Clinicomorphological parallels of physical and sexual development of juvenile girls in contemporary conditions

The data about features of physical and sexual development of juvenile girls in Krasnoyarsk city is presented. The evnuchoidisation of constitution, astenic somatic type, increasing of frequency of trophological insufficiency, disproportion of figure and intensification of functional disorders in reproductive system have been determined

The Dosimetric Parameters Investigation of the Pulsed X-ray and Gamma Radiation Sources

The most common type of radiation used for diagnostic purposes are X-rays. However, X-rays methods have limitations related to the radiation dose for the biological objects. It is known that the use of the pulsed emitting source synchronized with the detection equipment for internal density visualization of objects significant reduces the radiation dose to the object. In the article the analysis of the suitability of the different dosimetric equipment for the radiation dose estimation of the pulsed emitting sources is carried out. The approbation results on the pulsed X-ray generator RAP-160-5 of the dosimetry systems workability with the pulse radiation and its operation range are presented. The results of the dose field investigation of the portable betatron OB-4 are demonstrated. The depth dose distribution in the air, lead and water of the pulsed bremsstrahlung generated by betatron are shown

Methods of radiation and environmental studies of build-up areas and their analysis

The most objective assessment of radon hazard of build-up area can be the amount of radon released from the underlying rocks. In the Russian Federation, the criterion of radon hazard is the radon flux density, measured by the method of accumulation chambers. The paper presents the results of measurements obtained by the method of accumulation chamber using two measuring complexes and the method of "two depths". The measurements were performed on a testing site of Tomsk (Russia); the type of soil is loam. Studies have shown that the considered assessment methods of radon risk have significant drawbacks, because they do not allow reliable determination of the amount of radon coming from the soil surface

The Orbital Order Parameter in La0.95Sr0.05MnO3 probed by Electron Spin Resonance

The temperature dependence of the electron-spin resonance linewidth in La0.95Sr0.05MnO3 has been determined and analyzed in the paramagnetic regime across the orbital ordering transition. From the temperature dependence and the anisotropy of linewidth and $g$-value the orbital order can be unambiguously determined via the mixing angle of the wave functions of the $e_{\rm g}$-doublet. The linewidth shows a similar evolution with temperature as resonant x-ray scattering results

Оценка клинической эффективности щадящей и стандартной панретинальной лазеркоагуляции сетчатки при непролиферативной диабетической ретинопатии

We have shown that the classical panretinal laser coagulation is a rather traumatic procedure, damaging all layers of the retina, leadingbto a narrowing of visual fields and decrease the electrical activityof the retina that can impair quality of life. Using sparing laser coagulation is a highly effective metod of prolonged of visual function.Проведено сравнительное исследование вариантов лазеркоагуляции сетчатки при сахарном диабете. Установлено, что стандартная панретинальная лазеркоагуляция является достаточно травматичной процедурой, повреждающей все слои сетчатки, приводящей к сужению полей зрения и снижению электрической активности сетчатки, ухудшающим качество жизни пациента. Щадящая (субпороговая) лазеркоагуляция сетчатки является высокоэффективным методом длительного сохранения зрительных функций

Value-meaningful conceptualisation of educational material in the process of foreign language teaching at the university: A hermeneutic approach

Introduction. One of the main tasks of teaching foreign languages for professional purposes is the formation of professional communicative competence of students. In this regard, it is important for university teachers to create conditions for students to master the methods and techniques of productive communication, not only from the perspective of language and culture, but also their future profession. In addition to the logical and rational aspect, it is important for pedagogical students to focus on the value and semantic significance of educational information, to deeply understand rather than to memorise information, to be emotionally “engaged” into knowledge, filling it with personal meaning, in order to avoid formal mastering of pedagogical profession. This is possible in the context of the value and semantic conceptualisation of acquired knowledge, which is carried out in the process of interpreting and structuring the content of training by the principle of linguistic concept. Aim. The present research aims to substantiate the content, methods, techniques and forms of value meaningful conceptualisation of educational material in the process of teaching foreign languages to pedagogical students. Methodology and research methods are based on the study of the value-semantic foundations of pedagogical practice with reference to the cultural-historical concept; on the phenomenological-hermeneutical approach, aimed at the actualisation of the interpretive potential of the teaching content; on the utilisation of the methods of theoretical analysis and synthesis, deduction and induction, comparison, modelling, and methods of inclusive observation. The empirical study was conducted during one academic year (from September 2020 to June 2021) in the course “English for Specific Purposes (ESP)” with 60 students of Pedagogical Education major of the University of Tyumen. To assess the results of the experimental work the following tools were used: L. Michelson’s test, free associative experiment, the method of expert evaluation based on the level scale developed by the authors. Results. The obtained data confirmed the effectiveness of structuring learning content according to the linguistic concept image. In the course of the final test of communicative and professional skills, most students demonstrated a confident command of the basics of professional communication in English. Compared to the initial stage of the study, students’ professional communication in English became more productive. Students’ statements were distinguished by their meaningfulness, structure. They used additional material from other fields of knowledge, emotional and value coloring in the form of metaphors, idioms, statements of famous teachers, precedent texts, the ability to improvise, etc. Scientific novelty. The authors didactically proved the productivity of the hermeneutic approach in the design of teaching foreign languages on the basis of structuring teaching material by the principle of linguistic concept, which is a mediating link between the scientific concept, on the one hand, and the individual consciousness and the subjective personal experience of students, on the other hand. Practical significance. The results of this study can be used by teachers in order to achieve a balance between technological and axiological aspects of learning and cognitive activities of students for mastering their pedagogical knowledge, professional and personal experience, which will ultimately contribute to the enhancement of professional training of future educators.Введение. Одной из основных задач преподавания иностранных языков для профессиональных целей является формирование профессиональной коммуникативной компетенции студентов. В этой связи в процессе обучения преподавателям вуза важно создать условия для освоения студентами способов и приемов осуществления продуктивного общения не только с позиции языка и культуры, но и их будущей профессии. Во избежание формального освоения педагогической профессии студентам педагогических специальностей важно, помимо логико-гносеологического аспекта, ориентироваться на ценностно-смысловую значимость учебной информации, глубоко понимать, а не запоминать, эмоционально «проживать» знание, наполняя его личностными смыслами. Это возможно в условиях ценностно-смысловой концептуализации осваиваемого знания, осуществляемой в процессе интерпретации и структурирования содержания обучения по образу лингвоконцепта. Цель – обоснование содержания, методов, приемов и форм ценностно-смысловой концептуализации учебного материала в процессе обучения иностранным языкам студентов педагогических специальностей. Методология, методы и методика. В основу работы положены исследование ценностно-смысловых оснований педагогической деятельности с обращением к культурно-исторической концепции, а также феноменолого-герменевтический подход, направленный на актуализацию интерпретационного потенциала содержания обучения. Использованы методы теоретического анализа и синтеза, дедукции и индукции, сравнения, моделирования, включённого наблюдения. Эмпирическое исследование проводилось в течение одного академического года (с сентября 2020 года по июнь 2021 года) на занятиях по «Иностранному языку в профессиональной сфере (английский язык)» с участием 60 студентов, обучающихся на направлении «Педагогическое образование» Тюменского государственного университета. Для оценки результатов опытной работы использовались: тест Л. Михельсона, свободный ассоциативный эксперимент, метод экспертной оценки на основе разработанной авторами уровневой шкалы. Результаты. Полученные в результате исследования данные подтвердили эффективность структурирования содержания обучения по образу лингвоконцепта. В ходе итогового тестирования коммуникативных и профессиональных умений и навыков большинство студентов продемонстрировали уверенное владение основами профессиональной коммуникации на английском языке. По сравнению с начальным этапом исследования профессиональная коммуникация студентов на английском языке стала более продуктивной. Высказывания отличались осмысленностью, структурированностью, привлечением дополнительного материала из других областей знания, эмоционально-ценностной окрашенностью в виде метафор, идиом, высказываний известных педагогов, прецедентных текстов, умением осуществлять импровизацию и др. Научная новизна. Дидактически обоснована продуктивность герменевтического подхода в проектировании обучения иностранным языкам на основе структурирования учебного материала по принципу лингвоконцепта, который является опосредующим звеном между научным понятием, с одной стороны, и индивидуальным сознанием и субъективно-личностным опытом обучающихся, с другой.Авторы выражают благодарность рецензентам за экспертное мнение и конструктивный подход.The authors express their gratitude to the reviewers for their expert opinion and constructive approach

Project-oriented technology for formation of professional competence due to interdisciplinary connections

На примере одной из дисциплин архитектурно-градостроительного направления творческого вуза демонстрируется применение проектно-ориентированных технологий, опирающихся на обширную коллекцию трехмерных моделей реального предприятия. Это позволяет установить межпредметные связи для формирования профессиональных компетенций.On the example of one of the disciplines of Architecture and urban areas we show the usage of project-oriented technologies, based on an extensive collection of three-dimensional models of real company. This approach allows to set the interdisciplinary communication for the formation of professional competencies

Peculiarities of immunological manifestations in patients with rheumatoid arthritis in the presence of chronic infection with <i>Helicobacter pylori</i> variant encoding cytotoxin-associated gene A

The study aimed to evaluate the association between cyclic citrullinated peptide antibody seropositivity and chronic Helicobacter pylori (H. pylori) infection in patients with rheumatoid arthritis (RA). We examined 92 women with moderate RA activity. Serum antibodies to cyclic citrullinated peptide (antiCCP), antibodies to H. pylori (anti-H. pylori-IgG), and total antibodies to H. pylori CagA antigen (antiCagA) were determined by enzyme immunoassay; the presence of anti-CagA-IgG positivity was confirmed by immunoblot. 68.5% of RA patients were positive for anti-H. pylori-IgG, and 44.4% of patients in this group were positive for anti-CagA-IgG. All the study participants were divided into three groups: I – H. pylori seronegative (H. pylori- ); II – H. pylori positive, CagA negative (H. pylori+/CagA- ); III – H. pylori positive and CagA positive (CagA+). The anti-CCP values in RA patients with CagA+ (group III) were significantly higher not only in comparison with patients seronegative for H. pylori (p &lt; 0.001), but also in comparison with patients from group II (H. pylori+/CagA- ) (p = 0.041). A study of the influence of the RA activity, the presence of RF and H. pylori on anti-CCP content demonstrated a small proportion of anti-CCP variability (R2 = 0.09), with a high contribution of H. pylori (beta = 0.25). The addition of the CagA(+) index (beta = 0.503) to the presented model allowed us to describe the variability of anti-CCP in almost 30% of cases (R2 = 0.29). In the group of RA patients with anti-CCP values exceeding the established threshold value of 20 U/mL (normal index), there was an increase in the proportion of patients infected with H. pylori (p &lt; 0.001), but not the proportion of CagA-positive patients (p = 0.06). When the threshold level was increased to 60 U/mL (three times the upper limit of normal) in patients with significantly high anti-CCP, the association with positivity for CagA became significant (p = 0.005). CagA is highly immunogenic and is capable of inducing an inflammatory response in the host that goes beyond the effect of H. pylori itself. Additional experimental studies are needed to investigate possible clinical and laboratory associations that may influence the treatment tactics of CagA+ patients with RA who are seropositive for anti-citrullinated antibodies, as well as to evaluate the possible effects of therapeutic intervention aimed at the eradication of H. pylori in this group

Influence of human peripheral blood samples preprocessing on the quality of Hi-C libraries

The genome-wide variant of the chromatin conformation capture technique (Hi-C) is a powerful tool for revealing patterns of genome spatial organization, as well as for understanding the effects of their disturbance on disease development. In addition, Hi-C can be used to detect chromosomal rearrangements, including balanced translocations and inversions. The use of the Hi-C method for the detection of chromosomal rearrangements is becoming more widespread. Modern high-throughput methods of genome analysis can effectively reveal point mutations and unbalanced chromosomal rearrangements. However, their sensitivity for determining translocations and inversions remains rather low. The storage of whole blood samples can affect the amount and integrity of genomic DNA, and it can distort the results of subsequent analyses if the storage was not under proper conditions. The Hi-C method is extremely demanding on the input material. The necessary condition for successfully applying Hi-C and obtaining high-quality data is the preservation of the spatial chromatin organization within the nucleus. The purpose of this study was to determine the optimal storage conditions of blood samples for subsequent Hi-C analysis. We selected 10 different conditions for blood storage and sample processing. For each condition, we prepared and sequenced Hi-C libraries. The quality of the obtained data was compared. As a result of the work, we formulated the requirements for the storage and processing of samples to obtain high-quality Hi-C data. We have established the minimum volume of blood sufficient for conducting Hi-C analysis. In addition, we have identified the most suitable methods for isolation of peripheral blood mononuclear cells and their long-term storage. The main requirement we have formulated is not to freeze whole blood