Comprehensive HIV care and Anti-Retroviral Therapy in a conflict setting-outcomes, experiences, and lessons learned from Bukavu, Democratic Republic of Congo

2006 AIDS Conference in Toront

Public and Private Spheres of Neighborhood Disorder: Assessing Pathways to Violence Using Large-scale Digital Records

Objectives: “Broken windows” theory is an influential model of neighborhood change, but there is disagreement over whether public disorder leads to more serious crime. This article distinguishes between public and private disorder, arguing that large-scale administrative data provide new opportunities to examine broken windows theory and alternative models of neighborhood change. Method: We apply an ecometric methodology to two databases from Boston: 1,000,000+ 911 dispatches and indicators of physical disorder from 200,000+ requests for nonemergency services. Both distinguish between disorder in public and private spaces. A cross-lag longitudinal analysis was conducted using two full years of data (2011–2012). Results: The two databases provided six dimensions of physical and social disorder and crime. The cross-lag model revealed eight pathways by which one form of disorder or crime in 2011 predicted a significant increase in another in 2012. Although traditional interpretations of broken windows emphasize the role of public disorder, private conflict most strongly predicted future crime. Conclusions: Our results describe a social escalation model where future disorder and crime emerge not from public cues but from private disorder within the community, demonstrating how “big data” from administrative records, when properly measured and interpreted, represent a growing resource for studying neighborhood change.Sociolog

Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey

Short linear motifs (SLiMs) are functional stretches of protein sequence that are of crucial importance for numerous biological processes by mediating protein–protein interactions. These motifs often comprise peptides of less than 10 amino acids that modulate protein–protein interactions. While well-characterized in eukaryotic intracellular signaling, their role in prokaryotic signaling is less well-understood. We surveyed the distribution of known motifs in prokaryotic extracellular and virulence proteins across a range of bacterial species and conducted searches for novel motifs in virulence proteins. Many known motifs in virulence effector proteins mimic eukaryotic motifs and enable the pathogen to control the intracellular processes of their hosts. Novel motifs were detected by finding those that had evolved independently in three or more unrelated virulence proteins. The search returned several significantly over-represented linear motifs of which some were known motifs and others are novel candidates with potential roles in bacterial pathogenesis. A putative C-terminal G[AG].$motif found in type IV secretion system proteins was among the most significant detected. A KK$ motif that has been previously identified in a plasminogen-binding protein, was demonstrated to be enriched across a number of adhesion and lipoproteins. While there is some potential to develop peptide drugs against bacterial infection based on bacterial peptides that mimic host components, this could have unwanted effects on host signaling. Thus, novel SLiMs in virulence factors that do not mimic host components but are crucial for bacterial pathogenesis, such as the type IV secretion system, may be more useful to develop as leads for anti-microbial peptides or drugs

Ecometrics in the Age of Big Data: Measuring and Assessing "Broken Windows" Using Large-scale Administrative Records

The collection of large-scale administrative records in electronic form by many cities provides a new opportunity for the measurement and longitudinal tracking of neighborhood characteristics, but one that requires novel methodologies that convert such data into research-relevant measures. The authors illustrate these challenges by developing measures of “broken windows” from Boston’s constituent relationship management (CRM) system (aka 311 hotline). A 16-month archive of the CRM database contains more than 300,000 address-based requests for city services, many of which reference physical incivilities (e.g., graffiti removal). The authors carry out three ecometric analyses, each building on the previous one. Analysis 1 examines the content of the measure, identifying 28 items that constitute two independent constructs, private neglect and public denigration. Analysis 2 assesses the validity of the measure by using investigator-initiated neighborhood audits to examine the “civic response rate” across neighborhoods. Indicators of civic response were then extracted from the CRM database so that measurement adjustments could be automated. These adjustments were calibrated against measures of litter from the objective audits. Analysis 3 examines the reliability of the composite measure of physical disorder at different spatiotemporal windows, finding that census tracts can be measured at two-month intervals and census block groups at six-month intervals. The final measures are highly detailed, can be tracked longitudinally, and are virtually costless. This framework thus provides an example of how new forms of large-scale administrative data can yield ecometric measurement for urban science while illustrating the methodological challenges that must be addressed.Sociolog

Bidirectional magnetic nanowire shift register

We experimentally demonstrate a shift register based on an open-ended chain of ferromagnetic NOT gates which can support bidirectional data flow. Up to eight data bits are electrically input to the device, stored for extended periods without power, and then output either in a first in first out or last in first out scheme. Comparing to traditional transistor-based logic, this bidirectionality offers a range of devices that are reversible and not limited to only one mode of operation

Strategies for the Follow-up of Gravitational Wave Transients with the Cherenkov Telescope Array

The observation of the electromagnetic counterpart of gravitational-wave (GW) transient GW170817 demonstrated the potential in extracting astrophysical information from multimessenger discoveries. The forthcoming deployment of the first telescopes of the Cherenkov Telescope Array (CTA) observatory will coincide with Advanced LIGO/Virgo's next observing run, O3, enabling the monitoring of gamma-ray emission at E > 20 GeV, and thus particle acceleration, from GW sources. CTA will not be greatly limited by the precision of GW localization as it will be be capable of rapidly covering the GW error region with sufficient sensitivity. We examine the current status of GW searches and their follow-up effort, as well as the status of CTA, in order to identify some of the general strategies that will enhance CTA's contribution to multimessenger discoveries.Comment: 10 page

Chirality dependence of nanoscale ferromagnetic NOT gates

The behavior of a transverse domain wall (DW) interacting with a ferromagnetic NOT gate is studied with specific emphasis on the role of the DW chirality (sense of rotation of magnetization crossing the DW). We examine both the effect of the incoming DW chirality on the operation of the NOT gate and the effect of the gate on the DW chirality. We find that the chirality of the incoming DW does not affect the range of fields over which the NOT gate operates correctly. The effect of the NOT gate on the DW chirality depends on the chirality of the incoming DW: when the DW is incident on the NOT gate with the wide side of the DW on the inside of the V-shape formed by the gate, the chirality is conserved, but when the DW is incident on the gate with its wide side on the outside of the V-shape, the chirality may reverse

Direct measurement of stellar angular diameters by the VERITAS Cherenkov Telescopes

The angular size of a star is a critical factor in determining its basic properties. Direct measurement of stellar angular diameters is difficult: at interstellar distances stars are generally too small to resolve by any individual imaging telescope. This fundamental limitation can be overcome by studying the diffraction pattern in the shadow cast when an asteroid occults a star, but only when the photometric uncertainty is smaller than the noise added by atmospheric scintillation. Atmospheric Cherenkov telescopes used for particle astrophysics observations have not generally been exploited for optical astronomy due to the modest optical quality of the mirror surface. However, their large mirror area makes them well suited for such high-time-resolution precision photometry measurements. Here we report two occultations of stars observed by the VERITAS Cherenkov telescopes with millisecond sampling, from which we are able to provide a direct measurement of the occulted stars' angular diameter at the $\leq0.1$ milliarcsecond scale. This is a resolution never achieved before with optical measurements and represents an order of magnitude improvement over the equivalent lunar occultation method. We compare the resulting stellar radius with empirically derived estimates from temperature and brightness measurements, confirming the latter can be biased for stars with ambiguous stellar classifications.Comment: Accepted for publication in Nature Astronom

The Ensemble Photometric Variability of ~25000 Quasars in the Sloan Digital Sky Survey

Using a sample of over 25000 spectroscopically confirmed quasars from the Sloan Digital Sky Survey, we show how quasar variability in the rest frame optical/UV regime depends upon rest frame time lag, luminosity, rest wavelength, redshift, the presence of radio and X-ray emission, and the presence of broad absorption line systems. The time dependence of variability (the structure function) is well-fit by a single power law on timescales from days to years. There is an anti-correlation of variability amplitude with rest wavelength, and quasars are systematically bluer when brighter at all redshifts. There is a strong anti-correlation of variability with quasar luminosity. There is also a significant positive correlation of variability amplitude with redshift, indicating evolution of the quasar population or the variability mechanism. We parameterize all of these relationships. Quasars with RASS X-ray detections are significantly more variable (at optical/UV wavelengths) than those without, and radio loud quasars are marginally more variable than their radio weak counterparts. We find no significant difference in the variability of quasars with and without broad absorption line troughs. Models involving multiple discrete events or gravitational microlensing are unlikely by themselves to account for the data. So-called accretion disk instability models are promising, but more quantitative predictions are needed.Comment: 41 pages, 21 figures, AASTeX, Accepted for publication in Ap