Low-complexity medium access control protocols for QoS support in third-generation radio access networks

One approach to maximizing the efficiency of medium access control (MAC) on the uplink in a future wideband code-division multiple-access (WCDMA)-based third-generation radio access network, and hence maximize spectral efficiency, is to employ a low-complexity distributed scheduling control approach. The maximization of spectral efficiency in third-generation radio access networks is complicated by the need to provide bandwidth-on-demand to diverse services characterized by diverse quality of service (QoS) requirements in an interference limited environment. However, the ability to exploit the full potential of resource allocation algorithms in third-generation radio access networks has been limited by the absence of a metric that captures the two-dimensional radio resource requirement, in terms of power and bandwidth, in the third-generation radio access network environment, where different users may have different signal-to-interference ratio requirements. This paper presents a novel resource metric as a solution to this fundamental problem. Also, a novel deadline-driven backoff procedure has been presented as the backoff scheme of the proposed distributed scheduling MAC protocols to enable the efficient support of services with QoS imposed delay constraints without the need for centralized scheduling. The main conclusion is that low-complexity distributed scheduling control strategies using overload avoidance/overload detection can be designed using the proposed resource metric to give near optimal performance and thus maintain a high spectral efficiency in third-generation radio access networks and that importantly overload detection is superior to overload avoidance

A High-Resolution Sensor Network for Monitoring Glacier Dynamics

This paper provides an overview of a wide area wireless sensor network that was deployed on the calving front of the Helheim Glacier in Greenland during the summer of 2013. The purpose of the network was to measure the flow rate of the glacier using accurate satellite positioning data. The challenge in this extreme environment was to collect data in real time at the calving edge of the glacier. This was achieved using a solar powered 2.4-GHz Zigbee wireless sensor network operated in a novel hybrid cellular/mesh access architecture consisting of ice nodes communicating with base stations placed on the rock adjacent to the glacier. This highly challenging transmission environment created substantial signal outage conditions, which were successfully mitigated by a radio network diversity scheme. The network development and measurement campaign were highly successful yielding significant results on glacial dynamics associated with climate change

Quiescence: early evolutionary origins and universality do not imply uniformity

Cell cycle investigations have focused on relentless exponential proliferation of cells, an unsustainable situation in nature. Proliferation of cells, whether microbial or metazoan, is interrupted by periods of quiescence. The vast majority of cells in an adult metazoan lie quiescent. As disruptions in this quiescence are at the foundation of cancer, it will be important for the field to turn its attention to the mechanisms regulating quiescence. While often presented as a single topic, there are multiple forms of quiescence each with complex inputs, some of which are tied to conceptually challenging aspects of metazoan regulation such as size control. In an effort to expose the enormity of the challenge, I describe the differing biological purposes of quiescence, and the coupling of quiescence in metazoans to growth and to the structuring of tissues during development. I emphasize studies in the organism rather than in tissue culture, because these expose the diversity of regulation. While quiescence is likely to be a primitive biological process, it appears that in adapting quiescence to its many distinct biological settings, evolution has diversified it. Consideration of quiescence in different models gives us an overview of this diversity

Supercurrent transport through 1ee-periodic full-shell Coulomb islands

We experimentally investigate supercurrent through Coulomb islands, where island and leads are fabricated from semiconducting nanowires with fully surrounding superconducting shells. Applying flux along the wire yields a series of destructive Little-Parks lobes with reentrant supercurrent. We find Coulomb blockade with 2$e$ peak spacing in the zeroth lobe and 1$e$ average spacing, with regions of significant even-odd modulation, in the first lobe. Evolution of Coulomb-peak amplitude through the first lobe is consistent with a theoretical model of supercurrent carried predominantly by zero-energy states in the leads and the island.Comment: 11 pages, 5+5 figure

Evidence for Dirac nodes from quantum oscillations in SrFe2As2

We present a detailed study of quantum oscillations in the antiferromagnetically ordered pnictide compound SrFe2As2 as the angle between the applied magnetic field and crystalline axes is varied. Our measurements were performed on high-quality single crystals in a superconducting magnet, and in pulsed magnetic fields up to 60 T, allowing us to observe orbits from several small Fermi-surface pockets. We extract the cyclotron effective mass m☆ and frequency F for these orbits and track their values as the field is rotated away from the c axis. While a constant ratio of m☆/F is expected for a parabolic band, we observe deviations from this behavior. We conclude that this observation points to orbits derived from a band with Dirac dispersion near the Fermi level

Emotions and ethics: A Foucauldian framework for becoming an ethical educator

This paper provides examples of how a teacher and a principal construct their ‘ethical selves’. In doing so we demonstrate how Foucault's four-part ethical framework can be a scaffold with which to actively connect emotions to a personal ethical position. We argue that ethical work is and should be an ongoing and dynamic life long process rather than a more rigid adherence to a ‘code of ethics’ that may not meaningfully engage its adherents. We use Foucault's four-part framework of ethical practice as a framework through which an ‘ethical self’ can be purposely constructed. This is important work, as those who have authority over others must know how to monitor themselves against the misuse of the power of their positions

Neurocognitive function in HIV infected patients on antiretroviral therapy

OBJECTIVE To describe factors associated with neurocognitive (NC) function in HIV-positive patients on stable combination antiretroviral therapy. DESIGN We undertook a cross-sectional analysis assessing NC data obtained at baseline in patients entering the Protease-Inhibitor-Monotherapy-Versus-Ongoing-Triple therapy (PIVOT) trial. MAIN OUTCOME MEASURE NC testing comprised of 5 domains. Raw results were z-transformed using standard and demographically adjusted normative datasets (ND). Global z-scores (NPZ-5) were derived from averaging the 5 domains and percentage of subjects with test scores >1 standard deviation (SD) below population means in at least two domains (abnormal Frascati score) calculated. Patient characteristics associated with NC results were assessed using multivariable linear regression. RESULTS Of the 587 patients in PIVOT, 557 had full NC results and were included. 77% were male, 68% Caucasian and 28% of Black ethnicity. Mean (SD) baseline and nadir CD4+ lymphocyte counts were 553(217) and 177(117) cells/µL, respectively, and HIV RNA was <50 copies/mL in all. Median (IQR) NPZ-5 score was -0.5 (-1.2/-0) overall, and -0.3 (-0.7/0.1) and -1.4 (-2/-0.8) in subjects of Caucasian and Black ethnicity, respectively. Abnormal Frascati scores using the standard-ND were observed in 51%, 38%, and 81%, respectively, of subjects overall, Caucasian and Black ethnicity (p<0.001), but in 62% and 69% of Caucasian and Black subjects using demographically adjusted-ND (p = 0.20). In the multivariate analysis, only Black ethnicity was associated with poorer NPZ-5 scores (P<0.001). CONCLUSIONS In this large group of HIV-infected subjects with viral load suppression, ethnicity but not HIV-disease factors is closely associated with NC results. The prevalence of abnormal results is highly dependent on control datasets utilised. TRIAL REGISTRY ClinicalTrials.gov, NCT01230580

Detection and discrimination of herpes simplex viruses, haemophilus ducreyi, treponema pallidum, and calymmatobacterium (klebsiella) granulomatis from genital ulcers

Background. Genital ulcer disease (GUD) is commonly caused by pathogens for which suitable therapies exist, but clinical and laboratory diagnoses may be problematic. This collaborative project was undertaken to address the need for a rapid, economical, and sensitive approach to the detection and diagnosis of GUD using noninvasive techniques to sample genital ulcers. Methods. The genital ulcer disease multiplex polymerase chain reaction (GUMP) was developed as an inhouse nucleic acid amplification technique targeting serious causes of GUD, namely, herpes simplex viruses (HSVs), Haemophilus ducreyi, Treponema pallidum, and Klebsiella species. In addition, the GUMP assay included an endogenous internal control. Amplification products from GUMP were detected by enzyme linked amplicon hybridization assay (ELAHA). Results. GUMP-ELAHA was sensitive and specific in detecting a target microbe in 34.3% of specimens, including 1 detection of HSV-1, three detections of HSV-2, and 18 detections of T. pallidum. No H. ducreyi has been detected in Australia since 1998, and none was detected here. No Calymmatobacterium (Klebsiella) granulomatis was detected in the study, but there were 3 detections during ongoing diagnostic use of GUMP-ELAHA in 2004 and 2005. The presence of C. granulomatis was confirmed by restriction enzyme digestion and nucleotide sequencing of the 16S rRNA gene for phylogenetic analysis. Conclusions. GUMP-ELAHA permitted comprehensive detection of common and rare causes of GUD and incorporated noninvasive sampling techniques. Data obtained by using GUMP-ELAHA will aid specific treatment of GUD and better define the prevalence of each microbe among at-risk populations with a view to the eradication of chancroid and donovanosis in Australia.Ian M. Mackay, Gerry Harnett, Neisha Jeoffreys, Ivan Bastian, Kadaba S Sriprakash, David Siebert, and Theo P. Sloot

Balancing selection on MHC class I in wild brown trout Salmo trutta

Evidence is reported for balancing selection acting on variation at major histocompatibility complex (MHC) in wild populations of brown trout Salmo trutta. First, variation at an MHC class I (satr-uba)–linked microsatellite locus (mhc1) is retained in small S. trutta populations isolated above waterfalls although variation is lost at neutral microsatellite markers. Second, populations across several catchments are less differentiated at mhc1 than at neutral markers, as predicted by theory. The population structure of these fish was also elucidated.HEA PRTLI Cycle 3; Beaufort Marine Research Award: Fish population genetics. Irish Government NDP (2007-2014) administered by the Marine Institute; Inland Fisheries Ireland; Science Foundation Ireland (Microbial Phylogeography 05/FE1/B882)