3,760 research outputs found
Cosmic-ray Monte Carlo predictions for forward particle production in p-p, p-Pb, and Pb-Pb collisions at the LHC
We present and compare the predictions of various cosmic-ray Monte Carlo
models for the energy (dE/deta) and particle (dN/deta) flows in p-p, p-Pb and
Pb-Pb collisions at sqrt(s) = 14, 8.8, and 5.5 TeV respectively, in the range
covered by forward LHC detectors like CASTOR or TOTEM (5.2<|eta|<6.6) and ZDC
or LHCf (|eta|>8.1 for neutrals).Comment: 5 pages, 5 figs. Poster proceedings Quark-Matter'08, Jaipur. To
appear in Indian J. of Phy
Theorems on shear-free perfect fluids with their Newtonian analogues
In this paper we provide fully covariant proofs of some theorems on
shear-free perfect fluids. In particular, we explicitly show that any
shear-free perfect fluid with the acceleration proportional to the vorticity
vector (including the simpler case of vanishing acceleration) must be either
non-expanding or non-rotating. We also show that these results are not
necessarily true in the Newtonian case, and present an explicit comparison of
shear-free dust in Newtonian and relativistic theories in order to see where
and why the differences appear.Comment: 23 pages, LaTeX. Submitted to GR
Cortactin Is Involved in the Entry of Coxiella burnetii into Non-Phagocytic Cells
BACKGROUND: Cortactin is a key regulator of the actin cytoskeleton and is involved in pathogen-host cell interactions. Numerous pathogens exploit the phagocytic process and actin cytoskeleton to infect host cells. Coxiella burnetii, the etiologic agent of Q fever, is internalized by host cells through a molecular mechanism that is poorly understood. METHODOLOGY/PRINCIPAL FINDING: Here we analyzed the role of different cortactin motifs in the internalization of C. burnetii by non-phagocytic cells. C. burnetii internalization into HeLa cells was significantly reduced when the cells expressed GFP-cortactin W525K, which carries a mutation in the SH3 domain that renders the protein unable to bind targets such as N-WASP. However, internalization was unaffected when the cells expressed the W22A mutant, which has a mutation in the N-terminal acidic region that destroys the protein's ability to bind and activate Arp2/3. We also determined whether the phosphorylation status of cortactin is important for internalization. Expression of GFP-cortactin 3F, which lacks phosphorylatable tyrosines, significantly increased internalization of C. burnetii, while expression of GFP-cortactin 3D, a phosphotyrosine mimic, did not affect it. In contrast, expression of GFP-cortactin 2A, which lacks phosphorylatable serines, inhibited C. burnetii internalization, while expression of GFP-cortactin SD, a phosphoserine mimic, did not affect it. Interestingly, inhibitors of Src kinase and the MEK-ERK kinase pathway blocked internalization. In fact, both kinases reached maximal activity at 15 min of C. burnetii infection, after which activity decreased to basal levels. Despite the decrease in kinase activity, cortactin phosphorylation at Tyr421 reached a peak at 1 h of infection. CONCLUSIONS/SIGNIFICANCE: Our results suggest that the SH3 domain of cortactin is implicated in C. burnetii entry into HeLa cells. Furthermore, cortactin phosphorylation at serine and dephosphorylation at tyrosine favor C. burnetii internalization. We present evidence that ERK and Src kinases play a role early in infection by this pathogen
Water flow between soil aggregates
Aggregated soils are structured systems susceptible to non-uniform flow. The hydraulic properties depend on the aggregate fabric and the way the aggregates are assembled. We examined the hydraulic behavior of an aggregate packing. We focused on conditions when water mostly flows through the aggregates, leaving the inter-aggregate pore space air-filled. The aggregates were packed in 3mm thick slabs forming a quasi two-dimensional bedding. The larger aggregates were wetted with water and embedded in smaller aggregates equilibrated at a lower water content. The water exchange between wet and drier aggregates was monitored by neutron radiography. The three-dimensional arrangement of the aggregates was reconstructed by neutron tomography. The water flow turned out to be controlled by the contacts between aggregates, bottle-necks that slow down the flow. The bottle-neck effect is due to the narrow flow cross section of the contacts. The water exchange was simulated by considering the contact area between aggregates as the key parameter. In order to match the observed water flow, the contact area must be reduced by one to two orders of magnitude relative to that obtained from image analysis. The narrowness of the contacts is due to air-filled voids within the contact
Water flow between soil aggregates
Aggregated soils are structured systems susceptible to non-uniform flow. The hydraulic properties depend on the aggregate fabric and the way the aggregates are assembled. We examined the hydraulic behavior of an aggregate packing. We focused on conditions when water mostly flows through the aggregates, leaving the inter-aggregate pore space air-filled. The aggregates were packed in 3mm thick slabs forming a quasi two-dimensional bedding. The larger aggregates were wetted with water and embedded in smaller aggregates equilibrated at a lower water content. The water exchange between wet and drier aggregates was monitored by neutron radiography. The three-dimensional arrangement of the aggregates was reconstructed by neutron tomography. The water flow turned out to be controlled by the contacts between aggregates, bottle-necks that slow down the flow. The bottle-neck effect is due to the narrow flow cross section of the contacts. The water exchange was simulated by considering the contact area between aggregates as the key parameter. In order to match the observed water flow, the contact area must be reduced by one to two orders of magnitude relative to that obtained from image analysis. The narrowness of the contacts is due to air-filled voids within the contact
HEP Applications Evaluation of the EDG Testbed and Middleware
Workpackage 8 of the European Datagrid project was formed in January 2001
with representatives from the four LHC experiments, and with experiment
independent people from five of the six main EDG partners. In September 2002
WP8 was strengthened by the addition of effort from BaBar and D0. The original
mandate of WP8 was, following the definition of short- and long-term
requirements, to port experiment software to the EDG middleware and testbed
environment. A major additional activity has been testing the basic
functionality and performance of this environment. This paper reviews
experiences and evaluations in the areas of job submission, data management,
mass storage handling, information systems and monitoring. It also comments on
the problems of remote debugging, the portability of code, and scaling problems
with increasing numbers of jobs, sites and nodes. Reference is made to the
pioneeering work of Atlas and CMS in integrating the use of the EDG Testbed
into their data challenges. A forward look is made to essential software
developments within EDG and to the necessary cooperation between EDG and LCG
for the LCG prototype due in mid 2003.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics
Conference (CHEP03), La Jolla, CA, USA, March 2003, 7 pages. PSN THCT00
Gaia on-board metrology: basic angle and best focus
The Gaia payload ensures maximum passive stability using a single material,
SiC, for most of its elements. Dedicated metrology instruments are, however,
required to carry out two functions: monitoring the basic angle and refocusing
the telescope. Two interferometers fed by the same laser are used to measure
the basic angle changes at the level of as (prad, micropixel), which is
the highest level ever achieved in space. Two Shack-Hartmann wavefront sensors,
combined with an ad-hoc analysis of the scientific data are used to define and
reach the overall best-focus. In this contribution, the systems, data analysis,
procedures and performance achieved during commissioning are presentedComment: 18 pages, 14 figures. To appear in SPIE proceedings 9143-30. Space
Telescopes and Instrumentation 2014: Optical, Infrared, and Millimeter Wav
GeantV: Results from the prototype of concurrent vector particle transport simulation in HEP
Full detector simulation was among the largest CPU consumer in all CERN
experiment software stacks for the first two runs of the Large Hadron Collider
(LHC). In the early 2010's, the projections were that simulation demands would
scale linearly with luminosity increase, compensated only partially by an
increase of computing resources. The extension of fast simulation approaches to
more use cases, covering a larger fraction of the simulation budget, is only
part of the solution due to intrinsic precision limitations. The remainder
corresponds to speeding-up the simulation software by several factors, which is
out of reach using simple optimizations on the current code base. In this
context, the GeantV R&D project was launched, aiming to redesign the legacy
particle transport codes in order to make them benefit from fine-grained
parallelism features such as vectorization, but also from increased code and
data locality. This paper presents extensively the results and achievements of
this R&D, as well as the conclusions and lessons learnt from the beta
prototype.Comment: 34 pages, 26 figures, 24 table
Stirring Strongly Coupled Plasma
We determine the energy it takes to move a test quark along a circle of
radius L with angular frequency w through the strongly coupled plasma of N=4
supersymmetric Yang-Mills (SYM) theory. We find that for most values of L and w
the energy deposited by stirring the plasma in this way is governed either by
the drag force acting on a test quark moving through the plasma in a straight
line with speed v=Lw or by the energy radiated by a quark in circular motion in
the absence of any plasma, whichever is larger. There is a continuous crossover
from the drag-dominated regime to the radiation-dominated regime. In the
crossover regime we find evidence for significant destructive interference
between energy loss due to drag and that due to radiation as if in vacuum. The
rotating quark thus serves as a model system in which the relative strength of,
and interplay between, two different mechanisms of parton energy loss is
accessible via a controlled classical gravity calculation. We close by
speculating on the implications of our results for a quark that is moving
through the plasma in a straight line while decelerating, although in this case
the classical calculation breaks down at the same value of the deceleration at
which the radiation-dominated regime sets in.Comment: 27 pages LaTex, 5 figure
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