STATS SRS v11.0

The objective of this project is the delivery of an application that will provide a unified, web-based system for collecting, verifying and analyzing the achievements for Laboratory employees. The application will enable individual Directorates to manage and report achievement record data for their employees using an LLNL standard web browser. In addition, cross directorate data reporting and analysis will be available for such organizations as LSTO and programmatic directorates. This system is intended to store reference data and metadata for employee achievements. Abstracts and entire publications will not be stored in this system.Directorates are expected to use this system at all levels of management in preparing for Annual Self-Assessments, peer reviews, LDRD reviews, work force reviews, performance appraisals, and requests from sponsors. This document represents the primary deliverable for the Requirements Definition stage of system development. As part of a successful Requirements Definition, this document provides the development staff, the project sponsor, and the user community with a clear understanding of the product's operational, data, and other requirements. With this understanding, the development staff will take the opportunity to refine estimates regarding the cost, schedule, and deliverables reflected in it

Nonlinear effects in tunnelling escape in N-body quantum systems

We consider the problem of tunneling escape of particles from a multiparticle system confined within a potential trap. The process is nonlinear due to the interparticle interaction. Using the hydrodynamic representation for the quantum equations of the multiparticle system we find the tunneling rate and time evolutions of the number of trapped particles for different nonlinearity values.Comment: 10 pages, 3 figure

A single dose of ketamine cannot prevent protracted stress-induced anhedonia and neuroinflammation in rats

Worldwide, millions of people suffer from treatment-resistant depression. Ketamine, a glutamatergic receptor antagonist, can have a rapid antidepressant effect even in treatment-resistant patients. A proposed mechanism for the antidepressant effect of ketamine is the reduction of neuroinflammation. To further explore this hypothesis, we investigated whether a single dose of ketamine can modulate protracted neuroinflammation in a repeated social defeat (RSD) stress rat model, which resembles features of depression. To this end, male animals exposed to RSD were injected with ketamine (20 mg/kg) or vehicle. A combination of behavioral analyses and PET scans of the inflammatory marker TSPO in the brain were performed. Rats submitted to RSD showed anhedonia-like behavior in the sucrose preference test, decreased weight gain, and increased TSPO levels in the insular and entorhinal cortices, as observed by [11C]-PK11195 PET. Whole brain TSPO levels correlated with corticosterone levels in several brain regions of RSD exposed animals, but not in controls. Ketamine injection 1 day after RSD disrupted the correlation between TSPO levels and serum corticosterone levels, but had no effect on depressive-like symptoms, weight gain or the protracted RSD-induced increase in TSPO expression in male rats. These results suggest that ketamine does not exert its effect on the hypothalamic-pituitary-adrenal axis by modulation of neuroinflammation

Gamma Irradiation Effect of

In order to know the influence of 60Co gamma radiation, on the germination of two semitropical species, roselle seeds and sunflower were irradiated at the Transelektro LGI-01 of the InstitutoNacional de InvestigacionesNucleares, At doses 0, 5, 10, 15, 20, 25, 30 and 35 Gy, to determine the radiosensitivity curve and to determine the LD50 of both species, under a randomized complete block design with factorial arrangement, Where the study factors were: radiation doses and species. The results indicate that sunflower is more sensitive to gamma radiation than roselle, so the LD50 for sunflower and roselle was not reached, because the doses of radiation used, did not achieve 0% germination. Thus, the radiosensitivity curves were fitted to a linear model, with a high coefficient of determination. From the present investigation, It can be concluded that to determine the LD50 in the species in question, It is necessary to increase the dose of irradiation, perhaps up to 1000 Gy

A análise econômico-ecológica de um agroecossistema no município de Paraty-RJ como ferramenta de planejamento e apoio à transição agroecológica.

A Metodologia de Análise Econômico-Ecológica de Agroecossistemas considera estratégias singulares nas dinâmicas socioecológicas de gestão na agricultura familiar invisibilizadas nos métodos convencionais de agricultura. A metodologia foi aplicada em um sistema agroecológico na região costa verde, estado do Rio de Janeiro, com objetivo realizar uma análise para viabilizar e fortalecer a produção na perspectiva da agroecologia. As etapas do método são: visita ao agroecossistema, entrevista semiestruturada, elaboração da linha do tempo e da modelização e análise econômica-ecológica. A família aposta na diversificação da produção como estratégia de comercialização. Identificou-se que maior parte dos insumos foi produzida internamente diminuindo custo e aumentando rentabilidade. Pode-se inferir que a estratégia de produção e de organização social adotada pela família permitiu a interação da produção econômica e reprodução ecológica do agroecossistema viabilizando a permanência da família na propriedade.Edição dos Anais do VI Congresso Latino-americano de Agroecologia; X Congresso Brasileiro de Agroecologia; V Seminário de Agroecologia do Distrito Federal e Entorno, Brasília, DF, set. 2017

Acute Seroconversion of Eastern Equine Encephalitis Coinfection With California Serogroup Encephalitis Virus

Eastern equine encephalitis (EEE) is a severe arboviral neuroinvasive disease with high mortality and neurological sequelae. Treatment for EEE is primarily supportive. Intravenous immunoglobulin (IVIg) and high-dose steroids have been used as empirical therapy for EEE with some case reports of benefit. We report a case of a patient who presented with encephalopathy with initial cerebrospinal spinal fluid (CSF) serology analysis showing California serogroup encephalitis virus IgG positivity. However, the rapid clinical deterioration of the patient into a comatose state prompted a second CSF serology analysis that showed seroconversion of high titer Eastern Equine Encephalitis virus IgM and positive titer of California serogroup encephalitis virus IgG. The patient completed a 5-day course of empiric IVIg without concurrent corticosteroid therapy but did not show significant clinical improvement

A de novo transcriptional atlas in Danaus plexippus reveals variability in dosage compensation across tissues

A detailed knowledge of gene function in the monarch butterfly is still lacking. Here we generate a genome assembly from a Mexican nonmigratory population and used RNA-seq data from 14 biological samples for gene annotation and to construct an atlas portraying the breadth of gene expression during most of the monarch life cycle. Two thirds of the genes show expression changes, with long noncoding RNAs being particularly finely regulated during adulthood, and male-biased expression being four times more common than female-biased. The two portions of the monarch heterochromosome Z, one ancestral to the Lepidoptera and the other resulting from a chromosomal fusion, display distinct association with sex-biased expression, reflecting sample-dependent incompleteness or absence of dosage compensation in the ancestral but not the novel portion of the Z. This study presents extended genomic and transcriptomic resources that will facilitate a better understanding of the monarch's adaptation to a changing environment