Objective: The present study was undertaken to appraise the antioxidant and antiaging properties of some important medicinal plants like Syzygium cumini L. (Jamun, the Indian Blackberry), Tinospora cordifolia L. (Giloy) and Trigonella foenum-graecum L. (Methi).Methods: The methanolic extracts of these plants were prepared, incubated with Pheochromocytoma (PC-12) cells and total antioxidant potential of these plants was determined by 2, 2-diphenylpicrylhydrazyl (DPPH) and Ferric reducing ability of plasma (FRAP) assay. Lipid peroxidation assay was also performed to compare the free radical generating potential of these plants. Lipofuscin estimation was done in methanolic extracts of these plants to check which extract can reduce the lipofuscin accumulation in cells which is an anti-aging parameter.Results: The highest inhibition of DPPH radical and ferric reducing ability (FRAP assay) was observed in methanolic extract of Syzygium cumini leaves followed by Trigonella foenum-graecum leaves and lowest inhibition was shown by Tinospora cordifolia leaf extracts. Lipid peroxidation assay done by determining the amount of Malondialdehyde(MDA) formed and highest levels of MDA was produced by Tinospora cordifolia leaf extracts followed by Trigonella foenum-graecum leaf extracts and lowest values were obtained were from Syzygium cumini leaf extracts. The anti-aging parameter which is a determination of lipofuscin pigments in PC-12 cells treated with methanolic extracts of different plants was also examined. Highest accumulation of lipofuscin pigment was observed in cells treated with Tinospora cordifolia leaf extracts followed by Trigonella foenum-graecum leaf extracts and lowest values were obtained were from Syzygium cumini leaf extracts.Conclusion: The results of these findings revealed that the plants which have highest antioxidant potential could be a potent source of anti-aging drugs.Â
