Fourier transform spectroscopy and coupled-channel deperturbation treatment of the A1Sigma+ ~ b3Pi complex of KCs molecule

The laser induced fluorescence (LIF) spectra A1Sigma ~ b3Pi --> X1Sigma+ of KCs dimer were recorded in near infrared region by Fourier Transform Spectrometer with a resolution of 0.03 cm-1. Overall more than 200 LIF spectra were rotationally assigned to 39K133Cs and 41K133Cs isotopomers yielding with the uncertainty of 0.003-0.01 cm-1 more than 3400 rovibronic term values of the strongly mixed singlet A1Sigma+ and triplet b3Pi states. Experimental data massive starts from the lowest vibrational level v_A=0 of the singlet and nonuniformly cover the energy range from 10040 to 13250 cm-1 with rotational quantum numbers J from 7 to 225. Besides of the dominating regular A1Sigma+ ~ b3P Omega=0 interactions the weak and local heterogenous A1S+ ~ b3P Omega=1 perturbations have been discovered and analyzed. Coupled-channel deperturbation analysis of the experimental 39K133Cs e-parity termvalues of the A1S+ ~ b3P complex was accomplished in the framework of the phenomenological 4 x 4 Hamiltonian accounting implicitly for regular interactions with the remote states manifold. The resulting diabatic potential energy curves of the interacting states and relevant spin-orbit coupling matrix elements defined analytically by Expanded Morse Oscillators model reproduce 95% of experimental data field of the 39K133Cs isotopomer with a standard deviation of 0.004 cm-1 which is consistent with the uncertainty of the experiment. Reliability of the derived parameters was additionally confirmed by a good agreement between the predicted and experimental termvalues of 41K133Cs isotopomer. Calculated intensity distributions in the A ~ b --> X LIF progressions are also consistent with their experimental counterparts.Comment: 17 pages, 14 figure

Silent, but salient: gestures in simultaneous interpreting

This study is aimed at studying the saliency in the gestures of simultaneous interpreters. To distinguish between distinguished gestures and non-selected ones, two groups of parameters are proposed - main and auxiliary, which are evaluated in relation to the general gesticulation style of the same interprete

Economic aspects of local authorities functioning

© The authors. The relevance of the study on economic aspects of local authorities' functioning is due to their dual nature in the complex system of market relations. In this regard, this article is aimed at economic aspects' revealing of local authorities' functioning, as well as the disclosure of various interest levels' interaction in the system of municipal management. A leading approach in the study of this problem is the method of the effectiveness assessing of local authorities' functioning. The article presents the analysis of domestic researchers' different points of view in relation to the substantial characteristics of municipal economy, reveals the nature of the interaction of various interest levels in the system of municipal relations, discloses the duality of local authorities' position in the municipal system of economic relations, proposes a classification of business entities under the municipal economy, proves the specificity of the economic and moral relations in the system of local authorities. The article is valuable for researchers, teachers and students studying the problems of formation and development of the national municipal economy, research methods within the discipline "Economics of public (government) services", "Municipal economy", as well as specialists of local authorities who are concerned with the improvement and development of municipal economy

Fashion design in a multicultural space

The collective monograph contains the results of the synthesis of theoretical materials, as well as the authors` applied research developments on the design of the clothes of different assortment and purpose, made from different materials considering the modern scientific methods

СИСТЕМНЫЙ ПОДХОД К ИНФОРМАЦИОННОЙ ПОДДЕРЖКЕ ФАРМАЦЕВТИЧЕСКОЙ РАЗРАБОТКИ ГОТОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ

The article considers the application of the system approach for constructing informational support for the life cycle of the production of medicinal products. The principal difficulties of creating a single informational system of the entire life cycle are considered in this article. A brief analysis of the information and computer support of individual links in the life cycle is given. Particular attention is paid to the use of a systematic approach to the creation of information support for the pharmaceutical development of medicines. The principle of QbD - “Quality planned for development” - was taken as a basis. For the implementation the QbD principle on the basis of the system approach, it is proposed to use the Shewhart-Deming iteration cycle to create an information support for a sustainable search for the optimal version (the program) of the conducted studies. The possibility of combining the PDCA cycle and the methodology of the system approach is shown. On its basis, system-theoretic multiple models of nformation support for pharmaceutical development in the graphic-analytical nomination were constructed. The method of applying the criterial approach for the formation of global and local criteria for managing research and the construction of system management models in the Melentiev’s brackets nomination are presented. The information modeling of the stage of pharmaceutical development has been carried out. Functional models have been constructed in the IDEF0 nomination.В статье рассматривается применение системного подхода для построения информационной поддержи жизненного цикла производства лекарственных препаратов. Рассмотрены принципиальные трудности создания единой информационной системы всего жизненного цикла. Дается краткий анализ информационной и компьютерной поддержки отдельных звеньев жизненного цикла. Особое внимание уделено применению системного подхода к созданию информационной поддержки звена фармацевтической разработки лекарственных средств. За основу взят принцип QbD - «Качество, запланированное при разработке». Для реализации принципа QbD на основе системного подхода при создании информационной поддержки устойчивого поиска оптимального варианта (программы) проводимых исследований предложено использовать итерационный цикл Шухарта-Деминга. Показана возможность совмещения цикла PDCA и методики системного подхода. На его основе проведено построение системных теоретико-множественных моделей информационной поддержки фармацевтической разработки в графо-аналитической номинации. Приводится методика применения критериального подхода для формирования глобального и локальных критериев управления исследованиями и построение системных моделей управления в скобочной номинации Мелентьева. Проведено информационное моделирование этапа фармацевтической разработки, построены функциональные модели в номинации IDEF0

Лечение хронической тампонады сердца при его новообразованиях

Among complications of malignant neoplasms of the heart, tumor exudative pericarditis requires emergency surgical measures with the development of chronic tamponade. At the frst stage, puncture drainage of the pericardial cavity is advisable. In case of a common tumor process and the impossibility of radical surgical treatment by the second stage, it is advisable to perform video assisted thoracoscopic pericardial fenestration with biopsy and pleurodesis, if necessary. This tactic improves the quality of life in patients and complies with modern standards of treatment of this disease.Среди осложнений злокачественных новообразований сердца опухолевый экссудативный перикардит с развитием хронической тампонады требует проведения экстренных хирургических мероприятий. На первом этапе целесообразно пункционное дренирование полости перикарда. В случае распространенного опухолевого процесса и невозможности радикального хирургического лечения вторым этапом предлагается выполнение видеоторакоскопической фенестрации перикарда, биопсии новообразования и, при необходимости, — плевродеза. Такая тактика улучшает качество жизни пациентов и соответствует современным стандартам лечения злокачественных опухолей сердца

NucTools: analysis of chromatin feature occupancy profiles from high-throughput sequencing data

Background: Biomedical applications of high-throughput sequencing methods generate a vast amount of data in which numerous chromatin features are mapped along the genome. The results are frequently analysed by creating binary data sets that link the presence/absence of a given feature to specific genomic loci. However, the nucleosome occupancy or chromatin accessibility landscape is essentially continuous. It is currently a challenge in the field to cope with continuous distributions of deep sequencing chromatin readouts and to integrate the different types of discrete chromatin features to reveal linkages between them. Results: Here we introduce the NucTools suite of Perl scripts as well as MATLAB- and R-based visualization programs for a nucleosome-centred downstream analysis of deep sequencing data. NucTools accounts for the continuous distribution of nucleosome occupancy. It allows calculations of nucleosome occupancy profiles averaged over several replicates, comparisons of nucleosome occupancy landscapes between different experimental conditions, and the estimation of the changes of integral chromatin properties such as the nucleosome repeat length. Furthermore, NucTools facilitates the annotation of nucleosome occupancy with other chromatin features like binding of transcription factors or architectural proteins, and epigenetic marks like histone modifications or DNA methylation. The applications of NucTools are demonstrated for the comparison of several datasets for nucleosome occupancy in mouse embryonic stem cells (ESCs) and mouse embryonic fibroblasts (MEFs). Conclusions: The typical workflows of data processing and integrative analysis with NucTools reveal information on the interplay of nucleosome positioning with other features such as for example binding of a transcription factor CTCF, regions with stable and unstable nucleosomes, and domains of large organized chromatin K9me2 modifications (LOCKs). As potential limitations and problems we discuss how inter-replicate variability of MNase-seq experiments can be addressed

Harnessing collective intelligence for the future of learning – a co-constructed research and development agenda

Learning, defined as the process of constructing meaning and developing competencies to act on it, is instrumental in helping individuals, communities, and organizations tackle challenges. When these challenges increase in complexity and require domain knowledge from diverse areas of expertise, it becomes difficult for single individuals to address them. In this context, collective intelligence, a capacity of groups of people to act together and solve problems using their collective knowledge, becomes of great importance. Technologies are instrumental both to support and understand learning and collective intelligence, hence the need for innovations in the area of technologies that can support user needs to learn and tackle collective challenges. Use-inspired research is a fitting paradigm that spans applied solutions and scientific explanations of the processes of learning and collective intelligence, and that can improve the technologies that may support them. Although some conceptual and theoretical work explaining and linking learning with collective intelligence is emerging, technological infrastructures as well as methodologies that employ and evidence that support them are nascent. We convened a group of experts to create a middleground and engage with the priorities for use-inspired research. Here we detail directions and methods they put forward as most promising for advancing a scientific agenda around learning and collective intelligence

Traslation Strategies of Modern English Filmonyms into Russian and Spanish (the example of films released in 2008-2014)

The article discusses strategies of translating titles of American films into Russian and Spanish considering their semantic and pragmatic aspects. Though different translation strategies might be applied (direct or literally translation, transformation or replacement, etc.), titles translated should comply with the story, idea, philosophy and style of a film so that they be attractive for the target audience. Disregarding one of those conditions may cause infelicity or translation failures. The article studies some examples of successful and unsuccessful translation into Russian and Spanish