Using the blockchain to enable transparent and auditable processing of personal data in cloud- based services: Lessons from the Privacy-Aware Cloud Ecosystems (PACE) project

The architecture of cloud-based services is typically opaque and intricate. As a result, data subjects cannot exercise adequate control over their personal data, and overwhelmed data protection authorities must spend their limited resources in costly forensic efforts to ascertain instances of non-compliance. To address these data protection challenges, a group of computer scientists and socio-legal scholars joined forces in the Privacy-Aware Cloud Ecosystems (PACE) project to design a blockchain-based privacy-enhancing technology (PET). This article presents the fruits of this collaboration, highlighting the capabilities and limits of our PET, as well as the challenges we encountered during our interdisciplinary endeavour. In particular, we explore the barriers to interdisciplinary collaboration between law and computer science that we faced, and how these two fields’ different expectations as to what technology can do for data protection law compliance had an impact on the project's development and outcome. We also explore the overstated promises of techno-regulation, and the practical and legal challenges that militate against the implementation of our PET: most industry players have no incentive to deploy it, the transaction costs of running it make it prohibitively expensive, and there are significant clashes between the blockchain's decentralised architecture and GDPR's requirements that hinder its deployability. We share the insights and lessons we learned from our efforts to overcome these challenges, hoping to inform other interdisciplinary projects that are increasingly important to shape a data ecosystem that promotes the protection of our personal data

Musical revitalisation of the schoolyard: results of a service-learning project

This research presents and discusses the results of a Service-Learning project developed by student teachers of Primary Education at the University of Valladolid during the academic years 2016/17, 2017/18, 2018/19, and 2019/20. The project aimed to revitalize recess through musical activities for children aged 6 to 12 in seven schools in Segovia (Spain). The results of the qualitative analysis show that the project has promoted the musical development of the children through singing, the experience of rhythm, and expression through movement, using a selected repertoire of popular children folk songs. In the university students, it helped foster commitment to primary school students through the promotion of co-education and socio-cultural diversity—values which have fostered the development of social and civic competences. The student teachers also achieved professional growth by obtaining through this project skills typical of Music Education teachers

Space Operations in the Suborbital Space Flight Simulator and Mission Control Center: Lessons Learned with XCOR Lynx

This study was conducted to better understand the performance of the XCOR Lynx vehicle. Because the Lynx development was halted, the best knowledge of vehicle dynamics can only be found through simulator flights. X-Plane 10 was chosen for its robust applications and accurate portrayal of dynamics on a vehicle in flight. The Suborbital Space Flight Simulator (SSFS) and Mission Control Center (MCC) were brought to the Applied Aviation Sciences department in fall 2015 at Embry-Riddle Aeronautical University, Daytona Beach campus. This academic and research tool is a department asset capable of providing multiple fields of data about suborbital simulated flights. This tool will allow flight navigators to assess different aspects of a suborbital flight dynamics and generate various trajectory maps to establish procedures and preventive measures when the vehicle goes through the NAS. It was found that the XCOR Lynx is an unstable platform but has good glide capabilities. This information is useful to pilots who may someday fly the XCOR Lynx as well as air traffic controllers who may have Lynx operations at their airports

Mycoplasmal infection in a guigna (Leopardus guigna) from central Chile

Routine blood analysis indicated the presence of Mycoplasma-like bodies in a guigna (Leopardus guigna). Evidence of infection with Candidatus Mycoplasma haemominutum was found in blood samples using PCR and DNA sequencing of the 16S rRNA gene of Mycoplasma. Mycoplasma spp. are documented in cats but their role in the transmission of Mycoplasma to guigna populations requires investigation

Abriendo puertas. Programa municipal de Educación al Desarrollo

The follow forms a part of an educative development initiative which is part of Local Administration in collaboration with Non-Governmental Organizations for Development (ONGD, Spanish initials) and secondary schools. For this reason we shall situate these non-profit organizations within the frame of administration and educative development within secondary schools. ‘Opening Doors’ is an initiative that has been functioning now for seven years, under the auspicious of the Social Cooperation, Cádiz Town Hall. The objectives of this programme is to showcase to the general public the different international projects that the Cádiz town hall is currently involved in, through distinct audio-visual and written discourses. We feel it is important that young people should be aware of the distinct initiatives that the citizens of Cádiz are involved in other parts of the globe, and in this way foment values such as empathy for distinct and complex social realities.La experiencia que se presenta a continuación va precedida de varios apartados que enmarcan la Educación al Desarrollo como una experiencia de la Administración Local en colaboración con las Organizaciones No Gubernamentales para el Desarrollo (en adelante ONGD) y los Institutos de Secundaria. Por ello hemos querido situar el surgimiento de las entidades sin ánimo de lucro y la legislación que ampara su relación con la Administración y la Educación al Desarrollo en los IES. La buena práctica que se presenta recoge el Programa que venimos desarrollando desde hace ya siete años desde el área de Cooperación Social del Ayuntamiento de Cádiz; “Abriendo Puertas”. Un programa de Educación para el Desarrollo, que intenta a través de la información, las imágenes y la comunicación mostrar a la ciudadanía la situación actual de diferentes países y los proyectos de cooperación internacional descentralizada que desde la administración local gaditana se están ejecutando. Creemos importante que los jóvenes conozcan de primera mano las distintas acciones que se realizan en otras partes del mundo con las aportaciones de todos los gaditanos y gaditanas, y poder fomentar así nuevos valores de cercanía y proximidad hacia realidades sociales más complejas

Density biases and temperature relations for DESIRED HII regions

We present a first study based on the analysis of the DEep Spectra of Ionized REgions Database (DESIRED). This is a compilation of 190 high signal-to-noise ratio optical spectra of HII regions and other photoionized nebulae, mostly observed with 8-10m telescopes and containing $\sim$29380 emission lines. We find that the electron density --$n_{\rm e}$-- of the objects is underestimated when [SII] $\lambda6731/\lambda6716$ and/or [OII] $\lambda3726/\lambda3729$ are the only density indicators available. This is produced by the non-linear density dependence of the indicators in the presence of density inhomogeneities. The average underestimate is $\sim 300$ cm$^{-3}$ in extragalactic HII regions, introducing systematic overestimates of $T_{\rm e}$([OII]) and $T_{\rm e}$([SII]) compared to $T_{\rm e}$([NII]). The high-sensitivity of [OII] $\lambda\lambda7319+20+30+31/\lambda\lambda3726+29$ and [SII] $\lambda\lambda4069+76/\lambda\lambda6716+31$ to density makes them more suitable for the diagnosis of the presence of high-density clumps. If $T_{\rm e}$([NII]) is adopted, the density underestimate has a small impact in the ionic abundances derived from optical spectra, being limited to up to $\sim$0.1 dex when auroral [SII] and/or [OII] lines are used. However, these density effects are critical for the analysis of infrared fine structure lines, such as those observed by the JWST in local star forming regions, implying strong underestimates of the ionic abundances. We present temperature relations between $T_{\rm e}$([OIII]), $T_{\rm e}$([ArIII]), $T_{\rm e}$([SIII]) and $T_{\rm e}$([NII]) for the extragalactic HII regions. We confirm a non-linear dependence between $T_{\rm e}$([OIII])-$T_{\rm e}$([NII]) due to a more rapid increase of $T_{\rm e}$([OIII]) at lower metallicities.Comment: Accepted for publication in MNRA

The capacity of apob-depleted plasma in inducing atp-binding cassette a1/g1-mediated macrophage cholesterol efflux-but not gut microbial-derived metabolites-is independently associated with mortality in patients with st-segment elevation myocardial infarction

Altres ajuts: Fundació per a la Bioquímica Clínica i Patologia MolecularImpaired HDL-mediated macrophage cholesterol efflux and higher circulating concentrations of trimethylamine N-oxide (TMAO) levels are independent risk factors for cardiovascular mortality. The TMAO precursors, γ-butyrobetaine (γBB) and Trimethyllysine (TML), have also been recently associated with cardiovascular death, but their interactions with HDL-mediated cholesterol efflux remain unclear. We aimed to determine the associations between APOB depleted plasma-mediated macrophage cholesterol efflux and plasma TMAO, γBB, and TML concentrations and explore their association with two-year follow-up mortality in patients with acute ST-elevation myocardial infarction (STEMI) and unstable angina (UA). Baseline and ATP-binding cassette transporter ABCA1 and ABCG1 (ABCA1/G1)-mediated macrophage cholesterol efflux to APOB-depleted plasma was decreased in patients with STEMI, and the latter was further impaired in those who died during follow-up. Moreover, the circulating concentrations of TMAO, γBB, and TML were higher in the deceased STEMI patients when compared with the STEMI survivors or UA patients. However, after statistical adjustment, only ABCA1/G1-mediated macrophage cholesterol efflux remained significantly associated with mortality. Furthermore, neither the TMAO, γBB, nor TML levels altered the HDL-mediated macrophage cholesterol efflux in vitro. We conclude that impaired ABCA1/G1-mediated macrophage cholesterol efflux is independently associated with mortality at follow-up in STEMI patients

Cardiac dysfunction and remodeling regulated by anti-angiogenic environment in patients with preeclampsia : the ANGIOCOR prospective cohort study protocol

Background: Cardiovascular diseases (CVD) are cause of increased morbidity and mortality in spite of advances for diagnosis and treatment. Changes during pregnancy affect importantly the maternal CV system. Pregnant women that develop preeclampsia (PE) have higher risk (up to 4 times) of clinical CVD in the short- and long-term. Predominance of an anti-angiogenic environment during pregnancy is known as main cause of PE, but its relationship with CV complications is still under research. We hypothesize that angiogenic factors are associated to maternal cardiac dysfunction/remodeling and that these may be detected by new cardiac biomarkers and maternal echocardiography. Methods: Prospective cohort study of pregnant women with high-risk of PE in first trimester screening, established diagnosis of PE during gestation, and healthy pregnant women (total intended sample size n = 440). Placental biochemical and biophysical cardiovascular markers will be assessed in the first and third trimesters of pregnancy, along with maternal echocardiographic parameters. Fetal cardiac function at third trimester of pregnancy will be also evaluated and correlated with maternal variables. Maternal cardiac function assessment will be determined 12 months after delivery, and correlation with CV and PE risk variables obtained during pregnancy will be evaluated. Discussion: The study will contribute to characterize the relationship between anti-angiogenic environment and maternal CV dysfunction/remodeling, during and after pregnancy, as well as its impact on future CVD risk in patients with PE. The ultimate goal is to improve CV health of women with high-risk or previous PE, and thus, reduce the burden of the disease. Trial registration: NCT04162236

Auditory Enhancement and Second Language Experience in Spanish and English Weighting of Secondary Voicing Cues

The role of secondary cues in voicing categorization was investigated in three listener groups: Monolingual English (n=20) and Spanish speakers (n=20), and Spanish speakers with significant English experience (n=16). Results showed that, in all three groups, participants used onset f0 in making voicing decisions only in the positive voice onset time (VOT) range (short lag and long lag tokens), while there was no effect of onset f0 on voicing categorization within the negative VOT range (voicing lead tokens) for any of the participant groups. These results support an auditory enhancement view of perceptual cue weighting: Onset f0 serves as a secondary cue to voicing only in the positive VOT range where it is not overshadowed by the presence of pre-voicing. Moreover, results showed that Spanish learners of English gave a significantly greater weight to onset f0 in their voicing decisions than did listeners in either of the other two groups. This result supports the view that learners may overweight secondary cues to distinguish between non-native categories that are assimilated to the same native category on the basis of a primary cue

The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chemotherapy often generates intratumoral senescent cancer cells that strongly modify the tumor microenvironment, favoring immunosuppression and tumor growth. We discovered, through an unbiased proteomics screen, that the immune checkpoint inhibitor programmed cell death 1 ligand 2 (PD-L2) is highly upregulated upon induction of senescence in different types of cancer cells. PD-L2 is not required for cells to undergo senescence, but it is critical for senescent cells to evade the immune system and persist intratumorally. Indeed, after chemotherapy, PD-L2-deficient senescent cancer cells are rapidly eliminated and tumors do not produce the senescence-associated chemokines CXCL1 and CXCL2. Accordingly, PD-L2-deficient pancreatic tumors fail to recruit myeloid-derived suppressor cells and undergo regression driven by CD8 T cells after chemotherapy. Finally, antibody-mediated blockade of PD-L2 strongly synergizes with chemotherapy causing remission of mammary tumors in mice. The combination of chemotherapy with anti-PD-L2 provides a therapeutic strategy that exploits vulnerabilities arising from therapy-induced senescence. © 2024, The Author(s)