108 research outputs found
Technologies and Approaches to Elucidate and Model the Virulence Program of Salmonella
- Author
- Publication venue
- Frontiers Research Foundation
- Publication date
- 01/01/2011
- Field of study
Salmonella is a primary cause of enteric diseases in a variety of animals. During its evolution into a pathogenic bacterium, Salmonella acquired an elaborate regulatory network that responds to multiple environmental stimuli within host animals and integrates them resulting in fine regulation of the virulence program. The coordinated action by this regulatory network involves numerous virulence regulators, necessitating genome-wide profiling analysis to assess and combine efforts from multiple regulons. In this review we discuss recent high-throughput analytic approaches used to understand the regulatory network of Salmonella that controls virulence processes. Application of high-throughput analyses have generated large amounts of data and necessitated the development of computational approaches for data integration. Therefore, we also cover computer-aided network analyses to infer regulatory networks, and demonstrate how genome-scale data can be used to construct regulatory and metabolic systems models of Salmonella pathogenesis. Genes that are coordinately controlled by multiple virulence regulators under infectious conditions are more likely to be important for pathogenesis. Thus, reconstructing the global regulatory network during infection or, at the very least, under conditions that mimic the host cellular environment not only provides a bird's eye view of Salmonella survival strategy in response to hostile host environments but also serves as an efficient means to identify novel virulence factors that are essential for Salmonella to accomplish systemic infection in the host
Human embryonic stem cell cultivation: historical perspective and evolution of xeno-free culture systems
- Author
- A Bongso
- A Galan
- A Trounson
- AJ Engler
- AJ Engler
- AJ Want
- AK Chen
- AK Chen
- Arsela Gishto
- BE Reubinoff
- C Aguilar-Gallardo
- C Geron
- C Unger
- C Xu
- CA Cowan
- CA Llewelyn
- CJ Taylor
- CM Lo
- D Ilic
- D James
- D Steiner
- DA Brafman
- E Ratcliffe
- EF Irwin
- F Cobo
- FK Kidwai
- G Chen
- G Giritharan
- G Meng
- GM Beattie
- H Baharvand
- H Baharvand
- H Hakala
- H Hentze
- H Hongisto
- H Nandivada
- H Priddle
- H Tsutsui
- HF Chen
- HF Lu
- HK Kleinman
- HS Keirstead
- I Hyun
- I Klimanskaya
- I Klimanskaya
- I Kubikova
- J Alper
- J Ratajczak
- J Valk van der
- J Xi
- JA Carlson Scholz
- JA Thomson
- JB Lee
- JB Lee
- JD Whittard
- JM Crook
- JR Klim
- K Hasegawa
- K Hasegawa
- K Miyamoto
- K Rajala
- K Rajala
- L Cai
- L Cheng
- L Li
- L Li
- L Vallier
- L Vallier
- LA Couture
- LG Villa-Diaz
- LG Villa-Diaz
- M Amit
- M Amit
- M Amit
- M Amit
- M Cho
- M Jang
- M Marti
- M Nagaoka
- M Nakagawa
- M Richards
- M Serra
- M Sundberg
- ME Levenstein
- MH Johnson
- MJ Martin
- MK Furue
- MP Lutolf
- MP Lutolf
- N Desai
- N Desai
- N Siti-Ismail
- N Tanaka
- Nina Desai
- O Genbacev
- P Loser
- P Menendez
- PA Marinho
- Pooja Rambhia
- Q Wang
- R Montes
- R Pal
- RH Xu
- RM Albano
- S Abraham
- S Chen
- S Frank
- S Gerecht
- S Jin
- S Rodin
- S Rodin
- S Strauss
- S Strom
- S Wu
- S Yao
- SD Schwartz
- SE Tannenbaum
- SK Oh
- SM Badenes
- SM Dellatore
- SN Brimble
- SR Braam
- ST Lee
- T Ludwig
- T Miki
- T Miki
- T Miyazaki
- T Miyazaki
- T Turetsky
- T Yeung
- TE Ludwig
- TG Otsuji
- TP Kraehenbuehl
- X Fu
- X Fu
- X Gao
- Y Chung
- Y Li
- Y Mei
- Y Nie
- Y Park
- Y Wang
- Y Wang
- Y Xu
- YR Lou
- Z Li
- Z Melkoumian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions
- Author
- A Kaupisch
- A Margariti
- AJ Rufaihah
- AJ Rufaihah
- B Borchin
- BC Heng
- CM Sturgeon
- D James
- D Moyon
- DA Turner
- DJ Nolan
- ES Lippmann
- ES Lippmann
- ES Ng
- F Lanner
- FK Kidwai
- G Narazaki
- G Oliver
- H Bai
- J Boyer-Di Ponio
- J Torres-Vazquez
- JY Tan
- K Rajala
- K Yamamizu
- KJ Vinoth
- KL Hill
- L Coultas
- L Kurian
- LS Cooley
- LS Ferreira
- M Mercola
- M Pick
- M Sahara
- M Shelton
- MP White
- N Cao
- ND Lawson
- ND Lawson
- NL Harvey
- NM Kane
- O Naujok
- O Naujok
- R Bergstrom
- R Samuel
- S Levenberg
- S Rodin
- SH Song
- SS Nunes
- T Lei
- T Sampsell-Barron
- T Yurugi-Kobayashi
- V Rosa
- VV Orlova
- WC Aird
- X Fu
- X Lian
- XL Aranguren
- Y Wang
- Z Li
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multi-centre observational study
- Author
- A Abdu
- A Ackerman
- A Adeyeye
- A Ahmed
- A Allana
- A Aquilina
- A Arch
- A AâCourt
- A Brewer
- A Burtt
- A Curtis
- A Dabrowicz
- A Feneley
- A Gadre
- A Gandhi
- A Groves
- A Guha
- A Gunawardhana
- A Gupta
- A Harrison
- A Hartopp
- A Heavyside
- A Ignacka
- A Jalaly
- A Langton
- A Mckskeane
- A Monkhouse
- A Moon
- A Moreton
- A Morris
- A Nicholson
- A Nicklin
- A Prenter
- A Price
- A Rand
- A Ratnasingham
- A Reddy
- A Riccoboni
- A Sadeghi
- A Salberg
- A Shonfeld
- A Sinha
- A Smith
- A Soundararaja
- A Stilwell
- A Stokes
- A Sutherland
- A Swinson
- A Tan
- A Tiller
- A Tufchi
- A Veal
- A Webber
- A White
- A Yusaf
- A. Oâ Dwyer
- A. Sau Kuk Poon
- A. Visram
- A. Wickham
- B Akindele
- B Avery
- B Baytug
- B Goodman
- B OâNeill
- B Peers
- B Peirce
- B Sawarzynskaâryszka
- B Sivarajan
- B Straughan
- B. Post
- Becky Black
- C Abisogun
- C Adamson
- C Atkinson
- C Balaka
- C Berwick
- C BorkettâJones
- C Bressington
- C Calvert
- C Cashell
- C Cruz
- C Dean
- C Donovan
- C Finlay
- C Grother
- C Hays
- C Hemeson
- C Hindmoor
- C Honeywell
- C Huson
- C Hussain
- C Jeganathan
- C Joannides
- C Johnston
- C Kenyon
- C King
- C Kuan Yeow
- C Marsh
- C Martella
- C McCormick
- C Michael
- C Moser
- C Muir
- C Nolan
- C Oakes
- C Papageorgiou
- C Papoutsos
- C Quamina
- C Rao
- C Routley
- C Rowley
- C Ryan
- C Saad
- C Sellers
- C Skeoch
- C Smith
- C Smith
- C Smith
- C Smyth
- C Snipe
- C Srivastava
- C Stone
- C Swarbrick
- C Topham
- C Turnbull
- C Wang
- C Watts
- C. Johnston
- C. Morkane
- C. Oliver
- Cook TM
- D AbdelâGadir
- D Ahmed
- D Brunnen
- D Cheyne
- D Das
- D Fernando
- D Green
- D Griffin
- D Hadi
- D Harpham
- D Harshan
- D Magee
- D Mead
- D Monks
- D Morland
- D Neeley
- D Onwochei
- D OâFlaherty
- D Pandya
- D Rangarajan
- D Senaratne
- D Seneviratna
- D Trodd
- D Uncles
- D Vidanagamage
- D Wilson
- D Zeinali
- D. Highton
- D. Martin
- D. N. Lucas
- E Auer
- E Bielskute
- E Clarey
- E Coulborn
- E Crowther
- E Duckham
- E Fawcett
- E Harty
- E Hawkins
- E Hyde
- E Innes
- E Kingston
- E Kursumovic
- E McMaster
- E Meadows
- E Morgan
- E Nurmi
- E Pack
- E Poimenidi
- E Reel
- E Smith
- E Smith
- E Spence
- E Stevens
- E Syrrakou
- E Tyagi
- E Walker
- E Walshe
- E Winkley
- E Young
- E. Emeakaraoha
- F Amoakwaâadu
- F Atkinson
- F CampbellâJones
- F Chin
- F Faulds
- F Ismail
- F Mazzola
- F Pearson
- F Pilkington
- F Ricco
- F Roberts
- F Walbridge
- G Arbane
- G Ashiru
- G Badham
- G Foster
- G Garvey
- G Graham
- G Grounds
- G Harris
- G Hawkins
- G Jackson
- G Kar
- G Miller
- G Narasimha Murthy
- G Papanastasiou
- G Singleton
- G Stocks
- G Waters
- G Wong
- H Bader
- H Boyle
- H Brown
- H Bykar
- H Farooq
- H Gardiner
- H Griffiths
- H Hammerbeck
- H Hampanna
- H Hancock
- H Handapangoda
- H Kaskos
- H King
- H Kuttambakam
- H Latif
- H Laycock
- H Lightfoot
- H Lynes
- H McKevitt
- H McNamara
- H McPhee
- H Murray
- H Nei
- H Osborn
- H Owston
- H Patel
- H Patel
- H Perry
- H Rosser
- H Sellers
- H Sivadhas
- H Smithers
- H Stafford
- H Tarft
- H Tolliday
- H Wain
- H Wong
- H. Kemp
- H. Laycock
- Holly Blake
- I Murdoch
- I Sharieff
- I Sheldrake
- I Taylor
- I Veronica
- I Wrench
- J Abrams
- J Allam
- J Berg
- J Boselli
- J Bowyer
- J Bray
- J Briscoe
- J Cantliffe
- J Carvalho
- J Cohen
- J Comar
- J Corfe
- J Cronin
- J Crooks
- J Dash
- J Dawson
- J Dean
- J Denman
- J Douglass
- J Ekpa
- J Eldridge
- J Elliott
- J Ferns
- J Forbes
- J Francis
- J Goddard
- J Griffith
- J Grindey
- J Groome
- J Gutsell
- J Hilton
- J Hunte
- J Hyams
- J Jackson
- J Kane
- J Kelly
- J Kelly
- J Kua
- J Lowe
- J Major
- J Man Wong
- J Marway
- J Masters
- J McGarry
- J Meikle
- J Monk
- J Moran
- J Onslow
- J Overend
- J Parry
- J Patel
- J Perinpanayagam
- J Plumb
- J Pullen
- J Qureshi
- J Razzaque
- J Riches
- J Sellick
- J Shambly
- J Short
- J Siah
- J Smith
- J Tebbot
- J Venkaya
- J Wu
- J. Andrade
- J. Cronin
- J. J. Pandit
- J. OâCarroll
- K Allen
- K Ashpole
- K Barrett
- K Batte
- K Burijintichenna
- K Cassim
- K Chima
- K Collins
- K Constantin
- K Davidson
- K Doughty
- K Dyer
- K Edwards
- K Elliott
- K ElâBoghdadly
- K Fraser
- K Henderson
- K House
- K Kuntumalla
- K Kurzatkowski
- K Lane
- K Light
- K Machavarapu
- K Manso
- K Marciniak
- K Miltsios
- K Morris
- K Murrell
- K Neil
- K Oliver
- K Patel
- K Patel
- K Powell Monaghan
- K Preston
- K Ranatunga
- K Redington
- K Roberts
- K Robins
- K Sinha
- K Stacey
- K Turley
- K Wankhade
- K Wimble
- K Wloch
- K Wynn
- K. ElâBoghdadly
- K. Grailey
- Knight M
- L Amarasekara
- L Barnes
- L Bates
- L Bridge
- L Camarasa
- L Collis
- L Dudgeon
- L Dunn
- L Elgie
- L Fletcher
- L Friedman
- L Fruggeri
- L Fulton
- L Hammon
- L Herbert
- L Hobbs
- L James
- L Kavanagh
- L Kelliher
- L Kessack
- L Maronge
- L Mason
- L Mason
- L Mcewan
- L McRae
- L Misquita
- L Montague
- L Powell
- L Roughley
- L Sharifi
- L Sharpe
- L Smith
- L Tarry
- L Vedham
- L Whitefield
- L Williams
- L Winslow
- L Zucco
- L. Phylactides
- M AduseâPoku
- M Anderson
- M BabioâGalan
- M Baldwin
- M Behravesh
- M Bowen
- M Cairney
- M Chandler
- M Conroy
- M Doraiswami
- M Dower
- M Earl
- M Ellington
- M Elmi
- M Evans
- M Everett
- M Fleet
- M Forth
- M Homsy
- M Huniak
- M Jackson
- M James
- M Kadr
- M Khaku
- M Laverdino
- M Lungu
- M Lunn
- M Mackenzie
- M Maquinana
- M MatonâHowarth
- M Rich
- M Rojo
- M Samuel
- M Shao Chong
- M Shaw
- M Simpson
- M Sinnott
- M Spiliopoulos
- M Thomas
- M Traves
- M Turnbull
- M Verghese
- M Walters
- M Wee
- M Whitear
- M. Gray
- M. McMonagle
- M. Mehta
- M. Mittal
- M. Mohamed
- M. Morosan
- M. Mount
- M. Mupudzi
- M. Murali
- M. Nel
- M. OchoaâFerraro
- M. Oliver
- M. Patel
- M. Patel
- M. Purohit
- N Ahmad
- N Amaradasa
- N Barot
- N Brice
- N Campbell
- N Carmela Romano
- N Coker
- N Crowther
- N Daines
- N Desai
- N Hadjipavlou
- N Haslam
- N Higgins
- N Hoque
- N Lau
- N Lucas
- N Martin
- N Martins
- N Masood
- N Oakes
- N Panesar
- N Patel
- N Petrova
- N Pritchard
- N Richards
- N Schumacher
- N Schwartz
- N Sonawane
- N Staines
- N Tovell
- N. Blunt
- N. Odeleye
- O Akindele
- O Allen
- O Egole
- O Elbasir
- O ElâAmin
- O Henry
- O Morgan
- O Osagie
- O Siddique
- O Turner
- Oliver Blightman
- P Anandageetha
- P Balfour
- P Barclay
- P Chen
- P Chowdhury
- P Dannatt
- P Dewan
- P Fabb
- P Jadhav
- P Khan
- P Krishnan
- P Padhi
- P Palani
- P Sultan
- P Suppiah
- P Surve
- P Tamhane
- P Tamilselvan
- P Vadnere
- P Walsh
- P Winwright
- P. Hopkins
- P. M. Odor
- P. Remeta
- P. Rice
- P. Rudra
- P. Sceales
- P. Shinde
- P. Slater
- Q. Lo
- R Addison
- R Adler
- R Anandanadesan
- R Arya
- R Benloch
- R Bentley
- R Berwick
- R Bhadange
- R Bolton
- R Bowen
- R Chapman
- R Charles
- R Chirvasuta
- R Coe
- R Crone
- R Elnoumeir
- R Farrimond
- R George
- R Gupta
- R Haddon
- R Hitchcock
- R Howle
- R Iqbal
- R Jacobs
- R Johnson
- R Jones
- R Kainth
- R Kanji
- R Kaye
- R Konig
- R Lee
- R McCarthy
- R Pandey
- R Patel
- R Patel
- R Russell
- R Samuels
- R Shah
- R Smith
- R Stead
- R Swanton
- R Varadan
- R Vincent
- R Williams
- Ruth Bird
- S Adyanthaya
- S Akrimi
- S AlâRawi
- S Anandakrishnan
- S Apps
- S Armstrong
- S Bagchi
- S Bailey
- S Bali
- S Banks
- S Barrett
- S Bell
- S Bhattacharyya
- S Birch
- S Bird
- S Brayshaw
- S Brocklesby
- S Brown
- S Burnard
- S Cassie
- S Choudhury
- S Chughwani
- S Ciechanowicz
- S Curtis
- S Davies
- S Dimont
- S Downing
- S Dukes
- S Eapen
- S Eason
- S Fitzgerald
- S Funnell
- S Gillespie
- S Glover
- S Grigsby
- S Hammond
- S Hawksey
- S Ioannidis
- S Jani
- S Kannanparambil
- S Kelliot
- S Kestner
- S Khaleeq
- S Khan
- S Lane
- S Laxman
- S Leonardi
- S Liu
- S Liyanage
- S McCready
- S McDougall
- S Mckinley
- S Miller
- S Milne
- S Misquita
- S Pararajasingham
- S Pathak
- S Pepper
- S Phillips
- S Ramage
- S Randive
- S Rao Pelluri
- S Ripoll
- S Robinson
- S Roche
- S Sanapala
- S Sanusi
- S Sarao
- S Sathyabhama
- S Sen
- S Senbeto
- S Shah
- S Sharafudeen
- S Sibug
- S Siew
- S Sivakumar
- S Sivarajan
- S Slade
- S Smith
- S Smolen
- S Soltanifar
- S Sudunagunta
- S Tadbiri
- S Tanna
- S Taylor
- S Theron
- S Todd
- S Turney
- S Uz Zafar
- S Wellstead
- S Wilkinson
- S Wilson
- S Wray
- S Zhang
- S Zope
- S. Anwar
- S. Bampoe
- S. Phillips
- S. R. Moonesinghe
- Susara Blunden
- T Barnes
- T Christmas
- T Follet
- T Gately
- T Gopal
- T Hazelton
- T Husain
- T Hussain
- T Johnson
- T Jones
- T Kasianandan
- T McAllister
- T Murray
- T Nejim
- T Nolan
- T Oommen
- T Orr
- T Phillips
- T Potter
- T Ramanathan
- T Setty
- T Smith
- T Snel
- T Wedgwood
- T Wood
- Tatyana Blagova
- U Kidwai
- U Poultney
- U Ranasinghe
- V Barrett
- V Buswell
- V Cowie
- V Dalal
- V Duraiswamy
- V Fludder
- V Male
- V Millar
- V Peciulene
- V Salota
- V Subbarathnam
- V Unsworth
- V Vasishta
- V Vyapury
- V. Grover
- W Carrol
- W Duberry
- W Kok
- W Turner
- William Birts
- Y Ali
- Y Baird
- Y Davis
- Y HaroonâMowahed
- Y Metodiev
- Y Wan
- Y Yap
- Z Aboud
- Z Brar
- Z Edwards
- Z Garner
- Z Hussein
- Z Konstantinova
- Z Malik
- Z Rajput
- Z Saunders
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct reporting of awareness in maternity patients' (DREAMY) study of accidental awareness during obstetric anaesthesia aimed to describe practice for obstetric general anaesthesia in England and compare with earlier surveys and best-practice recommendations. Consenting patients who received general anaesthesia for obstetric surgery in 72 hospitals from May 2017 to August 2018 were included. Baseline characteristics, airway management, anaesthetic techniques and major complications were collected. Descriptive analysis, binary logistic regression modelling and comparisons with earlier data were conducted. Data were collected from 3117 procedures, including 2554 (81.9%) caesarean deliveries. Thiopental was the induction drug in 1649 (52.9%) patients, compared with propofol in 1419 (45.5%). Suxamethonium was the neuromuscular blocking drug for tracheal intubation in 2631 (86.1%), compared with rocuronium in 367 (11.8%). Difficult tracheal intubation was reported in 1 in 19 (95%CI 1 in 16-22) and failed intubation in 1 in 312 (95%CI 1 in 169-667). Obese patients were over-represented compared with national baselines and associated with difficult, but not failed intubation. There was more evidence of change in practice for induction drugs (increased use of propofol) than neuromuscular blocking drugs (suxamethonium remains the most popular). There was evidence of improvement in practice, with increased monitoring and reversal of neuromuscular blockade (although this remains suboptimal). Despite a high risk of difficult intubation in this population, videolaryngoscopy was rarely used (1.9%)
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro CarĂ Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
- Beane Abigail
- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
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- Bonten Marc J. M.
- Borgatta Barbara
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- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
- de Jong Menno
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- del Sorbo Lorenzo
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- Depuydt Pieter
- Dequin Pierre-François
- Derde Lennie P. G.
- Deshpande Kush
- Detry Michelle A.
- Deye Nicolas
- de la Fuente Carmen
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- Dyas Sarah
- Eapen Beena
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- Ebenezer R
- Edmunds Natasha
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- Efford Georgia
- Egreteau Pierre
- Ehrmann Stephan
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- Eisenbeis Simone
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- Ferreira Ricardo Manuel Castro
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- Goddard Wendy
- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
- Golden David
- Goldman John
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- Gommans Frank
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- Gopinath Amitha
- Goralski Patricia
- Gordon Anthony C.
- Gosbell Iain
- Gould Richard
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- Göpel Siri
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- Hakak Sheeba
- Halden Sandra
- Haldeos Anne
- Hall Alistair S
- Hall Amelia
- Hall Andrew
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- Hall Rebecca
- Hamilton David
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- Harris Jade
- Harris John
- Harrison David A.
- Harrison Susan
- Harrow Kath
- Hartley Melissa
- Harvala-Simmonds Heli
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- Hayes Amber
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- Headlam Evie
- Healey Gail
- Hegazy Ahmed
- Hegazy Mohamed
- Heinonen Jonna
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- Henderson Steven
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- Henry Joanne
- Henry Lavinia
- Hensley Joseph
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- Hernandez Erik
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- Hey Samuel
- Hickey John
- Hierons Sarah
- Higgins Alisa M.
- Hill Claire
- Hill Dianne
- Hill Helen
- Hilldrith Anette
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- Hird Clare
- Hodge Christopher
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- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
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- Hulse Sarah
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- Hunt Beverley
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- Jayakumar Devachandran
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- Jenkins Steve
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- Kremling Julius
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- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
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- Lavana Jayshree
- Laver Russell D.
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- Lawler Patrick R.
- Le Basnier Elliot
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- Lewis Roger J.
- Lewis Sarah
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- Linstrum Kelsey M.
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- Weber Lisa
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- Wilcox Louise
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- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
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- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James D
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Jean
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
International Consensus Statement on Rhinology and Allergy: Rhinosinusitis
- Author
- Aanaes K
- Abadie WM
- Abi Najm S
- Abigail P
- Abrahams JJ
- Abrass LJ
- Abreu CB
- Abreu NA
- Abshirini H
- Abuzeid WM
- Abuzeid WM
- Achar P
- Ackerhans M
- Adam P
- Adappa ND
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- Adriaensen G
- Agache I
- Aghamohammadi A
- Agius AM
- Agyeman AA
- Ahn CN
- Ahn HJ
- Ahn JC
- Ahn SH
- AhovuoâSaloranta A
- Aitken M
- Ajaiyeoba A
- Akbari E
- Akdis CA
- Akira S
- Akiyama K
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- Al Komser MK
- Alam ES
- Alandejani T
- Alanin MC
- Albritton FDT
- Albu S
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- Aldini G
- Alexander NS
- Aljebab F
- Alkire BC
- Allen EK
- Alobid I
- Alobid I
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- Alsaleh S
- Alsharif S
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- AlâQudah M.
- AlâRawi MM
- AlâShaikh S
- AlâShemari H
- AlâSwiahb JN
- Amali A
- Amar YG
- Amble FR
- American Academy of Pediatrics Steering Committee on Quality Improvement and Management (AAP SCQIM)
- Amin MR
- Amine M
- Amodu EJ
- Anamika A
- Anand V
- Anderson DE
- Anderson WC
- Andhale S
- Ankichetty SP
- Annamalai S
- Anon JB
- AnselmoâLima WT
- Antisdel JL
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- Antunes MB
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- Ayoub N
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- Azbell C
- Azila A
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- Babinski D
- Bachert C
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- Bachmann G
- Badia L
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- Zurlo JJ
- Zuskin E
- Äulig J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2021
- Field of study
Background: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICARâRS) has witnessed foundational progress in our understanding and treatment of rhinologic disease. These advances are reflected within the more than 40 new topics covered within the ICARâRSâ2021 as well as updates to the original 140 topics. This executive summary consolidates the evidenceâbased findings of the document. Methods: ICARâRS presents over 180 topics in the forms of evidenceâbased reviews with recommendations (EBRRs), evidenceâbased reviews, and literature reviews. The highest grade structured recommendations of the EBRR sections are summarized in this executive summary. Results: ICARâRSâ2021 covers 22 topics regarding the medical management of RS, which are grade A/B and are presented in the executive summary. Additionally, 4 topics regarding the surgical management of RS are grade A/B and are presented in the executive summary. Finally, a comprehensive evidenceâbased management algorithm is provided. Conclusion: This ICARâRSâ2021 executive summary provides a compilation of the evidenceâbased recommendations for medical and surgical treatment of the most common forms of RS
Is there an axonal transport of amino acids?
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
A stimulatory effect of insulin on phosphorylation of a peptide in sarcolemma-enriched membrane preparation from rat skeletal muscle
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
A Simple Synthesis of Dibenzo[ b
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
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