Summative and Formative Assessment in Medicine: The Experience of an Anaesthesia Trainee

The practice of medicine is becoming increasingly onerous for doctors, with growing demands coming from both patients and peers. Therefore, we need to equip doctors of the future with the appropriate skills to negotiate a very complex environment. Assessment should be central to this goal with a renewed focus on a more rounded examination process. Rather than a compete reliance on summative assessment, an increased focus should be placed on formative assessment, which has been historically neglected in medicine. In addition, it is important for educators to realise that a mutimodal approach is required to establish competence in a valid fashion and that each assessment modality should be used for both summative and formative assessment where possible. This will not only serve to address the external pressures placed on the teacher to streamline students but it will facilitate student learning as they become active participants in assessment. Other areas of development in medical education going forward include peer assessment, which may be the answer to increasing cohort sizes. We also need to address the issue of maintaining adequate standards of assessment. Furthermore, we need to conduct further research to ensure that our assessment methods are an adequate predictor of future performance otherwise we as educational leaders will be failing both our students and the wider community

International Students’ Awareness of U.S. Tax Filings

International students studying in the United States (U.S.) must follow many rules and regulations implemented by the federal government, including tax filing requirements. Generally, international students must file Form 8843 with the U.S. Internal Revenue Service (IRS) indicating that they are nonresidents exempt from taxation on worldwide income during their first five years in the U.S. In addition, they must file Form 1040-NR if they earn any taxable income in the U.S. This exploratory study examines the level of tax filing knowledge international students possess, as well as the characteristics of both international students and their educational institutions to ascertain if they may have a bearing on the students’ knowledge of the U.S. tax filings that should be filed. Data suggest that governmental and educational institutions may wish to bolster the dissemination of educational tax materials; otherwise, perhaps a significant number of international students may not be compliant with current IRS regulations

Are Eastern Oysters Being Bored to Death? Influence of \u3cem\u3eCliona celata\u3c/em\u3e on \u3cem\u3eCrassostrea virginica\u3c/em\u3e Condition, Growth and Survival

The boring sponge Cliona celata is a nuisance species that can have deleterious effects on eastern oyster Crassostrea virginica growth, condition, and survival. Surprisingly, however, these effects have not been well documented and when examined, results have been equi-vocal. In this study, we provide a direct comparison of growth, condition, and survival of sponge-colonized and uncolonized oysters in southeast North Carolina in 2 separate experiments. In the first experiment, sponge-colonized oysters exhibited significantly slower growth rates, reduced condition, and lower survival relative to uncolonized oysters, although results may have been confounded by oyster source. In the second experiment, using smaller oysters from the same source population, growth rate was again significantly reduced in colonized oysters relative to uncolonized oysters, however neither condition nor survival differed. In field surveys of the same population, colonized individuals across a range of sizes demonstrated significantly reduced condition. Further, condition index was negatively correlated with sponge biomass, which was positively correlated with oyster size, suggesting that the impact of the sponge changes with ontogeny. By investigating clearance rates, tissue isotopic and nutrient content, as well as caloric value, this study provides further evidence that sponge presence causes the oysters to divert energy into costly shell maintenance and repair at the expense of shell and somatic growth. Thus, although variable, our results demonstrate negative impacts of sponge infestation on oyster demographics, particularly as oysters grow larger

Crop response to thermal stress without yield loss in irrigated maize and soybean in Nebraska

Thermal sensing provides rapid and accurate estimation of crop water stress through canopy temperature data. Canopy temperature is highly dependent on the transpiration rate of the leaves. It is usually assumed that any reduction in crop evapotranspiration (ET) leads to crop yield loss. As a result, an increase in canopy temperature due to a decrease in crop ET would indicate crop yield loss. This research evaluated the hypothesis that crop water stress could be detected using canopy temperature measurements (increased leaf temperature) from infrared thermometers (IRTs) before incurring crop yield loss. This would be possible in a narrow range when the photosynthesis rate (and carbon assimilation) is limited by solar radiation (energy-limiting water stress) while the leaf has abundant carbon dioxide for photosynthesis. Once photosynthesis becomes limited by carbon dioxide (carbon-dioxide-limiting water stress), then yield reduction would occur. In this field experiment, measured response variables included the integrated crop water stress index (iCWSI), ET, and crop yield for maize and soybean during the 2020 and 2021 growing seasons. The irrigation was applied at four different refill levels: rainfed (0%), deficit (50%), full (100%), and over (150%). The irrigation depth was prescribed using four different irrigation methods. The field was irrigated with a center pivot irrigation system, which was also used as a platform to mount IRT sensors. The iCWSI thresholds required for irrigation management were determined using the iCWSI dataset collected in 2020. The low, medium, and high iCWSI thresholds were 120, 150, and 180, respectively for maize and 110, 130, and 150, respectively for soybean. These thresholds should be updated with iCWSI data from future studies in this region to increase the credibility of the thresholds for irrigation management. The mean iCWSI values for consecutive days after a wetting event substantially increased with time for each irrigation level and a larger range in iCWSI values was observed among the irrigation levels after three days from a wetting event. The seasonal iCWSI for different levels were found to be negatively correlated with seasonal evapotranspiration for both years. The correlations between seasonal ET and crop yield were significant with the rainfed and deficit levels for maize (p-value \u3c 0.001) and soybean (p-value = 0.04) in 2020. The iCWSI and yield data for the fully watered plots indicated that thermal stress was detected using the sensing system without incurring yield loss (i.e., energy-limiting water stress). The ET and yield data for 2021 indicated that reduction in seasonal crop ET did not result in yield loss which also supported the hypothesis. Future studies should investigate whether this phenomenon of detecting crop water stress in an early stage without yield loss is observed in other climates and locations

Radiometer Footprint Model to Estimate Sunlit and Shaded Components for Row Crops

Th is article describes a geometric model for computing the relative proportion of sunlit vegetation, shaded vegetation, sunlit soil, and shaded soil appearing in a circular or elliptical radiometer footprint for row crops, where the crop rows were modeled as continuous ellipses. Th e model was validated using digital photographs of row crops, where each component was determined by supervised classification. Root mean squared errors (RMSE) between modeled and observed components were 35, 49, 29, and 44% of observed means for sunlit vegetation, shaded vegetation, sunlit soil, and shaded soil, respectively. Mean bias errors (MBE) were, respectively, –5.6, 16.6, –4.0, and –0.5% of observed means. Th e continuous ellipse model was compared to the commonly used clumping index model, where the latter estimates total vegetation and total soil, but does not resolve these into their sunlit or shaded components and does not account for radiometer footprint shape dimensions. Th e continuous ellipse model resulted in RMSE for vegetation and soil of 22 and 19%, respectively, whereas the clumping index model resulted in respective RMSE of 37 and 31%. Th e continuous ellipse model had MBE of 3.3 and –2.6% for vegetation and soil, respectively, which was slightly greater than the respective MBE of –1.5 and 1.4% for clumping index model. Given the model sensitivity and uncertainty of leaf area index (LAI), the RMSE and MBE resulting from the continuous ellipse model would not be expected to be less than 20% of the observed means, and model performance was therefore deemed reasonable in this study

Search for the Neutron Decay n→\rightarrow X+γ\gamma where X is a dark matter particle

In a recent paper submitted to Physical Review Letters, Fornal and Grinstein have suggested that the discrepancy between two different methods of neutron lifetime measurements, the beam and bottle methods can be explained by a previously unobserved dark matter decay mode, n$\rightarrow$ X+$\gamma$ where X is a dark matter particle. We have performed a search for this decay mode over the allowed range of energies of the monoenergetic gamma ray for X to be a dark matter particle. We exclude the possibility of a sufficiently strong branch to explain the lifetime discrepancy with greater than 4 sigma confidence.Comment: 6 pages 3 figure

Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione- Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target

negative pathogen Pseudomonas aeruginosa, and this enzyme orchestrates several physiopathological events during bacteria-host interplays. LasB is considered to be a potential target for the development of an innovative chemotherapeutic approach, especially against multidrug-resistant strains. Recently, our group showed that 1,10-phenanthroline-5,6-dione (phendione), [Ag(phendione)2]ClO4 (Ag-phendione) and [Cu(phendione)3](ClO4)2.4H2O (Cu-phendione) had anti-P. aeruginosa action against both planktonic- and biofilm-growing cells. In the present work, we have evaluated the effects of these compounds on the (i) interaction with the lasB active site using in silico approaches, (ii) lasB proteolytic activity by using a specific fluorogenic peptide substrate, (iii) lasB gene expression by real time-polymerase chain reaction, (iv) lasB protein secretion by immunoblotting, (v) ability to block the damages induced by lasB on a monolayer of lung epithelial cells, and (vi) survivability of Galleria mellonella larvae after being challenged with purified lasB and lasB-rich bacterial secretions. Molecular docking analyses revealed that phendione and its Ag+ and Cu2+ complexes were able to interact with the amino acids forming the active site of lasB, particularly Cu-phendione which exhibited the most favorable interaction energy parameters. Additionally, the test compounds were effective inhibitors of lasB activity, blocking the in vitro cleavage of the peptide substrate, aminobenzyl-Ala-Gly-Leu-Ala-p-nitrobenzylamide, with Cu- phendione having the best inhibitory action (Ki = 90 nM). Treating living bacteria with a sub-inhibitory concentration (1/2 × MIC value) of the test compounds caused a significant reduction in the expression of the lasB gene as well as its mature protein production/secretion. Further, Ag-phendione and Cu-phendione offered protective rg 1 August 2019 | Volume 10 | Article 1701 1,10-Phenanthroline-5,6-Dione-Based Compounds: As Anti-Virulence Drugs action for lung epithelial cells, reducing the A549 monolayer damage by approximately 32 and 42%, respectively. Interestingly, Cu-phendione mitigated the toxic effect of both purified lasB molecules and lasB-containing bacterial secretions in the in vivo model, increasing the survival time of G. mellonella larvae. Collectively, these data reinforce the concept of lasB being a veritable therapeutic target and phendione-based compounds (mainly Cu-phendione) being prospective anti-virulence drugs against P. aeruginosa