3,701 research outputs found
Clinical parameters as predictors of bacterial isolation in the uterine content of dogs suspected of pyometra
In this study, female canines referred with clinical signs consistent with pyometra were prospectively evaluated. Signalment, clinical signs, laboratory findings and surgical findings were compared between dogs with and without bacterial isolation based on aerobic techniques. Patients with positive bacterial isolation were placed in the pyometra group, whereas patients with negative bacterial isolation were grouped as mucometra. A total of 140 dogs (118 with pyometra and 22 with mucometra) met the inclusion criteria.
Prereferral antibiotic administration was associated with a prolonged duration of clinical signs in the patients of the pyometra group (12 +/- 2 days versus 7 +/- 1 days; P=0.006). In the pyometra patients, clinical signs, like pyrexia, anorexia and discomfort on abdominal palpation, were observed more commonly than in the mucometra group. The total leukocyte count was the only parameter that differed significantly between the two groups (P=0.01). Although no difference in color and consistency of the uterine fluid was noted, the uteri of the pyometra group were heavier (851.80 +/- 800.30 g compared to 263.50 +/- 297.10 g). E. coil was the most commonly isolated bacterium (92/123)
Local Stellar Kinematics from RAVE data - VII. Metallicity Gradients from Red Clump Stars
We investigate the Milky Way Galaxy's radial and vertical metallicity
gradients using a sample of 47,406 red clump stars from the RAVE DR4. This
sample is more than twice the size of the largest sample in the literature
investigating radial and vertical metallicity gradients. The absolute magnitude
of Groenewegen (2008) is used to determine distances to our sample stars. The
resulting distances agree with the RAVE DR4 distances Binney et al. (2014) of
the same stars. Our photometric method also provides distances to 6185 stars
that are not assigned a distance in RAVE DR4. The metallicity gradients are
calculated with their current orbital positions ( and ) and with
their orbital properties (mean Galactocentric distance, and ),
as a function of the distance to the Galactic plane:
d[Fe/H]/d- dex/kpc for kpc and
d[Fe/H]/d- dex/kpc for kpc. This
reaffirms the radial metallicity gradient in the thin disc but highlights that
gradients are sensitive to the selection effects caused by the difference
between and . The radial gradient is flat in the distance
interval 0.5-1 kpc from the plane and then becomes positive greater than 1 kpc
from the plane. The radial metallicity gradients are also eccentricity
dependent. We showed that d[Fe/H]/d-, -,
- and - dex/kpc for , ,
and sub-samples, respectively, in the distance
interval kpc. Similar trend is found for vertical
metallicity gradients. Both the radial and vertical metallicity gradients are
found to become shallower as the eccentricity of the sample increases. These
findings can be used to constrain different formation scenarios of the thick
and thin discs.Comment: 18 pages, including 16 figures and 6 tables, accepted for publication
in PAS
Consumer credit in comparative perspective
We review the literature in sociology and related fields on the fast global growth of consumer credit and debt and the possible explanations for this expansion. We describe the ways people interact with the strongly segmented consumer credit system around the worldâmore specifically, the way they access credit and the way they are held accountable for their debt. We then report on research on two areas in which consumer credit is consequential: its effects on social relations and on physical and mental health. Throughout the article, we point out national variations and discuss explanations for these differences. We conclude with a brief discussion of the future tasks and challenges of comparative research on consumer credit.Accepted manuscrip
Developing a Vocational Training Computer Game Workplace Simulator: The Vocational Game Project
Abstract This study presents the research and production processes for the development of a Vocational Training computer game workplace simulator that will be used to deliver competency-based The study focuses on the design and development of immersive educational environments and assesses the optimal level of interactivity and game play necessary to achieve identified learning outcomes. This application of games technologies and the development of immersive learning environments enables the targeted delivery of flexible, customised learning programs in the workplace ensuring participant engagement through active learning
Electronic band structure and carrier effective mass in calcium aluminates
First-principles electronic band structure investigations of five compounds
of the CaO-Al2O3 family, 3CaO.Al2O3, 12CaO.7Al2O3, CaO.Al2O3, CaO.2Al2O3 and
CaO.6Al2O3, as well as CaO and alpha-, theta- and kappa-Al2O3 are performed. We
find that the conduction band in the complex oxides is formed from the oxygen
antibonding p-states and, although the band gap in Al2O3 is almost twice larger
than in CaO, the s-states of both cations. Such a hybrid nature of the
conduction band leads to isotropic electron effective masses which are nearly
the same for all compounds investigated. This insensitivity of the effective
mass to variations in the composition and structure suggests that upon a proper
degenerate doping, both amorphous and crystalline phases of the materials will
possess mobile extra electrons
Enhancement of electroporation facilitated immunogene therapy via T-reg depletion
Regulatory T cells (T-regs) can negatively impact tumor antigen-specific immune responses after infiltration into tumor tissue. However, depletion of T-regs can facilitate enhanced anti-tumor responses, thus augmenting the potential for immunotherapies. Here we focus on treating a highly aggressive form of cancer using a murine melanoma model with a poor prognosis. We utilize a combination of T-reg depletion and immunotherapy plasmid DNA delivered into the B16F10 melanoma tumor model via electroporation. Plasmids encoding murine granulocyte macrophage colony-stimulating factor and human B71 were transfected with electroporation into the tumor and transient elimination of T-regs was achieved with CD25-depleting antibodies (PC61). The combinational treatment effectively depleted T-regs compared to the untreated tumor and significantly reduced lung metastases. The combination treatment was not effective in increasing the survival, but only effective in suppression of metastases. These results indicate the potential for combining T-reg depletion with immunotherapy-based gene electrotransfer to decrease systemic metastasis and potentially enhance survival
Orthostatic Changes in Hemodynamics and Cardiovascular Biomarkers in Dysautonomic Patients
Background Impaired autonomic control of postural homeostasis results in orthostatic intolerance. However, the role of neurohormones in orthostatic intolerance has not been explained. Methods Six-hundred-and-seventy-one patients (299 males; 55±22 years) with unexplained syncope underwent head-up tilt (HUT) with serial blood sampling. Systolic blood pressure (SBP) and heart rate (HR) supine, after 3min, and lowest BP/highest HR during HUT were recorded. Plasma levels of epinephrine, norepinephrine, renin, C-terminal-pro-arginine-vasopressin (CT-proAVP), C-terminal- endothelin-1 (CT-proET-1), and mid-regional-fragment of pro-atrial-natriuretic-peptide (MR-proANP) were determined at supine and 3min of HUT. Multivariate-adjusted logistic regression model was applied to compare 1st (reference) with 4th quartile of 3 min and maximal ÎSBP/ÎHR (i.e. pronounced hypotension or tachycardia) vs. changes in neuroendocrine biomarkers, respectively. Results Higher resting CT-proET-1 predicted BP fall at 3min (Odds ratio (OR) per 1 SD: 1.62, 95% CI 1.18â2.22; p = 0.003), and max BP fall during HUT (1.82, 1.28â2.61; p = 0.001). Higher resting CT-proAVP predicted BP fall at 3min (1.33, 1.03â1.73; p = 0.03), which was also associated with increase in CT-proAVP (1.86, 1.38â2.51; p = 0.00005) and epinephrine (1.47, 1.12â1.92; p = 0.05) during HUT. Lower resting MR-proANP predicted tachycardia at 3min (0.37, 0.24â0.59; p = 0.00003), and max tachycardia during HUT (0.47, 0.29â0.77; p = 0.002). Further, tachycardia during HUT was associated with increase in epinephrine (1.60, 1.15â2.21; p = 0.005), and norepinephrine (1.87, 1.38â2.53; p = 0.005). Conclusions Resting CT-proET-1 and CT-proAVP are increased in orthostatic hypotension, while resting MR-proANP is decreased in postural tachycardia. Moreover, early BP fall during orthostasis evokes increase in CT-proAVP and epinephrine, while postural tachycardia is associated with increase in norepinephrine and epinephrine
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