308 research outputs found

    Quality assurance for digital learning object repositories: issues for the metadata creation process

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    Metadata enables users to find the resources they require, therefore it is an important component of any digital learning object repository. Much work has already been done within the learning technology community to assure metadata quality, focused on the development of metadata standards, specifications and vocabularies and their implementation within repositories. The metadata creation process has thus far been largely overlooked. There has been an assumption that metadata creation will be straightforward and that where machines cannot generate metadata effectively, authors of learning materials will be the most appropriate metadata creators. However, repositories are reporting difficulties in obtaining good quality metadata from their contributors, and it is becoming apparent that the issue of metadata creation warrants attention. This paper surveys the growing body of evidence, including three UK-based case studies, scopes the issues surrounding human-generated metadata creation and identifies questions for further investigation. Collaborative creation of metadata by resource authors and metadata specialists, and the design of tools and processes, are emerging as key areas for deeper research. Research is also needed into how end users will search learning object repositories

    Ci siamo già passati: modelli che si ripetono nella re-invenzione dei ruoli del bibliotecario nella biblioteca accademica

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    Dopo una panoramica generale sull’educazione superiore nel Regno Unito, l’articolo si sofferma sul mutato ruolo della biblioteca e dei bibliotecari universitari in relazione alle nuove tecnologie, all’Open access, alla gestione dei dati di ricerca. In particolare, approfondisce le nuove sfide rappresentate dall’e-learning e dalla ricerca accademica, nonché dalla questione sempre più rilevante dell’Open access nel mondo accademico, provando a ipotizzare il ruolo che i bibliotecari potrebbero giocare in questo contesto. L’associazione professionale dei bibliotecari britannici (CILIP – Chartered Institute of Library and Information Professionals) ha risposto a queste sfide con la creazione di una nuova struttura, il Body of Professional Knowledge and Skills (BPKS)

    Constraining alternative polarization states of gravitational waves from individual black hole binaries using pulsar timing arrays

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    Pulsar timing arrays are sensitive to gravitational wave perturbations produced by individual supermassive black hole binaries during their early inspiral phase. Modified gravity theories allow for the emission of gravitational dipole radiation, which is enhanced relative to the quadrupole contribution for low orbital velocities, making the early inspiral an ideal regime to test for the presence of modified gravity effects. Using a theory-agnostic description of modified gravity theories based on the parametrized post-Einsteinian framework, we explore the possibility of detecting deviations from general relativity using simulated pulsar timing array data, and provide forecasts for the constraints that can be achieved. We generalize the enterprise pulsar timing software to account for possible additional polarization states and modifications to the phase evolution, and study how accurately the parameters of simulated signals can be recovered. We find that while a pure dipole model can partially recover a pure quadrupole signal, there is little possibility for confusion when the full model with all polarization states is used. With no signal present, and using noise levels comparable to those seen in contemporary arrays, we produce forecasts for the upper limits that can be placed on the amplitudes of alternative polarization modes as a function of the sky location of the source

    Insights into the Hunt Report’s Research Recommendations: considering their influence on government research policy and the potential impact on educational research in the area of the Health Promoting School

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    National Strategy for Higher Education to 2030 in Ireland (January 2011) and what it may mean for educational research in Ireland during this time of transformation. Strategy is a major review of all aspects of contemporary higher education in Ireland commissioned by previous government Context For our Presentation: Specific focus today is the chapter on Research (Chapter 4, pp. 63-73) to provide some insights and discuss some potential impacts on educational research in particular

    Variations on Instant Insanity

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    In one of the first papers about the complexity of puzzles, Robertson and Munro [14] proved that a generalized form of the then-popular Instant Insanity puzzle is NP-complete. Here we study several variations of this puzzle, exploring how the complexity depends on the piece shapes and the allowable orientations of those shapes

    A protocol for a feasibility randomised controlled trial to assess the difference between functional bracing and plaster cast for the treatment of ankle fractures

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    Background: UK Hospital Episode Statistics 2013–2014 recorded 57,286 fractures of the lower limb including the ankle. This figure is expected to continue to increase due to a greater population of older adults. Following an ankle fracture, patients usually have their ankle immobilised with a plaster cast. This provides maximum support for the healing ankle but is associated with stiffness and muscle wasting. A Cochrane Review has concluded that functional bracing may reduce muscle wasting and speed recovery of ankle movement. The aim of this study is to determine the feasibility of conducting a full randomised controlled trial in adults with an ankle fracture followed by functional bracing and exercises versus standard plaster cast care. Methods: This is a single-centre feasibility randomised controlled trial. All patients with a fractured ankle are potentially eligible. The trial will employ 1:1 random allocation, stratified by age and non-operative/operative management. Baseline demographic and pre-injury functional data, the Manchester-Oxford Foot and Ankle Questionnaire (MOXFQ) and Olerud and Molander Ankle Score (OMAS) will be collected alongside the EuroQol EQ-5D-5 L health-related quality of life questionnaire. A research associate will perform a clinical assessment and obtain X-rays in 6 weeks and 6 months post randomisation to record complications. Functional outcome and health-related quality of life will be collected in 6 weeks, 3 and 6 months post randomisation. Discussion: This feasibility trial will provide authoritative high-quality evidence to inform the design of a definitive trial in this important area

    Constraining alternative polarization states of gravitational waves from individual black hole binaries using pulsar timing arrays

    Get PDF
    Pulsar timing arrays are sensitive to gravitational wave perturbations produced by individual supermassive black hole binaries during their early inspiral phase. Modified gravity theories allow for the emission of gravitational dipole radiation, which is enhanced relative to the quadrupole contribution for low orbital velocities, making the early inspiral an ideal regime to test for the presence of modified gravity effects. Using a theory-agnostic description of modified gravity theories based on the parametrized post-Einsteinian framework, we explore the possibility of detecting deviations from general relativity using simulated pulsar timing array data, and provide forecasts for the constraints that can be achieved. We generalize the enterprise pulsar timing software to account for possible additional polarization states and modifications to the phase evolution, and study how accurately the parameters of simulated signals can be recovered. We find that while a pure dipole model can partially recover a pure quadrupole signal, there is little possibility for confusion when the full model with all polarization states is used. With no signal present, and using noise levels comparable to those seen in contemporary arrays, we produce forecasts for the upper limits that can be placed on the amplitudes of alternative polarization modes as a function of the sky location of the source

    Linking cohort data with administrative health data to develop a new hypertension prediction model to aid precision health approach

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    Introduction Hypertension is a common medical condition, affecting 1 in 5 Canadians, and is a major risk factor for heart attack, stroke, and kidney disease. Predicting the risk of developing incident hypertension may help to inform targeted preventive strategies. Objectives and Approach Identification of major risk factors and incorporation into a multivariable model for risk stratification may help to identify individuals who are at highest risk for developing incident hypertension and would potentially benefit most from intervention. The goal of the proposed research is to develop a robust hypertension prediction model for the general population using the Alberta Tomorrow Project (ATP) cohort data linked with Alberta’s administrative health data. ATP is Alberta's largest population health cohort, contains baseline data on socio-demographic characteristic, personal and family history of disease, medication use, lifestyle and health behavior, environmental exposures, physical measures and bio samples. Results Alberta’s administrative health data additionally provides information on health care utilization, enrollment, drugs, physician services, and hospital services. A prediction model for hypertension will be developed using logistic regression where information on candidate variables for the model will be gathered from ATP data and outcome (incident hypertension) will be ascertained from administrative health data (physicians/practitioner claim data and hospital discharge abstract data). Lacking follow-up information in current ATP data has laid the foundation of linking the two data sources through an anonymous unique person identifier (e.g. PHN) that will eventually provide follow-up information on ATP participants who are free of hypertension at baseline developed the disease as well as information on other potential variables. Conclusion/Implications The proposed prediction model will help to identify individuals at highest risk for developing hypertension and those who may benefit most from targeted healthy behavioral interventions and/or treatment. Such identification of high risk people may help prevent hypertension as well as the continuing costly cycle of managing hypertension and its complications

    Development and validation of a quantitative confirmatory method for 30 β-lactam antibiotics in bovine muscle using liquid chromatography coupled to tandem mass spectrometry

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    peer-reviewedA method was developed for the confirmatory and quantitative analysis of 30 β-lactam antibiotic residues in bovine muscle. The method includes 12 penicillins (amoxicillin, ampicillin, cloxacillin, dicloxacillin, mecillinam, methicillin, nafcillin, oxacillin, penicillin G, penicillin V, piperacillin, ticarcillin), 12 cephalosporins (cefacetrile, cefadroxil, cephalexin, cefalonium, cefazolin, cefoperazone, cefotaxime, cefquinome, cefuroxime, desacetyl cephapirin, desfuroylceftiofur cysteine disulfide, desfuroylceftiofur dimer), five carbapenems (biapenem, doripenem, ertapenem, imipenem, meropenem) and faropenem. Samples were extracted using a simple solvent extraction with acetonitrile:water (80:20, v/v) and C18 dispersive solid-phase extraction (d-SPE) clean-up, followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) detection. Chromatography was performed on a reversed phase CSH C18 column, using a binary gradient separation comprising of 0.01% formic acid and 0.2 mM ammonium acetate in water (mobile phase A) and 0.01% formic acid in acetonitrile (mobile phase B). The mass spectrometer was operated in the positive electrospray ionisation mode (ESI(+)). Validation was performed following the 2002/657/EC guidelines. Trueness ranged between 69% and 143% and precision ranged between 2.0% and 29.9% under within-laboratory reproducibility conditions. The developed method uses minimal sample preparation and 30 test samples can be analysed by a single analyst in a single day. To the best of our knowledge, this is the first method for carbapenems in foodstuff that does not require derivatisation.FIRM programm
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