BeppoSAX observations of the Seyfert 1 Galaxy NGC 3516

We present the results of two observations of the bright Seyfert 1 galaxy NGC 3516, obtained with BeppoSAX in 1996 November and 1997 March. Useful signal is detected between 0.2 and 60 keV, allowing for the first time the simultaneous observation of all main spectral features. The source was brighter by a factor 2 at the second epoch of observation. Both spectra present a strong Fe Kalpha line, and a reflection hump at high energy. An absorption edge at 0.8 keV is visible in the later spectrum, but not in the earlier one, indicating that this feature is strongly variable.Comment: to appear in : The Active X-ray Sky: Results from BeppoSAX and Rossi-XTE, Nuclear Physics B Proceedings Supplements, L. Scarsi, H. Bradt, P. Giommi and F. Fiore (eds.), Elsevier Science B.V. 4 pages LateX and 6 ps figures, using espcrc2 and epsfi

The Gravitational-wave Optical Transient Observer (GOTO)

The Gravitational-wave Optical Transient Observer (GOTO) is a wide-field telescope project focused on detecting optical counterparts to gravitational-wave sources. GOTO uses arrays of 40 cm unit telescopes (UTs) on a shared robotic mount, which scales to provide large fields of view in a cost-effective manner. A complete GOTO mount uses 8 unit telescopes to give an overall field of view of 40 square degrees, and can reach a depth of 20th magnitude in three minutes. The GOTO-4 prototype was inaugurated with 4 unit telescopes in 2017 on La Palma, and was upgraded to a full 8-telescope array in 2020. A second 8-UT mount will be installed on La Palma in early 2021, and another GOTO node with two more mount systems is planned for a southern site in Australia. When complete, each mount will be networked to form a robotic, dual-hemisphere observatory, which will survey the entire visible sky every few nights and enable rapid follow-up detections of transient sources

Complex relationships among personality traits, job characteristics, and work behaviors

The aim of the study was to investigate the additive, mediating, and moderating effects of personality traits and job characteristics on work behaviors. Job applicants (N = 161) completed personality questionnaires measuring extraversion, neuroticism, achievement motivation, and experience seeking. One and a half years later, supervisors rated the applicants' job performance, and the job incumbents completed questionnaires about skill variety, autonomy, and feedback, work stress, job satisfaction, work self-efficacy, and propensity to leave. LISREL was used to test 15 hypotheses. Perceived feedback mediated the relationship between achievement motivation and job performance. Extraversion predicted work self-efficacy and job satisfaction. Work stress mediated the relationship between neuroticism and job satisfaction. Job satisfaction and experience seeking were related to propensity to leave. Autonomy, skill variety, and feedback were related to job satisfaction

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

A population of >6 million people worldwide at high risk of Alzheimer’s disease (AD) are those with Down Syndrome (DS, caused by trisomy 21 (T21)), 70% of whom develop dementia during lifetime, caused by an extra copy of β-amyloid-(Aβ)-precursor-protein gene. We report AD-like pathology in cerebral organoids grown in vitro from non-invasively sampled strands of hair from 71% of DS donors. The pathology consisted of extracellular diffuse and fibrillar Aβ deposits, hyperphosphorylated/pathologically conformed Tau, and premature neuronal loss. Presence/absence of AD-like pathology was donor-specific (reproducible between individual organoids/iPSC lines/experiments). Pathology could be triggered in pathology-negative T21 organoids by CRISPR/Cas9-mediated elimination of the third copy of chromosome-21-gene BACE2, but prevented by combined chemical β and γ-secretase inhibition. We found that T21-organoids secrete increased proportions of Aβ-preventing (Aβ1-19) and Aβ-degradation products (Aβ1-20 and Aβ1-34). We show these profiles mirror in cerebrospinal fluid of people with DS. We demonstrate that this protective mechanism is mediated by BACE2-trisomy and cross-inhibited by clinically trialled BACE1-inhibitors. Combined, our data prove the physiological role of BACE2 as a dose-sensitive AD-suppressor gene, potentially explaining the dementia delay in ~30% of people with DS. We also show that DS cerebral organoids could be explored as pre-morbid AD-risk population detector and a system for hypothesis-free drug screens as well as identification of natural suppressor genes for neurodegenerative diseases