1,064 research outputs found
Cinacalcet Treatment of Primary Hyperparathyroidism
Although parathyroidectomy remains the only curative approach to most primary hyperparathyroidism cases, medical treatment with cinacalcet HCl has been proven to be a reasonable alternative for several patient subgroups. Cinacalcet almost always controls hypercalcemia and hypophosphatemia sufficiently. PTH levels are lowered, and cognitive parameters improve. While an increase in bone mineral density DEXA scan scores was not demonstrated in cinacalcet trials, the same applies to more than half of patients after parathyroidectomy. Medical therapy should be first choice in patients with hyperplasia in all glands rather than an isolated adenoma (10–15%), patients with persisting HPT following unsuccessful surgery or inoperable cases due to comorbidities, and patients detected in lab screens for hypercalcemia before developing symptoms who should be treated early but are usually reluctant to undergo surgery. Nephrolithiasis was not found to occur more frequently in cinacalcet trial groups, but urine calcium excretion as one major risk factor of this complication of primary HPT may increase on cinacalcet. Patients carrying the rs1042636 polymorphism of the calcium-sensing receptor gene respond more sensitively to cinacalcet and have a higher risk of calcium stone formation. Cinacalcet is usually administered twice daily but three or four doses per day should be discussed to mimic the beneficial pulsatile PTH-pattern
The role of clustering and gridlike ordering in epidemic spreading
The spreading of an epidemic is determined by the connectiviy patterns which
underlie the population. While it has been noted that a virus spreads more
easily on a network in which global distances are small, it remains a great
challenge to find approaches that unravel the precise role of local
interconnectedness. Such topological properties enter very naturally in the
framework of our two-timestep description, also providing a novel approach to
tract a probabilistic system. The method is elaborated for SIS-type epidemic
processes, leading to a quantitative interpretation of the role of loops up to
length 4 in the onset of an epidemic.Comment: Submitted to Phys. Rev. E; 15 pages, 11 figures, 5 table
Bias reduction in traceroute sampling: towards a more accurate map of the Internet
Traceroute sampling is an important technique in exploring the internet
router graph and the autonomous system graph. Although it is one of the primary
techniques used in calculating statistics about the internet, it can introduce
bias that corrupts these estimates. This paper reports on a theoretical and
experimental investigation of a new technique to reduce the bias of traceroute
sampling when estimating the degree distribution. We develop a new estimator
for the degree of a node in a traceroute-sampled graph; validate the estimator
theoretically in Erdos-Renyi graphs and, through computer experiments, for a
wider range of graphs; and apply it to produce a new picture of the degree
distribution of the autonomous system graph.Comment: 12 pages, 3 figure
High-power ultrafast thin disk laser oscillators and their potential for sub-100-femtosecond pulse generation
Ultrafast thin disk laser oscillators achieve the highest average output powers and pulse energies of any mode-locked laser oscillator technology. The thin disk concept avoids thermal problems occurring in conventional high-power rod or slab lasers and enables high-power TEM00 operation with broadband gain materials. Stable and self-starting passive pulse formation is achieved with semiconductor saturable absorber mirrors (SESAMs). The key components of ultrafast thin disk lasers, such as gain material, SESAM, and dispersive cavity mirrors, are all used in reflection. This is an advantage for the generation of ultrashort pulses with excellent temporal, spectral, and spatial properties because the pulses are not affected by large nonlinearities in the oscillator. Output powers close to 100W and pulse energies above 10μJ are directly obtained without any additional amplification, which makes these lasers interesting for a growing number of industrial and scientific applications such as material processing or driving experiments in high-field science. Ultrafast thin disk lasers are based on a power-scalable concept, and substantially higher power levels appear feasible. However, both the highest power levels and pulse energies are currently only achieved with Yb:YAG as the gain material, which limits the gain bandwidth and therefore the achievable pulse duration to 700 to 800fs in efficient thin disk operation. Other Yb-doped gain materials exhibit a larger gain bandwidth and support shorter pulse durations. It is important to evaluate their suitability for power scaling in the thin disk laser geometry. In this paper, we review the development of ultrafast thin disk lasers with shorter pulse durations. We discuss the requirements on the gain materials and compare different Yb-doped host materials. The recently developed sesquioxide materials are particularly promising as they enabled the highest optical-to-optical efficiency (43%) and shortest pulse duration (227fs) ever achieved with a mode-locked thin disk lase
Renormalization : A number theoretical model
We analyse the Dirichlet convolution ring of arithmetic number theoretic
functions. It turns out to fail to be a Hopf algebra on the diagonal, due to
the lack of complete multiplicativity of the product and coproduct. A related
Hopf algebra can be established, which however overcounts the diagonal. We
argue that the mechanism of renormalization in quantum field theory is modelled
after the same principle. Singularities hence arise as a (now continuously
indexed) overcounting on the diagonals. Renormalization is given by the map
from the auxiliary Hopf algebra to the weaker multiplicative structure, called
Hopf gebra, rescaling the diagonals.Comment: 15 pages, extended version of talks delivered at SLC55 Bertinoro,Sep
2005, and the Bob Delbourgo QFT Fest in Hobart, Dec 200
Quantum Langevin theory of excess noise
In an earlier work [P. J. Bardroff and S. Stenholm], we have derived a fully
quantum mechanical description of excess noise in strongly damped lasers. This
theory is used here to derive the corresponding quantum Langevin equations.
Taking the semi-classical limit of these we are able to regain the starting
point of Siegman's treatment of excess noise [Phys. Rev. A 39, 1253 (1989)].
Our results essentially constitute a quantum derivation of his theory and allow
some generalizations.Comment: 9 pages, 0 figures, revte
Pathways for cross-boundary effects of biodiversity on ecosystem functioning
The biodiversity-ecosystem functioning concept asserts that processes in ecosystems are markedly influenced by species richness and other facets of biodiversity. However, biodiversity-ecosystem functioning studies have been largely restricted to single ecosystems, ignoring the importance of functional links - such as the exchange of matter, energy, and organisms - between coupled ecosystems. Here we present a basic concept and outline three pathways of cross boundary biodiversity effects on ecosystem processes and propose an agenda to assess such effects, focusing on terrestrial-aquatic linkages to illustrate the case. This cross-boundary perspective of biodiversity-ecosystem functioning relationships presents a promising frontier for biodiversity and ecosystem science with repercussions for the conservation, restoration, and management of biodiversity and ecosystems from local to landscape scales.Peer reviewe
Quantum Maxwell-Bloch equations for spatially inhomogeneous semiconductor lasers
We present quantum Maxwell-Bloch equations (QMBE) for spatially inhomogeneous
semiconductor laser devices. The QMBE are derived from fully quantum mechanical
operator dynamics describing the interaction of the light field with the
quantum states of the electrons and the holes near the band gap. By taking into
account field-field correlations and field-dipole correlations, the QMBE
include quantum noise effects which cause spontaneous emission and amplified
spontaneous emission. In particular, the source of spontaneous emission is
obtained by factorizing the dipole-dipole correlations into a product of
electron and hole densities. The QMBE are formulated for general devices, for
edge emitting lasers and for vertical cavity surface emitting lasers, providing
a starting point for the detailed analysis of spatial coherence in the near
field and far field patterns of such laser diodes. Analytical expressions are
given for the spectra of gain and spontaneous emission described by the QMBE.
These results are applied to the case of a broad area laser, for which the
frequency and carrier density dependent spontaneous emission factor beta and
the evolution of the far field pattern near threshold are derived.Comment: 22 pages RevTex and 7 figures, submitted to Phys.Rev.A, revisions in
abstract and in the discussion of temporal coherenc
Avalanches in self-organized critical neural networks: A minimal model for the neural SOC universality class
The brain keeps its overall dynamics in a corridor of intermediate activity
and it has been a long standing question what possible mechanism could achieve
this task. Mechanisms from the field of statistical physics have long been
suggesting that this homeostasis of brain activity could occur even without a
central regulator, via self-organization on the level of neurons and their
interactions, alone. Such physical mechanisms from the class of self-organized
criticality exhibit characteristic dynamical signatures, similar to seismic
activity related to earthquakes. Measurements of cortex rest activity showed
first signs of dynamical signatures potentially pointing to self-organized
critical dynamics in the brain. Indeed, recent more accurate measurements
allowed for a detailed comparison with scaling theory of non-equilibrium
critical phenomena, proving the existence of criticality in cortex dynamics. We
here compare this new evaluation of cortex activity data to the predictions of
the earliest physics spin model of self-organized critical neural networks. We
find that the model matches with the recent experimental data and its
interpretation in terms of dynamical signatures for criticality in the brain.
The combination of signatures for criticality, power law distributions of
avalanche sizes and durations, as well as a specific scaling relationship
between anomalous exponents, defines a universality class characteristic of the
particular critical phenomenon observed in the neural experiments. The spin
model is a candidate for a minimal model of a self-organized critical adaptive
network for the universality class of neural criticality. As a prototype model,
it provides the background for models that include more biological details, yet
share the same universality class characteristic of the homeostasis of activity
in the brain.Comment: 17 pages, 5 figure
Emergent complex neural dynamics
A large repertoire of spatiotemporal activity patterns in the brain is the
basis for adaptive behaviour. Understanding the mechanism by which the brain's
hundred billion neurons and hundred trillion synapses manage to produce such a
range of cortical configurations in a flexible manner remains a fundamental
problem in neuroscience. One plausible solution is the involvement of universal
mechanisms of emergent complex phenomena evident in dynamical systems poised
near a critical point of a second-order phase transition. We review recent
theoretical and empirical results supporting the notion that the brain is
naturally poised near criticality, as well as its implications for better
understanding of the brain
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