Non Equilibrium Modeling of Sorption of Gases and Vapors in Polymers of Intrinsic Microporosity (PIM)

In this work, we show that the latter interpretation can efficiently represent the solubility of several gases and vapors in such polymer. Indeed, the Non Equilibrium Thermodynamic model for Glassy Polymer (NET-GP), which assumes that the polymeric phase is a dense and homogeneous one, can be applied successfully to evaluate the solubility in PIM-1 at room temperature

Arbeitsorientierte Gestaltung von Informationsprozessen

The work-oriented formation of information processes embraces the shaping of the system of work in which new technologies are or should be applied, and also that of the preparatory and introductory process itself. The authors present concepts and criteria for the shaping of systems of work, which apply to such systems in general, and software houses in particular. Task orientation and the concept of `total activity' play a central part. Questions of man/machine functional division remain to be answered before work-shaping by software engineering can be extended significantly. On the basis of these general concepts and shaping criteria, a structure and a compatible process organisation for software preparation are presented and discusse

In vitro biotransformation of the selective serotonin reuptake inhibitor citalopram, its enantiomers and demethylated metabolites by monoamine oxidase in rat and human brain preparations

This study was conducted to identify enzyme systems eventually catalysing a local cerebral metabolism of citalopram, a widely used antidepressant of the selective serotonin reuptake inhibitor type. The metabolism of citalopram, of its enantiomers and demethylated metabolites was investigated in rat brain microsomes and in rat and human brain mitochondria. No cytochrome P-450 mediated transformation was observed in rat brain. By analysing H2O2 formation, monoamine oxidase A activity in rat brain mitochondria could be measured. In rat whole brain and in human frontal cortex, putamen, cerebellum and white matter of five brains monoamine oxidase activity was determined by the stereoselective measurement of the production of citalopram propionate. All substrates were metabolised by both forms of MAO, except in rat brain, where monoamine oxidase B activity could not be detected. Apparent Km and Vmax of S-citalopram biotransformation in human frontal cortex by monoamine oxidase B were found to be 266 microM and 6.0 pmol min(-1) mg(-1) protein and by monoamine oxidase A 856 microM and 6.4 pmol min(-1) mg(-1) protein, respectively. These Km values are in the same range as those for serotonin and dopamine metabolism by monoamine oxidases. Thus, the biotransformation of citalopram in the rat and human brain occurs mainly through monoamine oxidases and not, as in the liver, through cytochrome P-450