Overcoming Restraint: Composing Verification of Foreign Functions with Cogent

Cogent is a restricted functional language designed to reduce the cost of developing verified systems code. Because of its sometimes-onerous restrictions, such as the lack of support for recursion and its strict uniqueness type system, Cogent provides an escape hatch in the form of a foreign function interface (FFI) to C code. This poses a problem when verifying Cogent programs, as imported C components do not enjoy the same level of static guarantees that Cogent does. Previous verification of file systems implemented in Cogent merely assumed that their C components were correct and that they preserved the invariants of Cogent's type system. In this paper, we instead prove such obligations. We demonstrate how they smoothly compose with existing Cogent theorems, and result in a correctness theorem of the overall Cogent-C system. The Cogent FFI constraints ensure that key invariants of Cogent's type system are maintained even when calling C code. We verify reusable higher-order and polymorphic functions including a generic loop combinator and array iterators and demonstrate their application to several examples including binary search and the BilbyFs file system. We demonstrate the feasibility of verification of mixed Cogent-C systems, and provide some insight into verification of software comprised of code in multiple languages with differing levels of static guarantees

Synthesis and characterisation of novel ru(II) complexes with selective deuteriation

The aim of my research was to investigate Ru(II) mixed ligand complexes through synthesis and characterisation and through the use of deuteriation. The location of the excited state in the dinuclear species was to be determined through use of selective deuteriation of ligands. Acid/ base dependency o f these 1,2,4-triazolecontaining complexes may be applied in the area of supramolecular chemistry due to its switch on/off effect. However to arrive at this stage a series of studies were necessary. In chapter 3, reveals the description of the synthesis of the starting material [Ru(L)2Cl2].2H2O, where L is bipyridyl, phenanthroline and biquinoline. This is followed by the deuteriation of these ligands (bpy, phen and biq) and the Hpytr and Hpztr ligands. The starting materials with the deuteriated ligands dg-bpy, dg-phen and di2-biq where consequently prepared .The synthesis and characterisation of the ligands 3-(pyridin-2-yl)-l,2,4-triazole, Hpytr and 3-(pyrazin-2-yl)-l,2,4-triazole, Hpztr and their complexes are shown in chapter 3. The use of deuteriation in the location of the excited state of the pztr' complexes was not as facile as first thought as the complex was found to have dual emitting properties due to close-lying excited states. New developments arose in the isolation of the stereoisomers of the pytr' and pztr complexes in collaboration with Dr. C. Villani, University of Rome, also a new concept of 99R u NMR was investigated of the pytr' and pztr isomers in collaboration with Prof. C. Elsevier, University of Amsterdam. Chapter 4 is the investigation of complexes containing the ligand 3-(pyrazin-2-yl)-5- (pyridin-2-yl)-l,2,4-triazole, Hppt. This ligand was synthesised and also deuteriated to prepare selectively deuteriated complexes as in chapter 3 with the same starting materials. The synthesis and characterisation was described in this chapter for these complexes and y9Ru NMR was obtained. Also a crystal structure of the N2 of the triazole ring to the pyrazine isomer of the ppf complex was achieved. Chapter 5 is the conclusive chapter of this text, which describes the synthesis of the dinuclear complexes of the ppf ligand, and this is prepared via two routes the indirect and the direct route. The indirect route is prepared using the isolated isomers of the monomers. The characterisation and selective deuteriation is discussed. From the redox and photophysical behaviour of the dinuclear complexes some theories were derived. Chapter 6 is conclusions and future work, which sums up the results o f this thesis and the consequential studies, which have evolved

Preventing Zoonotic Canine Leishmaniasis in Northeastern Brazil: Pet Attachment and Adoption of Community Leishmania Prevention

Visceral leishmaniasis (VL), caused by Leishmania infantum chagasi (L.i. chagasisyn. infantum) in northeastern Brazil, was responsible for 51,000 new VL cases from 1980 to 2003. Household presence of L. infantum-infected dogs is a major risk factor for human infection. Despite culling of dogs based on seropositivity, canine L. infantum seroprevalence remains near 20%, suggesting that dog culling is ineffective for preventing VL spread. We administered a cross-sectional survey to 224 households within 300 m of the homes of VL human patients diagnosed within the last year. The goal was to develop a model for voluntary preventative use based on characteristics and motivations of dog owners. We identified that owner knowledge deficiencies regarding canine transmission of L. infantum associated with increased risk of dog infection (odds ratio [OR] = 3.681, confidence interval [CI] = 1.223, 11.08). Higher owner education was associated with decreased levels of dog seropositivity (OR = 0.40, CI = 0.20, 0.81). Pet attachment (P = 0.036) and perception of risk/disease knowledge (P = 0.040) were significantly associated with willingness to voluntarily purchase canine VL prevention. These results highlight the importance of owner attachment to their pet in implementing reservoir-targeted zoonotic VL prevention

Citizen or consumer? Reconsidering energy citizenship

The transition to more sustainable energy systems has set about redefining the social roles and responsibilities of citizens. Implicit in this are expectations around participation, though the precise contours of what this might mean remain open. Debates around the energy transition have been skewed towards a normative construct of what it means to be a ‘good citizen’, the parameters for which are shaped by predetermined visions of statist and/or market-driven determinations of the energy systems of the future. This article argues that concepts such as ‘energy citizen’ are co-opted to reflect popular neoliberal discourses, and ignore crucial questions of unequal agency and access to resources. Paradoxically, official discourses that push responsibility for the energy transition onto the ‘citizen-as-consumer’ effectively remove agency from citizens, leaving them largely disconnected and disempowered. Consequently, energy citizenship needs to be reconceptualised to incorporate more collective and inclusive contexts for action. Considering how much energy consumption occurs in (traditionally female) domestic spheres, do conventional notions of citizenship (especially with regards to its associated rights and duties) need to be recalibrated in order for the concept to be usefully applied to the energy transition

Déjà vu experiences in anxiety

Déjà vu occurs when a novel event is experienced with an erroneous sense of familiarity. Memory researchers theorise that this arises due to an error in the processes underlying the recognition memory system. Research has indicated that there may be a link between high levels of anxiety and increased frequency and intensity of déjà vu, however there has been comparatively little characterisation of déjà vu as experienced by individuals with clinical anxiety. We used an online questionnaire to collect data from individuals self-reporting a clinical diagnosis of anxiety, as well as from age-matched controls. The Anxiety Group reported a significantly higher frequency of déjà vu episodes over the previous month than controls. They also reported experiencing déjà vu more frequently and with higher intensity during periods of high anxiety. In addition, the Anxiety Group reported finding déjà vu episodes significantly more distressing than the control group. The findings indicate that there are differences in déjà vu experienced by people reporting high levels of anxiety compared to healthy controls without an anxiety diagnosis. We discuss structural and neural mechanisms thought to underpin déjà vu in relation to these results.PostprintPeer reviewe

Management Factors Associated with Operation-Level Prevalence of Antibodies to Cache Valley Virus and Other Bunyamwera Serogroup Viruses in Sheep in the United States

A cross-sectional study was performed to identify operation-level risk factors associated with prevalence of antibody to Bunyamwera (BUN) serogroup viruses in sheep in the United States. Sera were obtained from 5150 sheep in 270 operations located in 22 states (three in the west, nine central states, and 10 in the east) and tested at a dilution of 1:20 by a plaque reduction neutralization test (PRNT) using Cache Valley virus (CVV). Antibodies that neutralized CVV were identified in 1455 (28%) sheep. Animal-level seroprevalence was higher in the east (49%) than the central (17%) and western (10%) states. A convenient subset (n = 509) of sera with antibodies that neutralized CVV was titrated and further analyzed by PRNT using all six BUN serogroup viruses that occur in the United States: CVV, Lokern virus (LOKV), Main Drain virus (MDV), Northway virus (NORV), Potosi virus (POTV), and Tensaw virus (TENV). Antibodies to CVV and LOKV were identified in sheep in all three geographic regions; MDV and POTV activity was detected in the central and eastern states, NORV activity was restricted to the west, and antibodies to TENV were not detected in any sheep. Several management factors were significantly associated with the presence of antibodies to BUN serogroup viruses. For instance, sheep housed during the lambing season inside structures that contained four walls and a roof and a door closed most of the time were more likely to be seropositive than other sheep. In contrast, herded/open-range sheep were less likely to be seropositive than their counterparts. These data can be used by producers to implement strategies to reduce the likelihood of BUN serogroup virus infection and improve the health and management practices of sheep

Testing mood-activated psychological markers for suicidal ideation

To what extent are death- and life-oriented psychological processes among suicidal individuals activated by mood? According to Teasdale’s (1988) Differential Activation Hypothesis, we would expect that negative mood-activated psychological processes are maladaptive among suicide ideators (vs. non-ideators) and predictive of subsequent suicidal ideation. This, however, has never been prospectively studied. To address this knowledge gap, we conducted a prospective study assessing psychological risk factors via the Death/Life Implicit Association Test (IAT) and the Suicide Stroop task before and after a temporary negative mood induction. Suicidal ideation was assessed one and six months later. Results based on Death/Life IAT performance largely supported hypotheses, such that suicide ideators demonstrated significantly weaker implicit identification with life after (vs. before) the negative mood induction. Non-ideators demonstrated no significant change, maintaining strong identification with life irrespective of mood. Of note, this baseline interaction may have been accounted for by depressive symptoms. Identification with death (vs. life) predicted greater likelihood of suicidal ideation one month later, controlling for depressive symptoms and baseline suicidal ideation. Only negative mood-activated identification with death predicted suicidal ideation six months later. Suicide Stroop scores did not change as a function of mood or predict subsequent suicidal ideation. Death/Life IAT findings support the Differential Activation Hypothesis and suggest that suicide ideators’ identification with life is more variable and easily weakened by negative mood relative to non-ideators. We encourage future work to consider the potential role of transient mood and the importance of measuring psychological processes that pertain to both death and life

Cogent: uniqueness types and certifying compilation

This paper presents a framework aimed at significantly reducing the cost of proving functional correctness for low-level operating systems components. The framework is designed around a new functional programming language, Cogent. A central aspect of the language is its uniqueness type system, which eliminates the need for a trusted runtime or garbage collector while still guaranteeing memory safety, a crucial property for safety and security. Moreover, it allows us to assign two semantics to the language: The first semantics is imperative, suitable for efficient C code generation, and the second is purely functional, providing a user-friendly interface for equational reasoning and verification of higher-level correctness properties. The refinement theorem connecting the two semantics allows the compiler to produce a proof via translation validation certifying the correctness of the generated C code with respect to the semantics of the Cogent source program. We have demonstrated the effectiveness of our framework for implementation and for verification through two file system implementations