EDUCATIONAL FACTORS AS DETERMINANT OF INTERNATIONAL RESERVES ACCUMULATION IN ORGANISATION OF PETROLEUM EXPORTING COUNTRIES

There has been tepid growth of international reserves in OPEC economies despite huge chunks of oil revenue with high developmental needs. This study investigated the influence of educational factors using various levels of literacy in stimulating macroeconomic determinants of international reserves in OPEC member states with data between 2008 and 2018 obtained from World Bank Development Indicators across 15 member states. The study employed dynamic panel model and analysed the data using System of Generalised Method of Moment (SGMM). The findings show that educational levels, such as, adult, youth literacy, tertiary school and secondary school enrolment mitigate the adverse effect of exchange rate and stimulate the effect of crude oil prices while tertiary enrolment stimulate the effect of foreign direct investment and reduce the adverse effect of economic crises. In all, youth literacy was most impactful for these economies while economic crises were significantly positive at all levels as a primary determinant of international reserve accumulation. It was therefore concluded that educational enhance the economy to accumulate more reserves. The study recommended among others that national governments should ensure adequate funding is channelled to educational sector to improve the quality of education at institutions youth and secondary education levels in order to harness adequate knowledge and skills to enhance the efficiency of foreign investments

Determinants of International Reserves Among Organisation of Petroleum Exporting Countries (OPEC)

Member countries of the Organisation of Petroleum Exporting Countries (OPEC) are always in the news regarding the prices and supply of crude oil to the international market. One of the economic reasons for this is liquidity and the desire to accumulate international reserves by the respective countries. This paper examined the determinants of international reserves among the cartel against the backdrop of the motives for keeping reserves. With data from 2005 to 2018, the adopted variables that were tested with the system of generalised methods of moments (Sy-GMM) are inflation, exchange rates, oil prices, crude oil dependence, economic crises and others. The results and outputs show that inflation was negatively impactful externally and internally, while FDI inflows recorded negative significance. Economic crises and economic openness were positively significant, while oil prices and exchange rates were not significant determinants of international reserves accumulation. The paper recommends the maximisation of opportunities available by members during economic crises to accumulate reserves that will enable them to diversify from dependence on crude oil exports to include other products and a higher level of openness to open the economy up for competition to make the economies stronger

OPTIMIZATION PRINCIPLE AND ITS’ APPLICATION IN OPTIMIZINGLANDMARK UNIVERSITY BAKERY PRODUCTION USING LINEAR PROGRAMMING

This paper deals with the applications ofoptimization principle in optimizing profits of a production industry using linear programming to examine the production cost and determine its optimal profit. Linear programming is an operation research technique which is widely used in finding solutionsto managerial decision problems. However, many enterprises make more use of the trial-and-error method. As such, firms have been finding it difficult in allocating scarce resources in a manner that will ensure profit maximization and/or cost minimization.This paper makse use of secondary data collected from the records of the Landmark University Bakery on five types of bread produced in the firm which include Family loaf, sliced family bread, Chocolate loaf, medium size bread, small size bread. A problemof this nature was identified as a linear programming problem, formulated in Mathematical terms and solved using AMPL software. The solution obtained revealed that Landmark bakery unit should concentrate much more in production of 14,000 loaves of Family loaf and 10,571 loaves of Chocolate bread while others type should be less produced since their value is turning to zero in order to achieve a maximum monthly profit ofN1,860,000. From the analysis, it was observed that Family loaf and the Chocolate breadcontributed objectively to the profit. Hence, more of Family loaf and Chocolate bread are needed to be produced and sold in order to maximize the profi

Distribution of radionuclides and assessment of risk exposure to the miners on a kaolin field

Mining of kaolin deposits are common in Nigeria without considering the background radiation in such environment and the health risks it might pose on the miners. In this study, in-situ measurements of the naturally occurring radionuclides were carried out with the aim of determining the distribution of these radionuclides on the mining field and estimation of the hazard indices exposure risks (γ- and α-radiation risks) to the miners. The study was achieved with the aid of gamma ray detector Super-Spec (RS-125) and global positioning system. The detector used has ability to measure activity concentrations of 238U, 232Th and 40K and gamma doses. For the purpose of this study, only the concentrations of the three radionuclides were considered. For each location, measurements were taken four times, while its mean value was estimated for better accuracy. In all, nineteen locations were occupied in order to cover the study area. Basic kriging method was adopted for the production of spatial distribution of these radionuclides and their corresponding γ- and α-radiation hazard indices. The mean values of 238U, 232Th and 40K are 46.7, 71.8 and 108.7 Bq kg-1 , respectively. When compared to the global standard, it was revealed that 238U and 232Th are greater than the global standard, while 40K fall below the permissible limit. The γ- and α-radiation exposure risks estimated revealed that the mean values of Iγ and Iα are 0.6 and 0.2 respectively. Though the estimated γ- and α-radiation indices showed that the kaolin field is safe for the miners, periodic check is required in order to monitor the rate at which these natural primordial radionuclides (238U and 232Th and their progenies) are being enhanced

In Silico Evaluation of Inhibitors of Plasmodium Falciparum AP2-I Transcription Factor and Plasmodium Falciparum Bromodomain Protein 1

Recent treatment failures observed for Artemisinin-based combination therapy (ACT) have raised concerns about the efficacy of the front-line drug to treat malaria and the need to develop a new antimalarial drug regimen. Plasmodium falciparum Apicomplexan Apetala 2 Invasion (PfAP2-I) transcription factor (TF) is a protein that regulates the expression of a subset of gene families involved in Plasmodium falciparum red blood cell (RBC) invasion. PfAP2-I associates with several chromatin proteins, including the Plasmodium falciparum bromodomain protein 1 (PfBDP1) and that complex formation is associated with transcriptional regulation. Inhibiting PfAP2-I TF and PfBDP1 with small molecules represents a potential new antimalarial therapeutic target to combat drug resistance, which this study aims to achieve

Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity

Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till date, reports showing the hepatoprotective molecular mechanism of the plant are lacking. The aim of this study was therefore to identify compounds from the plant bearing hepatoprotective activity and the related molecular mechanism by assessing their effects against acetaminophen (APAP)-induced hepatotoxicity in normal human liver L-02 cells line. The cells were exposed to APAP (10 mM) or co-treated with phytochemical compounds (40 μM) over a period of 36 h and, biochemical and molecular parameters assessed. Three known limonoids namely 17-epi-methyl-6-hydroxylangolensate, 7-deacetoxy-7-oxogedunin and deacetoxy-7R-hydroxygedunin were identified. The results of cells viability and membrane integrity, reactive oxygen species generation and lipid membrane peroxidation assays, cellular glutathione content determination as well as expression of cytochrome P450 2E1 demonstrated the protective action of the limonoids. Immunoblotting analysis revealed that limonoids inhibited APAP-induced c-Jun N-terminal Kinase phosphorylation (p-JNK), mitochondrial translocation of p-JNK and Bcl2-associated X Protein, and the release of Apoptosis-inducing Factor into the cytosol. Interestingly, limonoids increased the expression of Mitogen-activated Protein Kinase Phosphatase (Mkp)-1, an endogenous inhibitor of JNK phosphorylation and, induced the nuclear translocation of Nuclear Factor Erythroid 2-related Factor-2 (Nrf2) and decreased the expression of Kelch-like ECH-associated Protein-1. The limonoids also reversed the APAP-induced decreased mRNA levels of Catalase, Superoxide Dismutase-1, Glutathione-S-Transferase and Methionine Adenosyltransferase-1A. The obtained results suggest that the isolated limonoids protect L-02 hepatocytes against APAP-induced hepatotoxicity mainly through increase expression of Mkp-1 and nuclear translocation of Nrf2. Thus, these compounds are in part responsible of the hepatoprotective activity of K. grandifoliola and further analysis including in vivo and toxicological studies are needed to select the most potent compound that may be useful as therapeutic agents against DILI

Inflammatory biomarkers in Alzheimer's disease plasma

Introduction: Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a \u201cHoly Grail\u201d of AD research and intensively sought; however, there are no well-established plasma markers. Methods: A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. The discovery phase measured 53 inflammatory proteins in elderly control (CTL; 259), mild cognitive impairment (MCI; 199), and AD (262) subjects from AddNeuroMed. Results: Ten analytes showed significant intergroup differences. Logistic regression identified five (FB, FH, sCR1, MCP-1, eotaxin-1) that, age/APO\u3b54 adjusted, optimally differentiated AD and CTL (AUC: 0.79), and three (sCR1, MCP-1, eotaxin-1) that optimally differentiated AD and MCI (AUC: 0.74). These models replicated in an independent cohort (EMIF; AUC 0.81 and 0.67). Two analytes (FB, FH) plus age predicted MCI progression to AD (AUC: 0.71). Discussion: Plasma markers of inflammation and complement dysregulation support diagnosis and outcome prediction in AD and MCI. Further replication is needed before clinical translation

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer's disease, and experimental data have demonstrated microglial proliferation as a significant component of the neuropathology. In this study, we tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 (JNJ-527) in the P301S mouse tauopathy model. We first demonstrated the anti-proliferative effects of JNJ-527 on microglia in the ME7 prion model, and its impact on the inflammatory profile, and provided potential CNS biomarkers for clinical investigation with the compound, including pharmacokinetic/pharmacodynamics and efficacy assessment by TSPO autoradiography and CSF proteomics. Then, we showed for the first time that blockade of microglial proliferation and modification of microglial phenotype leads to an attenuation of tau-induced neurodegeneration and results in functional improvement in P301S mice. Overall, this work strongly supports the potential for inhibition of CSF1R as a target for the treatment of Alzheimer's disease and other tau-mediated neurodegenerative diseases