Efficiency of the using singulyar at treatment of the bronchial asthma beside children

Using singulyar for reinforcement base treatment beside children allows to reach checking on clinical symptoms of the bronchial asthma and vastly perfect the factors to functions of the external breathing at more short periods

Анкилозирующий спондилоартрит в ревматологической практике Карелии

The paper describes the pathological aspects of an inflammatory process in ankylosing spondyloarthritis (AS), the role of muscle spasm in maintaining the intensity of pain syndrome and stiffness, the need for the early diagnosis of AS, and the significance of the early use of nonster-oidal anti-inflammatory drugs in these patients. The results of clinical trials and the authorsX data demonstrate the high efficacy and good tolerance of nimesulide (nise) in AS.Представлены патоморфологические аспекты воспалительного процесса при анкилозирующем спондилоартрите (АС), роль мышечного спазма в поддержании интенсивности болевого синдрома и скованности, необходимость ранней диагностики АС, значение раннего применения нестероидных противовоспалительных препаратов у таких пациентов. Результаты клинических исследований и собственные данные авторов демонстрируют высокую эффективность и хорошую переносимость нимесулида (найз) при АС

A Novel Ecdysone Receptor Mediates Steroid-Regulated Developmental Events during the Mid-Third Instar of Drosophila

The larval salivary gland of Drosophila melanogaster synthesizes and secretes glue glycoproteins that cement developing animals to a solid surface during metamorphosis. The steroid hormone 20-hydroxyecdysone (20E) is an essential signaling molecule that modulates most of the physiological functions of the larval gland. At the end of larval development, it is known that 20E—signaling through a nuclear receptor heterodimer consisting of EcR and USP—induces the early and late puffing cascade of the polytene chromosomes and causes the exocytosis of stored glue granules into the lumen of the gland. It has also been reported that an earlier pulse of hormone induces the temporally and spatially specific transcriptional activation of the glue genes; however, the receptor responsible for triggering this response has not been characterized. Here we show that the coordinated expression of the glue genes midway through the third instar is mediated by 20E acting to induce genes of the Broad Complex (BRC) through a receptor that is not an EcR/USP heterodimer. This result is novel because it demonstrates for the first time that at least some 20E-mediated, mid-larval, developmental responses are controlled by an uncharacterized receptor that does not contain an RXR-like component

The concept of creating a modern terminal and warehouse complex as a tool for the development of transport and logistics infrastructure

Структура магистерской диссертации включает в себя введение, три главы, заключение, список использованных источников и приложения. Во введении обоснован выбор темы исследования, ее актуальность, сформулированы цель и задачи работы, определены предмет и объект исследования, его теоретические и методологические основы, источники получения информации, сформулирована научная новизна. В первой главе рассмотрены подходы ученых к определению понятия девелопмента, выделены виды девелопмента и особенности его функционирования. Во второй главе проанализирован рынок складской недвижимости. Представлена классификация складской недвижимости. А также выявлены основные проблемы транспортно-логистической инфраструктуры региона. В третьей главе подробно описан проект создания терминально-складского комплекса. Описаны характеристики планируемой застройки, этапы реализации проекта и проведен анализ финансовых результатов проекта. В заключении сформулированы основные выводы и обобщены результаты исследования.Structure of master's thesis includes introduction, three chapters, conclusion, list of used sources and applications. In the introduction the choice of the research topic, its topicality, formulates the goal and objectives, defined the subject and object of research, its theoretical and methodological foundations, sources of information, formulated the scientific novelty. In the first Chapter the approaches of scientists to definition of the concept of development, highlighted the types of development and peculiarities of its functioning. The second Chapter analyzes the market of warehouse real estate. The classification of warehouses. As well as the basic problems of transport and logistics infrastructure of the region. The third Chapter describes in detail the project of creation of terminal and warehouse complex. Describes the characteristics of the proposed development, the stages of the project and the analysis of the financial results of the project. In conclusion the main conclusions and summarizes the results of the stud

Ankylosing spondyloarthritis in the rheumatology practice of Karelia

The paper describes the pathological aspects of an inflammatory process in ankylosing spondyloarthritis (AS), the role of muscle spasm in maintaining the intensity of pain syndrome and stiffness, the need for the early diagnosis of AS, and the significance of the early use of nonster-oidal anti-inflammatory drugs in these patients. The results of clinical trials and the authorsX data demonstrate the high efficacy and good tolerance of nimesulide (nise) in AS

Determining specific thyroid transcripts in peripheral blood: A single center study experience

Thyroid carcinoma (TC) comprises a spectrum of different tumors with a wide range of biological behavior and prognosis. The techniques based on the latest trends in molecular biology may have application in diagnosis of metastatic TC. The aim of this study was to apply and analyze mRNA expression in peripheral blood of thyrotropin receptor [thyroid stimulating hormone receptor (TSHR-mRNA)] gene and thyroglobulin (Tg-mRNA) gene using 2–ΔΔCt method in differentiated TC patients and healthy individuals. Fifty-seven subjects were included in the study, consisting of 40 patients with TC and 17 healthy volunteers as a control group. Total RNA was isolated from peripheral blood and used for two-step reverse transcriptase-polymerase chain reaction (PCR). Real-time PCR was performed with appropriate primers. Relative quantification using the 2–ΔΔCt method was applied. Thyroid carcinoma patients with metastatic disease or loco-regional relapse expressed TSHR-mRNA by a 8.57-fold higher level than healthy controls. Thyroid carcinoma patients with biochemical relapse expressed TSHR-mRNA by a 14.17-fold higher level than healthy controls, while expression of Tg-mRNA was 6.6-fold higher in TC patients with metastatic disease and loco-regional relapse than healthy controls and 8.34-fold higher level compared with TC patients with excellent response to treatment. Our preliminary study showed that the TSHR gene expression might have more useful application as a biomarker compared to detection of Tg gene expression