Effect of Type 2 Diabetes on the Dynamic Response Characteristics of Leg Vascular Conductance During Exercise

Abstract In this study we tested the hypothesis that type 2 diabetes impairs the dynamic response of leg vascular conductance (LVC) during exercise. LVC (leg blood flow/mean arterial pressure) responses were studied during intermittent contractions of the calf muscle in subjects with type 2 diabetes (n = 9), heavy controls (n = 10) and lean controls (n = 8) using a biexponential function and an estimate of the mean response time (MRT). The time constant of the second phase of LVC was significantly greater in type 2 diabetes (66.4 ± 29.2 s) than the heavy (22.2 ± 13.4 s) and lean (21.8 ± 9.3 s) controls, resulting in a significantly greater MRT in the diabetic group (median [IQR] = 30.7 [24.6-46.5] s versus 16.3 [4.3-23.2] s and 18.4 [13.7-19.3] s). These data support the hypothesis and suggest that a slowed hyperaemic response in the exercising limb might contribute to exercise intolerance in diabetic subjects

Contamination source review for Building E5032, Edgewood Area, Aberdeen Proving Ground, Maryland

This report by Argonne National Laboratory (ANL) documents results of a contamination source review of Building E5032 at the Aberdeen Proving Ground (APG) in Maryland. The review included a historical records search, physical inspection, photographic documentation, geophysical investigation, and review of available records regarding underground storage tanks associated with Building E5032. The field investigations were performed by ANL during 1994 and 1995. Building E5032 (APG designation), originally known as Building 99, is located at the northwest comer of the intersection of Hoadley Road and Magnolia Road in the Edgewood Area of APG. It was constructed during World War I as an incendiary bomb filling plant and in 1920s and 1930s maintained as a filling facility. During World War II the building was a pilot plant for the development of a dry white phosphorus filling process. Since then the building has been used for white phosphorus filling pilot studies. Most of the dry filling methods were developed in Building E5032 between 1965 and 1970. Other filling operations in Building E5032 have included mustard during the period shortly after World War II and triethyl aluminum (TEA) during the late 1960s and early 1970s. During the World War II period, the building was connected to the sanitary sewer system with one large and at least one small interior sump. There are also seven sumps adjacent to the exterior of the building: two on the west elevation, four near the four bays on the south elevation, and one at the northeast corner of the building. All of these sumps are connected with the chemical sewer system and received most, if not all, of the production operation wastewater. The discharge from this system was released into the east branch of Canal Creek; the discharge pipe was located southeast of Building E5032. There are no records indicating the use of Building E5032 after 1974, and it is assumed that the building has been out of service since that time

The Future of U.S. Natural Gas Production, Use, and Trade

Abstract and PDF report are also available on the MIT Joint Program on the Science and Policy of Global Change website (http://globalchange.mit.edu/)Two computable general equilibrium models, one global and the other providing U.S. regional detail, are applied to analysis of the future of U.S. natural gas as an input to an MIT study of the topic. The focus is on uncertainties including the scale and cost of gas resources, the costs of competing technologies, the pattern of greenhouse gas mitigation, and the evolution of global natural gas markets. Results show that the outlook for gas over the next several decades is very favorable. In electric generation, given the unproven and relatively high cost of other low-carbon generation alternatives, gas likely is the preferred alternative to coal. A broad GHG pricing policy would increase gas use in generation but reduce use in other sectors, on a balance increasing its role from present levels. The shale gas resource is a major contributor to this optimistic view of the future of gas, but it is far from a panacea over the longer term. Gas can be an effective bridge to a lower emissions future, but investment in the development of still lower CO2 technologies remains an important priority. Also, international gas resources may well prove to be less costly than those in the U.S., except for the lowest-cost domestic shale resources, and the emergence of an integrated global gas market could result in significant U.S. gas imports.American Clean Skies Foundation, with additional support from the Hess Corporation, the Agencia Nacional de Hidrocarburos (Columbia), the Energy Futures Coalition, and the MIT Energy Initiative

OS-WALK-EU: An open-source tool to assess health-promoting residential walkability of European city structures

Introduction This paper introduces OS-WALK-EU, a new open-source walkability assessment tool developed specifically for urban neighbourhoods and using open-source spatial data. A free and open-source tool, OS-WALK-EU is accessible to the general public. It uses open data available worldwide and free online services to compute accessibility, while at the same time allowing users to integrate local datasets if available. Based on a review of existing measurement concepts, the paper adopts dimensions of walkability that were tested in European city environments and explains their conceptualization for software development. We invite the research community to collaboratively test, adopt and use the tool as part of the increasing need to monitor walkability as part of health-promoting urban development. Methods Tool development is based on spatial analysis methods to compute indicators for five dimensions of walkability: residential density, weighted proximities to amenities, pedestrian radius of activity, share of green and blue infrastructure, and slope. Sample uses in the cities of Dublin, Düsseldorf and Lisbon test the validity of input data and results, including scenarios for target groups like older people. Results Overall, application of the tool in Dublin, Düsseldorf and Lisbon shows conclusive results that conform to local knowledge. Shortcomings can be attributed to deficiencies in open source input data. Local administrative data, if available, is suitable to improve results. Conclusions OS-WALK-EU is the first software tool that allows free and open walkability assessments with pedestrian routing capacities for ‘proximity to facilities’ calculations. Large scale implementation for 33 German city regions in an online application shows the value of comparative assessments of walkable neighbourhoods between urban and suburban neighbourhoods. Such assessments are important to monitor progress in a mobility transition towards improved walkability and public health

Restricted and unrestricted Hartree-Fock calculations of conductance for a quantum point contact

Very short quantum wires (quantum contacts) exhibit a conductance structure at a value of conductance close to $0.7 \times 2e^2/h$. It is believed that the structure arises due to the electron-electron interaction, and it is also related to electron spin. However details of the mechanism of the structure are not quite clear. Previously we approached the problem within the restricted Hartree-Fock approximation. This calculation demonstrated a structure similar to that observed experimentally. In the present work we perform restricted and unrestricted Hartree-Fock calculations to analyze the validity of the approximations. We also consider dependence of the effect on the electron density in leads. The unrestricted Hartree-Fock method allows us to analyze trapping of the single electron within the contact. Such trapping would result in the Kondo model for the ``0.7 structure''. The present calculation confirms the spin-dependent bound state picture and does not confirm the Kondo model scenario.Comment: 6 pages, 9 figure

Extreme sensitivity of the spin-splitting and 0.7 anomaly to confining potential in one-dimensional nanoelectronic devices

Quantum point contacts (QPCs) have shown promise as nanoscale spin-selective components for spintronic applications and are of fundamental interest in the study of electron many-body effects such as the 0.7 x 2e^2/h anomaly. We report on the dependence of the 1D Lande g-factor g* and 0.7 anomaly on electron density and confinement in QPCs with two different top-gate architectures. We obtain g* values up to 2.8 for the lowest 1D subband, significantly exceeding previous in-plane g-factor values in AlGaAs/GaAs QPCs, and approaching that in InGaAs/InP QPCs. We show that g* is highly sensitive to confinement potential, particularly for the lowest 1D subband. This suggests careful management of the QPC's confinement potential may enable the high g* desirable for spintronic applications without resorting to narrow-gap materials such as InAs or InSb. The 0.7 anomaly and zero-bias peak are also highly sensitive to confining potential, explaining the conflicting density dependencies of the 0.7 anomaly in the literature.Comment: 23 pages, 7 figure

Interpreting physical performance in professional soccer match-play: Should we be more pragmatic in our approach?

Academic and practitioner interest in the physical performance of male professional soccer players in the competition setting determined via time-motion analyses has grown substantially over the last four decades leading to a substantial body of published research and aiding development of a more systematic evidence-based framework for physical conditioning. Findings have forcibly shaped contemporary opinions in the sport with researchers and practitioners frequently emphasising the important role that physical performance plays in match outcomes. Time-motion analyses have also influenced practice as player conditioning programmes can be tailored according to the different physical demands identified across individual playing positions. Yet despite a more systematic approach to physical conditioning, data indicate that even at the very highest standards of competition, the contemporary player is still susceptible to transient and end-game fatigue. Over the course of this article, the author suggests that a more pragmatic approach to interpreting the current body of time-motion analysis data and its application in the practical setting is nevertheless required. Examples of this are addressed using findings in the literature to examine: a) the association between competitive physical performance and ‘success’ in professional soccer, b) current approaches to interpreting differences in time-motion analysis data across playing positions and, c) whether data can realistically be used to demonstrate the occurrence of fatigue in match-play. Gaps in the current literature and directions for future research are also identified

The MIT Emissions Prediction and Policy Analysis (EPPA) Model: Version 4

Abstract in HTML and technical report in PDF available on the Massachusetts Institute of Technology Joint Program on the Science and Policy of Global Change website (http://mit.edu/globalchange/www/).The Emissions Prediction and Policy Analysis (EPPA) model is the part of the MIT Integrated Global Systems Model (IGSM) that represents the human systems. EPPA is a recursive-dynamic multi-regional general equilibrium model of the world economy, which is built on the GTAP dataset and additional data for the greenhouse gas and urban gas emissions. It is designed to develop projections of economic growth and anthropogenic emissions of greenhouse related gases and aerosols. The main purpose of this report is to provide documentation of a new version of EPPA, EPPA version 4. In comparison with EPPA3, it includes greater regional and sectoral detail, a wider range of advanced energy supply technologies, improved capability to represent a variety of different and more realistic climate policies, and enhanced treatment of physical stocks and flows of energy, emissions, and land use to facilitate linkage with the earth system components of the IGSM. Reconsideration of important parameters and assumptions led to some revisions in reference projections of GDP and greenhouse gas emissions. In EPPA4 the global economy grows by 12.5 times from 2000 to 2100 (2.5% per year) compared with an increase of 10.7 times (2.4% per year) in EPPA3. This is one of the important revisions that led to an increase in CO2 emissions to 25.7 GtC in 2100, up from 23 GtC in 2100 projected by EPPA3. There is considerable uncertainty in such projections because of uncertainty in various driving forces. To illustrate this uncertainty we consider scenarios where the global GDP grows 0.5% faster (slower) than the reference rate, and these scenarios result in CO2 emissions in 2100 of 34 (17) GtC. A sample greenhouse gas policy scenario that puts the world economy on a path toward stabilization of atmospheric CO2 at 550 ppmv is also simulated to illustrate the response of EPPA4 to a policy constraint.This research was supported by the U.S Department of Energy, U.S. Environmental Protection Agency, U.S. National Science Foundation, U.S. National Aeronautics and Space Administration, U.S. National Oceanographic and Atmospheric Administration; and the Industry and Foundation Sponsors of the MIT Joint Program on the Science and Policy of Global Change: Alstom Power (France), American Electric Power (USA), BP p.l.c. (UK/USA), Chevron Corporation (USA), CONCAWE (Belgium), DaimlerChrysler AG (Germany), Duke Energy (USA), J-Power (Japan), Electric Power Research Institute (USA), Electricité de France, ExxonMobil Corporation (USA), Ford Motor Company (USA), General Motors (USA), Murphy Oil Corporation (USA), Oglethorpe Power Corporation (USA), RWE Power (Germany), Shell Petroleum (Netherlands/UK), Southern Company (USA), Statoil ASA (Norway), Tennessee Valley Authority (USA), Tokyo Electric Power Company (Japan), Total (France), G. Unger Vetlesen Foundation (USA)

ff-minimal surface and manifold with positive mm-Bakry-\'{E}mery Ricci curvature

In this paper, we first prove a compactness theorem for the space of closed embedded $f$-minimal surfaces of fixed topology in a closed three-manifold with positive Bakry-\'{E}mery Ricci curvature. Then we give a Lichnerowicz type lower bound of the first eigenvalue of the $f$-Laplacian on compact manifold with positive $m$-Bakry-\'{E}mery Ricci curvature, and prove that the lower bound is achieved only if the manifold is isometric to the $n$-shpere, or the $n$-dimensional hemisphere. Finally, for compact manifold with positive $m$-Bakry-\'{E}mery Ricci curvature and $f$-mean convex boundary, we prove an upper bound for the distance function to the boundary, and the upper bound is achieved if only if the manifold is isometric to an Euclidean ball.Comment: 15 page

Skilful seasonal predictions of Summer European rainfal

This is the author accepted manuscript. The final version is available from American Geophysical Union (AGU) via the DOI in this record.Year-to-year variability in Northern European summer rainfall has profound societal and economic impacts; however current seasonal forecast systems show no significant forecast skill. Here we show skilful predictions are possible (r~0.5, p80 members) are required for skilful predictions. This work is promising for the development of European summer rainfall climate services.This work was supported by the Joint DECC/Defra Met Office Hadley Centre Climate Programme (GA01101), the EU FP7 SPECS project. We acknowledge the E-OBS dataset from the EU-FP6 project ENSEMBLES (http://ensembles-eu.metoffice.com) and the data providers in the ECA&D project (http://www.ecad.eu). We also would like to thank Gerard van der Schrier and Else Van Den Besselaar for kindly providing us the pre-release E-OBS dataset version 'v16e' and further support. Model data used to create the figures are available from the authors upon request for academic use