1,298 research outputs found
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation.
Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of identifying key factors for improved patient treatment, we characterized the tumor immune landscape in 58 uterine sarcoma cases with full clinicopathological annotation. Immune cell characterization revealed the overall prevalence of FOXP3+ cells and pro-tumor M2-like macrophages. Hierarchical clustering of patients showed four tumor type-independent immune signatures, where infiltration of FOXP3+ cells and M1-like macrophages associated with favorable prognosis. High CD8+/FOXP3+ ratio in UUS and ESS correlated with poor survival, upregulation of immunosuppressive markers, extracellular matrix (ECM)-related genes and proteins, and YAP activation. This study shows that uterine sarcomas present distinct immune signatures with prognostic value, independent of tumor type, and suggests that targeting the ECM could be beneficial for future treatments
Recommended from our members
Does surgeon sex and anthropometry matter for tool usability in traditional laparoscopic surgery? A systematic review and meta-analysis
Copyright © The Author(s) 2023 Introduction:
Hand size, strength, and stature all impact a surgeon’s ability to perform Traditional Laparoscopic Surgery (TLS) comfortably and effectively. This is due to limitations in instrument and operating room design. This article aims to review performance, pain, and tool usability data based on biological sex and anthropometry.
Methods:
PubMed, Embase, and Cochrane databases were searched in May 2023. Retrieved articles were screened based on whether a full-text, English article was available in which original results were stratified by biological sex or physical proportions. Article quality was discussed using the Mixed Methods Appraisal Tool (MMAT). Data were summarized in three main themes: task performance, physical discomfort, and tool usability and fit. Task completion times, pain prevalence, and grip style results between male and female surgeons formed three meta-analyses.
Results:
A total of 1354 articles were sourced, and 54 were deemed suitable for inclusion. The collated results showed that female participants, predominantly novices, took 2.6–30.1 s longer to perform standardized laparoscopic tasks. Female surgeons reported pain at double the frequency of their male colleagues. Female surgeons and those with a smaller glove size were consistently more likely to report difficulty and require modified (potentially suboptimal) grip techniques with standard laparoscopic tools.
Conclusions:
The pain and stress reported by female or small-handed surgeons when using laparoscopic tools demonstrates the need for currently available instrument handles, including robotic hand controls, to become more size-inclusive. However, this study is limited by reporting bias and inconsistencies; furthermore, most data was collected in a simulated environment. Additional research into how anthropometric tool design impacts the live operating performance of experienced female surgeons would further inform this area of investigation.Open Access funding enabled and organized by CAUL and its Member Institutions. This review was commissioned and funded by CMR Surgical Ltd
A measurement of the differential cross section for the two-body photodisintegration of 3He at theta_LAB = 90deg using tagged photons in the energy range 14 -- 31 MeV
The two-body photodisintegration of 3He has been investigated using tagged
photons with energies from 14 -- 31 MeV at MAX-lab in Lund, Sweden. The
two-body breakup channel was unambiguously identified by the (nonsimultaneous)
detection of both protons and deuterons. This approach was made feasible by the
over-determined kinematic situation afforded by the tagged-photon technique.
Proton- and deuteron-energy spectra were measured using four silicon
surface-barrier detector telescopes located at a laboratory angle of 90deg with
respect to the incident photon-beam direction. Average statistical and
systematic uncertainties of 5.7% and 6.6% in the differential cross section
were obtained for 11 photon-energy bins with an average width of 1.2 MeV. The
results are compared to previous experimental data measured at comparable
photon energies as well as to the results of two recent Faddeev calculations
which employ realistic potential models and take into account three-nucleon
forces and final-state interactions. Both the accuracy and precision of the
present data are improved over the previous measurements. The data are in good
agreement with most of the previous results, and favor the inclusion of
three-nucleon forces in the calculations.Comment: 12 pages, 13 figures; further Referee comments addresse
Near-threshold measurement of the 4He(g,n) reaction
A near-threshold 4He(g,n) cross-section measurement has been performed at
MAX-lab. Tagged photons from 23 < Eg < 42 MeV were directed toward a liquid 4He
target, and neutrons were detected by time-of-flight in two liquid-scintillator
arrays. Seven-point angular distributions were measured for eight photon
energies. The results are compared to experimental data measured at comparable
energies and Recoil-Corrected Continuum Shell Model, Resonating Group Method,
and recent Hyperspherical-Harmonic Expansion calculations. The angle-integrated
cross-section data is peaked at a photon energy of about 28 MeV, in
disagreement with the value recommended by Calarco, Berman, and Donnelly in
1983.Comment: 10 pages, 3 figures, some revisions, submitted to Physics Letters
Compton Scattering from the Deuteron and Extracted Neutron Polarizabilities
Differential cross sections for Compton scattering from the deuteron were
measured at MAX-lab for incident photon energies of 55 MeV and 66 MeV at
nominal laboratory angles of , , and . Tagged
photons were scattered from liquid deuterium and detected in three NaI
spectrometers. By comparing the data with theoretical calculations in the
framework of a one-boson-exchange potential model, the sum and difference of
the isospin-averaged nucleon polarizabilities, and (in units of fm),
have been determined. By combining the latter with the global-averaged value
for and using the predictions of the Baldin sum rule for
the sum of the nucleon polarizabilities, we have obtained values for the
neutron electric and magnetic polarizabilities of (total) (model) and (total) (model), respectively.Comment: 4 pages, 2 figures, revtex. The text is substantially revised. The
cross sections are slightly different due to improvements in the analysi
PCA-based lung motion model
Organ motion induced by respiration may cause clinically significant
targeting errors and greatly degrade the effectiveness of conformal
radiotherapy. It is therefore crucial to be able to model respiratory motion
accurately. A recently proposed lung motion model based on principal component
analysis (PCA) has been shown to be promising on a few patients. However, there
is still a need to understand the underlying reason why it works. In this
paper, we present a much deeper and detailed analysis of the PCA-based lung
motion model. We provide the theoretical justification of the effectiveness of
PCA in modeling lung motion. We also prove that under certain conditions, the
PCA motion model is equivalent to 5D motion model, which is based on physiology
and anatomy of the lung. The modeling power of PCA model was tested on clinical
data and the average 3D error was found to be below 1 mm.Comment: 4 pages, 1 figure. submitted to International Conference on the use
of Computers in Radiation Therapy 201
Multi-domain design assessment for aerospace components including weld accessibility
AbstractAeroengine manufacturers need to better include assessment of risk and cost for realising the novel products needed to meet the ambitions sustainability driven targets for air transport. Radical technologies are needed that simultaneously require critical manufacturing processes to be assessed already in conceptual design.In this paper, a multi-domain framework for conceptual design and evaluation is proposed that provide the ability to interactively explore the concepts that simultaneously allow a wider range of architectures can be assessed and still include weldability of the concepts.It has been demonstrated how high level, and function driven conceptual design alternatives can be modelled and evaluated to analyse risk and resilience of architectures. Geometrical concepts generated for the most interesting regimes using design of experiments covering a desired design space. For each CAD-model the welding process can be simulated to assess feasibility and lead time for welding, and return quantified results to be included in an integrated results data set for interactive decision making. The paper is the first report from a research project that improve concurrent design of product and production concepts.Clean Sky 2 Joint Undertaking under
the European Union’s Horizon 2020 research and innovation programme. Grant agreement No 887174
- …