Inadequacy of zero-width approximation for a light Higgs boson signal

In the Higgs search at the LHC, a light Higgs boson (115 GeV <~ M_H <~ 130 GeV) is not excluded by experimental data. In this mass range, the width of the Standard Model Higgs boson is more than four orders of magnitude smaller than its mass. The zero-width approximation is hence expected to be an excellent approximation. We show that this is not always the case. The inclusion of off-shell contributions is essential to obtain an accurate Higgs signal normalisation at the 1% precision level. For gg (-> H) -> VV, V= W,Z, O(10%) corrections occur due to an enhanced Higgs signal in the region M_VV > 2 M_V, where also sizable Higgs-continuum interference occurs. We discuss how experimental selection cuts can be used to exclude this region in search channels where the Higgs invariant mass cannot be reconstructed. We note that the H -> VV decay modes in weak boson fusion are similarly affected.Comment: 26 pages, 18 figures, 6 tables; added references, expanded introduction, version to appear in JHE

Determining the Structure of Higgs Couplings at the LHC

Higgs boson production via weak boson fusion at the CERN Large Hadron Collider has the capability to determine the dominant CP nature of a Higgs boson, via the tensor structure of its coupling to weak bosons. This information is contained in the azimuthal angle distribution of the two outgoing forward tagging jets. The technique is independent of both the Higgs boson mass and the observed decay channel.Comment: 5 pages, 4 figures, version accepted for publication in PR

NLO Higgs boson production via vector-boson fusion matched with shower in POWHEG

We present a next-to-leading order calculation of Higgs boson production in vector-boson fusion processes interfaced to shower Monte Carlo programs, implemented according to the POWHEG method.Comment: 16 pages, 9 figures. A few references and a new figure adde

QCD corrections to electroweak l nu_l jj and l^+ l^- jj production

The production of W or Z bosons in association with two jets is an important background to the Higgs boson search in vector-boson fusion at the LHC. The purely electroweak component of this background is dominated by vector-boson fusion, which exhibits kinematic distributions very similar to the Higgs boson signal. We consider the next-to-leading order QCD corrections to the electroweak production of l nu_l jj and l^+ l^- jj events at the LHC, within typical vector-boson fusion cuts. We show that the QCD corrections are modest, increasing the total cross sections by about 10%. Remaining scale uncertainties are below 2%. A fully-flexible next-to-leading order partonic Monte Carlo program allows to demonstrate these features for cross sections within typical vector-boson-fusion acceptance cuts. Modest corrections are also found for distributions.Comment: 26 pages, 10 figures. PRD final version. One reference corrected, introduction expande

Higgs-Boson Production Induced by Bottom Quarks

Bottom quark-induced processes are responsible for a large fraction of the LHC discovery potential, in particular for supersymmetric Higgs bosons. Recently, the discrepancy between exclusive and inclusive Higgs boson production rates has been linked to the choice of an appropriate bottom factorization scale. We investigate the process kinematics at hadron colliders and show that it leads to a considerable decrease in the bottom factorization scale. This effect is the missing piece needed to understand the corresponding higher order results. Our results hold generally for charged and for neutral Higgs boson production at the LHC as well as at the Tevatron. The situation is different for single top quark production, where we find no sizeable suppression of the factorization scale. Turning the argument around, we can specify how large the collinear logarithms are, which can be resummed using the bottom parton picture.Comment: 18 page

CP asymmetries in the supersymmetric trilepton signal at the LHC

In the CP-violating Minimal Supersymmetric Standard Model, we study the production of a neutralino-chargino pair at the LHC. For their decays into three leptons, we analyze CP asymmetries which are sensitive to the CP phases of the neutralino and chargino sector. We present analytical formulas for the entire production and decay process, and identify the CP-violating contributions in the spin correlation terms. This allows us to define the optimal CP asymmetries. We present a detailed numerical analysis of the cross sections, branching ratios, and the CP observables. For light neutralinos, charginos, and squarks, the asymmetries can reach several 10%. We estimate the discovery potential for the LHC to observe CP violation in the trilepton channel.Comment: 39 pages, 8 figures, version to appear in EPJC, discussion(s) added, typo in (D.79), (D.118) corrected, new Fig. 7; The European Physical Journal C, Volume 72, Issue 3, 201

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the genetic hallmark of this disease. In this study, a broad range of 3,325 experimental compounds, among them FDA approved drugs and natural products, were screened for their effect on EwS cell viability depending on EWS-FLI1 expression. In a network-based approach we integrated the results from drug perturbation screens and RNA sequencing, comparing EWS-FLI1-high (normal expression) with EWS-FLI1-low (knockdown) conditions, revealing novel interactions between compounds and EWS-FLI1 associated biological processes. The top candidate list of druggable EWS-FLI1 targets included genes involved in translation, histone modification, microtubule structure, topoisomerase activity as well as apoptosis regulation. We confirmed our in silico results using viability and apoptosis assays, underlining the applicability of our integrative and systemic approach. We identified differential sensitivities of Ewing sarcoma cells to BCL-2 family inhibitors dependent on the EWS-FLI1 regulome including altered MCL-1 expression and subcellular localization. This study facilitates the selection of effective targeted approaches for future combinatorial therapies of patients suffering from Ewing sarcoma.(VLID)471264

Charged Higgs Boson Production in Bottom-Gluon Fusion

We compute the complete next-to-leading order SUSY-QCD corrections for the associated production of a charged Higgs boson with a top quark via bottom-gluon fusion. We investigate the applicability of the bottom parton description in detail. The higher order corrections can be split into real and virtual corrections for a general two Higgs doublet model and into additional massive supersymmetric loop contributions. We find that the perturbative behavior is well under control. The supersymmetric contributions consist of the universal bottom Yukawa coupling corrections and non-factorizable diagrams. Over most of the relevant supersymmetric parameter space the Yukawa coupling corrections are sizeable, while the remaining supersymmetric loop contributions are negligible.Comment: 18 pages, v2: some discussions added, v3: published versio

Self-organization in the olfactory system: one shot odor recognition in insects

We show in a model of spiking neurons that synaptic plasticity in the mushroom bodies in combination with the general fan-in, fan-out properties of the early processing layers of the olfactory system might be sufficient to account for its efficient recognition of odors. For a large variety of initial conditions the model system consistently finds a working solution without any fine-tuning, and is, therefore, inherently robust. We demonstrate that gain control through the known feedforward inhibition of lateral horn interneurons increases the capacity of the system but is not essential for its general function. We also predict an upper limit for the number of odor classes Drosophila can discriminate based on the number and connectivity of its olfactory neurons

Higgs Physics at Future Colliders: recent theoretical developments

I review the physics of the Higgs sector in the Standard Model and its minimal supersymmetric extension, the MSSM. I will discuss the prospects for discovering the Higgs particles at the upgraded Tevatron, at the Large Hadron Collider, and at a future high--energy $e^+e^-$ linear collider with centre--of--mass energy in the 350--800 GeV range, as well as the possibilities for studying their fundamental properties. Some emphasis will be put on the theoretical developments which occurred in the last two years.Comment: 20 pages, latex, 12 figures. Talk given at PASCOS 2003 (Bombay, India