionnaire, are proved by data from the expert survey

SOCIAL-PSYCHOLOGICAL PREREQUISITES FOR FORMING THE YOUTH’S SELF-PERFORMANCE

In the article the questions of forming independency and separation from parent family by modern young people are reviewed. Characteristics of independency are described, reasoning is given that nurturing of independency requires forming of dedication, independency, breadth of views, thinking, flexibility of mind and deals, enterprise and sober analysis of situations and events going on in life. Results of the study of preconditions to forming independency in modern students are given. Preconditions that had been found as a result of the questionnaire, are proved by data from the expert survey

«Marshall Plan» for Donbass: prerequisites for investment development

The preconditions for restoration and investment development of Donbass according to the international "Marshall Plan" in case of peaceful settlement of armed conflict are determined. Significant advantages of Donbass as an object of the Marshall Plan implementation are shown, in particular, depending on the stages of the peaceful settlement in the Donbass, as well as the directions of investment of the enterprises of the largest cities of Donbas. The proposed estimation of volumes of annual investments, receipt of additional products, possibilities of its immediate consumption is offered.Визначено передумови відновлення й інвестиційного розвитку Донбасу згідно з міжнародним «Планом Маршалла» у разі мирного врегулювання збройного конфлікту. Показано суттєві переваги Донбасу як об’єкту запровадження «плану Маршалла», зокрема, у залежності від етапів мирного врегулювання в Донбасі, а також напрямки інвестування підприємств найбільших міст Донбасу. Запропоновано укрупнену оцінку обсягів щорічних інвестицій, отримання додаткової продукції, можливості її негайного споживання.Определены предпосылки восстановления и инвестиционного развития Донбасса в соответствии с международным «Планом Маршалла» в случае мирного урегулирования вооруженного конфликта. Показаны существенные преимущества Донбасса как объекта осуществления «плана Маршалла», в частности, в зависимости от этапов мирного урегулирования в Донбассе, а также направления инвестирования предприятий крупнейших городов Донбасса. Предложена укрупненная оценка объемов ежегодных инвестиций, получения дополнительной продукции, возможности ее немедленного потребления

Socio-psychological diagnostics and forecasting protest behavior of youth in the digital environment

The article provides the results of a search empirical study of the impact of digital communications on the protest behavior of young people in the digital environment. The authors conducted the study on the basis of the State University of Management from November 2019 to April 2020. In the course of its implementation, the civil and political practices of student youth during the first wave of the COVID-19 pandemic and mass self-isolation were studied and updated. The paper determines the most common forms of protest activity of university students, names the main reasons for their participation or non-participation in mass protest actions. It has been empirically proven that the increase in protest behavior of young people is determined by an increase in the amount of political information with a high number of likes and reposts. In order to deactivate protest moods among young people, reduce the threats of their protest behavior and improve attitudes towards the authorities, the authors developed practical recommendations that involve social monitoring of sites, forums, pages and communities on the Internet, where young people can freely express their opinions, express dissatisfaction, and receive explanations about the actions of the authorities. The study also recommends to stimulate “feedback” with the authorities, improve public opinion on the actions or inaction of the authorities, increase the influence of citizens’ assessments on the work of state and municipal authorities. The paper states the importance of tracking youth groups prone to extremism, carrying out preventive measures with students in schools, students in colleges and universities, teaching them legal literacy. To get answers to questions about the political and economic consequences awaiting our country after the end of the coronavirus pandemic, as well as about the essence of the predicted threats, the authors plan the study on a more representative sample

High-resolution NMR structure of the antimicrobial peptide protegrin-2 in the presence of DPC micelles

© 2014 Springer Science+Business Media Dordrecht. PG-1 adopts a dimeric structure in dodecylphosphocholine (DPC) micelles, and a channel is formed by the association of several dimers but the molecular mechanisms of the membrane damage by non-α-helical peptides are still unknown. The formation of the PG-1 dimer is important for pore formation in the lipid bilayer, since the dimer can be regarded as the primary unit for assembly into the ordered aggregates. It was supposed that only 12 residues (RGGRL-CYCRR-RFCVC-V) are needed to endow protegrin molecules with strong antibacterial activity and that at least four additional residues are needed to add potent antifungal properties. Thus, the 16-residue protegrin (PG-2) represents the minimal structure needed for broad-spectrum antimicrobial activity encompassing bacteria and fungi. As the peptide conformation and peptide-to-membrane binding properties are very sensitive to single amino acid substitutions, the solution structure of PG-2 in solution and in a membrane mimicking environment are crucial. In order to find evidence if the oligomerization state of PG-1 in a lipid environment will be the same or not for another protegrins, we investigate in the present work the PG-2 NMR solution structure in the presence of perdeuterated DPC micelles. The NMR study reported in the present work indicates that PG-2 form a well-defined structure (PDB: 2MUH) composed of a two-stranded antiparallel β-sheet when it binds to DPC micelles

Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: A high-resolution NMR study

© 2015 Springer Science+Business Media Dordrecht. A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore formation. Generally there are two distinct model of PG-1 dimerization in either a parallel or antiparallel β-sheet. But despite the wealth of data available today, protegrin dimer structure and pore formation is still not completely understood. In order to investigate a more detailed dimerization process of PG-1 and if it will be the same for another type of protegrins, in this work we used a high-resolution NMR spectroscopy for structure determination of protegrin-3 (RGGGL-CYCRR-RFCVC-VGR) in the presence of perdeuterated DPC micelles and demonstrate that PG-3 forms an antiparallel NCCN dimer with a possible association of these dimers. This structural study complements previously published solution, solid state and computational studies of PG-1 in various environments and validate the potential of mean force simulations of PG-1 dimers and association of dimers to form octameric or decameric β-barrels

Influence of Antioxidant SkQ1 on Accumulation of Mitochondrial DNA Deletions in the Hippocampus of Senescence-Accelerated OXYS Rats

Human and animal aging is associated with gradual decline of cognitive functions (especially learning ability and memory) and increased risk of development of neurodegenerative diseases 596 Abbreviations: bp, base pairs; mtDNA, mitochondrial DNA; ∆mtDNA, deletion in mitochondrial DNA; ∆mtDNA 4834 , 4834-bp mitochondrial DNA deletion; ROS, reactive oxygen species; SkQ1, antioxidant 10-(6′-plastoquinonyl)decyltriphenylphosphonium. * To whom correspondence should be addressed. Abstract-Reduction of efficiency of oxidative phosphorylation associated with aging and the development of neurodegenerative diseases including Alzheimer's disease is thought to be linked to the accumulation of deletions in mitochondrial DNA (∆mtDNA), which are seen as a marker of oxidative damage. Recently, we have shown that mitochondria-targeted antioxidant SkQ1 (10-(6′-plastoquinonyl)decyltriphenylphosphonium) can slow the development of signs of Alzheimer's disease in senescence-accelerated OXYS rats. The purpose of this study was to explore the relationship between the development of neurodegenerative changes in the brain of OXYS rats and changes in the amount of mtDNA and the 4834-bp mitochondrial DNA deletion (∆mtDNA 4834 ) as well as the effect of SkQ1. We studied the relative amount of mtDNA and ∆mtDNA 4834 in the hippocampus of OXYS and Wistar (control) rats at ages of 1, 2, 6, 10, and 20 days and 3, 6, and 24 months. During the period crucial for manifestation of the signs of accelerated aging of OXYS rats (from 1.5 to 3 months of age), we evaluated the effects of administration of SkQ1 (250 nmol/kg) and vitamin E (670 mmol/kg, reference treatment) on the amount of mtDNA and ∆mtDNA 4834 and on the formation of the behavioral feature of accelerated senescence in OXYS rats -passive type of behavior in the open field test. In OXYS rats, the level of ∆mtDNA 4834 in the hippocampus is increased compared to the Wistar rats, especially at the stage of completion of brain development in the postnatal period. This level remains elevated not only at the stages preceding the manifestation of the signs of accelerated brain aging and the development of pathological changes linked to Alzheimer's disease, but also during their progression. However, at age of 24 months, there were no detectable differences between the two strains. SkQ1 treatment reduced the level of ∆mtDNA 4834 in the hippocampus of Wistar and OXYS rats and slowed the formation of passive behavior in OXYS rats. These results support the possible use of SkQ1 for prophylaxis of brain aging. Influence of Antioxidant SkQ1 o

Cytokine profile in hospitalized patients with COVID-19 of different severity

Analysis of cytokine profile markers in conjunction with the clinical manifestations of coronavirus disease 2019 (COVID-19) can provide valuable information about the pathogenetic manifestations of the disease, and therefore, in the future, determine drugs that affect the cytokine storm and have an anti-inflammatory effect.Aim. To identify correlations between the parameters of the developed cytokine profile and the clinical course in hospitalized patients with COVID-19 of different severity.Material and methods. The study included 70 hospitalized patients with a confirmed diagnosis of COVID-19, with a mean age of 58 [50;69] years, including 40 men (57%) and 30 women (43%). The average lung involvement according to computed tomography (CT) at admission was CT-2 [1;3]. Peripheral venous blood was taken at admission, which averaged 7 [6; 8] days from the symptom onset. Standard biochemical parameters were studied, as well as 47 cytokines and chemokines using the Multiplex system (Merck KGaA, Darmstadt, Germany).Results. Correlations was found between the lung involvement degree and the level of IL-8 (r=0,31, p<0,05), IL-15 (r=0,35, p<0,05), IL-18 (r=0,31, p<0,05), MCP-1 (r=0,36, p<0,05), MIG (r=0,50, p<0,05), TNF-α (r=0,41, p<0,05). An inverse correlation was also found in the level of blood oxygen saturation with the same indicators as follows: IL-8 (r=-0,27, p<0,05), IL-15 (r=-0,34, p<0,05), IL-18 (r=-0,31, p<0,05), MCP-1 (r=-0,40, p<0,05), MIG (r=-0,56, p<0,05), TNF-α (r=-0,45, p<0,05). IL-6 levels were significantly elevated in patients with severe COVID-19 (CT3, CT4), while no increase in IL-6 was observed in patients with moderate disease (CT1, CT2). It is noteworthy that in patients with diabetes, the highest values of IL-12, IL-9 were recorded.Conclusion. Hyperinflammatory syndrome in severe COVID-19 is manifested by high levels of IL-6, MIG, MDC, MCP-1, M-CSF, TNF-α, β, IL-8, IL-18, IL-15. With the CT-1 and CT-2, an increase in only the level of IL-18, IL-8 is noted. The identified patterns prove and make it possible to explain a number of systemic inflammatory changes that occur with COVID-19

Challenges in QCD matter physics - The Compressed Baryonic Matter experiment at FAIR

Substantial experimental and theoretical efforts worldwide are devoted to explore the phase diagram of strongly interacting matter. At LHC and top RHIC energies, QCD matter is studied at very high temperatures and nearly vanishing net-baryon densities. There is evidence that a Quark-Gluon-Plasma (QGP) was created at experiments at RHIC and LHC. The transition from the QGP back to the hadron gas is found to be a smooth cross over. For larger net-baryon densities and lower temperatures, it is expected that the QCD phase diagram exhibits a rich structure, such as a first-order phase transition between hadronic and partonic matter which terminates in a critical point, or exotic phases like quarkyonic matter. The discovery of these landmarks would be a breakthrough in our understanding of the strong interaction and is therefore in the focus of various high-energy heavy-ion research programs. The Compressed Baryonic Matter (CBM) experiment at FAIR will play a unique role in the exploration of the QCD phase diagram in the region of high net-baryon densities, because it is designed to run at unprecedented interaction rates. High-rate operation is the key prerequisite for high-precision measurements of multi-differential observables and of rare diagnostic probes which are sensitive to the dense phase of the nuclear fireball. The goal of the CBM experiment at SIS100 (sqrt(s_NN) = 2.7 - 4.9 GeV) is to discover fundamental properties of QCD matter: the phase structure at large baryon-chemical potentials (mu_B > 500 MeV), effects of chiral symmetry, and the equation-of-state at high density as it is expected to occur in the core of neutron stars. In this article, we review the motivation for and the physics programme of CBM, including activities before the start of data taking in 2022, in the context of the worldwide efforts to explore high-density QCD matter.Comment: 15 pages, 11 figures. Published in European Physical Journal