Gamow-Teller sum rule in relativistic nuclear models

Relativistic corrections are investigated to the Gamow-Teller(GT) sum rule with respect to the difference between the $\beta_-$ and $\beta_+$ transition strengths in nuclei. Since the sum rule requires the complete set of the nuclear states, the relativistic corrections come from the anti-nucleon degrees of freedom. In the relativistic mean field approximation, the total GT strengths carried by the nucleon sector is quenched by about 12% in nuclear matter, while by about 8% in finite nuclei, compared to the sum rule value. The coupling between the particle-hole states with the nucleon-antinucleon states is also discussed with the relativistic random phase approximation, where the divergence of the response function is renormalized with use of the counter terms in the Lagrangian. It is shown that the approximation to neglect the divergence, like the no-sea approximation extensively used so far, is unphysical, from the sum-rule point of view.Comment: 12 pages, Brief review for Mod. Phys. Lett. A, using ws-mpla.cl

Momentum Distribution in Nuclear matter within a Perturbation Approximation

It is shown that the norm corrections, introduced to avoid the violation of the constraints on the depletion of the hole states in the standard perturbative 2p2h approach, leads in nuclear matter to a dependence of the momentum distribution with the total nucleon number. This unphysical behavior, which in turn makes the depletion to be non-extensive, arises from contributions of disconnected diagrams contained in the norm. It is found that the extensivity is again recovered when the 4p4h excitations in the ground state are included, and a reasonable value for the total number of nucleons promoted above the Fermi level is obtained.Comment: 11 pages, LaTeX, 5 figures, figures 1 to 3 included in the latex file, postscript files of figures 4 and 5 available from the Authors. Accepted for publication in Phys. Rev.

Renormalization group and Fermi liquid theory for many-nucleon systems

We discuss renormalization group approaches to strongly interacting Fermi systems, in the context of Landau's theory of Fermi liquids and functional methods, and their application to neutron matter.Comment: 40 pages, 23 figures, updated lectures given at ECT*, to appear in Springer Lecture Notes in Physic

Increased dopamine release after working-memory updating training: Neurochemical correlates of transfer

AbstractPrevious work demonstrates that working-memory (WM) updating training results in improved performance on a letter-memory criterion task, transfers to an untrained n-back task, and increases striatal dopamine (DA) activity during the criterion task. Here, we sought to replicate and extend these findings by also examining neurochemical correlates of transfer. Four positron emission tomography (PET) scans using the radioligand raclopride were performed. Two of these assessed DAD2 binding (letter memory; n-back) before 5 weeks of updating training, and the same two scans were performed post training. Key findings were (a) pronounced training-related behavioral gains in the letter-memory criterion task, (b) altered striatal DAD2 binding potential after training during letter-memory performance, suggesting training-induced increases in DA release, and (c) increased striatal DA activity also during the n-back transfer task after the intervention, but no concomitant behavioral transfer. The fact that the training-related DA alterations during the transfer task were not accompanied by behavioral transfer suggests that increased DA release may be a necessary, but not sufficient, condition for behavioral transfer to occur.</div

Scaling Of Chiral Lagrangians And Landau Fermi Liquid Theory For Dense Hadronic Matter

We discuss the Fermi-liquid properties of hadronic matter derived from a chiral Lagrangian field theory in which Brown-Rho (BR) scaling is incorporated. We identify the BR scaling as a contribution to Landau's Fermi liquid fixed-point quasiparticle parameter from "heavy" isoscalar meson degrees of freedom that are integrated out from a low-energy effective Lagrangian. We show that for the vector (convection) current, the result obtained in the chiral Lagrangian approach agrees precisely with that obtained in the semi-phenomenological Landau-Migdal approach. This precise agreement allows one to determine the Landau parameter that enters in the effective nucleon mass in terms of the constant that characterizes BR scaling. When applied to the weak axial current, however, these two approaches differ in a subtle way. While the difference is small numerically, the chiral Lagrangian approach implements current algebra and low-energy theorems associated with the axial response that the Landau method misses and hence is expected to be more predictive.Comment: 39 pages, latex with 4 eps figure, modified addresses and reference

Training adults and children with an autism spectrum disorder to be compliant with a clinical dental assessment using a TEACCH-based approach

The specific neuropsychological and sensory profile found in persons with autism spectrum disorders complicate dental procedures and as a result of this, most are treated under general anesthesia or unnecessary sedation. The main goal of the present study was to evaluate the effectiveness of a short treatment and education of autistic and related communication-handicapped children-based intervention program (five sessions) to facilitate a 10-component oral assessment in children (n = 38, aged 4¿9 years) and adults (n = 34, aged 19¿41) with autism spectrum disorder (with or without associated intellectual disability). The assessment ranges from entering into the examination room to the evaluation of the dental occlusion. There were statistically significant differences in the number of components reached and in compliance before and after the training program

Neutrino propagation and spin zero sound in hot neutron matter with Skyrme interactions

We present microscopic calculations of neutrino propagation in hot neutron matter above nuclear density within the framework of the Random Phase Approximation . Calculations are performed for non- degenerate neutrinos using various Skyrme effective interactions. We find that for densities just above nuclear density, spin zero sound is present at zero temperature for all Skyrme forces considered. However it disappears rapidly with increasing temperature due to a strong Landau damping. As a result the mean-free path is given, to a good approximation, by the mean field value. Because of the renormalization of the bare mass in the mean field, the medium is more transparent as compared to the free case. We find, in contrast, that at several times nuclear density, a new type of behavior sets in due to the vicinity of a magnetic instability. It produces a strong reduction of the mean free path. The corresponding transition density however occurs in a region where inputs from more realistic calculations are necessary for the construction of a reliable Skyrme type parametrization.Comment: 17 pages, 4 figure

Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer

<p>Abstract</p> <p>Background</p> <p>Childhood cancer and its treatment have considerable impact on a child's physical and mental wellbeing. Especially long-term administration of chemotherapy and/or radiotherapy impairs physical fitness both during and after therapy, when children often present with muscle weakness and/or low cardiorespiratory fitness. Physical exercise can improve these two elements of physical fitness, but the positive effects of physical exercise might be further increased when a child's wellbeing is simultaneously enhanced by psychosocial training. Feeling better may increase the willingness and motivation to engage in sports activities. Therefore, this multi-centre study evaluates the short and long-term changes in physical fitness of a child with a childhood malignancy, using a combined physical exercise and psychosocial intervention program, implemented during or shortly after treatment. Also examined is whether positive effects on physical fitness reduce inactivity-related adverse health problems, improve quality of life, and are cost-effective.</p> <p>Methods</p> <p>This multi-centre randomized controlled trial compares a combined physical and psychosocial intervention program for children with cancer, with care as usual (controls). Children with cancer (aged 8-18 years) treated with chemotherapy and/or radiotherapy, and who are no longer than 1 year post-treatment, are eligible for participation. A total of 100 children are being recruited from the paediatric oncology/haematology departments of three Dutch university medical centres. Patients are stratified according to pubertal stage (girls: age ≤10 or >10 years; boys: ≤11 or >11 years), type of malignancy (haematological or solid tumour), and moment of inclusion into the study (during or after treatment), and are randomly assigned to the intervention or control group.</p> <p>Discussion</p> <p>Childhood cancer patients undergoing long-term cancer therapy may benefit from a combined physical exercise and psychosocial intervention program since it may maintain or enhance their physical fitness and increase their quality of life. However, the feasibility, patient need, and effectiveness of such a program should be established before the program can be implemented as part of standard care.</p> <p>Trial registration number</p> <p>NTR1531 (The Netherlands National Trial Register)</p

Gene Expression Profile of Neuronal Progenitor Cells Derived from hESCs: Activation of Chromosome 11p15.5 and Comparison to Human Dopaminergic Neurons

BACKGROUND: We initiated differentiation of human embryonic stem cells (hESCs) into dopamine neurons, obtained a purified population of neuronal precursor cells by cell sorting, and determined patterns of gene transcription. METHODOLOGY: Dopaminergic differentiation of hESCs was initiated by culturing hESCs with a feeder layer of PA6 cells. Differentiating cells were then sorted to obtain a pure population of PSA-NCAM-expressing neuronal precursors, which were then analyzed for gene expression using Massive Parallel Signature Sequencing (MPSS). Individual genes as well as regions of the genome which were activated were determined. PRINCIPAL FINDINGS: A number of genes known to be involved in the specification of dopaminergic neurons, including MSX1, CDKN1C, Pitx1 and Pitx2, as well as several novel genes not previously associated with dopaminergic differentiation, were expressed. Notably, we found that a specific region of the genome located on chromosome 11p15.5 was highly activated. This region contains several genes which have previously been associated with the function of dopaminergic neurons, including the gene for tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, IGF2, and CDKN1C, which cooperates with Nurr1 in directing the differentiation of dopaminergic neurons. Other genes in this region not previously recognized as being involved in the functions of dopaminergic neurons were also activated, including H19, TSSC4, and HBG2. IGF2 and CDKN1C were also found to be highly expressed in mature human TH-positive dopamine neurons isolated from human brain samples by laser capture. CONCLUSIONS: The present data suggest that the H19-IGF2 imprinting region on chromosome 11p15.5 is involved in the process through which undifferentiated cells are specified to become neuronal precursors and/or dopaminergic neurons