A STUDY ON ANTIOXIDANT AND ANTI-AGING PROPERTIES OF FEW MEDICINAL PLANTS

Objective: The present study was undertaken to appraise the antioxidant and antiaging properties of some important medicinal plants like Syzygium cumini L. (Jamun, the Indian Blackberry), Tinospora cordifolia L. (Giloy) and Trigonella foenum-graecum L. (Methi).Methods: The methanolic extracts of these plants were prepared, incubated with Pheochromocytoma (PC-12) cells and total antioxidant potential of these plants was determined by 2, 2-diphenylpicrylhydrazyl (DPPH) and Ferric reducing ability of plasma (FRAP) assay. Lipid peroxidation assay was also performed to compare the free radical generating potential of these plants. Lipofuscin estimation was done in methanolic extracts of these plants to check which extract can reduce the lipofuscin accumulation in cells which is an anti-aging parameter.Results: The highest inhibition of DPPH radical and ferric reducing ability (FRAP assay) was observed in methanolic extract of Syzygium cumini leaves followed by Trigonella foenum-graecum leaves and lowest inhibition was shown by Tinospora cordifolia leaf extracts. Lipid peroxidation assay done by determining the amount of Malondialdehyde(MDA) formed and highest levels of MDA was produced by Tinospora cordifolia leaf extracts followed by Trigonella foenum-graecum leaf extracts and lowest values were obtained were from Syzygium cumini leaf extracts. The anti-aging parameter which is a determination of lipofuscin pigments in PC-12 cells treated with methanolic extracts of different plants was also examined. Highest accumulation of lipofuscin pigment was observed in cells treated with Tinospora cordifolia leaf extracts followed by Trigonella foenum-graecum leaf extracts and lowest values were obtained were from Syzygium cumini leaf extracts.Conclusion: The results of these findings revealed that the plants which have highest antioxidant potential could be a potent source of anti-aging drugs.Â

Combined spinal epidural anaesthesia in a case of primigravida with coarctation of aorta with severe hypertension for elective lower segment caesarean section

Brojne su vrste događaja među kojima se svakodnevno susreću promotivne, specijalne, kulturno–zabavne, humanitarne, medijske, sportske, protokolarne, korporativne, događaje na novim medijima i privatne. Najčešći ciljevi događaja su pridobiti zanimanje i potporu idejama, oblikovati željeni imidž, ojačati ugled, učvrstiti veze s potencijalnim korisnicima, povećati publicitet i prodaju te pridobiti potrebna sredstava. Glavni elementi koji utječu na uspješnost događaja su vrijeme, lokacija, sadržaj, organizacija, proračun i komuniciranje. Obično je uključeno više osoba organiziranje događaja. U mnogim slučajevima korisno je osnovati organizacijski odbor i jasno dodijeliti uloge i odgovornosti odboru članovi. Trebao bi postojati upravitelj događaja imenovan koji ima sveukupnu kontrolu nad događajem u konačnici odgovorna za glavne odluke upute odbora. Uspješan menadžer treba imati sposobnost snaći se u svim situacijama, i predvidivim i nepredvidivim.There are numerous types of events that meet with promotional, special, cultural, entertainment, humanitarian, media, sports, protocol, corporate events, new and private media events every day. The most common goals of the event are to attract interest and support ideas, shape the desired image, strengthen reputation, strengthen relationships with potential users, increase publicity and sales, and gain the necessary resources. The main elements that influence the success of an event are time, location, content, organization, budget, and communication. Usually, more people are involved in organizing events. In many cases, it is useful to set up an organizational committee and clearly assign the roles and responsibilities of the members of the board. There should be a named event manager who has overall control over the event ultimately responsible for the board's main decisions. A successful manager should have the ability to compete in all situations, both foreseeable and unpredictable

A Qualitative Assessment among Personnel Working in Community-Led Development Program Settings Regarding Sexualized Substance Use

Sexualized substance use (SSU) is the practice of psychotropic substance use before or during sex to increase sexual pleasure. The growing use of SSU has a strong association with sexually transmitted infections (STIs). Community health mobilizers (CHMs) are agents who assist in decreasing the global burden of disease in the communities they serve. They work as unit managers, counselors, or field workers. The managers and counselors have a minimum of a bachelor’s degree, and field workers have a minimum of a higher secondary education. This study aimed to qualitatively assess the knowledge gaps regarding SSU among CHMs. In-depth interviews (IDIs) were conducted in New Delhi, India with nineteen CHMs. Majority of the CHMs were men (n = 9, 47%) followed by transgender (TG) persons (TG females n = 5, 26.3%; TG males n = 1, 5.2%), and women (n = 4, 21.1%). Knowledge gaps were identified among the CHMs regarding different types of sexualized substances, drug procurement, human immunodeficiency virus (HIV) infection prevention, and complex health issues associated with SSU. It suggested the need for periodic workshops and training for upgradation of existing knowledge and practices among the CHMs. This formative research may help social scientists to develop protocols for conducting multi-centric, community-based studies across the country for further validation and exploration

Knowledge, attitude, and practice of elementary school teachers toward emergency management of dental trauma in Sirmaur District, Himachal Pradesh: A questionnaire study

Background: Traumatic dental injuries (TDIs) are widespread in the population and are a serious dental public health problem among children. Dental trauma may cause both functional and esthetic problems, with possible impacts on the patient's quality of life. Aim: The aim of the study is to assess the knowledge, attitude, and practice of elementary school teachers regarding dental trauma and its management. Materials and Methods: A questionnaire study consisting of 12 closed-ended questions were used to interview 150 elementary school teachers who participated in this study. The questions assessed the knowledge and attitude of teachers toward their student's dental trauma and its management. Statistical analysis was performed using Statistical Packages of Social Sciences (SPSS) version 17.0. Results: Among 150 teachers, 54% had dealt with trauma to their students, 91.3% school teachers said that they would save the avulsed tooth, 64% had heard about reimplantation of tooth, and 37% school teachers stated that they would not carry the tooth in any media reflecting their lack of knowledge regarding management of avulsed tooth. Conclusion: As many teachers have a low level of knowledge regarding dental trauma, there is a need for greater awareness to improve knowledge and attitude of teachers related to the emergency management of TDIs in children by organizing educative and motivational programs

Comparative evaluation of shear bond strength of two adhesive systems before and after contamination with oral fluids: An In vitro study

Aim: This study aims to evaluate the effect of saliva and blood contamination on the shear bond strength (SBS) of self- and total-etch adhesive systems on enamel and dentin. Materials and Methods: Sample of 100 extracted noncarious primary molars were taken as experimental groups, which were divided into two groups: self-etch group and total-etch group containing fifty teeth each. These groups were further divided into five subgroups - 10 teeth each. The specimens were then subjected to contamination with saliva or blood; before and after application of adhesive agent, whereas, in control group, there was no contamination done before and after adhesive application. Fresh saliva and blood were used. After the bonding procedure, resin composite was built up with diameter and height of 3 mm. After that, the specimens were tested for SBS in universal testing machine at a crosshead speed of 1 cm/min. The results were then statistically analyzed using one-way ANOVA. Results: The results of the study revealed that the SBS of self-etch adhesive system was better than the total-etch adhesive system and there was significant difference found among various subgroups of total-etch group, i.e., when adhesive application was done before, after and without saliva or blood contamination. There was no significant difference found within the subgroups of self-etch group when adhesive application was done before, after, and without saliva contamination. In case of blood contamination, significant difference was found in SBS in both self- and total-etch groups