21 research outputs found

    Image quality and high contrast improvements on VLT/NACO

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    NACO is the famous and versatile diffraction limited NIR imager and spectrograph with which ESO celebrated 10 years of Adaptive Optics at the VLT. Since two years a substantial effort has been put in to understanding and fixing issues that directly affect the image quality and the high contrast performances of the instrument. Experiments to compensate the non-common-path aberrations and recover the highest possible Strehl ratios have been carried out successfully and a plan is hereafter described to perform such measurements regularly. The drift associated to pupil tracking since 2007 was fixed in October 2011. NACO is therefore even better suited for high contrast imaging and can be used with coronagraphic masks in the image plane. Some contrast measurements are shown and discussed. The work accomplished on NACO will serve as reference for the next generation instruments on the VLT, especially those working at the diffraction limit and making use of angular differential imaging (i.e. SPHERE, VISIR, possibly ERIS).Comment: 14 pages, 5 figures, SPIE 2012 Astronomical Instrumentation Proceedin

    Status and new operation modes of the versatile VLT/NACO

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    This paper aims at giving an update on the most versatile adaptive optics fed instrument to date, the well known and successful NACO . Although NACO is only scheduled for about two more years at the Very Large Telescope (VLT), it keeps on evolving with additional operation modes bringing original astronomical results. The high contrast imaging community uses it creatively as a test-bench for SPHERE and other second generation planet imagers. A new visible wavefront sensor (WFS) optimized for Laser Guide Star (LGS) operations has been installed and tested, the cube mode is more and more requested for frame selection on bright sources, a seeing enhancer mode (no tip/tilt correction) is now offered to provide full sky coverage and welcome all kind of extragalactic applications, etc. The Instrument Operations Team (IOT) and Paranal engineers are currently working hard at maintaining the instrument overall performances but also at improving them and offering new capabilities, providing the community with a well tuned and original instrument for the remaining time it is being used. The present contribution delivers a non-exhaustive overview of the new modes and experiments that have been carried out in the past months.Comment: 10 pages, 7 figures, SPIE 2010 Astronomical Instrumentation Proceedin

    Surface Geometric and Electronic Structure of BaFe2As2(001)

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    BaFe2As2 exhibits properties characteristic of the parent compounds of the newly discovered iron (Fe)-based high-TC superconductors. By combining the real space imaging of scanning tunneling microscopy/spectroscopy (STM/S) with momentum space quantitative Low Energy Electron Diffraction (LEED) we have identified the surface plane of cleaved BaFe2As2 crystals as the As terminated Fe-As layer - the plane where superconductivity occurs. LEED and STM/S data on the BaFe2As2(001) surface indicate an ordered arsenic (As) - terminated metallic surface without reconstruction or lattice distortion. It is surprising that the STM images the different Fe-As orbitals associated with the orthorhombic structure, not the As atoms in the surface plane.Comment: 12 pages, 4 figure

    Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors

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    <p>Abstract</p> <p>Background</p> <p>Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of chondrosarcoma has been established - namely, the Swarm Rat Chondrosarcoma (SRC) - and shown to resemble the human disease. Previous studies with this model revealed that tumor microenvironment could significantly influence chondrosarcoma malignancy.</p> <p>Methods</p> <p>To examine the effect of the microenvironment, SRC tumors were initiated at different transplantation sites. Pyrosequencing assays were utilized to assess the DNA methylation of the tumors, and SAGE libraries were constructed and sequenced to determine the gene expression profiles of the tumors. Based on the gene expression analysis, subsequent functional assays were designed to determine the relevancy of the specific genes in the development and progression of the SRC.</p> <p>Results</p> <p>The site of transplantation had a significant impact on the epigenetic and gene expression profiles of SRC tumors. Our analyses revealed that SRC tumors were hypomethylated compared to control tissue, and that tumors at each transplantation site had a unique expression profile. Subsequent functional analysis of differentially expressed genes, albeit preliminary, provided some insight into the role that thymosin-β4, c-fos, and CTGF may play in chondrosarcoma development and progression.</p> <p>Conclusion</p> <p>This report describes the first global molecular characterization of the SRC model, and it demonstrates that the tumor microenvironment can induce epigenetic alterations and changes in gene expression in the SRC tumors. We documented changes in gene expression that accompany changes in tumor phenotype, and these gene expression changes provide insight into the pathways that may play a role in the development and progression of chondrosarcoma. Furthermore, specific functional analysis indicates that thymosin-β4 may have a role in chondrosarcoma metastasis.</p

    Code Coverage and Continuous Integration

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    This presentation is the code coverage and continuous integration section of the Better Scientific Software tutorial at ISC 2018. The presentation also includes link to hands-on for code coverage and demo of CI

    Small-angle, high-contrast exoplanet imaging with the L-band AGPM vector vortex coronagraph now offered at the VLT

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    In November 2012, we installed an L-band annular groove phase mask (AGPM) vector vortex coronagraph (VVC) inside NACO, the adaptive optics camera of ESO's Very Large Telescope. The mask, made out of diamond subwavelength gratings has been commissioned, science qualified, and is now offered to the community. Here we report ground-breaking on-sky performance levels in terms of contrast, inner working angle, and discovery space. This new practical demonstration of the VVC, coming a few years after Palomar's and recent record-breaking lab experiments in the visible (E. Serabyn et al. 2013, these proceedings), shows once again that this new-generation coronagraph has reached a high level of maturity.VORTE
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