The Influence of Molybdenum Equivalent on the Anisotropy of Thermal Expansion of Titanium Martensite Lattice

The structure of the martensite formed by quenching in titanium alloys, as well as the connection between the rhombic lattice α - martensite and anisotropy of thermal expansion was investigated. Τhe methods of the X-ray and thermal XRD phase analyzes have been used to study the relationship between martensite crystal lattice, the coefficient of thermal expansion (CTE) and molybdenum and aluminum equivalent.     Keywords: titanium alloys, martensite, CTE, XRD-analysi

The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing

The Notch gene plays a key role in the development of organs and tissues of neuroectodermic origin, including the nervous system. In eukaryotic organisms, the Notch pathway is involved in cell fate determination. The Notch gene was first discovered in Drosophila melanogaster. In mammals, the family of Notch receptors includes four homologues. In humans, mutations in the Notch gene cause several hereditary diseases and carcinogenesis. Studies of the regulatory zone of the Notch gene in D. melanogaster have been conducted for several decades. We review their results and methods. The regulatory zone of the Notch gene is in the region of open chromatin state that corresponds to the 3C6/3C7 interband on the cytological map of polytene chromosomes of D. melanogaster salivary glands. The development of new methods for directed genome editing made it possible to create a system for introducing directed changes into the regulatory zone of the gene. Using the CRISPR/Cas9 system, we obtained a directed 4-kilobase deletion including the 5’-regulatory zone, promoter, and the first exon of the Notch gene and introduced the attP site into the first intron of the Notch gene. This approach enabled targeted changes of the sequence of the regulatory and promoter regions of the gene. Thus, it provided a new powerful tool for studies of Notch gene regulation and the organization of the open chromatin state

Effectc of Deformation on Evolution of Ortorombic Martensite Lattice Periods in Titanium Alloy

The study was carried out by methods of XPDA and metallography the effect of deformation on the change of lattice periods of orthorhombic martensite in a hardened titanium alloy Ti-1,4Al-10,5Mo (wt. %). It was discovered that in samples hardened from critical and higher quenching temperatures of 785 °C and 850 °C, the change in the lattice periods of martensite At low degrees of deformation up to 5 % of a load occurs non-monotonically.Методом РФСА и металлографии проведено исследование по влиянию деформации на изменение периодов решетки орторомбического мартенсита в закаленном титановом сплаве Ti–1,4Al–10,5Mo (масс. %). Обнаружено, что в образцах, закаленных от критических и более высоких температурах закалки (785 °C и 850 °C) изменение периодов решетки мартенсита при малых степенях деформации (до 5 %) происходит немонотонно

THE RESEARCH OF CHANGEDLATTICE PERIODS OF THE TITANIUM MARTENSITE ON HEATING

В статье представлены результаты исследования титановых образцов сплава ВТ8, ВТ14 и модельного сплава Ti–4,8Al–0,9Mo–2,3V–0,35Cr–0,2Fe (23/2), и Ti–8Mo методом ренгеноструктурного и терморенгетгеновского фазового анализа определена взаимосвязь между ромбичностью решетки, анизотропей термического расширения и молибденового эквивалента.By the methods of the X-ray and thermal XRD phase analyses and transmission electronic microscope the phase structure of an titanium alloy VT8, VT14, model alloy Ti–4,8Al–0,9Mo–2,3V–0,35Cr–0,2Fe (23/2) and Ti–8Mo was studied. Communication between of the martensite crystal lattice and coefficient of thermal expansion (CTE), and molybdenum equivalent

THE STUDY OF THE STRUCTURE AND PHASE COMPOSITION OF THE ALLOY TI–NI–CU–FE SYSTEM

Рассмотрены вопросы формирования структуры и фазового состава многокомпонентных сплавов на основе титана. Проведен анализ структуры при помощи растровой электронной микроскопии, рентгеноспектрального анализа и рентгеноструктурного фазового анализа.Questions of formation of structure and phase structure of multicomponent alloys on the basis of the titanium were considered.Structural analysis by scanning electron microscopy, X-ray spectrum analysis and X-ray diffraction method was carried out.Работа выполнена при поддержке проекта № 2329 в рамках базовой части госзадания 236/2014 Минобрнауки РФ

Исследование влияния эластичных наполнителей на свойства эластомерных материалов

The article concerns an investigation of the influence of elastic fillers ratio - factice and the product of rubber recycling - on the properties of elastomeric materials based of binary polymer blend IR-BR.В работе рассмотрены вопросы, связанные с изучением влияния соотношения эластичных наполнителей - фактиса и продукта вторичной переработки резин на комплекс свойств эластомерных материалов на основе смеси каучуков СКИ-3-СКД

The N-Terminal Domain of the Drosophila Retinoblastoma Protein Rbf1 Interacts with ORC and Associates with Chromatin in an E2F Independent Manner

The retinoblastoma (Rb) tumor suppressor protein can function as a DNA replication inhibitor as well as a transcription factor. Regulation of DNA replication may occur through interaction of Rb with the origin recognition complex (ORC).We characterized the interaction of Drosophila Rb, Rbf1, with ORC. Using expression of proteins in Drosophila S2 cells, we found that an N-terminal Rbf1 fragment (amino acids 1-345) is sufficient for Rbf1 association with ORC but does not bind to dE2F1. We also found that the C-terminal half of Rbf1 (amino acids 345-845) interacts with ORC. We observed that the amino-terminal domain of Rbf1 localizes to chromatin in vivo and associates with chromosomal regions implicated in replication initiation, including colocalization with Orc2 and acetylated histone H4.Our results suggest that Rbf1 can associate with ORC and chromatin through domains independent of the E2F binding site. We infer that Rbf1 may play a role in regulating replication directly through its association with ORC and/or chromatin factors other than E2F. Our data suggest an important role for retinoblastoma family proteins in cell proliferation and tumor suppression through interaction with the replication initiation machinery

Observation of the Identical Rigidity Dependence of He, C, and O Cosmic Rays at High Rigidities by the Alpha Magnetic Spectrometer on the International Space Station

We report the observation of new properties of primary cosmic rays He, C, and O measured in the rigidity (momentum/charge) range 2 GV to 3 TV with 90 x 10(6) helium, 8.4 x 10(6) carbon, and 7.0 x 10(6) oxygen nuclei collected by the Alpha Magnetic Spectrometer ( AMS) during the first five years of operation. Above 60 GV, these three spectra have identical rigidity dependence. They all deviate from a single power law above 200 GV and harden in an identical way