Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant

Transplantation and immunomodulatio

Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients

A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia

PLANTAS HOSPEDERAS DEL GEMINIVIRUS DEL RIZADO AMARILLO DE LA HOJA DE TOMATE (TYLCV-Is)'

Con la finalidad de conseguir métodos de protecciôn de tomate contra la penetration temprana de "moscas blancas" Bemisia tabaci (Genn.) (Homoptera: Aleyrodidae), vectores del Virus del Rizado Amarillo de la Hoja de Tomate (TYLCV), se evaluaron 9 métodos de protecciôn de semilleros, durante el periodo julio-septiembre de 1995. Se observô eue los tratamientos con Cobertura (mulch) de cascarilla de arroz, Cobertura de plâstico amarillo y plâstico color plateado tuvieron las poblaciones mâs altas de adultos de B. tabaci, mientras que las de los tratamientos del insecticida sistémico Imidacloprid, del Testigo y de dos tûneles de mallas (AntiVirus® y Avgol®) fiieron muy inferiores. Para la presencia de sintomas de geminivirosis, los tratamientos malla AntiVirus®, malla Avgol® y Barrera viva con sorgo fueron significativamente mâs bajos que los demâs tratamientos. En cuanto al efecto sobre el desarrollo de las plantas tomando como parâmetro la lloraciôn y fructification en los diferentes tratamientos, se observô que ésta fue mâs temprana en los tratamientos cobertura de plâstico amarillo, cobertura de plâstico plateado, testigo cobertura con cascarilla de arroz y banda amarilla pegante. Una cobertura de las plantas con mallas por 30, 45 ô 60 dias conlleva un atraso en el desarrollo. Se comprobô que la protecciôn de las plantas con mallas resultan en temperaturas mâs elevadas dentro de los canteros, con respecto a los demâs tratamientos

Most relevant neuropathic pain treatment and Chronic Low Back Pain Management guidelines: A Change Pain Latin America advisory panel consensus

Objective. Chronic pain conditions profoundly affect the daily living of a significant number of people and are a major economic and social burden, particularly in developing countries. The Change Pain Latin America (CPLA) advisory panel aimed to identify the most appropriate guidelines for the treatment of neuropathic pain (NP) and chronic low back pain (CLBP) for use across Latin America. Methods. Published systematic reviews or practice guidelines were identified by a systematic search of PubMed, the Guidelines Clearinghouse, and Google. Articles were screened by an independent reviewer, and potential candidate guidelines were selected for more in-depth review. A shortlist of suitable guidelines was selected and critically evaluated by the CPLA advisory panel. Results. Searches identified 674 and 604 guideline articles for NP and CLBP, respectively. Of these, 14 guidelines were shortlisted for consensus consideration, with the following final selections made: • 'Recommendations for the pharmacological management of neuropathic pain from the Neuropathic Pain Special Interest Group in 2015-pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis.' • 'Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American College of Physicians and the American Pain Society' (2007). Conclusions. The selected guidelines were endorsed by all members of the CPLA advisory board as the best fit for use across Latin America. In addition, regional considerations were discussed and recorded. We have included this expert local insight and advice to enhance the implementation of each guideline across all Latin American countries. © 2017 American Academy of Pain Medicine

Most relevant neuropathic pain treatment and Chronic Low Back Pain Management guidelines: A Change Pain Latin America advisory panel consensus

Objective. Chronic pain conditions profoundly affect the daily living of a significant number of people and are a major economic and social burden, particularly in developing countries. The Change Pain Latin America (CPLA) advisory panel aimed to identify the most appropriate guidelines for the treatment of neuropathic pain (NP) and chronic low back pain (CLBP) for use across Latin America. Methods. Published systematic reviews or practice guidelines were identified by a systematic search of PubMed, the Guidelines Clearinghouse, and Google. Articles were screened by an independent reviewer, and potential candidate guidelines were selected for more in-depth review. A shortlist of suitable guidelines was selected and critically evaluated by the CPLA advisory panel. Results. Searches identified 674 and 604 guideline articles for NP and CLBP, respectively. Of these, 14 guidelines were shortlisted for consensus consideration, with the following final selections made: • 'Recommendations for the pharmacological management of neuropathic pain from the Neuropathic Pain Special Interest Group in 2015-pharmacotherapy for neuropathic pain in adults: A systematic review and meta-analysis.' • 'Diagnosis and treatment of low back pain: A joint clinical practice guideline from the American College of Physicians and the American Pain Society' (2007). Conclusions. The selected guidelines were endorsed by all members of the CPLA advisory board as the best fit for use across Latin America. In addition, regional considerations were discussed and recorded. We have included this expert local insight and advice to enhance the implementation of each guideline across all Latin American countries. © 2017 American Academy of Pain Medicine

Physical properties of furniture panels from macadamia shells

Most food industry activities result in large amounts of by-product that are often treated as waste and sent to landfill. In Australia, the macadamia nut industries generate as much as 28,000 tonnes of empty shells on an annual basis. These by products are under-utilized, often used for garden mulching or ground and used for animal filler, or else incinerated, as their disposal in landfill is cost-prohibitive, through sheer volume. However, these by-products are perfectly suited to the manufacture of panels, as they come clean and dry after processing, and present excellent physical properties when exposed to high humidity environments, particularly when compared to softwood. This makes them suited to applications such as panel furniture in high moisture environments, including kitchen and bathroom sink countertops or drawers where dimensional, swelling and adhesive problems are often an issue.This paper presents results of research into panels made from macadamia industry by-products in Australia, identified as being particularly abundant and underused. The matrices of these composite materials have been chosen from non-toxic and organic bonding agents, such as castor oil based adhesives. The present study considers and explores the suitability of these materials for high-moisture environment panel applications. Results are presented for the main physical properties and are compared with mixes already available in the market.The results show that these new materials compare well with commercially available materials, exceeding their performance in several cases, particularly with respect to water absorption and thickness swelling. These new panels have the potential to become a sustainable replacement option for high-humidity environment furniture particleboards, made with waste resource

Safety and immunogenicity of the Cuban heptavalent pneumococcal conjugate vaccine in healthy infants. Results from a double-blind randomized control trial Phase I

Background: Cuba has a new pneumococcal conjugate vaccine candidate (PCV7-TT). This study evaluates the safety and immunogenicity in healthy infants using 2p+1 vaccination schedule. Methods: A phase I, controlled, randomized and double blind clinical trial was designed. 30 unvaccinated healthy infants were included. 20 subjects were assigned to study group (PCV7-TT) and 10 to control group (Synflorix®) to receive the vaccines at 7, 8 months of age (primary series) and 11 months (booster dose). Blood samples were collected 30 days after second dose and post booster for antibodies measure analysis by ELISA and OPA. The statistics analysis included the frequency of occurrence for adverse events and the immune response. Non-parametric tests were used to compare the immune response. The clinical trial was published in the Cuban Public Register of Clinical Trials with code RPCEC00000173 available at http://registroclinico.sld.cu. Results: Overall, the safety profile of PCV7-TT was similar to Synflorix®. Local reactions were predominant and systemic events were mild in severity. Swelling and redness were frequently associated with PCV7-TT mainly after the first dose (50% and 40% respectively). 15% and 10% of subject reported severe swelling after first dose with PCV7-TT and after second dose with Synflorix®. Mild fever (≥38–≤39), vomiting and sleep disturb were the systemic events reported. 100% of infants achieved pneumococcal IgG antibody concentrations ≥0.35 µg/ml after booster dose for serotypes 1, 14, 18C and 19F in each vaccine group. For serotypes 5, 6B and 23F, more than 80% infants vaccinated with Synflorix® or PCV7-TT achieved protective IgG GMC ≥ 0.35 µg/ml after booster dose. OPA proportion’s responders to the seven common serotypes were 89.5% or more after the primary dose and 100% after booster dose in vaccinated with PCV7-TT. Conclusions: The Cuban PCV7-TT is safe, well tolerated and immunogenic in healthy infants

Sustainable furniture panel composites from forestry and food industry by-products in Australia

This paper presents results of research into polypropylene based wood plastic composites reinforced with food industry and forestry by-products, identified as being particularly abundant in Australia but underutilised, viz. macadamia shells, pine cones and eucalyptus capsules. The present study considers and explores the suitability of these materials for high-moisture environment furniture panel applications. Results are presented for the relevant physical and mechanical properties and are compared with a conventional wood plastic composite utilising radiata pine as the filler.The water absorption and swelling were generally lower in the forestry and food industry by-product composites than in the conventional radiata pine composite with the best results being obtained for the macadamia nut shell composite. The mechanical properties were however poorer than those of the conventional wood plastic composite. Nonetheless, it is considered that the forestry and food industry byproduct composites do provide a viable material and have the potential to become a sustainable replacement option for high-humidity environment furniture panel composites. This would provide much better utilisation of these currently undervalued agricultural waste resources

Executive summary of the 2020 clinical practice guidelines for the management of hypertension in the Philippines

Abstract Hypertension is the most common cause of death and disability worldwide with its prevalence rising in low to middle income countries. It remains to be an important cause of morbidity and mortality in the Philippines with poor BP control as one of the main causes. Different societies and groups worked and collaborated together to develop the 2020 Philippine Clinical Practice Guidelines of hypertension arising for the need to come up with a comprehensive local practice guideline for the diagnosis, treatment, and follow up of persons with hypertension. A technical working group was organized into six clusters that analyzed the 30 clinical questions commonly asked in practice, looking into the definition of hypertension, treatment thresholds, blood pressure targets, and appropriate medications to reach targets. This guideline also includes recommendations for the specific management of hypertension among individuals with uncomplicated hypertension, hypertension among those with diabetes, stroke, chronic kidney disease, as well as hypertension among pregnant women and pediatric populations. It also looked into the appropriate screening and monitoring of patients when managing hypertension, and identification of groups who are at high risk for cardiovascular (CV) events. The ADAPTE process was used in developing the statements and recommendations which were then presented to a panel of experts for discussion and approval to come up with the final statements. This guideline aims to aid Filipino healthcare professionals to provide evidence‐based care for persons with hypertension and help those with hypertension adequately control their blood pressure and reduce their CV ris