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Похідні 4-(R-аміно)-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-3-тіолів, як перспективні протимікробні та протигрибкові речовини
This article contains the results antimicrobial and antifungal activity 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-4-amines (1-6), N-R-eden-3-(nonylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-4-amines (7-9) and 2-((4-amino-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)-N’-R-acetohydra-zides are studied the results by the method of “serial dilutions”. Compound 6 and 20 show the same antifungal activity with comparing fluconazole. A substance 3 (MIC of 31.25 mg/ml) is the most active compound on S. Aureus bacteria which was studied among 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles-4-amine (1-6). Replacing of hexyl radical in atom of sulfur to nonyl and injection in the molecule 3-(alkylthio)-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazoles-4-amine 4-methoxybenzyl-iden substitute (9) led to increasing antimicrobial activity (MIC 15.6 mg/ml).Cтатья содержит результаты исследования противомикробного и противогрибкового действия 3-(алкилтио)-5-(тиофен-2-илметил)-4H-1,2,4-триазол-4-аминов (1-6), N-R-иден-3-(нонилтио)-5-(тиофен-2-илметил)-4H-1,2,4-триазол-4-аминов (7-9) и 2-((4-амино-5-(тиофен-2-илметил)-4H-1,2,4-триазол-3-ил)тио)-N’-R-ацетогидразидов методом серийных разведений. Соединения 6 и 20 проявляют одинаковую противогрибковую активность с препаратом сравнения флуконазолом. Наиболее активным соединением по бактерии S. Aureus среди исследованных 3-(алкилтио)-5-(тиофен-2-илметил)-4H-1,2,4-триазол-4-аминов (1-6) является вещество 3 (МИК31,25 мкг/мл). Замена гексильного радикала при атоме серы на нонильный и введение в молекулу 3-(алкилтио)-5-(тиофен-2-илметил)-4H-1,2,4-триазол-4-амина 4-метоксибензилиденового заместителя (9) приводит к повышению противомикробного действия (МИК 15,6 мкг/мл).Дана стаття містить результати дослідження протимікробної та протигрибкової дії 3-(алкілтіо)-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-4-амінів (1-6), N-R-іден-3-(нонілтіо)-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-4-амінів (7-9) та 2-((4-аміно-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-3-іл)тіо)-N'-R-ацетогідразидів методом серійних розведень. Сполука 6 та 20 проявляє однакову протигрибкову активність з препаратом порівняння флуконазол. Найбільш активною сполукою щодо бактерії S. Aureus серед досліджених 3-(алкілтіо)-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-4-амінів (1-6) є речовина 3 (мінімальна інгібуюча концентрація 31,25 мкг/мл). Заміна гексильного радикалу при атомі Сульфуру на нонільний та введення в молекулу 3-(алкілтіо)-5-(тіофен-2-ілметил)-4H-1,2,4-тріазол-4-аміну 4-метоксибензиліденового замісника (9) призводить до підвищення протимікробної дії (МІК 15,6 мкг/мл)
Bose-Einstein condensation of magnons under incoherent pumping
Bose-Einstein condensation in a gas of magnons pumped by an incoherent
pumping source is experimentally studied at room temperature. We demonstrate
that the condensation can be achieved in a gas of bosons under conditions of
incoherent pumping. Moreover, we show the critical transition point is almost
independent of the frequency spectrum of the pumping source and is solely
determined by the density of magnons. The electromagnetic power radiated by the
magnon condensate was found to scale quadratically with the pumping power,
which is in accordance with the theory of Bose-Einstein condensation in magnon
gases
Enhanced shot noise in resonant tunnelling via interacting localised states
In a variety of mesoscopic systems shot noise is seen to be suppressed in
comparison with its Poisson value. In this work we observe a considerable
enhancement of shot noise in the case of resonant tunnelling via localised
states. We present a model of correlated transport through two localised states
which provides both a qualitative and quantitative description of this effect.Comment: 4 pages, 4 figure
Atomic Deuterium Adsorbed on the Surface of Liquid Helium
We investigate deuterium atoms adsorbed on the surface of liquid helium in
equilibrium with a vapor of atoms of the same species. These atoms are studied
by a sensitive optical method based on spectroscopy at a wavelength of 122 nm,
exciting the 1S-2P transition. We present a direct measurement of the
adsorption energy of deuterium atoms on helium and show evidence for the
existence of resonantly enhanced recombination of atoms residing on the surface
to molecules.Comment: 6 pages 4 figure
Atomistic model of diopside–K-jadeite (CaMgSi2O6–KAlSi2O6) solid solution
Atomistic model was proposed to describe the thermodynamics of mixing in the diopside–K-jadeite solid solution (CaMgSi2O6–KAlSi2O6). The simulations were based on minimization of the latticeenergies of 800 structures within a 2 × 2 × 4 supercell of C2/c diopside with the compositions betweenCaMgSi2O6 and KAlSi2O6 and with variable degrees of order/disorder in the arrangement of Ca/K cations in M2 site and Mg/Al in Ml site. The energy minimization was performed with the help of a force-field model. The results of the calculations were used to define a generalized Ising model, which included 37 pair interaction parameters. Isotherms of the enthalpy of mixing within the range of 273–2023 K were calculated with a Monte Carlo algorithm, while the Gibbs free energies of mixing were obtained by thermodynamic integration of the enthalpies of mixing. The calculated T–X diagram for the system CaMgSi2O6–KAlSi2O6 at temperatures below 1000 K shows several miscibility gaps, which are separated by intervals of stability of intermediate ordered compounds. At temperatures above 1000 K a homogeneous solid solution is formed. The standard thermodynamic properties of K-adeite (KAlSi2O6) evaluated from quantum mechanical calculations were used to determine location of several mineral reactions with the participation of the diopside–K-jadeite solid solution. The results of the simulations suggest that the low content of KalSi2O6 in natural clinopyroxenes is not related to crystal chemical factors preventing isomorphism, but is determined by relatively high standard enthalpy of this end member
Extended parametric resonances in nonlinear Schrodinger systems
We study an example of exact parametric resonance in a extended system ruled
by nonlinear partial differential equations of nonlinear Schr\"odinger type. It
is also conjectured how related models not exactly solvable should behave in
the same way. The results have applicability in recent experiments in
Bose-Einstein condensation and to classical problems in Nonlinear Optics.Comment: 1 figur
Bose-Einstein condensation in quasi2D trapped gases
We discuss BEC in (quasi)2D trapped gases and find that well below the
transition temperature the equilibrium state is a true condensate,
whereas at intermediate temperatures one has a quasicondensate
(condensate with fluctuating phase). The mean-field interaction in a quasi2D
gas is sensitive to the frequency of the (tight) confinement in the
"frozen" direction, and one can switch the sign of the interaction by changing
. Variation of can also reduce the rates of inelastic
processes, which opens prospects for tunable BEC in trapped quasi2D gases.Comment: 4 revtex pages, 1 figure, text is revised, figure improve
A novel application of Fiber Bragg Grating (FBG) sensors in MPGD
We present a novel application of Fiber Bragg Grating (FBG) sensors in the
construction and characterisation of Micro Pattern Gaseous Detector (MPGD),
with particular attention to the realisation of the largest triple (Gas
electron Multiplier) GEM chambers so far operated, the GE1/1 chambers of the
CMS experiment at LHC. The GE1/1 CMS project consists of 144 GEM chambers of
about 0.5 m2 active area each, employing three GEM foils per chamber, to be
installed in the forward region of the CMS endcap during the long shutdown of
LHC in 2108-2019. The large active area of each GE1/1 chamber consists of GEM
foils that are mechanically stretched in order to secure their flatness and the
consequent uniform performance of the GE1/1 chamber across its whole active
surface. So far FBGs have been used in high energy physics mainly as high
precision positioning and re-positioning sensors and as low cost, easy to
mount, low space consuming temperature sensors. FBGs are also commonly used for
very precise strain measurements in material studies. In this work we present a
novel use of FBGs as flatness and mechanical tensioning sensors applied to the
wide GEM foils of the GE1/1 chambers. A network of FBG sensors have been used
to determine the optimal mechanical tension applied and to characterise the
mechanical tension that should be applied to the foils. We discuss the results
of the test done on a full-sized GE1/1 final prototype, the studies done to
fully characterise the GEM material, how this information was used to define a
standard assembly procedure and possible future developments.Comment: 4 pages, 4 figures, presented by Luigi Benussi at MPGD 2015 (Trieste,
Italy). arXiv admin note: text overlap with arXiv:1512.0848
Development and performance of Triple-GEM detectors for the upgrade of the muon system of the CMS experiment
The CMS Collaboration is evaluating GEM detectors for the upgrade of the muon system. This contribution will focus on the R&D performed on chambers design features and will discuss the performance of the upgraded detector
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