5 research outputs found
New filovirus disease classification and nomenclature.
The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision
Responding to the Challenge of the Dual COVID-19 and Ebola Epidemics in the Democratic Republic of Congo—Priorities for Achieving Control
Clinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congo
CITATION: Nachega, J. B. et al. 2020. Clinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congo. American Journal of Tropical Medicine and Hygiene, 103(6):2419–2428, doi:10.4269/ajtmh.20-1240.The original publication is available at https://www.ajtmh.orgENGLISH ABSTRACT: Little is known about the clinical features and outcomes of SARS-CoV-2 infection in Africa. We conducted a
retrospective cohort study of patients hospitalized for COVID-19 between March 10, 2020 and July 31, 2020 at seven
hospitals in Kinshasa, Democratic Republic of the Congo (DRC). Outcomes included clinical improvement within 30 days
(primary) and in-hospital mortality (secondary). Of 766 confirmed COVID-19 cases, 500 (65.6%) were male, with a median
(interquartile range [IQR]) age of 46 (34–58) years. One hundred ninety-one (25%) patients had severe/critical disease
requiring admission in the intensive care unit (ICU). Six hundred twenty patients (80.9%) improved and were discharged
within 30 days of admission. Overall in-hospital mortality was 13.2% (95% CI: 10.9–15.8), and almost 50% among those in
the ICU. Independent risk factors for death were age < 20 years (adjusted hazard ratio [aHR] = 6.62, 95% CI: 1.85–23.64),
40–59 years (aHR = 4.45, 95% CI: 1.83–10.79), and ³ 60 years (aHR = 13.63, 95% CI: 5.70–32.60) compared with those
aged 20–39 years, with obesity (aHR = 2.30, 95% CI: 1.24–4.27), and with chronic kidney disease (aHR = 5.33, 95% CI:
1.85–15.35). In marginal structural model analysis, there was no statistically significant difference in odds of clinical
improvement (adjusted odds ratio [aOR] = 1.53, 95% CI: 0.88–2.67, P = 0.132) nor risk of death (aOR = 0.65, 95% CI:
0.35–1.20) when comparing the use of chloroquine/azithromycin versus other treatments. In this DRC study, the high
mortality among patients aged < 20 years and with severe/critical disease is of great concern, and requires further
research for confirmation and targeted interventions.https://www.ajtmh.org/view/journals/tpmd/103/6/article-p2419.xmlPublisher's versio
Ebola Virus Disease Outbreak — Democratic Republic of the Congo, August 2018–November 2019
New filovirus disease classification and nomenclature
The recent large outbreak of Ebola virus disease (EVD) in Western Africa resulted in greatly increased accumulation of human genotypic, phenotypic and clinical data, and improved our understanding of the spectrum of clinical manifestations. As a result, the WHO disease classification of EVD underwent major revision.Federal funds from the National Cancer Institute, National Institutes of Health (NIH), under Contract No. HHSN261200800001E (I.C.). G.I. is grateful for support from the Italian Ministry of Health, grant Ricerca Corrente, Research programme n.1. The UK Public Health Rapid Support Team (D.G.B.) is funded by the UK Department of Health and Social Care.https://www.nature.com/nrmicrohj2020Veterinary Tropical Disease