Surface decontamination protocols for surgical treatment of peri-implantitis: A systematic review with meta-analysis

OBJECTIVE: To answer the following PICO question: “In patients requiring surgical treatment of peri‐implantitis (P), is any implant surface decontamination protocol (I) superior to others (C) in terms of clinical and radiographic parameters (O)?” METHODS: Randomized clinical trials (RCTs) comparing two or more decontamination protocols as part of the surgical treatment of peri‐implantitis were included. Two authors independently searched for eligible studies, screened titles and abstracts, did full‐text analysis, extracted data, and performed the risk‐of‐bias assessment. Whenever possible, results were summarized through random effects meta‐analyses. RESULTS: Twenty‐two manuscripts reporting on 16 RCTs were included, testing mechanical, chemical and physical decontamination protocols. All of them resulted in an improvement in clinical parameters; however, the superiority of specific protocols over others is mainly based on single RCTs. The use of titanium brushes and implantoplasty showed favorable results as single decontamination methods. Meta‐analyses indicated a lack of added effect of Er:Yag laser on probing pocket depth (PPD) reduction (n = 2, WMD = −0.24 mm, 95% confidence interval [CI] [−1.10; 0.63], p = .59); while systemic antimicrobials (amoxicillin or azithromycin) showed an added effect on treatment success ([PPD ≤5 mm, no bleeding or suppuration, no progressive bone loss]; n = 2, RR = 1.84, 95% CI [1.17;2.91], p = .008), but not in terms of PPD reduction (n = 2, WMD = 0.93 mm, 95% CI [−0.69; 2.55], p = .26), even if with substantial heterogeneity. CONCLUSIONS: No single decontamination method demonstrated clear evidence of superiority compared to the others. Systemic antibiotics, but not Er:Yag laser, may provide short‐term clinical benefits in terms of treatment success (CRD42020182303)

Association of thalassemia major and gingival inflammation: A pilot study

Peer reviewe

Masthead

PubMed: 31444906Aims: Periodontal diseases negatively affect implant osseointegration. Perturbations in non-neuronal cholinergic signalling mechanisms are associated with periodontitis; however, their role in generalized aggressive periodontitis (GAgP) is unknown. The aim of this prospective case–control study was to determine the relationship between non-neuronal cholinergic signalling mechanisms, secreted Ly-6/uPAR-related protein-1 (SLURP-1), interleukin-17 (IL-17) family cytokines and healing of dental implants in health and GAgP. Material and Methods: Thirteen GAgP patients and seven periodontally healthy individuals (PH) were recruited. Peri-implant crevicular fluid (PICF) was obtained at baseline and 1 month post-placement. Acetylcholine (ACh) levels and cholinesterase activity were determined biochemically. SLURP-1, IL-17A and IL-17E levels were determined by ELISA. Marginal bone loss (MBL) at 1 and 6 months post-placement was determined radiographically. Results: The concentration of ACh, cholinesterase activity and IL-17A levels was elevated in PICF of patients with GAgP compared to PH individuals at baseline and 1 month post-placement. The concentration of ACh and cholinesterase activity levels in PICF correlated with levels of IL-17A and MBL around implants 1 month post-placement in patients with GAgP. Conclusions: Non-neuronal cholinergic mechanisms may play a role in the aetiopathogenesis of GAgP and may directly or indirectly, through modulation of IL-17A, influence early implant osseointegration and potential long-term implant survival. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Lt

Apelin Enhances the Effects of Fusobacterium nucleatum on Periodontal Ligament Cells In Vitro.

This study aimed to explore effects of Fusobacterium nucleatum with or without apelin on periodontal ligament (PDL) cells to better understand pathomechanistic links between periodontitis and obesity. First, the actions of F. nucleatum on COX2, CCL2, and MMP1 expressions were assessed. Subsequently, PDL cells were incubated with F. nucleatum in the presence and absence of apelin to study the modulatory effects of this adipokine on molecules related to inflammation and hard and soft tissue turnover. Regulation of apelin and its receptor (APJ) by F. nucleatum was also studied. F. nucleatum resulted in elevated COX2, CCL2, and MMP1 expressions in a dose- and time-dependent manner. Combination of F. nucleatum and apelin led to the highest (p < 0.05) expression levels of COX2, CCL2, CXCL8, TNF-α, and MMP1 at 48 h. The effects of F. nucleatum and/or apelin on CCL2 and MMP1 were MEK1/2- and partially NF-κB-dependent. The combined effects of F. nucleatum and apelin on CCL2 and MMP1 were also observed at protein level. Moreover, F. nucleatum downregulated (p < 0.05) the apelin and APJ expressions. In conclusion, obesity could contribute to periodontitis through apelin. The local production of apelin/APJ in PDL cells also suggests a role of these molecules in the pathogenesis of periodontitis

Gestasyonel diyabetin klinik periodontal durum ve plazma NT-ProBNP düzeylerinin değerlendirilmesi

Amaç: Çok az araştırmada, gestasyonel diabetes mellitus (GDM) ile enflamatuvar periodontal hastalıkların olası ilişkisi incelenmiştir. Bu çalışmanın amacı, GDM'si olan ve olmayan gebelerde klinik periodontal durum ve plazma NT-ProBNP düzeylerinin karşılaştırmalı olarak incelenmesidir. Gereç ve Yöntemler: Yükleme sonrası üç saat boyunca saatlik kan sekeri ölçümleri, açlık glukoz, açlık insülin ve HOMA-IR değerleri belirlenerek GDM tanısı konan 43 gebe ve GDM'si olmayan 41 gebe olmak üzere toplam 84 kadın çalışmaya dahil edildi. Plazma NT-ProBNP değerlendirmesi için venöz kan alınarak plazma örnekleri ayrıldı. Klinik periodontal durumun değerlendirilmesi için sondalama derinliği (mm), klinik ataşman seviyesi (mm), plak ve kanama indeksleri (%) ağızdaki tüm dişlerin 4 bölgesinde ölçüldü. Gebelere ait polikistik over, düşük hikayesi, insülin direnci, sosyo-demografik veriler, doğum haftası ve bebeklerin doğum ağırlığı kaydedildi. İstatistiksel analizler için MannWhitney U Testi ve Pearson ki-kare testi kullanıldı. Bulgular: GDM'si olan gebelerde yaş, açlık glukoz, açlık insülin, HOMA-IR, 1., 2. ve 3. saat glukoz değerlerinin GDM'si olmayan gebelere göre daha yüksek olduğu belirlendi (p &lt; 0,05). Klinik periodontal veriler karşılaştırıldığında plak, kanama, ve sondalama derinliği ölçümleri her iki grupta benzer bulundu. Plazma NT-ProBNP seviyesi gruplar arasında anlamlı fark göstermedi. Sonuç: Çalışmamızın bulguları, GDM ile enflamatuvar periodontal hastalık şiddeti arasında anlamlı bir ilişki göstermemektedir. Ancak, konunun daha büyük çalışma gruplarında ve farklı biyokimyasal veriler aracılığıyla irdelenmesinin yararlı olacağını düşünüyoruz

Diabetes-related molecular signatures in infrared spectra of human saliva

WOS: 000290261500001PubMed ID: 20630088Background: There is an ongoing need for improvements in non-invasive, point-of-care tools for the diagnosis and prognosis of diabetes mellitus. Ideally, such technologies would allow for community screening. Methods: In this study, we employed infrared spectroscopy as a novel diagnostic tool in the prediction of diabetic status by analyzing the molecular and sub-molecular spectral signatures of saliva collected from subjects with diabetes (n = 39) and healthy controls (n = 22). Results: Spectral analysis revealed differences in several major metabolic components - lipid, proteins, glucose, thiocyanate and carboxylate - that clearly demarcate healthy and diseased saliva. The overall accuracy for the diagnosis of diabetes based on infrared spectroscopy was 100% on the training set and 88.2% on the validation set. Therefore, we have established that infrared spectroscopy can be used to generate complex biochemical profiles in saliva and identify several potential diabetes-associated spectral features. Conclusions: Infrared spectroscopy may represent an appropriate tool with which to identify novel diseases mechanisms, risk factors for diabetic complications and markers of therapeutic efficacy. Further study into the potential utility of infrared spectroscopy as diagnostic and prognostic tool for diabetes is warranted

What has COVID-19 taken from us and brought instead?

Buduneli, Nurcan/0000-0002-1590-5801WOS: 000539820700001PubMed: 32474987[No abstract available

Can we help smoking patients? How?

WOS: 000453409100001PubMed ID: 3046035

Ayse MAYDA: The first Turkish female orthodontist and a living centenary icon!

[No Abstract Available