48 research outputs found
Combining Sanford arylations on benzodiazepines with the nuisance effect
5-Phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ones react under palladium- and visible light photoredox catalysis, in refluxing methanol, with aryldiazonium salts to afford the respective 5-(2- arylphenyl) analogues. With 2- or 4-fluorobenzenediazonium derivatives, both fluoroaryl- and methoxyaryl- products were obtained, the latter resulting from a SNAr on the fluorobenzenediazonium salt (“nuisance effect”). A computational DFT analysis of the palladium-catalysed and the palladium/ruthenium-photocalysed mechanism for the functionalization of benzodiazepines indicated that in the presence of the photocatalyst the reaction proceeds via a low-energy SET pathway avoiding the high-energy oxidative addition step in the palladium-only catalysed reaction pathway
Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years
Objective The incidence of colorectal cancer (CRC)
declines among subjects aged 50 years and above. An
opposite trend appears among younger adults. In Europe,
data on CRC incidence among younger adults are
lacking. We therefore aimed to analyse European trends
in CRC incidence and mortality in subjects younger than
50 years.
Design Data on age-related CRC incidence and
mortality between 1990 and 2016 were retrieved from
national and regional cancer registries. Trends were
analysed by Joinpoint regression and expressed as
annual percent change.
Results We retrieved data on 143.7million people
aged 20–49 years from 20 European countries. Of
them, 187 918 (0.13%) were diagnosed with CRC. On
average, CRC incidence increased with 7.9% per year
among subjects aged 20–29 years from 2004 to 2016.
The increase in the age group of 30–39 years was 4.9%
per year from 2005 to 2016, the increase in the age
group of 40–49 years was 1.6% per year from 2004
to 2016. This increase started earliest in subjects aged
20–29 years, and 10–20 years later in those aged 30–39
and 40–49 years. This is consistent with an age-cohort
phenomenon. Although in most European countries the
CRC incidence had risen, some heterogeneity was found
between countries. CRC mortality did not significantly
change among the youngest adults, but decreased with
1.1%per year between 1990 and 2016 and 2.4% per
year between 1990 and 2009 among those aged 30–39
years and 40–49 years, respectively.
Conclusion CRC incidence rises among young
adults in Europe. The cause for this trend needs to be
elucidated. Clinicians should be aware of this trend. If
the trend continues, screening guidelines may need to be
reconsidered
Breast cancer screening in the Czech Republic: time trends in performance indicators during the first seven years of the organised programme
<p>Abstract</p> <p>Background</p> <p>The Czech Breast Cancer Screening Programme (CBCSP) was initiated in September 2002 by establishing a network of accredited centres. The aim of this article is to describe progress in the programme quality over time after the inception of the organised programme.</p> <p>Methods</p> <p>The CBCSP is monitored using an information system consisting of three principal components: 1) the national cancer registry, 2) a screening registry collecting data on all screening examinations, further assessments and final diagnoses at accredited programme centres, and 3) administrative databases of healthcare payers. Key performance indicators from the European Guidelines have been adopted for continuous monitoring.</p> <p>Results</p> <p>Breast cancer incidence in the Czech Republic has steadily been increasing, however with a growing proportion of less advanced stages. The mortality rate has recently stabilised. The screening registry includes 2,083,285 records on screening episodes between 2002 and 2008. In 2007-2008, 51% of eligible women aged 45-69 were screened. In 2008, the detection rates were 6.1 and 3.7 per 1,000 women in initial and subsequent screening respectively. Corresponding recall rates are 3.9% and 2.2%, however, it is necessary to pay attention to further assessment performed during the screening visits. Benign to malignant open biopsy ratio was 0.1. Of invasive cases detected in screening, 35.6% was less than 10 mm in diameter. Values of early performance indicators, as measured by both crude and standardized estimates, are generally improving and fulfil desirable targets set by European Guidelines.</p> <p>Conclusions</p> <p>Mammography screening in the Czech Republic underwent successful transformation from opportunistic prevention to an organised programme. Values of early indicators confirm continuous improvement in different aspects of process quality. Further stimulation of participation through invitation system is necessary to exploit the full potential of screening mammography at the population level.</p