Women and Peace: Female Political Empowerment & the Prevention of Civil Violence

Today conflict mainly occurs within nations (as opposed to between nations), and the importance of women in creating and maintaining peace (which can be most simply defined as the absence of violence) through informal and formal leadership roles has also become known, offering much for the possibility of the reduction of violence within nations. Testing this relationship through a Poisson regression for the hypothesis that countries that have higher political empowerment for women will have less civil violence in their nations than countries with a lower level of political empowerment for women, this study is able to reject the null hypothesis (that no such relationship exists) by finding that the political empowerment of women has a statistically significant impact in the reduction of civil violence. In testing three additional intervening variables (democracy, GDP per capita, and primary education), it is determined that the political empowerment of women has the greatest impact on the reduction of civil violence, implying that, in the future, more effort should be placed on empowering women as a means for establishing peace

Fearless Friday: Piper O\u27Keefe

This Friday we celebrate the fearless leadership of Piper O’Keefe! Piper is a senior studying globalization and political science. Currently, Piper is the president of the College Democrats, a fellow with the Eisenhower Institute, and involved with the service fraternity Alpha Phi Omega (APO). [excerpt

Modelling the hepatitis B vaccination programme in prisons

A vaccination programme offering hepatitis B (HBV) vaccine at reception into prison has been introduced into selected prisons in England and Wales. Over the coming years it is anticipated this vaccination programme will be extended. A model has been developed to assess the potential impact of the programme on the vaccination coverage of prisoners, ex-prisoners, and injecting drug users (IDUs). Under a range of coverage scenarios, the model predicts the change over time in the vaccination status of new entrants to prison, current prisoners and IDUs in the community. The model predicts that at baseline in 2012 57% of the IDU population will be vaccinated with up to 72% being vaccinated depending on the vaccination scenario implemented. These results are sensitive to the size of the IDU population in England and Wales and the average time served by an IDU during each prison visit. IDUs that do not receive HBV vaccine in the community are at increased risk from HBV infection. The HBV vaccination programme in prisons is an effective way of vaccinating this hard-to-reach population although vaccination coverage on prison reception must be increased to achieve this

Short- and Longer-Term Benefits of Temporary Alcohol Abstinence During ‘Dry January’ Are Not Also Observed Among Adult Drinkers in the General Population: Prospective Cohort Study

Aims The alcohol abstinence challenge ‘Dry January’ continues to grow, but there is a lack of knowledge of how Dry January participants compare to the general population. There is also a need to determine whether benefits experienced by Dry January participants are unique to that group or are also observed among other people. Methods We conducted a prospective cohort study using online questionnaires in early January, February and August 2019. We compared 1192 Dry January participants and 1549 adult drinkers who did not attempt to abstain from alcohol. Key outcomes were self-rated physical health, psychological well-being (Warwick–Edinburgh Mental Well-Being Scale), control over drinking (Drink Refusal Self-Efficacy Scale (DRSE)) and alcohol intake (Alcohol Use Disorders Identification Test–Consumption (AUDIT-C) subscale). Baseline differences in demographic and alcohol consumption variables were included as covariates in between-group analyses. Results Dry January participants had higher SES, poorer well-being, higher AUDIT-C scores and less control over their drinking than the general population. Beneficial changes in health, WEMWBS, DRSE and AUDIT-C observed among people completing Dry January were not observed among other adult drinkers. Conclusions Dry January appears to attract people who are heavier drinkers than the general population and who are more concerned about their alcohol intake. Completion of Dry January is associated with short- and longer-term benefits to well-being that are not observed in the general population

Heat transfer and pressure loss in small-scale pillow-plate heat exchangers

In this work, an experimental study of heat transfer between air and water in a small-scale pillow-plate heat exchanger (PPHE) consisting of two pillow plates assembled together in one unit was carried out. In the experiments, cooling water flows in two inner channels (i.e., channels inside welded pillow plates), whereas air is directed to the outer channel between the plates. Heat transfer and hydraulic resistance in inner and outer PPHE channels are analysed based on the experimental data. The measurements were used to develop correlations for the pressure loss and heat transfer coefficients in both inner and outer channels. For the detailed investigation of pressure loss and wall shear stress in the outer channel between pillow plates, CFD simulations were carried out for the considered geometry. The Reynolds number was equal to 5,173, which ensured fully developed turbulent flow. The proposed correlations derived from experimental data were compared with the CFD simulation results. They can be used to predict thermal and hydraulic performance of small-scale PPHEs

Heat transfer and pressure loss in small-scale pillow-plate heat exchangers

In this work, an experimental study of heat transfer between air and water in a small-scale pillow-plate heat exchanger (PPHE) consisting of two pillow plates assembled together in one unit was carried out. In the experiments, cooling water flows in two inner channels (i.e., channels inside welded pillow plates), whereas air is directed to the outer channel between the plates. Heat transfer and hydraulic resistance in inner and outer PPHE channels are analysed based on the experimental data. The measurements were used to develop correlations for the pressure loss and heat transfer coefficients in both inner and outer channels. For the detailed investigation of pressure loss and wall shear stress in the outer channel between pillow plates, CFD simulations were carried out for the considered geometry. The Reynolds number was equal to 5,173, which ensured fully developed turbulent flow. The proposed correlations derived from experimental data were compared with the CFD simulation results. They can be used to predict thermal and hydraulic performance of small-scale PPHEs

Fingolimod after a first unilateral episode of acute optic neuritis (MOVING) - preliminary results from a randomized, rater-blind, active-controlled, phase 2 trial

BACKGROUND: Neuroprotection and promotion of remyelination represent important therapeutic gaps in multiple sclerosis (MS). Acute optic neuritis (ON) is a frequent MS manifestation. Based on the presence and properties of sphingosine-1-phosphate receptors (S1PR) on astrocytes and oligodendrocytes, we hypothesized that remyelination can be enhanced by treatment with fingolimod, a S1PR modulator currently licensed for relapsing-remitting MS. METHODS: MOVING was an investigator-driven, rater-blind, randomized clinical trial. Patients with acute unilateral ON, occurring as a clinically isolated syndrome or MS relapse, were randomized to 6 months of treatment with 0.5 mg oral fingolimod or subcutaneous IFN-β 1b 250 μg every other day. The change in multifocal visual evoked potential (mfVEP) latency of the qualifying eye was examined as the primary (month 6 vs. baseline) and secondary (months 3, 6 and 12 vs. baseline) outcome. In addition, full field visual evoked potentials, visual acuity, optical coherence tomography as well as clinical relapses and measures of disability, cerebral MRI, and self-reported visual quality of life were obtained for follow-up. The study was halted due to insufficient recruitment (n = 15), and available results are reported. RESULTS: Per protocol analysis of the primary endpoint revealed a significantly larger reduction of mfVEP latency at 6 months compared to baseline with fingolimod treatment (n = 5; median decrease, 15.7 ms) than with IFN-β 1b treatment (n = 4; median increase, 8.15 ms) (p <  0.001 for interaction). Statistical significance was maintained in the secondary endpoint analysis. Descriptive results are reported for other endpoints. CONCLUSION: Preliminary results of the MOVING trial argue in support of a beneficial effect of fingolimod on optic nerve remyelination when compared to IFN-β treatment. Interpretation is limited by the small number of complete observations, an unexpected deterioration of the control group and a difference in baseline mfVEP latencies. The findings need to be confirmed in larger studies. TRIAL REGISTRATION: The trial was registered as EUDRA-CT 2011-004787-30 on October 26, 2012 and as NCT01647880 on July 24, 2012

Correlated polyhedral rotations in the absence of polarons during electrochemical insertion of lithium in ReO3

Understanding the structural transformations that materials undergo during (de)insertion of Li ions is crucial for designing high-performance intercalation hosts as these deformations can lead to significant capacity fade. Herein, we present a study of the metallic defect perovskite ReO3 to determine whether these distortions are driven by polaronic charge transport (i.e., the electrons and ions moving through the lattice in a coupled way) due to the semiconducting nature of most oxide hosts. Employing numerous techniques, including electrochemical probes, operando X-ray diffraction, X-ray photoelectron spectroscopy, and density functional theory calculations, we find that the cubic structure of ReO3 experiences multiple phase changes involving the correlated twisting of rigid octahedral subunits upon lithiation. This results in exceptionally poor long-term cyclability due to large strains upon lithiation, even though metallic character is maintained throughout. This suggests that phase transformations during alkali ion intercalation are the result of local strains in the lattice and not exclusively due to polaron migration