Declining prevalence of duodenal ulcer at endoscopy in Ile-Ife, Nigeria

Background. Duodenal ulcer is the most common peptic ulcer disease worldwide. In the past, sub-Saharan Africa has been described as an area of mixed prevalence for peptic ulcer disease, but recent reports have disputed this. Changes in the prevalence of duodenal ulcer have been reported, with various reasons given for these.Objective. To describe the change in endoscopic prevalence of duodenal ulcer at Obafemi Awolowo University Teaching Hospital (OAUTH), Ile-Ife, Nigeria, between January 2000 and December 2010.Methods. This was a retrospective, descriptive study of patients who underwent upper gastrointestinal endoscopy in the endoscopy unit of OAUTH between January 2000 and December 2010. The data were obtained from the endoscopy register, demographic indices, presenting symptoms and post-endoscopic diagnoses being retrieved for each patient. The study period was divided into the years 2000 - 2004 and 2005 - 2010, the frequencies of duodenal ulcer and other post-endoscopic diagnoses being compared between these two time periods to see whether there were changes.Results. Over the study period, 292 patients (15.8%) were diagnosed with duodenal ulcer, second only to 471 patients (26.2%) with acute gastritis. The prevalence of duodenal ulcer for 2000 - 2004 was 22.9% (n=211 patients) compared with 9.2% (n=81) for 2005 - 2010 (p<0.001).Conclusion. There was a significant decline in the endoscopic prevalence of duodenal ulcer over the decade

Clinical characterisation and management outcomes of COVID-19 infection in pregnancy in a Nigerian tertiary hospital

Background: Literature on the antenatal and perinatal management and outcomes of COVID-19 infection in pregnancy in Nigeria and sub-Saharan Africa is gradually emerging but sparse. There is an urgent need to build up the knowledge base of COVID-19 infection in Nigerian pregnant women. The objective of the current study was to determine the clinical characteristics and management outcomes of COVID-19 infection in pregnancy at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria.Methods: A one-year retrospective review of all cases of COVID-19 infection in pregnancy managed at the OAUTHC. Relevant data were extracted from the case records of all cases managed using a purpose-designed proforma. Data collected was analysed using IBM-SPSS, version 24. Associations between categorical variables were assessed using chi square, with level of significance set at <0.05.Results: A total of 22 cases were managed. Majority (15, 68.2%) of the women were either asymptomatic or had mild symptoms. The commonest symptom was cough (8, 36.4%). The mean duration of admission was 6.6±4.2 days. The most common maternal and perinatal complication was preterm delivery/birth (3, 13.6%). There was no maternal mortality. The mean birth weight of the babies was 3226g±597g, with mean 1- and 5- minutes Apgar scores of 8.0±1.3 and 9.5±0.6 respectively.Conclusions: Although COVID-19 infection in pregnancy is an asymptomatic or mild infection in the majority of cases in Ile-Ife, Nigeria, it is associated with adverse maternal and perinatal outcomes. Further studies are recommended to determine transplacental transmission of COVID-19 infection and antibodies

Contraceptive uptake among women attending family planning clinic in a Nigerian tertiary health facility: a 6 year review

Background: Contraceptive uptake is one of the most important determinants of pregnancy rates and birth rates in the world. Aim: To determine the principal trends in contraceptive use from 2004-2009 in the family planning unit of a tertiary health centre in South-Western Nigeria, and to identify the effect of age, marital status and parity on the choice of contraceptive method.Methods: The record of 1,862 clients attending the Family Planning unit of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun-State, Nigeria for the period between 2004-2009 were reviewed. Information related to the age, marital status, parity and the choice of contraception were obtained using a structured proforma and the data analyzed with SPSS version 16. Pearson chi-square test was used as test of significance where applicable.Results: Within the study period, the contraceptive uptake was 13.2%. Copper-T IUCD was the most commonly used method of contraception (77.9%), followed by the progestogen only injectable contraceptives (12.6%), then oral pills (4.1%) and progestin implants (2.3%). Single women and women of low parity are more likely to use pills than IUCD (69% vs. 38.3%) while long acting reversible contraception (injectables and IUCD) are preferred by women with higher parity (P=0.000).Conclusions: IUCD is the most popular method of contraception in Ife-Ijesha area of Nigeria. Contraceptive uptake is relatively low among the women. Age and parity are key influences on the uptake and choice of contraception practiced by the women, while the influence of marital status is not statistically significant

CHEMOTHERAPEUTIC INTERACTION BETWEEN KHAYA GRANDIFOLIOLA (WELW) CDC STEM BARK EXTRACT AND TWO ANTI-MALARIAL DRUGS IN MICE

In malarial endemic countries especially in the tropics, conventional antimalarial drugs are used with herbal remedies either concurrently or successively. Khaya grandifoliola is one of such popular herbs used in the treatment of malaria. Various doses of ethanol extract of K. grandifoliola stem bark (50-400 mg/kg/day) were administered orally to Swiss albino mice infected with Plasmodium yoelii nigerense. A dose of 100 mg/kg/day of the extract was also combined with 2.5 mg/kg/day of chloroquine or 6.25 mg/kg/day of halofantrine in both early and established malaria infection test models. The results showed that in the early malaria infection test, K. grandifoliola in combination with chloroquine or halofantrine elicited enhanced anti-plasmodial effect in the established infection, there was significantly greater parasite clearance following administration of the combination when compared to the effects of K. grandifoliola or the conventional drugs alone. The mean survival period of parasitized animals was also enhanced by the extract/halofantrine combination. Lower therapeutic doses of halofantrine may be required to potentiate parasite clearance when used in combination with K. grandifoliola. This may constitute great advantage to halofantrine which is associated with cardiotoxicity at high doses

Have you seen a rape kit? A snapshot at the quality of care of rape survivors in Nigerian tertiary hospitals

Context: The rape kit has become a fundamental tool in the evaluation of the rape survivor in many countries. Itsavailability and use in Nigeria has however not been documented.Objective: To assess the current availability and usage of the rape kit in Nigerian tertiary hospitals, and evaluate the management of rape survivors.Methodology: Resident Doctors attending the Obstetrics and Gynaecology update course, held in Abuja in March,2009 were interviewed using a self-administered questionnaire assessing experience in rape management, knowledge about the rape kit and its availability, as well as current management of rape survivors.Results: There were 138 respondents from 25 tertiary hospitals, with a male-to-female ratio of 2.8:1 and a meanduration of 3.3 (SD 1.4) years in training. 120 (87%) had personally managed one or more rape survivor(s), but none of the respondents had ever seen a rape kit, and only 29% were aware of it. Although all the respondents indicated availability of emergency contraception, antibiotics and tetanus prophylaxis in their centres, only 32.4% had access to HBV vaccine, and about 8% indicated lack of HIV prophylaxis. Only 28.7% and 45.6% indicated access to clinical psychologists and medical social workers respectively.Conclusion: The rape kit is not available in Nigerian tertiary hospitals. We recommend its provision, and regulartraining of doctors, especially Obstetrics and Gynaecology Residents on rape management, to improve the care ofrape survivors in Nigeria.Key Words: Rape, Rape kit, Rape survivor, Nigeria

Declining prevalence of duodenal ulcer at endoscopy in Ile-Ife, Nigeria

Background. Duodenal ulcer is the most common peptic ulcer disease worldwide. In the past, sub-Saharan Africa has been described as an area of mixed prevalence for peptic ulcer disease, but recent reports have disputed this. Changes in the prevalence of duodenal ulcer have been reported, with various reasons given for these.Objective. To describe the change in endoscopic prevalence of duodenal ulcer at Obafemi Awolowo University Teaching Hospital (OAUTH), Ile-Ife, Nigeria, between January 2000 and December 2010.Methods. This was a retrospective, descriptive study of patients who underwent upper gastrointestinal endoscopy in the endoscopy unit of OAUTH between January 2000 and December 2010. The data were obtained from the endoscopy register, demographic indices, presenting symptoms and post-endoscopic diagnoses being retrieved for each patient. The study period was divided into the years 2000 - 2004 and 2005 - 2010, the frequencies of duodenal ulcer and other post-endoscopic diagnoses being compared between these two time periods to see whether there were changes.Results. Over the study period, 292 patients (15.8%) were diagnosed with duodenal ulcer, second only to 471 patients (26.2%) with acute gastritis. The prevalence of duodenal ulcer for 2000 - 2004 was 22.9% (n=211 patients) compared with 9.2% (n=81) for 2005 - 2010 (p&lt;0.001).Conclusion. There was a significant decline in the endoscopic prevalence of duodenal ulcer over the decade.

Evaluation of Energy and Micronutrients Intake of Nigerian Adolescent Females: A Case Study of Institutionalized Secondary Schools in Akure South Local

Abstract: The objective of the study is to provide information on the energy and micronutrients intake of Nigerian adolescent females. A cross-sectional surrey was conducted among the 323 institutionalized adolescent females of 10-19 years age range in Akure South LGA, Ondo State. The energy and micronutrient intake were determined by weighing the food intake of the subjects and part of the food samples were subjected to chemical analysis The mean mineral intakes were: Ca 567 mg/kg, Mg 261 mg/kg, Zn 7.58mg/kg, Fe 19.8 mg/kg and P 136.8 mg/kg. And the vitamins intakes were vit. A 860 mg/kg, Thiamine 0.7 mg/kg, Riboflavin 0.28 mg/kg, Niacin 3.27 mg/kg, vit. C 9.1 mg/kg, Vit. D 2.14 mcg/kg Folic acid 9.8 mcg/kg and Vit. B 12 1.2 mcg/kg, and the energy intakes was 6.45 MJ. The result showed that high proportion of the subjects were not meeting the RDA for energy and some of the micronutrients intake. Key words: Institutionalized adolescent female, dietary intake, micronutrients intak

Phytochemical, Scavenging Properties and Glycemic Index of Soy-Enriched Maize-Based Gruel Fortified with Moringa Leaves and Wonderful Kola

In this study, defatted soybean cake, Moringa oleifera leaves and wonderful kola combination were used to raise the nutritional value and scavenging properties of maize-based formulated diets. After blanching and fermentation process, maize (popcorn), moringa leaves, wonderful kola seeds, defatted soybean cake were milled into flour and blended to obtain six samples (R1, R2, B1, B2, F1, F2). Samples were analyzed for antinutrients, phytochemicals, scavenging properties and glycemic index using standard methods. Both processing methods reduced antinutrient levels; particularly for phytic acid. Of the methods used, fermentation is the most effective in increasing the protein content of the formulated diets, it also had the highest scavenging ability and the lowest glycemic index. For DPPH (1,1 diphenyl-2-picryhydrazyl) assay, R1, B1, F1 had high&nbsp; scavenging abilities with F1 having the highest. Albino rats fed with 1 g of sample F1 showed a great decrease in blood glucose level below 5 mmol/l when compared with other samples and reference sample (glucose). This shows the importance of a healthy diet and the effectiveness of Moringa oleifera leaves in the prevention and management of diabetes

Obstetric outcome of teenage pregnancy and labour in Obafemi Awolowo University Teaching Hospitals complex, Ile-Ife: A ten year review

Background: Teenage or adolescent pregnancy is a recognized problem of public health significance. Every year, in excess of 14 million teenage girls give birth to a child; most of these young mothers are living in non-industrialized countries. In view of the high prevalence, there is a need to audit such cases regularly to identify areas of possible improvement in its management. Results obtained from the audit can help in policy formulation and strengthen advocacy on issues ranging from abortion complications to early marriage. Objectives: The objectives of this 10-year retrospective study are to document the pattern of prevalence, presentation, obstetric outcome of teenage pregnancy, and labor at the Ife Hospital unit of obafemi awolowo university teaching hospitals complex (OAUTHC), Ile-Ife. Materials and Methods: The study involved a 10-year retrospective analysis of the data collected from the records of all cases of teenage pregnancies during the period from January 1999 to December 2008. Results: During the period studied there were 6,250 deliveries of which teenage pregnancies accounted for 255 giving an incidence of 4.08% of the total deliveries. Majority (51.76%) of the pregnant teenagers were unbooked for antenatal care and 92.12% of them were nulliparous. Antepartum hemorrhage, abnormal presentations, obstructed labor, and anemia were the commonest complications seen occurring in 54.5, 36.5, 14.1, and 11.4 per cent of the teenagers respectively which was significantly higher when compared to the adult pregnant women (P = 0.000). Delivery was by caesarean section in 32.2% of the teenagers compared to 22.6% in the other women (P = 0.000). The overall perinatal mortality rate was 68.8/1000 births while teenagers had a perinatal mortality rate of 106/1000 births (P = 0.013). Conclusion: Teenage pregnancy still remains a major recognized problem of public health significance. Most of these patients are from low socio-economic class and their obstetric performance is relatively poor compared to the adult group. The concept of women's sexual and reproductive health rights needs to be reinforced in most developing countries. Improving access to contraception and discouragement of early marriage will help to reduce teenage pregnancy and the overall burden of maternal mortality. Optimal care should be given to teenage mothers not only to improve the pregnancy outcome but also to enhance their social, educational, and emotional adjustment