1,576 research outputs found
Thermal Infrared Observations of Asteroid (99942) Apophis with Herschel
The near-Earth asteroid (99942) Apophis is a potentially hazardous asteroid.
We obtained far-infrared observations of this asteroid with the Herschel Space
Observatory's PACS instrument at 70, 100, and 160 micron. These were taken at
two epochs in January and March 2013 during a close Earth encounter. These
first thermal measurements of Apophis were taken at similar phase angles before
and after opposition. We performed a detailed thermophysical model analysis by
using the spin and shape model recently derived from applying a 2-period
Fourier series method to a large sample of well-calibrated photometric
observations. We find that the tumbling asteroid Apophis has an elongated shape
with a mean diameter of 375 m (of an equal volume sphere) and a
geometric V-band albedo of 0.30. We find a thermal inertia in
the range 250-800 JmsK (best solution at 600
JmsK), which can be explained by a mixture of low
conductivity fine regolith with larger rocks and boulders of high thermal
inertia on the surface. The thermal inertia, and other similarities with
(25143) Itokawa indicate that Apophis might also have a rubble-pile structure.
If we combine the new size value with the assumption of an Itokawa-like density
and porosity we estimate a mass between 4.4 and 6.2 10 kg which is more
than 2-3 times larger than previous estimates. We expect that the newly derived
properties will influence impact scenario studies and influence the long-term
orbit predictions of Apophis.Comment: Accepted for publication in Astronomy & Astrophysics, 21 pages, 8
figures, 2 table
Physical Properties of OSIRIS-REx Target Asteroid (101955) 1999 RQ36 derived from Herschel, ESO-VISIR and Spitzer observations
In September 2011, the Herschel Space Observatory performed an observation
campaign with the PACS photometer observing the asteroid (101955) 1999 RQ36 in
the far infrared. The Herschel observations were analysed, together with ESO
VLT-VISIR and Spitzer-IRS data, by means of a thermophysical model in order to
derive the physical properties of 1999 RQ36. We find the asteroid has an
effective diameter in the range 480 to 511 m, a slightly elongated shape with a
semi-major axis ratio of a/b=1.04, a geometric albedo of 0.045 +0.015/-0.012,
and a retrograde rotation with a spin vector between -70 and -90 deg ecliptic
latitude. The thermal emission at wavelengths below 12 micron -originating in
the hot sub-solar region- shows that there may be large variations in roughness
on the surface along the equatorial zone of 1999 RQ36, but further measurements
are required for final proof. We determine that the asteroid has a
disk-averaged thermal inertia of Gamma = 650 Jm-2s-0.5K-1 with a 3-sigma
confidence range of 350 to 950 Jm-2s-0.5K-1, equivalent to what is observed for
25143 Itokawa and suggestive that 1999 RQ36 has a similar surface texture and
may also be a rubble-pile in nature. The low albedo indicates that 1999 RQ36
very likely contains primitive volatile-rich material, consistent with its
spectral type, and that it is an ideal target for the OSIRIS-REx sample return
mission.Comment: Accepted for publication in Astronomy & Astrophysics, 9 pages, 7
figure
Physical Properties of Asteroid (308635) 2005 YU55 derived from multi-instrument infrared observations during a very close Earth-Approach
The near-Earth asteroid (308635) 2005 YU55 is a potentially hazardous
asteroid which was discovered in 2005 and passed Earth on November 8th 2011 at
0.85 lunar distances. This was the closest known approach by an asteroid of
several hundred metre diameter since 1976 when a similar size object passed at
0.5 lunar distances. We observed 2005 YU55 from ground with a recently
developed mid-IR camera (miniTAO/MAX38) in N- and Q-band and with the
Submillimeter Array (SMA) at 1.3 mm. In addition, we obtained space
observations with Herschel/PACS at 70, 100, and 160 micron. Our thermal
measurements cover a wide range of wavelengths from 8.9 micron to 1.3 mm and
were taken after opposition at phase angles between -97 deg and -18 deg. We
performed a radiometric analysis via a thermophysical model and combined our
derived properties with results from radar, adaptive optics, lightcurve
observations, speckle and auxiliary thermal data. We find that (308635) 2005
YU55 has an almost spherical shape with an effective diameter of 300 to 312 m
and a geometric albedo pV of 0.055 to 0.075. Its spin-axis is oriented towards
celestial directions (lam_ecl, beta_ecl) = (60 deg +/- 30deg, -60 deg +/- 15
deg), which means it has a retrograde sense of rotation. The analysis of all
available data combined revealed a discrepancy with the radar-derived size. Our
radiometric analysis of the thermal data together with the problem to find a
unique rotation period might be connected to a non-principal axis rotation. A
low to intermediate level of surface roughness (r.m.s. of surface slopes in the
range 0.1 - 0.3) is required to explain the available thermal measurements. We
found a thermal inertia in the range 350-800 Jm^-2s^-0.5K^-1, very similar to
the rubble-pile asteroid (25143) Itokawa and indicating a mixture of low
conductivity fine regolith with larger rocks and boulders of high thermal
inertia on the surface.Comment: Accepted for publication in Astronomy & Astrophysics, 12 pages, 10
figure
An attempt to observe economy globalization: the cross correlation distance evolution of the top 19 GDP's
Economy correlations between the 19 richest countries are investigated
through their Gross Domestic Product increments. A distance is defined between
increment correlation matrix elements and their evolution studied as a function
of time and time window size. Unidirectional and Bidirectional Minimal Length
Paths are generated and analyzed for different time windows. A sort of critical
correlation time window is found indicating a transition for best observations.
The mean length path decreases with time, indicating stronger correlations. A
new method for estimating a realistic minimal time window to observe
correlations and deduce macroeconomy conclusions from such features is thus
suggested.Comment: to be published in the Dyses05 proceedings, in Int. J. Mod Phys C 15
pages, 5 figures, 1 tabl
Exact solution and interfacial tension of the six-vertex model with anti-periodic boundary conditions
We consider the six-vertex model with anti-periodic boundary conditions
across a finite strip. The row-to-row transfer matrix is diagonalised by the
`commuting transfer matrices' method. {}From the exact solution we obtain an
independent derivation of the interfacial tension of the six-vertex model in
the anti-ferroelectric phase. The nature of the corresponding integrable
boundary condition on the spin chain is also discussed.Comment: 18 pages, LaTeX with 1 PostScript figur
Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab
Trastuzumab (TZM), a monoclonal antibody against the ERBB2 protein, increases survival in ERBB2-positive breast cancer patients. Its clinical use, however, is limited by cardiotoxicity. We sought to evaluate whether TZM cardiotoxicity involves inhibition of human adult cardiac-derived stem cells, in addition to previously reported direct adverse effects on cardiomyocytes. To test this idea, we exposed human cardiosphere-derived cells (hCDCs), a natural mixture of cardiac stem cells and supporting cells that has been shown to exert potent regenerative effects, to TZM and tested the effects in vitro and in vivo. We found that ERBB2 mRNA and protein are expressed in hCDCs at levels comparable to those in human myocardium. Although clinically relevant concentrations of TZM had no effect on proliferation, apoptosis, or size of the c-kit-positive hCDC subpopulation, in vitro assays demonstrated diminished potential for cardiogenic differentiation and impaired ability to form microvascular networks in TZM-treated cells. The functional benefit of hCDCs injected into the border zone of acutely infarcted mouse hearts was abrogated by TZM: infarcted animals treated with TZM + hCDCs had a lower ejection fraction, thinner infarct scar, and reduced capillary density in the infarct border zone compared with animals that received hCDCs alone (n = 12 per group). Collectively, these results indicate that TZM inhibits the cardiomyogenic and angiogenic capacities of hCDCs in vitro and abrogates the morphological and functional benefits of hCDC transplantation in vivo. Thus, TZM impairs the function of human resident cardiac stem cells, potentially contributing to TZM cardiotoxicity
Structural properties of Silicon-Germanium and Germanium-Silicon Core-Shell Nanowires
Core-shell nanowires made of Si and Ge can be grown experimentally with excellent control for different sizes of both core and shell. We have studied the structural properties of Si/Ge and Ge/Si core-shell nanowires aligned along the [110] direction, with diameters up to 10.2 nm and varying core to shell ratios, using linear scaling Density Functional Theory (DFT). We show that Vegard's law, which is often used to predict the axial lattice constant, can lead to an error of up to 1%, underlining the need for a detailed ab initio atomistic treatment of the nanowire structure. We analyse the character of the intrinsic strain distribution and show that, regardless of the composition or bond direction, the Si core or shell always expands. In contrast, the strain patterns in the Ge shell or core are highly sensitive to the location, composition and bond direction. The highest strains are found at heterojunction interfaces and the surfaces of the nanowires. This detailed understanding of the atomistic structure and strain paves the way for studies of the electronic properties of core-shell nanowires and investigations of doping and structure defects
Exponential Distribution of Locomotion Activity in Cell Cultures
In vitro velocities of several cell types have been measured using computer
controlled video microscopy, which allowed to record the cells' trajectories
over several days. On the basis of our large data sets we show that the
locomotion activity displays a universal exponential distribution. Thus, motion
resulting from complex cellular processes can be well described by an
unexpected, but very simple distribution function. A simple phenomenological
model based on the interaction of various cellular processes and finite ATP
production rate is proposed to explain these experimental results.Comment: 4 pages, 3 figure
Integrating microarray analysis and the soybean genome to understand the soybeans iron deficiency response
<p>Abstract</p> <p>Background</p> <p>Soybeans grown in the upper Midwestern United States often suffer from iron deficiency chlorosis, which results in yield loss at the end of the season. To better understand the effect of iron availability on soybean yield, we identified genes in two near isogenic lines with changes in expression patterns when plants were grown in iron sufficient and iron deficient conditions.</p> <p>Results</p> <p>Transcriptional profiles of soybean (<it>Glycine max</it>, L. Merr) near isogenic lines Clark (PI548553, iron efficient) and IsoClark (PI547430, iron inefficient) grown under Fe-sufficient and Fe-limited conditions were analyzed and compared using the Affymetrix<sup>® </sup>GeneChip<sup>® </sup>Soybean Genome Array. There were 835 candidate genes in the Clark (PI548553) genotype and 200 candidate genes in the IsoClark (PI547430) genotype putatively involved in soybean's iron stress response. Of these candidate genes, fifty-eight genes in the Clark genotype were identified with a genetic location within known iron efficiency QTL and 21 in the IsoClark genotype. The arrays also identified 170 single feature polymorphisms (SFPs) specific to either Clark or IsoClark. A sliding window analysis of the microarray data and the 7X genome assembly coupled with an iterative model of the data showed the candidate genes are clustered in the genome. An analysis of 5' untranslated regions in the promoter of candidate genes identified 11 conserved motifs in 248 differentially expressed genes, all from the Clark genotype, representing 129 clusters identified earlier, confirming the cluster analysis results.</p> <p>Conclusion</p> <p>These analyses have identified the first genes with expression patterns that are affected by iron stress and are located within QTL specific to iron deficiency stress. The genetic location and promoter motif analysis results support the hypothesis that the differentially expressed genes are co-regulated. The combined results of all analyses lead us to postulate iron inefficiency in soybean is a result of a mutation in a transcription factor(s), which controls the expression of genes required in inducing an iron stress response.</p
Role of the Hsp90 cochaperone, FKBPL, in oestrogen receptor signalling and breast cancer growth and survival
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