Efek Antipiretik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih

Cassia siamea Lamk. (Johar) leaf is one of the Indonesian medicinal Simplicia which is empirically used by some people to overcome malaria disease. Traditional use of johar leaf against malaria disease might be effective to kill the malarial parasites or to reduce fever, because people who are suffering from malaria produce fever. This paper reports the antipyretic effect of the 70 % etanol extract of the johar leaf on the artificial fever in albino rats induced by chotypha vaccine. The result show that a dose of 3 mg/100 g b.w. of rat (equivalent to one thirths of man dose ) has antipyretic effect equivalent to acetosa! 30 mg/100 g b.w

Uji Toksisitas Akut Ekstrak Mahkota Dewa Pada Hewan Coba

Telah dilakukan uji toksisitas akut infus biji, infuse daging buah serta ekstrak daging buah mahkota dewa (Phaleria macrocarpa (Scheff) Boerl). Uji menggunakan cara Weill, dengan hewan uji mencit jantan dan betina. Ekstrak etanol dibuat dengan cara prokolasi menggunakan etanol 70%. Uji toksisitas dilakukan dengan mengamati jumlah kematian setelah 24 jam pemberian bahan uji, serta mengamati gelagat atau perilaku hewan uji. Data keamanan buah mahkota dewa menunjukkan harga W50 infus biji adalah 3,835 mg/10 g bb ip mencit; LD5o infus daging buah adalah 67,04 mg/10 g bb ip mencit dan harga LD50 ekstrak daging buah adalah 36,53 mg/10 g bb ip mencit. Dengan ekstrapolasi menggunakan cara Paget dan Barnes, dan kriteria Gleason, buah mahkota dewa tanpa biji, termasuk dalam katagori tidak toksik, namun biji mahkota dewa menunjukkan adanya efek-efek toksik. Karena itu perlu perhatian bagi masyarakat yang menggunakannya, untuk sama sekali tidak mengkonsumsi biji dan buah Mahkota Dewa, kecuali utuk pemakaian luar. Dari data pengamatan perilaku atau gelagat hewan uji, dapat diperkirakan arah penelitian farmakodinami lanjut adalah pada efek blockade sensorik, adrenergic namun terlihat adanya efek iritasi pada pemberian oral

Toksisitas Akut (Ld50) Dan Uji Gelagat Ekstrak Daun Teh Hijau (Camellia Sinensis (Linn.) Kunze) Pada Mencit

Among many kind of drinks, tea is the most preferable drink for Indonesian people. Compare to other drinks, tea has a lot of benefit to our healthy. Tea are able to prevent some diseases and help for recover process from simple diseasessuch as influenza, to chronic hard disease; that could cause death such as cancer. Variety of tea can be selected referring to the flavor. Acute toxicity test (Lethal Dose) has been conducted of the extract of green tea leave (Camellia sinensis (Linn.), Kunze.) to the safety and symptom test as well. The test used mice as an animal experiments. The acute toxicity test use Weil, C.S (1915) method for the acute toxicity test and Paget. GE and Barnes, JM (1964) method for symptom test, high dosage under LD50 value are given to the mice, while green tea leave extract is made by percolation according to the method in Indonesian Pharmacope III. One kilogram of green tea powder produced an extract of 375 g or 37.5% of rendemen (sample). The result showed, the LD50 value of green lea leave extract was 3.303 (2.10 - 5.14) mg/10 g body weight i.p. By extrapolating the value as per oral in mice based on Gleason test (1969), the extract was classified as a Practically Non Toxic (PNT). The symptom test proved that green tea leave extract in a dosage of 2,7 mg/10 g body weight influenced the nerve system

Toksisitas Subkronik Ekstrak Etanol Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih

The Indonesian people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk (daun johar) used for treatment offever as well as malaria. A lot ofpeople usually use it for a long period^ of time. It is preferable for medicinal plants to have no effect rather than toxic effects. Subchronic toxicity test of the 70% ethanolic extract of the leaf of Cassia siamea Lamk have been carried out on 72 male Spraque Dawley albino rats for 3 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of different dosages respectively 9,8 mg/100 g b.w.; 48 mg/100 g b.w. and 240 mg/100 g b.w. which means equivalent to lx; 5x and 25x the usual dose of man. The control group received water only. The result showed that the 70% ethanolic extract of the leaf of Cassia siamea Lamk. administered orally every day until 3 months, the dose of up to 240 mg/100 g b.w, equivalent to 25x the usual dose of man didn't show toxicological effect on the internal body organs of the test animals such as liver, lung, heart, spleen, kidney and intestine. Other parameters such as SGOT, SGPT, Hb, Ureum and Creatinin of blood serum didn't show significant differences

Kolesom (Talinum Triangulare Willd.) Tumbuhan Berkhasiat Afrodisiaka Yang Aman

KOLESOM (Talinum triangulare Willd.) TUMBUHAN BERKHASIAT AFRODISIAKA YANG AMA

Penelitian Toksisitas Subkronik Infus Daun Johar (Cassia Siamea Lamk.) Pada Tikus Putih

The Indonesian people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk. (claim johar,) used for treatment offevers/malaria and jaundice/hepatitis. A lot of people usually use it for long periods of time. It is preferable for medicinal plants to have no effect rather than toxic effects. Subchronic toxicity test of the infusion of the leaf of Cassia siamea Lamk. have been carried out on 72 female Wistar albino rats for 4 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of difference dosages respectively 25 mg/100 g b.w.; 250 mg/100 gb.w. and 500 mg/100 gb.w. that means equivalent to 5 x; 25 x and 50 x usual dose of man. The control group received water only. The results showed that the infusion of the leaf of Cassia siamea Lamk. administered orally, every day until 4 months, the dose of up to 500 mg/100 g b.w. didn't show toxicological effect on the internal body organs of the test animals such as liver, lung, heart, spleen, kidney and intestine

EFEK ANTIPIRETIK EKSTRAK ETANOL DAUN JOHAR (CASSIA SIAMEA LAMK.) PADA TIKUS PUTIH

Cassia siamea Lamk. (Johar) leaf is one of the Indonesian medicinal Simplicia which is empirically used by some people to overcome malaria disease. Traditional use of johar leaf against malaria disease might be effective  to kill the malarial parasites or to reduce fever, because people who are suffering from malaria produce fever. This paper reports the antipyretic effect of the 70 % etanol  extract of the johar leaf on the artificial fever in albino rats induced by chotypha vaccine. The result show that a dose of 3 mg/100 g b.w. of rat (equivalent to one thirths of man dose ) has antipyretic effect equivalent to acetosa! 30 mg/100 g b.w

PENELITIAN TOKSISITAS SUBKRONIK INFUS DAUN JOHAR (Cassia siamea Lamk.) PADA TIKUS PUTIH

<p class="Style5">The Indonesian people still empirically use medicinal plants to overcome their diseases or maintain their health. One of the medicinal plants is Cassia siamea Lamk. (claim johar,) used for treatment offevers/malaria and jaundice/hepatitis. A lot of people usually use it for long periods of time. It is preferable for medicinal plants to have no effect rather than toxic effects.</p> <p class="Style5">Subchronic toxicity test of the infusion of the leaf of Cassia siamea Lamk. have been carried out on 72 female Wistar albino rats for 4 months. The administration of the test materials were orally, every day except Sunday and there were three kinds of difference dosages respectively 25 mg/100 g b.w.; 250 mg/100 gb.w. and 500 mg/100 gb.w. that means equivalent to 5 x; 25 x and 50 x usual dose of man. The control group received water only.</p> <p class="Style5">The results showed that the infusion of the leaf of Cassia siamea Lamk. administered orally, every day until 4 months, the dose of up to 500 mg/100 g b.w. didn't show toxicological effect on the internal body organs of the test animals such as liver, lung, heart, spleen, kidney and intestine.</p