Goldfish: No More Attacks on Proof-of-Stake Ethereum

The latest message driven (LMD) greedy heaviest observed sub-tree (GHOST) consensus protocol is a critical component of proof-of-stake (PoS) Ethereum. In its current form, the protocol is brittle, as evidenced by recent attacks and patching attempts. We report on Goldfish, a considerably simplified candidate under consideration for a future Ethereum protocol upgrade. We prove that Goldfish satisfies the properties required of a drop-in replacement for LMD GHOST: Goldfish is secure in synchronous networks under dynamic participation, assuming a majority of the nodes (called validators) follows the protocol. Goldfish is reorg resilient (i.e., honestly produced blocks are guaranteed inclusion in the ledger) and supports fast confirmation (i.e., the expected confirmation latency is independent of the desired security level). We show that subsampling validators can improve the communication efficiency of Goldfish, and that Goldfish is composable with finality gadgets and accountability gadgets, which improves state-of-the-art ebb-and-flow protocols. Attacks on LMD GHOST exploit lack of coordination among honest validators, typically provided by a locking mechanism in classical BFT protocols. However, locking requires votes from a quorum of all participants and is not compatible with dynamic availability. Goldfish is powered by a novel coordination mechanism to synchronize the honest validators\u27 actions under dynamic participation. Experiments with our implementation of Goldfish demonstrate the practicality of this mechanism for Ethereum

Climate change effects and UV-B radiation in the Vojvodina region, Serbia under the SRES-A2

In this article we considered the extreme temperatures, precipitation and UV-B radiation in Vojvodina region, Serbia. We describe the actual climate conditions for the period 1981-2007 and applied a dynamic downscaling technique using the EBU-POM regional coupled climate model under the SRES-A2 scenario to assess the changes for the period 2021-2100. The results indicate that a warmer and drier climate in the Vojvodina region can be expected at the end of the century. Projection of climate indicates to a strong increase in the mean annual minimum temperatures, and much smaller increase in the mean annual maximum temperatures. The increase of both extreme temperatures is predicted to be the highest in the winter and the lowest in the summer. Mean annual precipitation is projected to increase toward the end of the first half of the 21st century and to decrease for the last 30 years of the 21st century. Precipitation amount will be the highest during the winter and spring. The model simulations show that, by the end of this century, annual mean UV-B dose will recover by 5.2%. Recovery will be faster in the first half of the 21st century and more slowly later on. The UV-B doses recovery is expected to be the highest during the autumn and spring

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Stability and Performance Analysis in an Uncertain World

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Some Results on Control Systems with Mixed Perturbations

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