The Techne of YouTube Performance: Musical Structure, Extended Techniques, and Custom Instruments in Solo Pop Covers

They begin with a note, a chord, the tap of a button, or the triggering of a loop: through progressively layered textures, samples, and extended performance techniques, solo cover songs on YouTube often construct themselves piece by piece before the viewer’s eyes and ears. Combining virtuosity and novelty in a package ready-made for viral online popularity, this recent and rapidly growing internet phenomenon draws together traditions old and new, from the “one man band” of the nineteenth century, to the experimental live looping of 1980s performance art, to contemporary electronic music. Building on a number of recent studies that examine the affordances and restrictions of writing and performing music on various instruments, the case studies in this article explore how these YouTube performers use theoretical and instrumental expertise to convey complex textures through a minimal collection of musical materials. In each case, the instruments themselves are arranged, modified, or even created in order to make these performances possible. These videos often incorporate looped or layered elements, arranged to take advantage of a song’s harmonic or rhythmic structures; and they frequently feature customized, self-created, or otherwise unconventional instrumentation. Through their sparse, economic construction, these intricate arrangements are each the end product of a careful analysis of each song, and they have much to teach us about the harmonic, melodic, and rhythmic structures of popular music

Phrase extension in Haydn’s string quartet minuets: A preliminary corpus study

This study examines a small but well-defined corpus: Franz Joseph Haydn’s string quartet minuets and trios (n=76 paired dances, or 152 individual minuets), composed between 1764 and 1803. Seeking to identify the metrical differences between a minuet intended for dancing and one intended for the salon or the concert stage, this study parses Haydn’s 8- and 10-measure minuet and trio sections (using the models of “tight-knit” theme types proposed by Caplin 1998), identifies patterns in Haydn’s phrase extensions, and discusses challenges and opportunities for further corpus-informed studies of phrase rhythm and hypermeter

Desert Hedgehog is a Mammal-Specific Gene Expressed During Testicular and Ovarian Development in a Marsupial

Desert hedgehog (DHH) belongs to the hedgehog gene family that act as secreted intercellular signal transducers. DHH is an essential morphogen for normal testicular development and function in both mice and humans but is not present in the avian lineage. Like other hedgehog proteins, DHH signals through the patched (PTCH) receptors 1 and 2. Here we examine the expression and protein distribution of DHH, PTCH1 and PTCH2 in the developing testes of a marsupial mammal (the tammar wallaby) to determine whether DHH signalling is a conserved factor in gonadal development in all therian mammals

The Wreck of the Julie Plante : French Canadian Habitant Song

https://digitalcommons.library.umaine.edu/mmb-vp/2775/thumbnail.jp

Second Generation of Law and Economics of Conflict of Laws: Baxter\u27s Comparative Impairment and Beyond

In his 1963 article in the Stanford Law Review, “Choice of Law and the Federal System,” Professor William F. Baxter criticized the choice-of-law approach of the First Restatement of the Conflict of Laws. According to the Restatement, courts should apply the law of the state where the last act or event deemed necessary to create a cause of action occurred. In contrast, Baxter advocated a comparative-impairment approach, whereby judges were obligated to apply the law of the state whose public policy would suffer the greatest impairment if its law was not applied. The authors contend that although Baxter’s approach caries intuitive appeal for one interested in economic theory, available empirical evidence and public choice insights together indicate that Baxter’s approach cannot work efficiently in practice. Because judges in practice have neither the data nor the intuitive understanding of the complexities of any legal problem to make the comparative-impairment determination in the scrupulous way that Baxter suggested, William H. Allen and Professor Erin A. O\u27Hara recommend a modified Restatement approach. They believe an approach that keeps the basic concepts of the Restatement but modifies rules that have not worked well in practice will generate greater predictability and less bias in decisionmaking

The Presence of a CMV Immunodominant Allele in the Recipient Is Associated With Increased Survival in CMV Positive Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation

Specific major histocompatibility (MHC) class I alleles dominate anti-CMV responses in a hierarchal manner. These CMV immunodominant (IMD) alleles are associated with a higher magnitude and frequency of cytotoxic lymphocyte responses as compared to other human leukocyte antigen (HLA) alleles. CMV reactivation has been associated with an increased incidence of graft-vs.-host disease and non-relapse mortality, as well as protection from relapse in HLA-matched HSCT settings. Less is known about the impact of CMV reactivation on these major outcomes after haploidentical (HI) HSCT, an increasingly applied therapeutic option. In HI HSCT, the efficiency of the immune response is decreased due to the immune suppression required to cross the MHC barrier as well as MHC mismatch between presenting and responding cells. We hypothesized that the presence of a CMV IMD allele would increase the efficiency of CMV responses after HI HSCT potentially impacting CMV-related outcomes. In this retrospective, multivariable review of 216 HI HSCT patients, we found that CMV+ recipients possessing at least 1 of 5 identified CMV IMD alleles had a lower hazard of death (HR = 0.40, p = 0.003) compared to CMV+ recipients not possessing a CMV IMD allele, and an overall survival rate similar to their CMV- counterparts. The analysis delineated subgroups within the CMV+ population at greater risk for death due to CMV reactivation

A 2-step approach to myeloablative haploidentical stem cell transplantation: a phase 1/2 trial performed with optimized T-cell dosing.

Studies of haploidentical hematopoietic stem cell transplantation (HSCT) have identified threshold doses of T cells below which severe GVHD is usually absent. However, little is known regarding optimal T-cell dosing as it relates to engraftment, immune reconstitution, and relapse. To begin to address this question, we developed a 2-step myeloablative approach to haploidentical HSCT in which 27 patients conditioned with total body irradiation (TBI) were given a fixed dose of donor T cells (HSCT step 1), followed by cyclophosphamide (CY) for T-cell tolerization. A CD34-selected HSC product (HSCT step 2) was infused after CY. A dose of 2 × 10(8)/kg of T cells resulted in consistent engraftment, immune reconstitution, and acceptable rates of GVHD. Cumulative incidences of grade III-IV GVHD, nonrelapse mortality (NRM), and relapse-related mortality were 7.4%, 22.2%, and 29.6%, respectively. With a follow-up of 28-56 months, the 3-year probability of overall survival for the whole cohort is 48% and 75% in patients without disease at HSCT. In the context of CY tolerization, a high, fixed dose of haploidentical T cells was associated with encouraging outcomes, especially in good-risk patients, and can serve as the basis for further exploration and optimization of this 2-step approach. This study is registered at www.clinicaltrials.gov as NCT00429143

A Preliminary Report of Percutaneous Craniofacial Osteoplasty in a Rat Calvarium

Objective: To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatibility and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model. Methods: Fourteen adult Sprague Dawley rats were injected in the parietal skull with hydroxylapatite (n=10) or a carrier gel control (n=4), using a subperiosteal injection technique on the right and a subcutaneous injection technique on the left. At 1, 3, and 6 months, 3 rats (1 negative control, 2 variables) were sacrificed. At 12 months, the remaining 5 rats were sacrificed. After each harvest, the calvaria were examined under both light and polarized microscopy. Results: The inflammatory response was limited in all specimens. Injectables were still present 12 months after the injection. New bone formation was only seen when the injection was located deep to a disrupted periosteum The odd of new bone formation was 48.949 times higher (95% CI (2.637, 3759.961), p = 0.002) with subperiosteal hydroxylapatite injections compared to all other combinations of injection plane and injectable. Conclusion: This preliminary report of subperiosteal hydroxylapatite (Radiesse) injection in a rat model has verified the biocompatibility of injectable hydroxylapatite at the bony interface and suggests the potential for new bone formation