Rural Parent\u27s Experiences of Stress and Resilience During the COVID-19 Pandemic and School Closure

The COVID-19 pandemic has generated social and economic disruptions, resulting in cascading effects on the health and well-being of global citizens. However, little research has focused on how COVID-19 has affected rural regions, despite rurality being a critical factor for understanding community impact and response to the pandemic. The purpose of this phenomenological study was to explore the experiences of rural Nebraskan parents with young children during the COVID-19 pandemic and school shutdown, and the strategies they used to support their families during that time. We conducted individual and group interviews with 22 white, non-Hispanic mothers living in rural towns, villages, and farms in the Great Plains region of the United States. Thematic analysis was used to generate the following themes related to pandemic challenges: Impacts on Children’s Education and Development, Impact on Parent’s Work, and Social-emotional Impacts. Additionally, we generated themes related to the ways that rural parents responded to those challenges: Successful Parenting Strategies, Children’s Strategies, Using Community Provided Resources, Finding Unexpected Benefits, and Hope. This study is meaningful because it documented the impact of the COVID-19 pandemic and school shutdown on rural families with young children, and their responses to pandemic-related stressors. Our findings provide further insights into families’ experiences of how COVID-19 affected their lives. Limitations and future directions are also discussed

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

Implementing CS1 With Embedded Instructional Research Design in Laboratories

Closed laboratories are becoming an increasingly popular approach to teaching introductory computer science courses. Unlike open laboratories that tend to be an informal environment provided for students to practice their skills with attendance optional, closed laboratories are structured meeting times that support the lecture component of the course, and attendance is required. This paper reports on an integrated approach to designing, implementing, and assessing laboratories with an embedded instructional research design. The activities reported here are parts of a department-wide effort not only to improve student learning in computer science and computer engineering (CE) but also to improve the agility of the Computer Science and Engineering Department in adapting the curriculum to changing technologies, incorporate research, and validate the instructional strategies used. This paper presents the design and implementation of the laboratories and the results and analysis of student performance. Also described in this paper is cooperative learning in the laboratories and its impact on student learning

L.-K.: Implementing CS1 with Embedded Instructional Research Design in Laboratories

Abstract—Closed laboratories are becoming an increasingly popular approach to teaching introductory computer science courses. Unlike open laboratories that tend to be an informal environment provided for students to practice their skills with attendance optional, closed laboratories are structured meeting times that support the lecture component of the course, and attendance is required. This paper reports on an integrated approach to designing, implementing, and assessing laboratories with an embedded instructional research design. The activities reported here are parts of a departmentwide effort not only to improve student learning in computer science and computer engineering (CE) but also to improve the agility of the Computer Science and Engineering Department in adapting the curriculum to changing technologies, incorporate research, and validate the instructional strategies used. This paper presents the design and implementation of the laboratories and the results and analysis of student performance. Also described in this paper is cooperative learning in the laboratories and its impact on student learning

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness