Consanguinity and Disorders of Sexual Developments in the Sudan

Background: Consanguinity is very common in the Sudanese society. There is a lack of studies on consanguinity and its impact on genetic diseases in Sudan. In this study we correlated Disorders of Sexual developments (DSDs), as an example of genetic conditions, in relation with consanguinity.Material and Methods: A cohort of twenty six cases from 15 Sudanese families were diagnosed with DSD between the years 2008-2010, Diagnosis was done in Al-Neelian Medical Research Centre, Al-Neelain University, Sudan in collaboration with the University of Lübeck, Germany.Results: Parental consanguinity was seen in 70 %, 10 % were not consanguineous while 20 % did not provide a detailed family pedigree.Conclusion: There is strong association between consanguinity and inheritance of DSDs in the Sudan, which is expected to be higher than that reported in the literature about non-consanguineous DSDs from western countries

A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes

Background: Herbal medicines long have been used in the management of diabetes mellitus (DM).Objective: This study was conducted to ascertain if fenugreek compared with glibenclamide had any impacts on controlling blood glucose in patients with uncontrolled type II DM on conventional therapy.Methods: A total of 12 patients with uncontrolled DM and on metformin were recruited and divided into two groups. Patients in group 1 received 2 g fenugreek per day, whereas those in group 2 received glibenclamide 5 mg once daily. The impacts of fenugreek on the glycemic control and lipid profile were measured before initiation of the regimen and then after 12 weeks.Results: Only 9 of the 12 study participants completed the study. Fenugreek at 2 g/day caused an insignificant drop in fasting blood glucose (P = 0.63), but the fasting insulin level increased significantly (P = 0.04). The ratio of high- to low-density lipopro- tein was significantly decreased from before to after treatment (P = 0.006). Fenugreek did not cause any notable adverse impacts on hepatic and renal functions throughout the study.Conclusion: Fenugreek could be used as adjuvant therapy to anti-diabetic drugs to control blood glucose, and further studies are needed.Keywords: Trigonella foenum-graecum (fenugreek), glibenclamide, diabetes

SOLVENT EFFECTS ON THE ELECTRONIC ABSORPTION SPECTRA OF SOME ANALYTICAL INDICATORS

Electronic absorption spectra of selected ligands (Alloxan, Carmine, Naphthol Yellow S, Hematoxylin and Cyanine) were recorded in presence of different solvents (H2O, Ethyl acetate, Ethanol, DMF, Isopropyl alcohol, Amyl alcohol and Butanol) of variable physical properties. The electronic transitions were assigned. The data are analyzed based on the multiple linear regression technique explained from the views of different solvent parameters. Statistical analyses of the effect of solvents on the electronic spectra of the present ligands have been investigated

Outcomes of integrating a clinical pharmacist in the pediatric cardiology ward

To date, very limited data are available on clinical pharmacist's services in pediatric cardiology. The aim of this review was to assess "drug-related problems" (DRPs) and patient outcomes during the involvement of the clinical pharmacist in the pediatric cardiology ward. Studies published between January 2000 and November 2021 were searched across Medline, PubMed, Google Scholar, Elsevier, and ScienceDirect for “DRPs” and “patient outcome” with “clinical pharmacist” and “pediatric cardiology”. Results revealed that the incorporation of clinical pharmacists in the multidisciplinary team can detect and resolve DRPs, reduce the overall burden of healthcare costs, and improve drug safety in pediatric cardiology patients. Most DRPs identified and interventions proposed by the clinical pharmacists were accepted by the physicians. Studies have also reported a positive impact on patient outcomes, including: shorter hospital stay, fewer disease events, optimal anticoagulation levels, lipid levels, and blood pressure. Moreover; pharmacist-led discharge medication counseling resulted in better medication adherence, fewer medication discrepancies, and a lower incidence of cardiovascular-associated hospital readmissions. In summary, there is growing evidence that integration and interventions of clinical pharmacists into cardiology ward has a positive influence on DRPs and patient outcomes

Factorization and Lie point symmetries of general Lienard-type equation in the complex plane

We present a variational approach to a general Lienard-type equation in order to linearize it and, as an example, the Van der Pol oscillator is discussed. The new equation which is almost linear is factorized. The point symmetries of the deformed equation are also discussed and the two-dimensional Lie algebraic generators are obtained

Suppressing bladder artifacts in bone SPECT of the pelvis

Objective: Bladder-filling reconstruction artifacts have a detrimental effect on the image quality of pelvic bone single photon emission computed tomography (SPECT). Using a simple protocol consisting of forced diuresis coupled with intravenous (IV) hydration, this study was undertaken to obtain an artifact-free pelvic SPECT after discarding the residual urinary activity. Methods: Thirty patients were enrolled. In group I, pelvic SPECT was performed directly after normal void, whereas in group II, SPECT was preceded by IV injection of 0.5 mg/kg furosemide (maximum 40 mg) coupled with IV infusion of 500 cc of physiologic saline. Bladder-filling reconstruction artifacts were analyzed in group I patients, who had their images reconstructed using both filtered backprojection and iterative algorithms, both qualitatively and quantitatively by means of regions of interest (ROIs) drawn around the artifact-bearing bone areas as well as the corresponding contralateral sites. For group II patients, besides visual analysis, ROIs were placed over the sites corresponding to those of the group I patients. In every patient, total counts of each ROI were normalized to a reference ROI placed over the sacrum, and a ratio was created. Results: Using filtered backprojection, two forms of artifacts were identified in group I patients: first, a streak pattern that extended to the sacro-iliac joint in nine (60%) patients, the hip joint in five (33%), the superior pubic rami in four (27%), the sacrum in three (20%), and the ischium in one (6%); second, a count loss subtype which extended to the hip joints in nine (60%) patients. Corresponding values after iterative reconstruction were two (13%) for the sacro-iliac joint, three (20%) for the hip joint, one (6%) for the superior pubic ramus, and one (6%) for the sacrum. In five (33%) patients, residual count loss artifacts were still identifiable after iterative reconstruction. However in group II, no such effects were observed because the bladder activity reached near background level in 14 (93%) of 15 patients after three successive voids with a 3.5-fold decrease in the mean value of total bladder count in comparison with group I patients. A statistically significant difference was found between artifact- and non-artifact-harboring ROIs in group I whichever the method used for reconstruction, whereas the values of right and left hemi-pelvis ROIs/sacrum in group II were almost identical. Conclusions: Forced diuresis coupled with parenteral hydration facilitates the acquisition of an artifact-free pelvic SPECT. Especially for clinical questions that focus on femoral heads and pubic bones, applying the aforementioned protocol may improve the diagnostic accuracy of pelvic bone SPEC