4,293 research outputs found

    Fiber-Flux Diffusion Density for White Matter Tracts Analysis: Application to Mild Anomalies Localization in Contact Sports Players

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    We present the concept of fiber-flux density for locally quantifying white matter (WM) fiber bundles. By combining scalar diffusivity measures (e.g., fractional anisotropy) with fiber-flux measurements, we define new local descriptors called Fiber-Flux Diffusion Density (FFDD) vectors. Applying each descriptor throughout fiber bundles allows along-tract coupling of a specific diffusion measure with geometrical properties, such as fiber orientation and coherence. A key step in the proposed framework is the construction of an FFDD dissimilarity measure for sub-voxel alignment of fiber bundles, based on the fast marching method (FMM). The obtained aligned WM tract-profiles enable meaningful inter-subject comparisons and group-wise statistical analysis. We demonstrate our method using two different datasets of contact sports players. Along-tract pairwise comparison as well as group-wise analysis, with respect to non-player healthy controls, reveal significant and spatially-consistent FFDD anomalies. Comparing our method with along-tract FA analysis shows improved sensitivity to subtle structural anomalies in football players over standard FA measurements

    Re-circumscription of the mimosoid genus Entada including new combinations for all species of the phylogenetically nested Elephantorrhiza (Leguminosae, Caesalpinioideae, mimosoid clade)

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    Recent phylogenomic analyses of 997 nuclear genes support the long-held view that the genus Entada is congeneric with Elephantorrhiza. Entada is resolved as monophyletic only if the genus Elephantorrhiza is subsumed within it. The two genera were distinguished solely by relatively minor differences in the mode of dehiscence of the fruits (a craspedium separating into one-seeded endocarp segments in Entada versus a craspedium with the whole fruit valve breaking away from the persistent replum in Elephantorrhiza) and the craspedial fruit type itself provides a shared synapomorphy for the re-circumscribed Entada. Here, we provide a synopsis of Entada, including 11 new combinations in total, for the eight species, one subspecies and one variety previously placed in Elephantorrhiza, as well as a new combination for a subspecies of Entada rheedei Spreng. not previously dealt with when Entada pursaetha DC. was placed in synonymy. These new combinations are: Entada burkei (Benth.) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada elephantina (Burch.) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada goetzei (Harms) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada goetzei subsp. lata (Brenan & Brummitt) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada obliqua (Burtt Davy) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada praetermissa (J.H. Ross) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada rangei (Harms) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada rheedei subsp. sinohimalensis (Grierson & D.G. Long) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada schinziana (Dinter) S.A. O’Donnell & G.P. Lewis, comb. nov.; Entada woodii (E. Phillips) S.A. O’Donnell & G.P. Lewis, comb. nov.; and Entada woodii var. pubescens (E. Phillips) S.A. O’Donnell & G.P. Lewis, comb. nov. We provide a revised circumscription of the genus Entada which now comprises 40 species distributed pantropically, with the greatest diversity of species in tropical Africa. We present a complete taxonomic synopsis, including a map showing the global distribution of the genus and photographs showing variation amongst species in habit, foliage, flowers and fruits. A short discussion about extrafloral nectaries, mainly observed in the Madagascan species, is presented

    Charm and Bottom Semileptonic Decays

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    We review the present status of theoretical attempts to calculate the semileptonic charm and bottom decays and then present a calculation of these decays in the light--front frame at the kinematic point q2=0q^2=0. This allows us to evaluate the form factors at the same value of q2q^2, even though the allowed kinematic ranges for charm and bottom decays are very different. Also, at this kinematic point the decay is given in terms of only one form factor A0(0)A_{0}(0). For the ratio of the decay rates given by the E653 collaboration we show that the determination of the ratio of the Cabibbo--Kobayashi--Maskawa (CKM) matrix elements is consistent with that obtained from the unitarity constraint. At present, though, the unitarity method still has greater accuracy. Since comparisons of the semileptonic decays into ρ\rho and either electrons or muons will be available soon from the E791 Fermilab experiment, we also look at the massive muon case. We show that for a range of q2q^2 the SU(3)FSU(3)_F symmetry breaking is small even though the contributions of the various helicity amplitudes becomes more complicated. For BB decays, the decay BKˉB \rightarrow K^{*} \ell \bar{\ell} at q2=0q^2=0 involves an extra form factor coming from the photon contribution and so is not amenable to the same kind of analysis, leaving only the decay BKννˉB \rightarrow K^{*}\nu \bar{\nu} as a possibility. As the mass of the decaying particle increases we note that the SU(3)SU(3) symmetry becomes badly broken at q2=0q^2=0.Comment: Latex, 19 pages, two figures are attached, a minor change in the manuscript related to thi

    B -> K^* gamma from D -> K^* l nu

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    The B -> K^* gamma branching fraction is predicted using heavy quark spin symmetry at large recoil to relate the tensor and (axial-)vector form factors, using heavy quark flavor symmetry to relate the B decay form factors to the measured D -> K^* l nu form form factors, and extrapolating the semileptonic B decay form factors to large recoil assuming nearest pole dominance. This prediction agrees with data surprisingly well, and we comment on its implications for the extraction of |Vub| from B -> rho l nu.Comment: 10 page

    Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction

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    A consistent treatment for pion form factors in space-like and time-like regions

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    We write down some relevant matrix elements for the scattering and decay processes of the pion by considering a quark-meson vertex function. The pion charge and transition form factors FπF_\pi, FπγF_{\pi\gamma}, and FπγF_{\pi\gamma^*} are extracted from these matrix elements using a relativistic quark model on the light-front. We found that, the form factors FπF_\pi and FπγF_{\pi\gamma} in the space-like region agree well with experiment. Furthermore, the branching ratios of all observed decay modes of the neutral pion, that are related to the form factors FπγF_{\pi\gamma} and FπγF_{\pi\gamma^*} in the time-like region, are all consistent with the data as well. Additionally, FπF_\pi in the time-like region, which deals with the nonvalence contribution, is also discussed.Comment: 24 pages, 6 figures, to appear in Phys. Rev.

    Improving bank erosion modelling at catchment scale by incorporating temporal and spatial variability

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    Bank erosion can contribute a significant portion of the sediment budget within temperate catchments, yet few catchment scale models include an explicit representation of bank erosion processes. Furthermore, representation is often simplistic resulting in an inability to capture realistic spatial and temporal variability in simulated bank erosion. In this study, the sediment component of the catchment scale model SHETRAN is developed to incorporate key factors influencing the spatio-temporal rate of bank erosion, due to the effects of channel sinuosity and channel bank vegetation. The model is applied to the Eden catchment, north-west England, and validated using data derived from a GIS methodology. The developed model simulates magnitudes of total catchment annual bank erosion (617 - 4063 t yr-1) within the range of observed values (211 - 4426 t yr-1). Additionally the model provides both greater inter-annual and spatial variability of bank eroded sediment generation when compared with the basic model, and indicates a potential 61% increase of bank eroded sediment as a result of temporal flood clustering. The approach developed within this study can be used within a number of distributed hydrologic models and has general applicability to temperate catchments, yet further development of model representation of bank erosion processes is required
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