Familial sleep and autism spectrum disorder: a pilot actigraphy study of sleep quality, quality of life and psychological distress

Sleep problems are common among children with autism spectrum disorder (ASD) and can have a negative impact on the child's behaviour and daytime functioning. The current pilot study examined objective measurements of child and parent sleep as factors associated with the stress, anxiety, depressive symptoms, social support and quality of life of parents of children with ASD. Participants were nine children with ASD and their parents (nine mothers and three fathers). Participants wore an actigraph for 7 consecutive days and nights. Measures of sleep habits and quality were used to ascertain child and parent sleep. Measures of parenting stress, anxiety, depressive symptoms, quality of life and social support were collated. Results indicated the emergence of high parental stress, anxiety and depressive symptoms. Significant correlations were observed between parent depressive symptoms, and both subjective sleep quality and child sleep disruptions. The present study found that parental well-being is affected by child sleep problems.peer-reviewe

Loneliness, living alone, and all-cause mortality: The role of emotional and social loneliness in the elderly during 19 years of follow-up

Published by Wolters Kluwer Health, Inc. on behalf of the American Psychosomatic Society. Objective The aims of the study were to examine the predictive value of social and emotional loneliness for all-cause mortality in the oldest-old who do and do not live alone and to test whether these varied by functional status and personality. Methods Participants were 413 older adults from the Berlin Aging Study (M [SD] = 84.53 [8.61] years of age) who either lived alone (n = 253) or did not live alone (n = 160). Significance values for hazard ratios are reported having adjusted for age, sex, education, income, marital status, depressive illness, and both social and emotional loneliness. Results Although social loneliness was not associated with mortality in those living alone, emotional loneliness was; with each 1 SD increase in emotional loneliness, there was an 18.6% increased risk of all-cause mortality in the fully adjusted model (HR = 1.186, p =.029). No associations emerged for social or emotional loneliness among those not living alone. Examinations of potential moderators revealed that with each 1 SD increase in functional status, the risk associated with emotional loneliness for all-cause mortality increased by 17.9% (hazard ratio interaction = 1.179, p =.005) in those living alone. No interaction between personality traits with loneliness emerged. Conclusions Emotional loneliness is associated with an increased risk of all-cause mortality in older adults who live alone. Functional status was identified as one potential pathway accounting for the adverse consequences of loneliness. Emotional loneliness that can arise out of the loss or absence of a close emotional attachment figure seems to be the toxic component of loneliness

The cardiovascular response to acute psychological stress is related to subjectively giving and receiving social support

he pathways linking giving and receiving emotional and instrumental social support, and cardiovascular reac tivity (CVR) are not yet fully understood. Eight-two healthy young adults completed psychometric measures of giving and receiving emotional and instrumental social support and participated in a standardised laboratory stress task. Cardiovascular and hemodynamic parameters were monitored throughout. Both giving and receiving emotional support were positively associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP), such that those reporting giving and receiving more emotional support had higher reactivity. Only receiving instrumental was associated with DBP, with those receiving more instrumental support having higher reactivity. Moreover, while the significant association between giving social support and CVR withstood adjustment for several confounding factors (e.g., BMI, sex) it was abolished when receiving support was controlled for. These findings are novel and extend the literature on social support and CVR. Taken together, these findings suggest that receipt of support, rather than giving, may be more influential in this context

Openness to experience and stress responsivity: An examination of cardiovascular and underlying hemodynamic trajectories within an acute stress exposure

The personality trait openness to experience has been implicated in health, and in particular cardiovascular wellbeing. In a sample of 62 healthy young female adults, the role of openness in cardiovascular responsivity during a stress exposure was examined. Traditionally, methodologies have averaged a stress exposure into a single reading. This may be limited in that it does not consider patterns of cardiovascular adaptation within a stress exposure. Continuous cardiovascular data were reduced to mean 10 second readings, with phases determined through examinations of shifts in responsivity between each 10 second pairing. Analyses revealed a significant linear interaction for openness across the entire exposure for systolic blood pressure, and cardiac output. A significant between-subjects effect for heart rate also emerged. Contrary to their lower counterparts, those highest in openness exhibited an increasingly myocardial hemodynamic response profile throughout the exposure. Comparisons of responsivity suggests adaptive stress response trajectories for those highest in openness. This study also provides evidence that an attenuation of myocardial responsivity may underpin blunted responsivity. This study provides a potential mechanism in reported openness-health associations

Personality traits and mediating pathways to mortality risk: A systematic review

Objectives Personality traits have been linked with all-cause mortality risk. However, underlying mechanisms linking them are unclear. We sought to systematically review the literature and provide an overview of the potential mechanisms that have been identified. Methods Five electronic databases (PubMed, Web of Science, CINAHL, PsychINFO, and Psycharticles) were searched from inception to the 27th of January 2023. From 611 studies initially identified, seven studies met the final inclusion criteria. These seven papers have a combined sample of 60,104 individuals (M = 8,585, SD = 14,600; range 957 – 44094). Results Several mechanisms were identified. These included, smoking, inflammation biomarkers, blood pressure, and sleep quality. These factors mediated the relation between various personality traits and mortality risk. There was considerable variation in the impact of results across cohorts, even when looking at similar variables and notable differences in methodological approaches and reporting were discussed. Conclusions Findings indicated a small but growing literature examining important pathways linking personality to future risk of mortality. Several important mediating variables were identified for a number of traits. Interestingly, neuroticism did not appear to have consistent findings in this literature. There was also a high degree of variance in the degree to which mediators accounted for the personality-mortality relation between different populations. While this growing literature is promising with respect to possible avenues for future intervention, much rigorous research is needed

Protocol for a qualitative study: exploring loneliness and social isolation in emerging adulthood (ELSIE)

Background: This article describes a protocol for a qualitative study to explore experiences and views and experiences of loneliness and social isolation in young adults, in Ireland. Methods: A youth Research Advisory Group will be consulted on the development of study materials. Our data collection methods will be guided by participant preferences, with potential participants choosing between virtual interviews, focus groups, and an online survey including the open-ended questions contained in the interview/focus group schedule. The data will be analyzed using framework analysis. Discussion: This protocol highlights methodological considerations relevant to a qualitative research study co-designed with young adults. Study findings will be relevant to mental health policy makers and other stakeholders involved in youth mental health

Allostatic load and mental health during COVID-19: The moderating role of neuroticism

Background During the COVID-19 pandemic increased risk of poor mental health has been evident across different cultures and contexts. This study aims to examine whether allostatic load (AL) prior to the pandemic was predictive of poor mental health during the pandemic, and if any associations were moderated by neuroticism. Methods Data were extracted from Waves 2 (2011, allostatic load), 3 (2012, neuroticism), and the COVID-19 study (April 2020) of the Understanding Society database in the UK; data were available for 956 participants. Results Mental health increased from 2012- to during the pandemic. Neuroticism and AL were positively associated with poorer mental health during COVID-19, such that those who had scored higher on neuroticism and had higher AL prior to the pandemic reported poorer mental health during the pandemic. Neuroticism was also a significant moderator; the effect of AL on mental health during the pandemic was exacerbated in those with high and moderate levels of neuroticism but not lower. Moreover, this was driven by the immune-related indices of AL. This withstood adjustment for age, gender, employment status and prior mental health. These findings are discussed in relation to the pathophysiological mechanisms of mental health

Vulnerability to stress: personality facet of vulnerability is associated with cardiovascular adaptation to recurring stress

It is increasingly suggested that personality traits are critical to understanding patterns of cardiovascular stress adaptation. However, studies have focused on higher-order traits with no research having examined underlying facet effects to repeated stress. The examination of facets provides a more granular examination, which has the potential to identify specific personality components that are relevant within the context of psychophysiological stress adaptation. This study objective was to determine if the underlying facets which encapsulate the dimension of emotional stability, are associated with cardiovascular adaptation to recurring stress. Continuous cardiovascular monitoring and psychometric measures were collated from 79 healthy young male and female adults, across a protocol of recurring active stress tasks. Multiple regression analysis revealed that the facet of vulnerability was associated with systolic and diastolic blood pressure adaptation across the protocol. More specifically, vulnerability was negatively associated with adaptation to recurring stress, such that those highest in vulnerability displayed a sensitization to the recurring stressor. No significant effects emerged for any other facet. Importantly, this research adds to the existing literature examining stress adaptation and has implications for future research on the relevance of examining facet effects. This study is the first to implicate the personality facet of vulnerability which encapsulates an individual's tendency to feel unable to cope with stress and becoming hopeless when faced with emergency situations, in the context of cardiovascular stress adaptation. Taken together, this study suggests that the facet of vulnerability is a critical component to consider in the context of cardiovascular stress adaptation

An integrative network analysis framework for identifying molecular functions in complex disorders examining major depressive disorder as a test case

In addition to the psychological depressive phenotype, major depressive disorder (MDD) patients are also associated with underlying immune dysregulation that correlates with metabolic syndrome prevalent in depressive patients. A robust integrative analysis of biological pathways underlying the dysregulated neural connectivity and systemic inflammatory response will provide implications in the development of effective strategies for the diagnosis, management and the alleviation of associated comorbidities. In the current study, focusing on MDD, we explored an integrative network analysis methodology to analyze transcriptomic data combined with the meta-analysis of biomarker data available throughout public databases and published scientific peer-reviewed articles. Detailed gene set enrichment analysis and complex protein–protein, gene regulatory and biochemical pathway analysis has been undertaken to identify the functional significance and potential biomarker utility of differentially regulated genes, proteins and metabolite markers. This integrative analysis method provides insights into the molecular mechanisms along with key glycosylation dysregulation underlying altered neutrophil-platelet activation and dysregulated neuronal survival maintenance and synaptic functioning. Highlighting the significant gap that exists in the current literature, the network analysis framework proposed reduces the impact of data gaps and permits the identification of key molecular signatures underlying complex disorders with multiple etiologies such as within MDD and presents multiple treatment options to address their molecular dysfunctio

Self-Acceptance and Purpose in Life Are Mechanisms Linking Adverse Childhood Experiences to Mortality Risk

Objective Adverse childhood experiences (ACEs) are associated with an increased risk of premature mortality, but it is not clear why. Individuals with ACEs tend to have lower self-acceptance and purpose in life, which may be pathways between ACEs and risk of premature mortality. As such, we tested whether purpose and self-acceptance are mechanisms that link ACEs to mortality risk. Methods We used the Midlife in the United States Survey (N = 6218; mean [standard deviation] = 46.89 [12.94] years) to test whether these factors were indirect pathways between ACEs and mortality hazards over 24 years of follow-up. We used a comprehensive ACE measure that included 20 possible childhood adversities including emotional and physical abuse, household instability, socioeconomic climate, and ill health. Results ACEs significantly increased mortality risk (hazard ratio = 1.028, 95% confidence interval = 1.008-1.047, p =.006). Self-acceptance and purpose accounted for an estimated 15% and 4% of the ACEs-mortality relation, respectively. These effects withstood a range of adjustments and sensitivity analyses. Conclusions ACEs may affect mortality risk partially through lower self-acceptance and purpose during adulthood. Given that self-acceptance and purpose may change through intervention, these factors may be useful targets for individuals with ACEs that could lead to a longer life.</p