Entanglement between charge qubit states and coherent states of nanomechanical resonator generated by ac Josephson effect

We considered a nanoelectromechanical system consisting of a movable Cooper-pair box qubit, which is subject to an electrostatic field, and coupled to the two bulk superconductors via tunneling processes. We suggest that qubit dynamics is related to that of a quantum oscillator and demonstrate that a bias voltage applied between superconductors generates states represented by the entanglement of qubit states and coherent states of the oscillator if certain resonant conditions are fulfilled. It is shown that a structure of this entanglement may be controlled by the bias voltage in a way that gives rise to the entanglement incorporating so-called cat-states—the superposition of coherent states. We characterize the formation and development of such states analyzing the entropy of entanglement and corresponding Wigner function. The experimentally feasible detection of the effect by measuring the average current is also considered

Electromechanics of charge shuttling in dissipative nanostructures

We investigate the current-voltage (IV) characteristics of a model single-electron transistor where mechanical motion, subject to strong dissipation, of a small metallic grain is possible. The system is studied both by using Monte Carlo simulations and by using an analytical approach. We show that electromechanical coupling results in a highly nonlinear IV-curve. For voltages above the Coulomb blockade threshold, two distinct regimes of charge transfer occur: At low voltages the system behave as a static asymmetric double junction and tunneling is the dominating charge transfer mechanism. At higher voltages an abrupt transition to a new shuttle regime appears, where the grain performs an oscillatory motion back and forth between the leads. In this regime the current is mainly mediated by charges that are carried on the grain as it moves from one lead to the other.Comment: 8 pages, 10 figures, final version to be published in PR

Umklapp-Assisted Electron Transport Oscillations in Metal Superlattices

We consider a superlattice of parallel metal tunnel junctions with a spatially non-homogeneous probability for electrons to tunnel. In such structures tunneling can be accompanied by electron scattering that conserves energy but not momentum. In the special case of a tunneling probability that varies periodically with period $a$ in the longitudinal direction, i.e., perpendicular to the junctions, electron tunneling is accompanied by "umklapp" scattering, where the longitudinal momentum changes by a multiple of $h/a$. We predict that as a result a sequence of metal-insulator transitions can be induced by an external electric- or magnetic field as the field strength is increased.Comment: 5 pages, 3 figure

Exosomes: From potential culprits to new therapeutic promise in the setting of cardiac fibrosis

Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents

Shuttle Mechanism for Charge Transfer in Coulomb Blockade Nanostructures

Room-temperature Coulomb blockade of charge transport through composite nanostructures containing organic inter-links has recently been observed. A pronounced charging effect in combination with the softness of the molecular links implies that charge transfer gives rise to a significant deformation of these structures. For a simple model system containing one nanoscale metallic cluster connected by molecular links to two bulk metallic electrodes we show that self-excitation of periodic cluster oscillations in conjunction with sequential processes of cluster charging and decharging appears for a sufficiently large bias voltage. This new `electron shuttle' mechanism of discrete charge transfer gives rise to a current through the nanostructure, which is proportional to the cluster vibration frequency.Comment: 4 pages, 4 figure

Electronic spin working mechanically

A single-electron tunneling (SET) device with a nanoscale central island that can move with respect to the bulk source- and drain electrodes allows for a nanoelectromechanical (NEM) coupling between the electrical current through the device and mechanical vibrations of the island. Although an electromechanical "shuttle" instability and the associated phenomenon of single-electron shuttling were predicted more than 15 years ago, both theoretical and experimental studies of NEM-SET structures are still carried out. New functionalities based on quantum coherence, Coulomb correlations and coherent electron-spin dynamics are of particular current interest. In this article we present a short review of recent activities in this area.Comment: 17 pages, 11 figures. arXiv admin note: substantial text overlap with arXiv:1303.074

Influence mechanisms of mineralocorticoid receptor antagonist (spironolactone) among elderly patients with chronic heartfailure against ischemic disease

It was determined that a significant positive dynamics of TNF-synthesis suppression by 67.0% (p 0.0001) was established in the 4th group of patients taking combined therapy with the blocker of mineralocorticoid receptors with spironolacton