830 research outputs found
Inadequacy of zero-width approximation for a light Higgs boson signal
In the Higgs search at the LHC, a light Higgs boson (115 GeV <~ M_H <~ 130
GeV) is not excluded by experimental data. In this mass range, the width of the
Standard Model Higgs boson is more than four orders of magnitude smaller than
its mass. The zero-width approximation is hence expected to be an excellent
approximation. We show that this is not always the case. The inclusion of
off-shell contributions is essential to obtain an accurate Higgs signal
normalisation at the 1% precision level. For gg (-> H) -> VV, V= W,Z, O(10%)
corrections occur due to an enhanced Higgs signal in the region M_VV > 2 M_V,
where also sizable Higgs-continuum interference occurs. We discuss how
experimental selection cuts can be used to exclude this region in search
channels where the Higgs invariant mass cannot be reconstructed. We note that
the H -> VV decay modes in weak boson fusion are similarly affected.Comment: 26 pages, 18 figures, 6 tables; added references, expanded
introduction, version to appear in JHE
Determining the Structure of Higgs Couplings at the LHC
Higgs boson production via weak boson fusion at the CERN Large Hadron
Collider has the capability to determine the dominant CP nature of a Higgs
boson, via the tensor structure of its coupling to weak bosons. This
information is contained in the azimuthal angle distribution of the two
outgoing forward tagging jets. The technique is independent of both the Higgs
boson mass and the observed decay channel.Comment: 5 pages, 4 figures, version accepted for publication in PR
NLO Higgs boson production via vector-boson fusion matched with shower in POWHEG
We present a next-to-leading order calculation of Higgs boson production in
vector-boson fusion processes interfaced to shower Monte Carlo programs,
implemented according to the POWHEG method.Comment: 16 pages, 9 figures. A few references and a new figure adde
QCD corrections to electroweak l nu_l jj and l^+ l^- jj production
The production of W or Z bosons in association with two jets is an important
background to the Higgs boson search in vector-boson fusion at the LHC. The
purely electroweak component of this background is dominated by vector-boson
fusion, which exhibits kinematic distributions very similar to the Higgs boson
signal. We consider the next-to-leading order QCD corrections to the
electroweak production of l nu_l jj and l^+ l^- jj events at the LHC, within
typical vector-boson fusion cuts. We show that the QCD corrections are modest,
increasing the total cross sections by about 10%. Remaining scale uncertainties
are below 2%. A fully-flexible next-to-leading order partonic Monte Carlo
program allows to demonstrate these features for cross sections within typical
vector-boson-fusion acceptance cuts. Modest corrections are also found for
distributions.Comment: 26 pages, 10 figures. PRD final version. One reference corrected,
introduction expande
Higgs-Boson Production Induced by Bottom Quarks
Bottom quark-induced processes are responsible for a large fraction of the
LHC discovery potential, in particular for supersymmetric Higgs bosons.
Recently, the discrepancy between exclusive and inclusive Higgs boson
production rates has been linked to the choice of an appropriate bottom
factorization scale. We investigate the process kinematics at hadron colliders
and show that it leads to a considerable decrease in the bottom factorization
scale. This effect is the missing piece needed to understand the corresponding
higher order results. Our results hold generally for charged and for neutral
Higgs boson production at the LHC as well as at the Tevatron. The situation is
different for single top quark production, where we find no sizeable
suppression of the factorization scale. Turning the argument around, we can
specify how large the collinear logarithms are, which can be resummed using the
bottom parton picture.Comment: 18 page
CP asymmetries in the supersymmetric trilepton signal at the LHC
In the CP-violating Minimal Supersymmetric Standard Model, we study the
production of a neutralino-chargino pair at the LHC. For their decays into
three leptons, we analyze CP asymmetries which are sensitive to the CP phases
of the neutralino and chargino sector. We present analytical formulas for the
entire production and decay process, and identify the CP-violating
contributions in the spin correlation terms. This allows us to define the
optimal CP asymmetries. We present a detailed numerical analysis of the cross
sections, branching ratios, and the CP observables. For light neutralinos,
charginos, and squarks, the asymmetries can reach several 10%. We estimate the
discovery potential for the LHC to observe CP violation in the trilepton
channel.Comment: 39 pages, 8 figures, version to appear in EPJC, discussion(s) added,
typo in (D.79), (D.118) corrected, new Fig. 7; The European Physical Journal
C, Volume 72, Issue 3, 201
Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
Ewing sarcoma (EwS) is an aggressive pediatric bone cancer in need of more effective therapies than currently available. Most research into novel targeted therapeutic approaches is focused on the fusion oncogene EWSR1-FLI1, which is the genetic hallmark of this disease. In this study, a broad range of 3,325 experimental compounds, among them FDA approved drugs and natural products, were screened for their effect on EwS cell viability depending on EWS-FLI1 expression. In a network-based approach we integrated the results from drug perturbation screens and RNA sequencing, comparing EWS-FLI1-high (normal expression) with EWS-FLI1-low (knockdown) conditions, revealing novel interactions between compounds and EWS-FLI1 associated biological processes. The top candidate list of druggable EWS-FLI1 targets included genes involved in translation, histone modification, microtubule structure, topoisomerase activity as well as apoptosis regulation. We confirmed our in silico results using viability and apoptosis assays, underlining the applicability of our integrative and systemic approach. We identified differential sensitivities of Ewing sarcoma cells to BCL-2 family inhibitors dependent on the EWS-FLI1 regulome including altered MCL-1 expression and subcellular localization. This study facilitates the selection of effective targeted approaches for future combinatorial therapies of patients suffering from Ewing sarcoma.(VLID)471264
Charged Higgs Boson Production in Bottom-Gluon Fusion
We compute the complete next-to-leading order SUSY-QCD corrections for the
associated production of a charged Higgs boson with a top quark via
bottom-gluon fusion. We investigate the applicability of the bottom parton
description in detail. The higher order corrections can be split into real and
virtual corrections for a general two Higgs doublet model and into additional
massive supersymmetric loop contributions. We find that the perturbative
behavior is well under control. The supersymmetric contributions consist of the
universal bottom Yukawa coupling corrections and non-factorizable diagrams.
Over most of the relevant supersymmetric parameter space the Yukawa coupling
corrections are sizeable, while the remaining supersymmetric loop contributions
are negligible.Comment: 18 pages, v2: some discussions added, v3: published versio
Self-organization in the olfactory system: one shot odor recognition in insects
We show in a model of spiking neurons that synaptic plasticity in the mushroom bodies in combination with the general fan-in, fan-out properties of the early processing layers of the olfactory system might be sufficient to account for its efficient recognition of odors. For a large variety of initial conditions the model system consistently finds a working solution without any fine-tuning, and is, therefore, inherently robust. We demonstrate that gain control through the known feedforward inhibition of lateral horn interneurons increases the capacity of the system but is not essential for its general function. We also predict an upper limit for the number of odor classes Drosophila can discriminate based on the number and connectivity of its olfactory neurons
Higgs Physics at Future Colliders: recent theoretical developments
I review the physics of the Higgs sector in the Standard Model and its
minimal supersymmetric extension, the MSSM. I will discuss the prospects for
discovering the Higgs particles at the upgraded Tevatron, at the Large Hadron
Collider, and at a future high--energy linear collider with
centre--of--mass energy in the 350--800 GeV range, as well as the possibilities
for studying their fundamental properties. Some emphasis will be put on the
theoretical developments which occurred in the last two years.Comment: 20 pages, latex, 12 figures. Talk given at PASCOS 2003 (Bombay,
India
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