Laboratory measurements of viscosity, density, and bulk contact angle on marble and soda lime glass for three naphthenic acid + n-decane solutions

Acknowledgments XZH was supported by the Mexican National Council for Science and Technology, Mexico (CONACyT); MC was supported by a University of Aberdeen College of Physical Sciences studentship; OA was supported by a University of Aberdeen Elphinstone PhD scholarship. The marble substrates were cut to size and polished by Walter Ritchie in the School of Geosciences at University of Aberdeen. The authors thank COREX (UK) Ltd. for allowing MC access to their viscometer in July 2017.Peer reviewedPublisher PD

Elaboração de E-Verbetes Português/Inglês para dicionários pedagógicos / Elaboration of Portuguese/English E-Verbals for pedagogical dictionaries

O uso das tecnologias digitais para elaboração de recursos pedagógicos na atualidade tem sido altamente recomendado pelos documentos oficiais, a saber a Base Nacional Comum Curricular (BNCC) e, no estado de São Paulo, o Currículo Paulista apresentam entre as competências para os alunos da Educação Básica a valorização e a utilização dos conhecimentos historicamente construídos sobre o mundo, incluindo o ambiente digital. Além disso, criar soluções tecnológicas com base nos conhecimentos das diferentes áreas, no caso da língua Inglesa “Utilizar novas tecnologias, com novas linguagens e modos de interação” é uma recomendação dentre as competências listadas na BNCC (competência 5). Para atender a essa demanda, recorremos a um estudo interdisciplinar unindo a e-Lexicografia à Pedagogia. O objetivo deste trabalho é apresentar a elaboração de e-verbetes português/inglês para compor o e-dicionário dos 100 verbos mais frequentemente utilizados por estudantes brasileiros da Educação Básica. A metodologia utilizada é de base quantitativa e qualitativa, bem como exploratória descritiva, uma vez utiliza como método investigativo a Linguística de Corpus para proceder, em seguida, a uma análise linguístico-semântica conceitual, por meio de dicionários e e-dicionários. A análise leva à identificação de equivalentes e à redação descritiva dos e-verbetes. Os resultados, e-verbetes, estão sendo organizados em meio digital para futura divulgação

Caso clínico tipo labirinto: uma proposta de tecnologia educacional para a área da saúde/ Clinical case labyrinth type: a proposal of educational technology for the health area

O uso de tecnologias tem sido largamente empregado em todos os campos, principalmente na área da educação. Na área da saúde, a tecnologia tem sido cada vez mais utilizada para desenvolver o raciocínio clínico e crítico dos futuros profissionais. O objetivo deste trabalho é apresentar uma proposta de tecnologia educacional tipo labirinto para a área da saúde. Para a criação da proposta de fluxograma educacional, foi utilizado o conceito da metodologia de Design Thinking (DT) e do software Ludcichart, com a finalidade de formular respostas através da compreensão dos questionamentos a serem respondidos, a partir de informações coletadas pelo estudante, durante a observação do problema clínico apresentado, com a finalidade do desenvolvimento de um aplicativo educacional. As pesquisas acerca de casos clínicos/pacientes virtuais ainda são discretas, mas esses recursos se mostram como importantes ferramentas de apoio pedagógico, preparando melhor o profissional para a prática, principalmente antes do contato direto com o paciente, reduzindo os riscos de iatrogenias. A proposta do caso clínico tipo labirinto será facilitar o aprendizado do aluno/usuário, bem como servir como ferramenta para a auto avaliação e ainda possibilitar o acompanhamento do desenvolvimento/evolução pedagógica pelo professor/tutor. Com o desenvolvimento deste aplicativo, espera-se que esta tecnologia educacional possibilite melhorarias da cognição do estudante/usuário, transformando-o num agente crítico, reflexivo e propositivo, além de ser um suporte didático para o ensino de profissionais da saúde

Type IIB supergravity solutions with AdS5 from Abelian and non-Abelian T dualities

We present a large class of new backgrounds that are solutions of type IIB supergravity with a warped AdS${}_5$ factor, non-trivial axion-dilaton, $B$-field and three-form Ramond-Ramond flux but yet have no five-form flux. We obtain these solutions and many of their variations by judiciously applying non-Abelian and Abelian T-dualities, as well as coordinate shifts to AdS${}_5\times X_5$ IIB supergravity solutions with $X_5=S^5, T^{1,1}, Y^{p,q}$. We address a number of issues pertaining to charge quantization in the context of non-Abelian T-duality. We comment on some properties of the expected dual super conformal field theories by studying their CFT central charge holographically. We also use the structure of the supergravity Page charges, central charges and some probe branes to infer aspects of the dual super conformal field theories.Comment: 71 pages, one table. v2: References added, some normalizations corrected, results unchange

LRP1 Receptor Controls Adipogenesis and Is Up-Regulated In Human and Mouse Obese Adipose Tissue

The cell surface low-density lipoprotein receptor-related protein 1, LRP1, plays a major role in lipid metabolism. The question that remains open concerns the function of LRP1 in adipogenesis. Here, we show that LRP1 is highly expressed in murine preadipocytes as well as in primary culture of human adipocytes. Moreover, LRP1 remains abundantly synthesised during mouse and human adipocyte differentiation. We demonstrate that LRP1 silencing in 3T3F442A murine preadipocytes significantly inhibits the expression of PPARγ, HSL and aP2 adipocyte differentiation markers after adipogenesis induction, and leads to lipid-depleted cells. We further show that the absence of lipids in LRP1-silenced preadipocytes is not caused by lipolysis induction. In addition, we provide the first evidences that LRP1 is significantly up-regulated in obese C57BI6/J mouse adipocytes and obese human adipose tissues. Interestingly, silencing of LRP1 in fully-differentiated adipocytes also reduces cellular lipid level and is associated with an increase of basal lipolysis. However, the ability of mature adipocytes to induce lipolysis is independent of LRP1 expression. Altogether, our findings highlight the dual role of LRP1 in the control of adipogenesis and lipid homeostasis, and suggest that LRP1 may be an important therapeutic target in obesity

Mesons from (non) Abelian T-dual backgrounds

In this work we study mesonic excitations in a Quantum Field Theory dual to the non Abelian T-dual of $AdS_5\times S^5$, using a D6 brane probe on the Sfetsos-Thompson background. Before and after the duality, we observe interesting differences between the spectra and interpret them. The spectrum of masses and the interactions among mesonic excitations teach valuable lessons about the character of non-Abelian T-duality and its implications for Holography. The case of Abelian T-duality is also studied.Comment: 26 pages plus many long appendice

Frequent CXCR4 tropism of HIV-1 subtype A and CRF02_AG during late-stage disease - indication of an evolving epidemic in West Africa

<p>Abstract</p> <p>Background</p> <p>HIV-1 is one of the fastest evolving pathogens, and is distinguished by geographic and genetic variants that have been classified into different subtypes and circulating recombinant forms (CRFs). Early in infection the primary coreceptor is CCR5, but during disease course CXCR4-using HIV-1 populations may emerge. This has been correlated with accelerated disease progression in HIV-1 subtype B. Basic knowledge of HIV-1 coreceptor tropism is important due to the recent introduction of coreceptor antagonists in antiretroviral therapy, and subtype-specific differences regarding how frequently HIV-1 CXCR4-using populations appear in late-stage disease need to be further investigated. To study how frequently CXCR4-using populations appear in late-stage disease among HIV-1 subtype A and CRF02_AG, we evaluated the accuracy of a recombinant virus phenotypic assay for these subtypes, and used it to determine the HIV-1 coreceptor tropism of plasma samples collected during late-stage disease in Guinea-Bissau. We also performed a genotypic analysis and investigated subtype-specific differences in the appearance of CXCR4 tropism late in disease.</p> <p>Results</p> <p>We found that the recombinant virus phenotypic assay accurately predicted HIV-1 coreceptor tropism of subtype A and CRF02_AG. Over the study period (1997-2007), we found an increasing and generally high frequency of CXCR4 tropism (86%) in CRF02_AG. By sequence analysis of the V3 region of our samples we developed a novel genotypic rule for predicting CXCR4 tropism in CRF02_AG, based on the combined criteria of the total number of charged amino acids and net charge. This rule had higher sensitivity than previously described genotypic rules and may be useful for development of future genotypic tools for this CRF. Finally, we conducted a literature analysis, combining data of 498 individuals in late-stage disease, and found high amounts of CXCR4 tropism for all major HIV-1 subtypes (60-77%), except for subtype C (15%).</p> <p>Conclusions</p> <p>The increase in CXCR4 tropism over time suggests an evolving epidemic of CRF02_AG. The results of the literature analysis demonstrate the need for further studies investigating subtype-specific emergence for CXCR4-tropism; this may be particularly important due to the introduction of CCR5-antagonists in HIV treatment regimens.</p