Estimation of Reserves for Improving the Results of Patients with Multipresistant Pulmonary Tuberculosis in the Application of Surgical Methods Based on Analysis of the Efficiency of Conservative Treatment of a Specified Cohort

In order to improve the results of treatment of patients with multi-resistant pulmonary tuberculosis with the use of surgical methods, the effectiveness estimation of conservative treatment of 176 patients with this form of tuberculosis according to cohort analysis data in two districts of Kyiv were done.In the list were included following parameters: type of the tuberculosis, its clinical-radiological form and the prevalence of the process, the results of conservative treatment in patients who completely finished the course of anti-TB chemotherapy and the results of conservative treatment of 81 patients who had indications for surgical treatment but had not been operated. Processing of the materials of the study was carried out with the use of licensed software products included in the Microsoft Office Professional 2007 package. The predicted results of treatment were calculated on the condition of surgical intervention.Out of the total sample of patients, 31.3 % of the patients completed treatment. Mortality was 16.5 %, transferred to palliative care 11.9 %. More than one in three patients (35.2 %) stopped treatment at different times from the start.According to the clinic of thoracic surgery SU "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky NAMS of Ukraine ", the overall effectiveness of treatment for patients with limited multidrug-resistant tuberculosis with the use of surgical intervention is about 95 % in the absence of mortality. We have modelled the potential results of treatment of the selected cohort in case of the surgical stage is fully and timely applied in a complex of therapeutic treatment. If all 81 patients with indications for surgical treatment used that way, then, with the above efficiency, a complete cure could be predicted in 77 patients (44.5 % of the total number of observations), which in turn would allow predicting the achievement completion of treatment at 64.2 % with complete cure for 60.6 % of patients.Thus, it is established that the positive result of surgical treatment in the general complex of treatment measures in patients with multidrug-resistant pulmonary tuberculosis is able to improve the results of treatment of this contingent more than twice, reduce the mortality almost by three times, reduce the need for repeated courses of treatment from 7.4 % to 1.7 %, as well as to reduce the epidemiological reservoir of infection due to a significant decrease in the number of patients with failure to treat tuberculosis, interrupted and palliative treatment

Binding sites of mirnas with transcription factors' genes of Camelus ferus

We searched binding sites of miRNAs in mRNAs of 157 transcription factors' genes of wild camel (Camelus ferus). The mRNAs of 96 genes of zincfinger transcription factors' family have 16, 210 and 34 binding sites in the 5'UTRs, CDSs and 3'UTRs, respectively. The mRNA of GLI2 gene has binding sites for eight miRNAs. The mRNAs of GLIS1 and ZNF236 genes contain seven binding sites. In the 3'UTR mRNA of ZFP91 gene were revealed 13 miR-574-5p binding sites arranged located through two nucleotides. The ΔG/ΔGm value is equal to 93%. miR-1322 has one binding site in GLI1, HINFP, HIVEP1, MTF1, SALL4, SP1, ZNF335 and ZNF451 genes, two sites in ZNF142, three sites in EGR1 gene. mRNA of VEZF1 gene has eight miR-1322 binding sites arranged located through three nucleotides. miRNAs with the length of 25 and 26 nucleotides have the highest binding energy. The ΔG value varied from -114,6 kJ/mole to -138,0 kJ/mole. Some miRNAs with a length of 23 and 24 nucleotides also have a high value ΔG varied from -112,5 kJ/mole to -129,5 kJ/mole. The results show a strong interaction between the expression of genes of transcription factors and miRNAs. (Résumé d'auteur

The Isothermal Section of Ag 2 Se–CdSe–In 2 Se 3 System at 820 K.

Методами рентгенофазового, мікроструктурного аналізів та вимірюванням мікротвердості досліджено квазіпотрійну систему Ag2Se–CdSe–In2Se3. За результатами досліджень та літературними даними побудовано ізотермічний переріз при 820 К. Встановлено існування тетрарної сполуки Ag0,4Cd0,4In6,3Se10. The quasi-ternary system Ag2Se–CdSe–In2Se3 was investigated by XRD and microstructure analysis and microhardness measurements. The isothermal section at 820 K was constructed from the investigation results and literature data. The existence of a quaternary compound Ag0,4Cd0,4In6,3Se10 was istablished

Structural and mechanical properties of NbN and Nb-Si-N films: Experiment and molecular dynamics simulations

The structural and mechanical properties of NbN and Nb-Si-N films have been investigated both experimentally and theoretically, in their as-deposited and annealed states. The films were deposited using magnetron sputtering at substrate bias (UB) between 0 and 70 V. While NbN films were found to crystallize in the cubic δ-NbN structure, Nb-Si-N films with Si content of 11–13 at% consisted of a twophases nanocomposite structure where δ-NbN nanocrystals were embedded in SiNx amorphous matrix. Films deposited at UB¼0 V were highly (001)-textured. Application of substrate bias potential led to a depletion of light atoms, and caused a grain size refinement concomitantly with the increase of (111) preferred orientations in both films. The maximum hardness was 28 GPa and 32 GPa for NbN and Nb-SiN films, respectively. NbN and Nb-Si-N films deposited at UB¼ 70 V exhibited compressive stress of 3 and 4 GPa, respectively. After vacuum annealing, a decrease in the stress-free lattice parameter was observed for both films, and attributed to alteration of film composition. To obtain insights on interface properties and related mechanical and thermal stability of Nb-Si-N nanocomposite films, first principles molecular dynamics simulations of NbN/SiNx heterostructures with different structures (cubic and hexagonal) and atomic configurations were carried out. All the hexagonal heterostructures were found to be dynamically stable and weakly dependent on temperature. Calculation of the tensile strain-stress curves showed that the values of ideal tensile strength for the δ-NbN(111)- and ε-NbN(001)-based heterostructures with coherent interfaces and Si3N4–like Si2N3 interfaces were the highest with values in the range 36–65 GPa, but lower than corresponding values of bulk NbN compound. This suggests that hardness enhancement is likely due to inhibition of dislocation glide at the grain boundary rather than interfacial strengthening due to Si-N chemical bondin

Статеві особливості рухової підготовленості дітей 6—10 років

The objective is to determine the gender-specific peculiarities of motor preparedness of children aged 6-10. Materials and methods: the participants in the study were girls aged 6 (n = 36), aged 7 (n = 48), aged 8 (n = 57), aged 9 (n = 38), aged 10 (n = 46); boys aged 6 (n = 48), aged 7 (n = 45), aged 8 (n = 60), aged 9 (n = 47), aged 10 (n = 40). To achieve the tasks set, the study relied on the following research methods: analysis of scientific literature, pedagogical testing and methods of mathematical statistics of research data reduction. The study used discriminant analysis as the modeling method.Results: the classification results of motor preparedness of girls and boys aged 6-10 indicate that the study has correctly classified 81.9-100% of the initial observations. The graphic material demonstrates the density of objects within each class and a clear distinction between the classes. This allows to maintain that there is a significant difference between girls and boys aged 6-10 in their motor preparedness.Conclusions. The girls aged 6-10 show the best results in movement coordination related to combinations of movements of arms and legs, as well as flexibility. The girls aged 10 show the best results in test No. 10 “300-m Race”. The boys aged 6-10, unlike the girls, show the best results in the development of general coordination of movements, strength, speed strength, strength and general endurance. It is possible to argue with a high level of reliability that by their classification characteristics girls and boys belong to different classes, and significantly differ in motor preparedness.Цель: определить гендерные особенности двигательной подготовленности детей 6–10 лет.Материалы и методы: в исследовании приняли участие девочки 6 лет (n = 36), 7 лет (n = 48), 8 лет (n = 57), 9 лет (n = 38), 10 лет (n = 46); мальчики 6 лет (n = 48), 7 лет (n = 45), 8 лет (n = 60), 9 лет (n = 47), 10 лет (n = 40). Для решения поставленных задач были применены следующие методы исследования: анализ научной литературы, педагогическое тестирование и методы математической статистики обработки результатов исследования. Как метод моделирования использован дискриминантный анализ.Результаты: результаты классификации двигательной подготовленности девочек и мальчиков 6-10 лет указывают, что 81,9–100% исходных наблюдений классифицированы верно. Графический материал свидетельствует о плотности объектов в каждом классе и о выразительной черте между классами. Это дает возможность утверждать, что между девочками и мальчиками 6–10 лет существует существенная разница в двигательной подготовленности.Выводы. Девочки 6–10 лет показывают лучшие результаты в координации движений, связанных с сочетанием движений рук и ног и гибкости. В 10 лет девочки показывают лучшие результаты в тесте № 10 «Бег 300 м». Мальчики 6–10 лет отличаются от девочек лучшим развитием общей координации движений, силы, скоростной силы, силовой и общей выносливости. По классификационным характеристикам с высокой степенью достоверности девочки и мальчики относятся к разным классам и существенно отличаются по уровню двигательной подготовленности. Мета: визначити статеві особливості рухової підготовленості дітей 6—10 років. Матеріали і методи: у дослідженні прийняли участь дівчатка 6 років (n=36), 7 років (n=48), 8 років (n=57), 9 років (n=38), 10 років (n=46); хлопчики 6 років (n=48), 7 років (n=45), 8 років (n=60), 9 років (n= 47), 10 років (n=40). Для вирішення поставлених завдань були застосовані такі методи дослідження: аналіз наукової літератури, педагогічне тестування та методи математичної статистики обробки результатів дослідження. Як метод моделювання використаний дискримінантний аналіз.Результати: результати класифікації рухової підготовленості дівчаток і хлопчиків 6—10 років вказують, що 81,9—100 % вихідних спостережень класифіковані вірно. Графічний матеріал свідчить про щільність об’єктів у кожному класі та про виразну межу між класами. Це дає можливість стверджувати, що між дівчатками та хлопчиками 6—10 років існує суттєва різниця у руховій підготовленості.Висновки. Дівчатка 6—10 років показують кращі результати у координації рухів, пов’язаних з поєднанням рухів рук і ніг та гнучкості. У 10 років дівчатка показують кращі результати у тесті № 10 «Біг 300 м». Хлопчики 6—10 років відрізняються від дівчаток кращим розвитком загальної координації рухів, сили, швидкісної сили, силової і загальної витривалості. За класифікаційними характеристиками з високою ступінню достовірності дівчатка і хлопчики відностяться до різних класів і суттєво відрізняються за руховою підготовленістю

REQUISITION POLICY OF AUSTRIA-GERMAN OCCUPING ADMINISTRATION IN UKRAINIAN VILLAGES (FEBRUARY - DECEMBER 1918)

In the article, the authors disclose the revisory measures of the Austro-German War in Ukrainian villages in February - March 1918. It shows the attitude of the Austro-Germanic authorities to the Ukrainian peasantry, the mechanism of imposing and recovering the continuities, as well as the attitude of the population towards such activit