ДИНАМИКА ПОКАЗАТЕЛЕЙ ЦИТОКИНОВОГО СТАТУСА БОЛЬНЫХ ХРОНИЧЕСКИМ СОЧЕТАННЫМ ГЕПАТИТОМ В+С ПРИ ПРОВЕДЕНИИ ПРОТИВОВИРУСНОЙ ТЕРАПИИ

The author studied the cytokine status in patients with chronic combined hepatitis B+C in a process of antiviral therapy. The examination embraced 49 patients aged from 18 to 47 years (pegylated interferon- alfa2а and ribavirin were used in 24 patients). It is established, that a significant increase of the interferon-α, interferon-γ, tumor necrosis factor-α (with following decrease of tumor necrosis factor-α) in blood serum content in patients with a stable virusologic response serves as an early criterion of the antiviral therapy effectiveness.Изучен цитокиновый статус у пациентов с хроническ м сочетанным гепатитом В+С в процессе противовирусной терапии. Обследованы 49 больных в возрасте от 18 до 47 лет (пегилированный интерферональфа2а и рибавирин были назначены 24 пациентам). Установлено, что значительное повышение содержания интерферона-α, интерферона-γ и фактора некроза опухоли-α (с последующим снижением) в сыворотке крови у больных с устойчивым вирусологическим ответом служит ранним критерием эффективности противовирусной терапии

Justification of the program therapy of acute hepatitis C

Treatment of acute hepatitis C remains one of the main problems of modern hepatology. There are many variants of treatment, but there is no common opinion about scheme and time of onset of the therapy. From the other hand, early treatment can prevent chronisation in more than 70% of cases. Specific therapy was used 135 patients with acute hepatitis C aged from 16 to 52 years (26,5+0,7 years). Our analysis has shown, that its better to start specific therapy on the second month of the disease with -interferon monotherapy by induction scheme

Justification of the program therapy of acute hepatitis C

Treatment of acute hepatitis C remains one of the main problems of modern hepatology. There are many variants of treatment, but there is no common opinion about scheme and time of onset of the therapy. From the other hand, early treatment can prevent chronisation in more than 70% of cases. Specific therapy was used 135 patients with acute hepatitis C aged from 16 to 52 years (26,5+0,7 years). Our analysis has shown, that its better to start specific therapy on the second month of the disease with -interferon monotherapy by induction scheme.Treatment of acute hepatitis C remains one of the main problems of modern hepatology. There are many variants of treatment, but there is no common opinion about scheme and time of onset of the therapy. From the other hand, early treatment can prevent chronisation in more than 70% of cases. Specific therapy was used 135 patients with acute hepatitis C aged from 16 to 52 years (26,5+0,7 years). Our analysis has shown, that its better to start specific therapy on the second month of the disease with -interferon monotherapy by induction scheme

Change of the indices of the cytokine status in patients with chronic combined hepatitis B+C in a process of antiviral therapy

The author studied the cytokine status in patients with chronic combined hepatitis B+C in a process of antiviral therapy. The examination embraced 49 patients aged from 18 to 47 years (pegylated interferon- alfa2а and ribavirin were used in 24 patients). It is established, that a significant increase of the interferon-α, interferon-γ, tumor necrosis factor-α (with following decrease of tumor necrosis factor-α) in blood serum content in patients with a stable virusologic response serves as an early criterion of the antiviral therapy effectiveness

Late Ordovician trilobites from the Taimyr Peninsula, Arctic Russia

Ordovician trilobites from the important sequences of the Taimyr Peninsula, Arctic Russia have been poorly studied since the work by Balashova (1959, 1960). Newly collected and well-preserved specimens from Late Ordovician sections, along with the original collections of Balashova, form the basis of a reappraisal of 56 Upper Ordovician (Sandbian-Katian) trilobites. New species include Bronteopsis tenuirhachis, Dionide trigintasegmentata, Failleana superba, Pararemopleurides ornatissimus, Raymondella plastron, Robergia subtilis and R. nikolaiseni. Probable new species include: Stenopareia sp. aff. S. glaber, and Stygina sp. aff. S. latifrons. A new subgenus Bilobaspis of the monorakine genus Evenkaspis, and a new species, Evenkaspis (Bilobaspis) mirabilis, are proposed. Thoracic segments and pygidium are correctly associated for the first time with cephala of the hitherto poorly understood Taimyraspis. The genera Effnaspis and Yumenaspis are likely junior synonyms of Taimyraspis. A placement within the Ityophoridae is suggested for Taimyraspis, together with the closely related genera Ityophorus and Frognaspis. Comparison of Goldillaenoides taimyricus with Failleana suggests that these are also closely related. A provisional placement of the former in the Styginidae is adopted. Bronteopsis nannus Balashova could be a juvenile B. tenuirhachis, and is regarded as a nomen dubium. The genus Ceratevenkaspis dominates among the monorakines on Taimyr, while Monorakos itself has not been collected. Robergia nikolaiseni has a narrow cranidial border, which is also present in the type species of Robergia. Two biofacies are identified in the current collections. The first, the raphiophorid association, is widespread around low latitude Ordovician palaeocontinents, identifying marginal shelf sites; the association is not critical in defining palaeocontinents themselves. Inner shelf faunas of the monorakine-cheirurid-illaenid association have taxa that comprise a distinctive group with a strong link between Taimyr and the Ordovician Siberian craton. The trilobites described herein support reconstructions showing Taimyr peripheral to the Siberian craton during the Ordovician.