SYNTHESIS OF BIOLOGICAL ACTIVE AZINYLFERROCENE DERIVATIVES

As a rule, the presence of a lipophilic ferrocene unit in the drug structure modulates, and often enhances, their physiological activity. In this work the synthesis of vinyl-containing azinylferrocene derivatives was presented. It was found that previously obtained by direct C-H functionalization in (hetero)azinylferrocenes 1a-d (SN H reactions) undergo regioselective Friedel-Crafts acetylation to form 1, 1'-disubstituted 2a-d products with good yields, which are able to enter the Wittig reaction to the corresponding vinylferrocenes 3a-d.This work was supported by the Russian Foundation for Basic Research, project # 20-43-660054

Synthesis of 1-azinyl-1'-isopropenylferrocenes

In this work we combine olefins and azines fragments on the ferrocene matrix by regioselective acetylation of azines followed by the Wittig reaction.This study was supported by the Russian Science Foundation (grant № 19-73-00243) and the Russian Foundation for Basic Research (Project № 20-43-660054)

AZINE-GRAPHENE-DYAD: SYNTHESIS AND PROPERTIES

This work was supported by the Russian Science Foundation, project № 22-13-00298

Transition Metal-Free Regioselective Cross-Coupling of Azine N-Oxides With Cymantrenyl Lithium

We are grateful for financial supports from the Russian Science Foundation (Project № 14-13-01177), the Russian Foundation for Basic Research (Projects № 16-03-00958), and the Ministry of Education and Science of the Russian Federation (Project № 4.6351.2017/8.9)

The Holocene Black Sea reconnection to the Mediterranean Sea: New insights from the northeastern Caucasian shelf

Recent findings about the evolution of palaeogeographic conditions of the Black Sea during the Holocene have significantly improved our understanding of the profound environmental changes that took place around 9 ka ago, when the Neoeuxinian Lake reconnected to the global ocean. In contrast to the western and southeastern regions where numerous studies have been recently performed, the northeast region remains relatively under investigated. We carried out the first multi-proxy continuous study of a sediment core (Ak-2575) from the northeastern Black Sea shelf that includes benthic calcareous fossils (ostracods, molluscs and foraminifers), dinoflagellate cysts (dinocysts) and sedimentology, thus providing reconstructions of surface and bottom-water conditions. The age model of the core is based on 10 AMS-14C dates. Calibrated ages are used throughout the manuscript. The first appearance of Mediterranean elements is documented at 9.6 cal. ka BP. Our data provide evidence of sustained cohabitation of benthic species of Caspian and Mediterranean origins, represented by different ontogenetic stages, from at least ~ 7.8 (or even 8.8) to 6.7 cal. ka BP with the gradual disappearance of brackish species suggesting a gradual increase in salinity and most likely a change in the salt composition. Dinocyst assemblages show species succession that is coherent across the Black Sea basin, with brackish taxa dominating until ~ 8.5 cal. ka BP and being slowly replaced by euryhaline species. The occurrences of authigenic gypsum crystals, especially abundant at ~ 7.4 and 6.5 cal. ka BP, suggest the temporal appearance of hydrogen sulphide at the shelf edge which during certain periods appears to reduce the abundance of benthic fauna

Efficiency of sanatorium and preventive treatment of working groups of the risk of development of lung dust pathology

The article presents the results of the sanatorium-preventive treatment in the conditions of the sanatorium-preventorium “SELEN” in 15 workers of “Uralelectromed” JSC. The positive dynamics of symptoms, improvement in general well-being after a course of physiotherapy was noted.В статье представлены результаты санаторно- профилактического лечения в условиях санатория-профилактория «СЕЛЕН» у 15 рабочих АО «Уралэлектромедь». Отмечена положительная динамика симптомов, улучшение общего самочувствия после курса физиотерапии

Efficiency of sanatorium and preventive treatment of working groups of the risk of development of lung dust pathology

The article presents the results of the sanatorium-preventive treatment in the conditions of the sanatorium-preventorium “SELEN” in 15 workers of “Uralelectromed” JSC. The positive dynamics of symptoms, improvement in general well-being after a course of physiotherapy was noted.В статье представлены результаты санаторно- профилактического лечения в условиях санатория-профилактория «СЕЛЕН» у 15 рабочих АО «Уралэлектромедь». Отмечена положительная динамика симптомов, улучшение общего самочувствия после курса физиотерапии

Analysis of the dynamics and structure of the incidence of hiv infection

The article reflects the dynamics of the main indicators of HIV infection in the Sverdlovsk oblast. The epidemiological situation is compared with a similar one in the Russian Federation. A detailed analysis of the structure of the incidence of HIV infection has been doneВ статье отражена динамика основных показателей заболеваемости ВИЧ-инфекцией в Свердловской области. Проведено сравнениеэпидемиологической ситуации с аналогичной по Российской Федерации.Подробно разобрана структура заболеваемости ВИЧ-инфекци