3,264 research outputs found

    Charge Transfer-oxy Radical Mechanism for Anti-cancer Agents

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    The proposal is advanced that anti-cancer drugs generally function by charge transfer resulting in formation of toxic oxy radicals which destroy the neoplasm. Electrochemical studies were performed with some of the main types of agents: iminium ions (adenine iminium from alkylating species, iminium metabolite of 6-mercaptopurine, nitidine, other polynuclear iminiums) and metal complexes (Pt(II)diaquodiammine-guanosine, copper salicylaldoximes). Reduction potentials ranged from -0.4 to -1.2 V. Literature data for quinones are presented and radiation is discussed. Based on the theoretical framework, a rationale is offered for the carcinogen-anti-cancer paradox and the role of antioxidants

    A Multi-User Mobile GIS Solution for Documenting Large Surface Scatters: An Example from the Doring River, South Africa

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    This article discusses the development and implementation of a mobile GIS catch-and-release system for documenting large surface artifact scatters along the Doring River in South Africa. An integrated, cloud-based mobile GIS solution was built using a suite of ESRI ArcGIS applications with an aim to maximize the speed and breadth of techno-typological data capture, while minimizing data collection errors and post-processing requirements. The system was successfully implemented during the 2019 field season of the Doring River Archaeological Project. With the ability for project-specific customization and interchangeable hardware components, the system transcends geographic region and temporal focus. Moreover, the system accommodates connectivity limitations commonly faced by archaeologists seeking distributed database solutions. Other challenges embraced in the design include rotating personnel throughout a field season, scalability without large financial investment, and the ability to accommodate data collection needs of other components of the larger multi-disciplinary research project

    In-trap conversion electron spectroscopy

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    The Penning trap REXTRAP at ISOLDE was used to test the feasibility of in-trap conversion electron spectroscopy. The results of simulations, experiments with solid conversion electron sources as well as first on-line and tests with trapped radioactive ions are presented. In addition to obtaining high-resolution spectroscopic data, the detection of conversion electrons was found to be a useful tool for the diagnostics of the trap operation. The tests proved the feasibility of in-trap spectroscopy but also revealed some potential problems to be addressed in the future

    WIRE Instrument Description: Focal Planes, Optics, Electronics

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    An elegantly simple cryogenic instrument has been proposed to measure far infrared radiation from starburst galaxies. The experiment—known as WIRE—employs a Cassegrain telescope with diamond-turned mirrors to provide a light-weight optical system for photon collection. A dichroic beamsplitter and filter separate the light into two broad, well-defined bands of interest. Two 128- x 128-pixel arsenic-doped silicon focal plane arrays spatially sample the incoming photons. These arrays feature exceptionally low dark current and low read noise, which allows the coaddition of thousands of images. The entire optical section and focal plane arrays are cooled to 12 Kelvin and 7.5 Kelvin, respectively, by a two-stage, solid-hydrogen cryostat. An uncomplicated electronics package provides some on-board coaddition of images, accepts the simple commands required by the WIRE instrument, and interfaces the data signals to the SMEX spacecraft for telemetry to the ground

    New results on group classification of nonlinear diffusion-convection equations

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    Using a new method and additional (conditional and partial) equivalence transformations, we performed group classification in a class of variable coefficient (1+1)(1+1)-dimensional nonlinear diffusion-convection equations of the general form f(x)ut=(D(u)ux)x+K(u)ux.f(x)u_t=(D(u)u_x)_x+K(u)u_x. We obtain new interesting cases of such equations with the density ff localized in space, which have large invariance algebra. Exact solutions of these equations are constructed. We also consider the problem of investigation of the possible local trasformations for an arbitrary pair of equations from the class under consideration, i.e. of describing all the possible partial equivalence transformations in this class.Comment: LaTeX2e, 19 page

    Current Studies in Japanese Law

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    Over the past fifteen years there has been a remarkable growth in the study of Japanese law in the United States. The foundation was laid during the late 1950\u27s when the Harvard-Michigan-Stanford program brought together Japanese legal specialists and their American counterparts for study and research. At the end of this program a major conference was held, and the resulting publication, Law in Japan, continues to serve as a point of departure in descriptive studies of Japanese law. During the 1960\u27s interest in Japan continued to develop among law faculty members, but an even more important development was the increase in the number of students coming to the law school who already had some Japanese language and area training. With these students as a nucleus, a few law schools have begun to offer work in Japanese law. Some of these courses have been taught by visiting Japanese professors, and a few are taught regularly by Americans trained in Japanese law. At the same time, the Japanese legal system has been studied by many non-lawyers, such as political scientists, sociologists, and anthropologists. Constitutional law, family law, and criminal law have been analyzed as political and social phenomena in studies which have gone beyond legal rules to origins and practices. The four papers in this volume represent these various developments. One is by a visiting scholar, two were written by students in a course dealing with Japanese law, and one is part of a doctoral thesis in anthropology.https://repository.law.umich.edu/books/1108/thumbnail.jp

    Group analysis and exact solutions of a class of variable coefficient nonlinear telegraph equations

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    A complete group classification of a class of variable coefficient (1+1)-dimensional telegraph equations f(x)utt=(H(u)ux)x+K(u)uxf(x)u_{tt}=(H(u)u_x)_x+K(u)u_x, is given, by using a compatibility method and additional equivalence transformations. A number of new interesting nonlinear invariant models which have non-trivial invariance algebras are obtained. Furthermore, the possible additional equivalence transformations between equations from the class under consideration are investigated. Exact solutions of special forms of these equations are also constructed via classical Lie method and generalized conditional transformations. Local conservation laws with characteristics of order 0 of the class under consideration are classified with respect to the group of equivalence transformations.Comment: 23 page
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