Pathology of the Nervous System in Von Hippel-Lindau Disease

Von Hippel-Lindau (VHL) disease is a tumor syndrome that frequently involves the central nervous system (CNS). It is caused by germline mutation of the VHL gene. Subsequent VHL inactivation in selected cells is followed by numerous well-characterized molecular consequences, in particular, activation and stabilization of hypoxia-inducible factors HIF1 and HIF2. The link between VHL gene inactivation and tumorigenesis remains poorly understood. Hemangioblastomas are the most common manifestation in the CNS; however, CNS invasion by VHL disease-associated endolymphatic sac tumors or metastatic renal cancer also occur, and their differentiation from primary hemangioblastoma may be challenging. Finally, in this review, we present recent morphologic insights on the developmental concept of VHL tumorigenesis which is best explained by pathologic persistence of temporary embryonic progenitor cells.

Utilization of Multimedia Services in Libraries for Students with Disabilities

This study has two primary objectives: first, to determine whether or not students with visual impairments make use of multimedia services, and second, to compile a list of the challenges that handicapped face while attempting to use such services. This research was a descriptive qualitative field study that used a qualitative technique of qualitative description. In addition to interviews and written documentation, observation was another method that was used while compiling this data. The study is significant as it shows the availability of media services in schools’ libraries for students with disabilities. According to the findings of this investigation, pupils seem to make effective use of the multimedia services provided by the library for patrons with disabilities. The library offers a variety of services and amenities. Students use of technology, such as laptops and projectors, to get access to material via both visual and audible channels might be seen as evidence that they have achieved this goal. The inadequacy of the service infrastructure and the antiquated nature of the technology makes it difficult to make use of the benefits offered by multimedia services. In addition, there is a severe lack of librarians with experience working with multimedia technology in the worlds educational institutions at the present moment

The Role of Media in Educational Social Construction of Children with Special Needs

This study tries to explore the function that the media plays in supporting the social construction process within the context of inclusive education services. The impact of the media is one of the multiple variables that contribute to the broad adoption of inclusive education. Other contributing aspects include: To be more specific, what part do different kinds of media play in the social construction that makes up inclusive education? It is vital to do qualitative research to shed light on the function that the media plays in building and inviting classrooms to create. The selection of the test population to evaluate the performance of the inclusive education program required a great deal of attention to detail and consideration. The data for this research was gathered using a variety of methods, including observation, interviews, and written records. When looking at the data that was acquired, a descriptive qualitative analysis was performed. It has been found, after considerable discussion, that the speed with which social construction may occur in the classroom is closely tied to the efficacy of the media in aiding student comprehension. This conclusion was reached after much deliberation

A Preliminary study of removal of some heavy metals from aqueous medium by a mesoporous hydroxysodalite zeolite prepared from basalt rich in calc-plagioclaseby alkali activation

This work presents an exploration of the use of hydroxysodalite zeolite prepared from basalt rich in calc-plagioclaseby alkali activation for removal of some heavy metals from aqueous medium. The preliminary results of batch and column experiments indicated a quantitative and fast removal of the three investigated ions, Cu2+, Pb2+ and Zn2+ from aqueous solutions. The data from the batch experiments and the column experiments jointly support the notion that hydroxysodalite zeolite prepared from basalt rich in calc-plagioclase is an efficient adsorbent for the investigated heavy metals.  Almost quantitative removal of the ions was achieved within a period of 15 min of exposure of the solution to the adsorbent in batch experiments and through passing a small column filled with the adsorbent. The highest removal efficiency  by the zeolite prepared from basalt rich in calc-plagioclase of  the three tested heavy metal Cu2+, Pb2+ and Zn2+ were 99.98% ,99.76% and 99.93 % respectively. Keywords: hydroxysodalite zeolite, basalt utilization, heavy ions removal, pollution  remediation DOI: 10.7176/CMR/12-7-09 Publication date:November 30th 2020

METHOD DEVELOPMENT AND VALIDATION OF THE CHROMATOGRAPHIC ANALYSIS OF FLUTICASONE PROPIONATE AND SALMETEROL XINAFOATE COMBINATION IN SOLUTIONS AND HUMAN PLASMA USING HPLC WITH UV DETECTION

Objective: A simple, Rapid, and sensitive HPLC method utilizing UV detection was developed and validated for the simultaneous estimation of Fluticasone propionate (FP) and Salmeterol xinafoate (SX) in solutions and in vitro human plasma. Methods: Chromatographic analysis was done on SUPELCO® RP-C18 column (150 x 4.6 mm, 5 μm particle size) with an isocratic mobile phase composed of methanol, acetonitrile, and water (50:20:30, v/v) mixture while flow rate was set to 1 ml/min. Detection with UV at maximum absorbance wavelength (ʎmax) values of 236 and 252 for FP and SX, respectively. Spiked plasma samples were liquid-liquid extracted by diethyl ether and reconstituted using methanol. Results: Method was accurate and precise over a linear (R2>0.995) range of (0.067-100 µg/ml) and (0.0333-50 µg/ml) for FP and SX, respectively. LOD/lOQ values were 0.13/0.6 and 0.06/0.3 µg/ml for FP and SX, respectively. The developed method was successfully applied for the analysis of FP and SX in spiked human plasma samples. The method is considered to be accurate and precise over a linear (R2>0.9969) range of (6.67-66.67 µg/ml) and (3.33-33.3 µg/ml) for FP and SX, respectively. Extraction efficiency was approved by recovery values of (94.98–102.46 %) and (96.54–102.62 %) for FP and SX, respectively. Conclusion: This validated method revealed simple and cheap extraction procedures and detectors, non-buffered mobile phase, and short retention times with excellent resolution

Expression invariant face recognition using multi-stage 3D face fitting with 3D morphable face model

This paper aims to propose a new fully automated three-dimensional model based, real-time capable approach to recognize facial expressions from visual images of human faces in real time scenario. A multistage 3D fitting algorithm is applied with a morphable model to ensure the high accuracy and speed of the process in addition to eliminating the pose and illumination effects during the recognition process. The idea of the model is to update parameters at each stage in the fitting process. Feature extraction will be done using active appearance model while the feature classification will be done using the tree model to insure a good processing speed. This proposed model will show good results when shape, texture and extrinsic variations occur in the 3D domain since the combination of multistage fitting algorithm and tree model can enhance the speed and accuracy of the system recognition capabilities. This 3D morphable model algorithm can be widely used for 3D face analysis and 3D face recognition in real time scenarios

A state of art on 3D face modeling approaches

The model-based face recognition approach is based on constructing a model of the human face, which is able to capture the facial variations. The basic knowledge of human face is highly utilized to create the model. In this paper, we try to address and review the approaches and techniques used in the last ten years for modeling the human face in the 3D domain. Our discussion also shows the pros and cons of each approach used in the 3D face modeling

Morphometric Analysis of the Corpus Callosum According to Age and Sex in Middle Eastern Arabs: Racial Comparisons and Clinical Correlations to Autism Spectrum Disorder

This study sought to examine the influence of age and sex on morphometric measurements of the corpus callosum (CC) within Middle Eastern Arab population, in order to obtain reference data and conduct racial comparisons with previously reported measurements from other ethnicities. Furthermore, it aimed to investigate CC variations that may occur in children with autism. To this end, magnetic resonance images of normal brains were acquired from three different age groups, consisting of children, younger adults, and older adults. Brain images were also acquired from boys with autism spectrum disorder (ASD). The CC length, area, and thickness were measured. The CC length was smaller in children than in the other age groups, but no difference in CC length was found between younger and older adults. The CC area and thickness were greater in younger adults than in children and older adults, and greater in older adults than in children. With regard to sexual dimorphism, the CC area and forebrain volume were larger in male children than in female children. No sex-related differences in CC area or thickness were found in adults. However, the ratio of CC area to the forebrain volume was greater in adult females than in males, owing to the smaller forebrain volume in females. The absolute length of the CC was greater in older adult males than in their female counterparts. In addition, significant differences in CC measurements were found in comparison to measurements obtained from other ethnicities. Lastly, significant reductions in CC area and thickness were found in boys with ASD compared to their neurotypical peers. In conclusion, age and sex significantly influence morphometric measurements of CC in Middle Eastern Arab population. This study points to the presence of racial differences in CC size. Finally, it reveals that children with ASD display a distinct reduction in CC size compared to neurotypical children of the same ethnicity.Funds for the conduction of this study were provided by the Deanship of Research at Jordan University of Science and Technology, Irbid, Jordan (Grant # 20160212). Publication fees were provided by a grant to MZA from the Office of Research at United Arab Emirates University, Al Ain, UAE (Grant # G00003289, Fund # 31M441)

Automatic Localization and Identification of Vertebrae in Arbitrary Field-of-View CT Scans

Abstract. This paper presents a new method for automatic localiza-tion and identification of vertebrae in arbitrary field-of-view CT scans. No assumptions are made about which section of the spine is visible or to which extent. Thus, our approach is more general than previous work while being computationally efficient. Our algorithm is based on re-gression forests and probabilistic graphical models. The discriminative, regression part aims at roughly detecting the visible part of the spine. Ac-curate localization and identification of individual vertebrae is achieved through a generative model capturing spinal shape and appearance. The system is evaluated quantitatively on 200 CT scans, the largest dataset reported for this purpose. We obtain an overall median localization error of less than 6mm, with an identification rate of 81%.