Radiation Cataractogenesis Induced by Neutron or Gamma Irradiation in the Rat Lens is Reduced by Vitamin E

Although cataract of the eye lens is a known late effect of ionizing radiation exposure, most of the experimental work to date has concentrated on single, acute high doses or multiple, fractionated, chronic exposures. Many papers have dealt with biochemical alterations in metabolism and cellular components, with microscopic and electron microscopic lesions to the epithelial and cortical layers, and with clinical cataract formation. However, the minimum cataractogenic dose for rats has for many years been considered to be about 2 Gy for a single, acute dose of low LET radiation. Our purpose in designing this pilot study was three fold: firstly, to determine whether any physical damage could be detected after low, acute exposure to neutron radiation (10 and 100 cGy); secondly, to compare the relative effectiveness of fast (14 MeV) neutrons with gamma-rays; and thirdly, to investigate the possibility that vitamin E could protect the lenses from radiation damage. The results revealed that morphological damage was already discernible within minutes after exposure to neutrons or gamma-rays, that it became greater after 24 hours, that neutrons were more damaging than gamma-rays, and that vitamin E could effectively reduce the cataractogenic damage induced by ionizing radiation. Control, non-irradiated lenses with or without vitamin E, either in vivo or in vitro, showed no damage. Also, it appeared that in vitro irradiation was more damaging to lenses than in vivo irradiation, so this culture technique may prove to be a sensitive tool for assessing early damage caused by ionizing radiation. However it must be noted that at this level of radiation exposure (10-100 cGy), the early damage we have described will probably be repaired so no clinical cataracts will develop, unless other factors contribute to their development

Response of the Brazilian gravitational wave detector to signals from a black hole ringdown

It is assumed that a black hole can be disturbed in such a way that a ringdown gravitational wave would be generated. This ringdown waveform is well understood and is modelled as an exponentially damped sinusoid. In this work we use this kind of waveform to study the performance of the SCHENBERG gravitational wave detector. This first realistic simulation will help us to develop strategies for the signal analysis of this Brazilian detector. We calculated the signal-to-noise ratio as a function of frequency for the simulated signals and obtained results that show that SCHENBERG is expected to be sensitive enough to detect this kind of signal up to a distance of $\sim 20\mathrm{kpc}$.Comment: 5 pages, 4 figures, Amaldi 5 Conference Proceedings contribution. Submitted to Class. Quantum Gra

Power, conflict and ritual on the fen-edge: the anarchy-period castle at Burwell, Cambridgeshire, and its pre-conquest landscape

Burwell, Cambridgeshire is best known as possessing a castle constructed by King Stephen during the mid-twelfth century civil war commonly referred to as ‘the Anarchy’. Documentary sources confirm that the king built a series of fortifications around the East Anglian fen-edge during A.D. 1144 in an attempt to restrict the activities of the rebellious baron Geoffrey de Mandeville, Earl of Essex, who was using the Isle of Ely as a base to raid the surrounding countryside. Written texts also reveal how de Mandeville was mortally wounded during a skirmish or siege which subsequently took place at Burwell. A combination of topographic and geophysical survey, supplemented by documentary analysis, suggests that the castle was constructed in a landscape with a complex earlier history. It is suggested that during the Romano-British period a temple complex was developed on the site, with a spring rising on the edge of the fens providing the likely focus for ritual activity. Burwell later developed into an important early medieval place and the castle itself may have been inserted into a thegnly enclosure — an act which probably sought to appropriate a recognised pre-existing centre of power. The current research provides the most comprehensive assessment of the site to date, and supports existing interpretations which consider the twelfth-century castle to be incomplete. Analysis also gives additional insight into the functional and symbolic significance of the castle at Burwell, and sheds important light on the character of power and conflict in the fenland during the mid-twelfth century

Entropy of Constant Curvature Black Holes in General Relativity

We consider the thermodynamic properties of the constant curvature black hole solution recently found by Banados. We show that it is possible to compute the entropy and the quasilocal thermodynamics of the spacetime using the Einstein-Hilbert action of General Relativity. The constant curvature black hole has some unusual properties which have not been seen in other black hole spacetimes. The entropy of the black hole is not associated with the event horizon; rather it is associated with the region between the event horizon and the observer. Further, surfaces of constant internal energy are not isotherms so the first law of thermodynamics exists only in an integral form. These properties arise from the unusual topology of the Euclidean black hole instanton.Comment: 4 pages LaTeX2e (RevTeX), 2 PostScript figures. Small corrections in the text and the reference

Anti-de Sitter Quotients, Bubbles of Nothing, and Black Holes

In 3+1 dimensions there are anti-de quotients which are black holes with toroidal event horizons. By analytic continuation of the Schwarzschild-anti-de Sitter solution (and appropriate identifications) one finds two one parameter families of spacetimes that contain these quotient black holes. One of these families consists of B-metrics ("bubbles of nothing"), the other of black hole spacetimes. All of them have vanishing conserved charges.Comment: 14 pages, 3 figures. References added, one explanation improve

Optimal shapes of compact strings

Optimal geometrical arrangements, such as the stacking of atoms, are of relevance in diverse disciplines. A classic problem is the determination of the optimal arrangement of spheres in three dimensions in order to achieve the highest packing fraction; only recently has it been proved that the answer for infinite systems is a face-centred-cubic lattice. This simply stated problem has had a profound impact in many areas, ranging from the crystallization and melting of atomic systems, to optimal packing of objects and subdivision of space. Here we study an analogous problem--that of determining the optimal shapes of closely packed compact strings. This problem is a mathematical idealization of situations commonly encountered in biology, chemistry and physics, involving the optimal structure of folded polymeric chains. We find that, in cases where boundary effects are not dominant, helices with a particular pitch-radius ratio are selected. Interestingly, the same geometry is observed in helices in naturally-occurring proteins.Comment: 8 pages, 3 composite ps figure

Comparisons of binary black hole merger waveforms

This a particularly exciting time for gravitational wave physics. Ground-based gravitational wave detectors are now operating at a sensitivity such that gravitational radiation may soon be directly detected, and recently several groups have independently made significant breakthroughs that have finally enabled numerical relativists to solve the Einstein field equations for coalescing black-hole binaries, a key source of gravitational radiation. The numerical relativity community is now in the position to begin providing simulated merger waveforms for use by the data analysis community, and it is therefore very important that we provide ways to validate the results produced by various numerical approaches. Here, we present a simple comparison of the waveforms produced by two very different, but equally successful approaches--the generalized harmonic gauge and the moving puncture methods. We compare waveforms of equal-mass black hole mergers with minimal or vanishing spins. The results show exceptional agreement for the final burst of radiation, with some differences attributable to small spins on the black holes in one case.Comment: Revtex 4, 5 pages. Published versio

Next generation ice core technology reveals true minimum natural levels of lead (Pb) in the atmosphere: insights from the Black Death

Current policies to reduce lead pollution in the air are based on the assumption that pre-industrial levels of lead in the air were negligible, safe or non-existent. This trans-disciplinary article shows that this is not the case, using ‘next-generation’ laser technology in climate science, in combination with detailed historical and archaeological records in as many as 7 languages, from all over Europe. We show that lead levels in the air have been elevated for the past 2000 years, except for a single 4-year period. This 4-year period corresponds with the largest known pandemic ever to ravage western Europe (the Black Death), resulting in a 40-50% reduction in population. This unprecedented historic population collapse was accompanied by dramatic economic collapse that halted lead mining and smelting, and related emissions in the air. This trans-disciplinary study is a collaboration led by Harvard University and the Climate Change Institute at the University of Maine, and researchers from the University of Heidelberg (Germany) and the University of Nottingham (UK). It uses next-generation technology and expertise in history, climate science, archaeology and toxicology, brought to bear in a highly detailed contribution to planetary health, with crucial implications for public health and environmental policy, and the history of human exposure to lead